Acta medica (Hradec Kralove)最新文献_第4页

Rapidly Progressive Interstitial Lung Disease Associated with Melanoma Differentiation-Associated Gene 5 Antibody. 快速进展间质性肺疾病与黑色素瘤分化相关基因5抗体

Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2022.15

Yosuke Maezawa, Mami Narita, Riho Tanimura, Sou Hattori, Hiroaki Satoh

{"title":"Rapidly Progressive Interstitial Lung Disease Associated with Melanoma Differentiation-Associated Gene 5 Antibody.","authors":"Yosuke Maezawa, Mami Narita, Riho Tanimura, Sou Hattori, Hiroaki Satoh","doi":"10.14712/18059694.2022.15","DOIUrl":"https://doi.org/10.14712/18059694.2022.15","url":null,"abstract":"Anti-melanoma differentiation-associated gene-5 (MDA-5) antibody is an autoantibody found in patients with dermatomyositis. These antibody-positive patients are clinically characterized by complications of rapidly progressive interstitial pneumonia resistant to treatment and with poor prognosis. We describe herein a patient with MDA-5 antibody-positive interstitial lung disease, which progressed rapidly to death after a period of slow progress. Recently, attention has been paid to the similarities in clinical courses and CT images between MDA-5 antibody-positive interstitial lung disease and coronavirus disease 2019 (COVID-19)-associated pneumonia. Patients with MDA-5 antibody do not always have diffuse and evenly distributed bilateral opacities at the time of first presentation. This patient had significant laterality of such opacities. It should be considered that MDA-5 antibody-positive patients with such laterality in opacities might progress rapidly. Chest physicians, dermatologists, and dermatologists need to be aware of the characteristics of the disease for optimal treatment choices.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"65 1","pages":"37-40"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40564592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose-Dependency of Toxic Signs and Outcomes of Paraoxon Poisoning in Rats. 对氧磷中毒大鼠毒性体征和结局的剂量依赖性。

Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2022.10

Žana M Maksimović, Ranko Škrbić, Miloš P Stojiljković

{"title":"Dose-Dependency of Toxic Signs and Outcomes of Paraoxon Poisoning in Rats.","authors":"Žana M Maksimović, Ranko Škrbić, Miloš P Stojiljković","doi":"10.14712/18059694.2022.10","DOIUrl":"https://doi.org/10.14712/18059694.2022.10","url":null,"abstract":"Organophosphorus compounds induce irreversible inhibition of acetylcholinesterase, which then produces clinically manifested muscarinic, nicotinic and central effects. The aim of the study was to analyse the clinical signs of acute paraoxon poisoning in rats and to determine the relationship between the intensity of signs of poisoning and the dose of paraoxon and/or the outcome of poisoning in rats. Animals were treated with either saline or atropine (10 mg/kg intramuscularly). The median subcutaneous lethal dose (LD50) of paraoxon was 0.33 mg/kg and protective ratio of atropine was 2.73. The presence and intensity of signs of poisoning in rats (dyspnoea, lacrimation, exophthalmos, fasciculations, tremor, ataxia, seizures, piloerection, stereotypic movements) were observed and recorded for 4 h after the injection of paraoxon. Intensity of these toxic phenomena was evaluated as: 0 - absent, 1 - mild/moderate, 2 - severe. Fasciculations, seizures and tremor were more intense at higher doses of paraoxon and in non-survivors. In unprotected rats piloerection occurred more often and was more intense at higher doses of paraoxon as well as in non-survivors. In atropine-protected rats, piloerection did not correlate with paraoxon dose or outcome of poisoning. The intensity of fasciculations and seizures were very strong prognostic parameters of the poisoning severity.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"65 1","pages":"8-17"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40476027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iatrogenic Fracture of the Lower Jaw: A Rare Complication of Lower Molar Extraction. 医源性下颌骨折:一种罕见的下颌磨牙拔除并发症。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.18

