Acta Medica Croatica最新文献

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[DWI MAGNETIC RESONANCE IN CHARACTERIZATION OF FOCAL LIVER LESIONS]. [dwi磁共振对局灶性肝脏病变的表征]。
Acta Medica Croatica Pub Date : 2016-09-01
E Jahić, A Sofić, A Husić-Selimović
{"title":"[DWI MAGNETIC RESONANCE IN CHARACTERIZATION OF FOCAL LIVER LESIONS].","authors":"E Jahić,&nbsp;A Sofić,&nbsp;A Husić-Selimović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this study was to examine the possibilities of measuring ADC/DWI values with the ROI method for precise\u0000differentiation of focal liver lesions from normal liver parenchyma. The study included 100 liver lesions sized ≥1 cm, previously\u0000detected in patients by ultrasound and computed tomography. It is done by measuring the diffusion coefficient ADC folder\u0000(MRI 3T), setting the ROI on the periphery of hepatic lesions, on the liver parenchyma around the focal hepatic lesions and\u0000on liver parenchyma that is distant to hepatic lesions. In our study, difference between the average ADC value of focal\u0000liver lesions (1.24 x10(-3) mm(2)/s) and normal liver parenchyma around focal liver lesions (1.001x10(-3) mm(2)/s) was statistically\u0000confirmed. There was statistically proven difference in the average ADC values between normal liver parenchyma around\u0000focal lesions and liver parenchyma located distant from focal lesions of (1.003x10-3 mm2/s). Wilcoxon rank test yielded\u0000differences in the average (median) ADC values between total lesions in patients and liver parenchyma directly around\u0000focal lesions (p<0.0005). Wilcoxon rank test showed no differences in the average (median) ADC between liver parenchyma\u0000directly around focal lesions and distant of focal hepatic lesions (p<0.0005). The results obtained for each focal liver lesion\u0000were compared with histopathology findings obtained by puncture or surgery, and for cystic lesions radiological follow up\u0000was sufficient. For all liver lesions, the resulting overall DWI/ADC sensitivity was 92% and specificity 77%. Kendall’s tau-b\u0000coefficient of concordance showed a statistically significant correlation between our DWI diagnosis and histopathology\u0000verification for all liver lesions (p<0.0005). He mangiomas and cysts showed greatest difference in ADC values as compared\u0000with healthy liver. ADC values of hepatocellular carcinoma (HCC) and the surrounding normal liver parenchyma were not\u0000statistically different, which can be explained by similarities in their cell structure. Related articles conclude that DWI has\u0000inadequate sensitivity in detecting HCC, explaining this minimal difference in cellularity of well differentiated HCC and liver\u0000parenchyma. DWI/ADC has the potential to differentiate and reliably define the limits of focal lesions of the normal liver\u0000parenchyma. ADC delimitation of focal lesions of the liver parenchyma is most reliable for hemangiomas and cysts, while\u0000ADC delimitation of HCC can pose diagnostic difficulties.</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":" ","pages":"179-84"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39983251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Letter]. (信)。
Acta Medica Croatica Pub Date : 2016-09-01
{"title":"[Letter].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":" ","pages":"199"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39983986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[ACUTE PAIN MANAGEMENT IN PATIENT ON OPIOID SUBSTITUTION THERAPY WITHMETHADONE OR BUPRENORPHINE]. [美沙酮或丁丙诺啡阿片类药物替代治疗患者的急性疼痛管理]。
Acta Medica Croatica Pub Date : 2016-09-01
V Nesek Adam, M Matolić, E Grizelj Stojčić, V Mršić, Ž Rašić
{"title":"[ACUTE PAIN MANAGEMENT IN PATIENT ON OPIOID SUBSTITUTION THERAPY WITH\u0000METHADONE OR BUPRENORPHINE].","authors":"V Nesek Adam,&nbsp;M Matolić,&nbsp;E Grizelj Stojčić,&nbsp;V Mršić,&nbsp;Ž Rašić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The result of the increase in drug abuse is a growing number of patients receiving methadone or buprenorphine\u0000substitution therapy. Physicians are increasingly confronted with patients on substitution therapy at the time when they\u0000are developing acute pain conditions or when they need surgery. Although pain has sensory qualities, it is a very personal\u0000and complex experience. The intensity and duration of pain are influenced by numerous factors. Poorly controlled pain\u0000leads to unnecessary suffering of the patients with the possibility of permanent changes in behavior and reduced quality\u0000of life. Efficacious pain treatment is considered a basic right of every patient. Because of the complex mechanisms of the\u0000emergence and transmission of pain and the emotional components that are involved in the experience of pain, appropriate\u0000pain relief in patients on substitution therapy is a major challenge for both the physicians and the patients. The article gives\u0000an overview of issues related to the treatment of acute pain and perioperative treatment in patients on substitution therapy\u0000with methadone and buprenorphine. The article highlights the wrong common misconception about pain treatment in these\u0000patients, which also are the most common cause of their inadequate treatment.</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":" ","pages":"173-8"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39983750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[RECONSTRUCTING THE LIFE OF AN UNKNOWN MAN--INTERDISCIPLINARY APPROACH]. [重建一个不知名的人的生活——跨学科的方法]。