Radovan Mottl, Martina Kunderová, Radovan Slezák, Jan Schmidt

{"title":"Iatrogenic Fracture of the Lower Jaw: A Rare Complication of Lower Molar Extraction.","authors":"Radovan Mottl, Martina Kunderová, Radovan Slezák, Jan Schmidt","doi":"10.14712/18059694.2021.18","DOIUrl":"https://doi.org/10.14712/18059694.2021.18","url":null,"abstract":"Iatrogenic mandible fracture is a rare complication of a tooth extraction with an incidence between 0.0033-0.0034%. This study retrospectively analyzes a total of 8 patients who underwent lower molar extraction associated with mandible fracture during tooth removal in the period from April 2006 to March 2019. The assessed parameters were age and sex of patients, method of tooth extraction, side distribution of fracture, type of extracted tooth, the position of a lower third molar, presence of bone pathological lesion formed in connection with a tooth, displacement of bone fragments, and sensory impairment in the innervation area of the mental nerve. The position and impaction of the lower third molars were evaluated according to Pell and Gregory's classification and Winter's classification. One fracture was left-sided, and 7 fractures were right-sided. In 6 cases, Winter's extraction elevator was used. In 7 patients, the mandible fracture was treated surgically by performing stable osteosynthesis with the plates and screws. One patient was treated conservatively. This work analyzes the causes of iatrogenic mandible fractures and provides recommendations to reduce the risk of their occurrence.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"64 2","pages":"101-107"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39261813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Innervation Patterns of the Pronator Teres Muscle and Their Possible Role in Neurotization: A Systematic Review of Cadaveric Studies. 旋前圆肌的神经支配模式及其在神经化中的可能作用:对尸体研究的系统回顾。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.14

Bhagath Kumar Potu, M V Ravishankar

{"title":"Innervation Patterns of the Pronator Teres Muscle and Their Possible Role in Neurotization: A Systematic Review of Cadaveric Studies.","authors":"Bhagath Kumar Potu, M V Ravishankar","doi":"10.14712/18059694.2021.14","DOIUrl":"https://doi.org/10.14712/18059694.2021.14","url":null,"abstract":"Background: Contrary to the classic anatomical description, many recent studies have reported wide variations in branching patterns and location of motor branches that are supplying the pronator teres muscle. To understand these variations and their implications in surgical procedures of the nerve transfers, a systematic review was performed on the innervation of pronator teres muscle from cadaveric studies.Methods: A systematic literature search was performed in databases such as Medline, PubMed, Google Scholar, SciELO, ScienceDirect, Cochrane reviews and orthopedics textbooks using the search terms \"pronator teres nerve branches\"; AND \"number\" OR \"location\" OR \"length\" OR \"diameter\" yielded 545 article links. Articles were evaluated according to PRISMA guidelines.Results: A total of twenty cadaveric studies including 648 branches have registered 52.9% of two branch innervation pattern followed by 31.3%-single branch pattern; 13.5%-three branch pattern; 1.7%-four branch pattern, and 0.4%-five branch patterns, respectively. Of the 403 branches studied for their location in relation with the humeral intercondylar line, most branches were located distal to the line (50.3%), followed by 32.7% (proximal to it) and 16.8% at the line, respectively. The distance of branches located proximal and distal to humeral intercondylar line was in the range of 1.25-10 cm, and 1.1-7.5 cm, respectively. The mean length and diameter of nerves reported were 4.37 ± 2.43 cm, and 1.5 mm, respectively.Conclusions: Our data defined the morphometrics of nerve branches and they often met the required diameter for neurotization procedures. Our findings also demonstrated that the morphometrics, branching pattern and their location vary between populations and this information is very vital for surgeons during the nerve transfers.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"64 2","pages":"77-84"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39261881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Horseshoe Kidney Complicated by Xanthogranulomatous Pyelonephritis in a Young Girl: A Case Report and Review of the Literature. 年轻女孩马蹄肾合并黄色肉芽肿性肾盂肾炎1例报告及文献复习。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.11

Jamal Musayev, Rashad Sholan, Adalat Hasanov, Rizvan Rustamov

引用次数: 1

Urban or Rural GP? In the Czech Republic It Is not just Distances That Matter. 城市还是农村全科医生?在捷克共和国，重要的不仅仅是距离。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.3

Jan Bělobrádek, Luděk Šídlo, Kateřina Javorská, David Halata

{"title":"Urban or Rural GP? In the Czech Republic It Is not just Distances That Matter.","authors":"Jan Bělobrádek, Luděk Šídlo, Kateřina Javorská, David Halata","doi":"10.14712/18059694.2021.3","DOIUrl":"https://doi.org/10.14712/18059694.2021.3","url":null,"abstract":"This article proposes a combined mixed methods approach to categorising GP practices. It looks not only at location but also at differences in the nature of the work that rural GPs perform. A data analysis was conducted of the largest health insurance company in the Czech Republic (5.9 million patients, 60% of the population, 100% coverage within the Czech Republic). We performed two data analyses, one for 2014-2015 and one for 2016, and divided GP practices into urban, intermediate, and rural groups (taking into account the OECD methodology). We compared groups in terms of the total annual cost in CZK per adult registered insurance holders. The total volume of data indicated the financial costs of €1.52 billion and €2.57 billion respectively. Both analysis showed differences between all groups of practises which confirmed the assumption that the work of the GP is influenced by regionality. A multidisciplinary hospital is the main factor that fundamentally affects the way a GP's work in that area. The proposed principle of categorising general practices combines geographical and cost characteristics. This requires knowledge of the cost data of healthcare payer and on the basic demographic knowledge of the area. We suggest this principe may be transferrable and particularly suitable for categorising general practice.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"64 1","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38881037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Obesity in Children with Leptin Receptor Gene Polymorphisms. 肥胖与瘦素受体基因多态性的儿童。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.27

Aleksandr Abaturov, Anna Nikulina

{"title":"Obesity in Children with Leptin Receptor Gene Polymorphisms.","authors":"Aleksandr Abaturov, Anna Nikulina","doi":"10.14712/18059694.2021.27","DOIUrl":"https://doi.org/10.14712/18059694.2021.27","url":null,"abstract":"Introduction: The study of single nucleotide polymorphisms (SNPs) of the leptin receptor gene (LEPR) based on next generation genomic sequencing (NGS) data is becoming an increasingly important aspect of diagnosis, treatment and prevention of both metabolically healthy (MHO) and metabolically unhealthy obesity (MUO) phenotypes.Material and methods: 35 obese children 6-18 years old were examined by the NGS method with bioinformatic analysis. The main group (n = 18) was formed by children with MUO, according to the recommendations of the expert group of the National Heart, Lung, and Blood Institute. The control group (n = 17) was represented by children with MHO. Statistical methods were used: analysis of variance, Wald's sequential analysis, Spearman's correlation analysis, analysis of nominal data and multiple discriminant analysis.Results: 10 types of non-synonymous SNPs (rs3790435, rs1137100, rs2186248, rs70940803, rs79639154, rs1359482195, rs1137101, rs1805094, rs13306520, rs13306522) of the LEPR gene in obese children have been identified. Multiple discriminant analysis demonstrated that the following LEPR SNPs are of greatest importance in the development of MUO: rs3790435, rs13306522, rs13306520. Analysis of nominal data revealed significant differences in the groups for Copy number variation (CNV) rs3790435 of the LEPR gene. Wald's analysis allowed us to identify 6 important predictors of MUO (І ≥ 0.5): 2 CNV rs3790435 (Relative Risk, RR = 2, Prognostic coefficient, PC = +2.76); male gender of the child (RR = 1.3, PC = +1.35); rs3790435 (RR = 1.9, PC = +2.76); hyperleptinemia more than 40.56 ng/ml (RR = 2, PC = +3); CNV rs1359482195 ≥ 3 (RR = 1.9, PC = +5.8); SNP of the LEPR gene ≥4 (RR = 3.8, PC = +5.8).Conclusion: Children with the genotype rs3790435 gene LEPR had signs of MUO more often.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"64 3","pages":"158-164"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39892205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Genotype Associations with the Different Phenotypes of Atopic Dermatitis in Children. 基因型与儿童特应性皮炎不同表型的关联。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.17

Volodymyr Dytiatkovskyi, Tetiana Drevytska, Tetiana Lapikova-Bryhinska, Victor Dosenko, Olexandr Abaturov

{"title":"Genotype Associations with the Different Phenotypes of Atopic Dermatitis in Children.","authors":"Volodymyr Dytiatkovskyi, Tetiana Drevytska, Tetiana Lapikova-Bryhinska, Victor Dosenko, Olexandr Abaturov","doi":"10.14712/18059694.2021.17","DOIUrl":"https://doi.org/10.14712/18059694.2021.17","url":null,"abstract":"This study deals with detecting the associations of atopic dermatitis' (AD) phenotypes in children: alone or combined with seasonal allergic rhino-conjunctivitis (SARC) and/or perennial allergic rhinitis (PAR), and/or with bronchial asthma (BA) with single nucleotide polymorphisms (SNP) of filaggrin (FLG), thymic stromal lymphopoietin (TSLP) and orsomucoid-like-1 protein 3 (ORMDL3) genes. Male and female pediatric patients aged from 3 to 18 years old were recruited into the main (AD in different combinations with SARC, PAR, BA) and control groups (disorders of digestives system, neither clinical nor laboratory signs of atopy). Patients were genotyped for SNP of rs_7927894 FLG, rs_11466749 TSLP, rs_7216389 ORMDL3 variants. Statistically significant associations of the increased risk were detected of AD combined with SARC and/or PAR and AD combined with BA (possibly, SARC and/or PAR) with C/T rs_7927894 FLG and T/T rs_7216389 ORMDL3 genotypes. Genotype C/C rs_7927894 FLG significantly decreases the risk of AD combined with SARC and/or PAR by 2.56 fold. Several genotypes' associations had a trend to significance: C/C rs_7216389 ORMDL3 decreases and C/T rs_7216389 ORMDL3 increases the risk for developing AD alone phenotype; A/G rs_11466749 TSLP decreases the risk of AD combined with BA (possibly, SARC and/or PAR) phenotype development.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"64 2","pages":"96-100"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39261812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Rasch Validation of the LVQOL Scale. LVQOL量表的Rasch验证。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.19

Ioanna Mylona, Vassilis Aletras, Nikolaos Ziakas, Ioannis Tsinopoulos

{"title":"Rasch Validation of the LVQOL Scale.","authors":"Ioanna Mylona, Vassilis Aletras, Nikolaos Ziakas, Ioannis Tsinopoulos","doi":"10.14712/18059694.2021.19","DOIUrl":"https://doi.org/10.14712/18059694.2021.19","url":null,"abstract":"Aim: This study proceeds to rigorously examine and validate the Low Vision Quality-of-Life Questionnaire (LVQOL) on a Greek population of ophthalmic patients employing Rasch measurement techniques.Methods: It is a prospective observational study of 150 cataract patients and 150 patients with other ophthalmic diseases, all followed longitudinally for a period of two months pending surgical or other corrective therapy, after which they were administered the LVQOL for a second time.Results: The original 25-item LVQOL demonstrated high reliability and validity, excellent measurement precision and ordered response category thresholds. A small number of items carry an acceptable level of measurement error while three items had some differential functioning for gender, Age and underlying disorder that did not exceed the established thresholds.Conclusions: This validation study is the first to employ Rasch measurement to examine the validity of the LVQOL and it supports its use with no changes to the original structure. The LVQOL can be employed in a large range of ophthalmic diseases and reliably assess improvements in quality-of-life following phacoemulsification surgery or any other intervention.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"64 2","pages":"108-118"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39261814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Difficult Path to Correct Diagnosis of Hepatolithiasis: A Case Report. 正确诊断肝内胆管结石的艰难之路:1例报告。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.21

Peter Mikolajčík, Alexander Ferko, Michal Demeter, Martin Vorčák, Ľudovít Laca

{"title":"The Difficult Path to Correct Diagnosis of Hepatolithiasis: A Case Report.","authors":"Peter Mikolajčík, Alexander Ferko, Michal Demeter, Martin Vorčák, Ľudovít Laca","doi":"10.14712/18059694.2021.21","DOIUrl":"https://doi.org/10.14712/18059694.2021.21","url":null,"abstract":"Hepatolithiasis is a benign disease, where stones are localized proximal to the confluence of hepatic ducts. The clinical picture may differ depending on whether the stones cause complete, partial, or intermittent biliary obstruction. The course can vary from asymptomatic to fatal, thus, early diagnosis and treatment is critical for a good prognosis. The gold standard in imaging is magnetic resonance cholangiopancreatography (MRCP). However, correct diagnosis can be challenging due to atypical clinical picture and laboratory findings. We present a case where hepatolithiasis was misdiagnosed initially due to incomplete reporting and documentation of MRCP. Choledocholithiasis was diagnosed based on initial MRCP, and endoscopic stone extraction was indicated. However, an unusual post-interventional course and signs of obstructive cholangitis led to an endoscopic re-intervention, which confirmed absence of pathology in extrahepatic biliary ducts. The cholangitis recurrence required intensive antibiotic treatment, and CT examination revealed intrahepatic S3 bile duct dilatation. Thus, a re-evaluation of initial MRCP and repeated MRCP confirmed hepatolithiasis. Further, laparoscopic bisegmentectomy was chosen as the definitive treatment due to the location of the lesion. The patient recovered and remained symptom free upon a 12 month follow up.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"64 2","pages":"125-128"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39261816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0