Acta Medica Croatica Pub Date : 2016-09-01
Z Hincak, K Filipec, P Iacumin, F Cavalli, D Mihelić, V Jeleč, A Korušić
{"title":"[RECONSTRUCTING THE LIFE OF AN UNKNOWN MAN--INTERDISCIPLINARY APPROACH].","authors":"Z Hincak,&nbsp;K Filipec,&nbsp;P Iacumin,&nbsp;F Cavalli,&nbsp;D Mihelić,&nbsp;V Jeleč,&nbsp;A Korušić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The remains of a tomb were discovered below the foundations of the Roman church of “Majka Bozja Gorska” in Lobor in\u00002002. It was a vaulted tomb carved from a single stone. The narthex of ancient Christian and pre-roman churches often\u0000served as the resting place of religious, secular and noble dignitaries, who were credited for founding the church at the\u0000time. By anthropological methods, the age, gender, height, pathological changes, tendon and ligament hinges and degree\u0000of development were able to be analysed. The stable isotopes of Carbon-13, Nitrogen-15 and Oxygen-18 were analysed\u0000and expressed as ��-values according to the PDB standard. Dental analysis showed a build-up of tartar on the buccal side,\u0000with 5 teeth missing from the dentition post-mortem and a partial lowering and accretion of the alveolar walls of the 2nd\u0000molar space secondary to tooth loss. The remains of the person from grave 107 show that the person was approximately\u000030-35 years of age, confirmed by microscopical analysis of the bone samples. Almost all of the cranial sutures were\u0000exposed with the exception of the saggital suture which was closed at the S3 position, while the transverse palatal suture\u0000was in the initial stages of closure on the lateral sides. Analysis of the iliac bone showed visible changes on the bone. The\u0000surface had retained its youthful appearance however with a microporous and pronounced granular structure and only\u0000a slight apical and marginal activity. The transverse striations are still apparent, but no longer along the entirety of the\u0000bone surface. Anthropometric analysis according to cranial cavity indexes, showed a cranium or relatively large volume\u0000(aristencephalic in type), long, narrow and medium in height. The index values were used in facial reconstruction. Analysis\u0000of the development of tendon and ligament hinges of the preserved anatomical elements, gave further information about\u0000the morphology and physical activity of the person. The hinge sites of the brachial and antebrachial muscles showed a\u0000significant development and these enthesopathies would be consistent with a strenuous physical activity, especially at the\u0000biceps tendon and shoulder girdle, portraying an anterior elevation, cubital flexion, pronation, circumduction and fixation. It\u0000can be said that the person predominantly used the left arm. The developed muscle hinges, show common pronatory and\u0000supinatory movements and presume a routine swinging motion of an object above the head or in front of the person. The\u0000left tibia was suggestive of the height and male gender of the person. According to Pearson’s regression formula, for the\u0000length of the brachium, radius and tibia, it can be reasoned that the person was approximately 169 cm tall. The upper third\u0000of the L3 vertebra shows a Schmorl’s hernia which can be secondary to strong anteroposterior and lateral flexion of the\u0000spine. On the supero-lateral surface of the left patella, there is a Messeri sign, suggestive of a long and ","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":"70 3","pages":"155-64"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35538565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[RARE LOCALIZATION OF OSTEOID OSTEOMA--DISTAL PHALANX OF THE RING FINGER]. [罕见的骨样骨瘤定位-无名指远端指骨]。
Acta Medica Croatica Pub Date : 2016-09-01
K Barbarić, M Prutki, D Starčević, S Seiwerth, I Bojanić
{"title":"[RARE LOCALIZATION OF OSTEOID OSTEOMA--DISTAL PHALANX OF THE RING FINGER].","authors":"K Barbarić,&nbsp;M Prutki,&nbsp;D Starčević,&nbsp;S Seiwerth,&nbsp;I Bojanić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With this clinical observation we would like to bring to mind osteoid osteoma as a possible cause of problems of distal\u0000phalanx of the fingers. Osteoid osteoma occurs rarely at this location and has atypical presentation. The main symptoms\u0000are swelling and redness of the fingertip with nail deformity, while typical night pain may not be present. Unusual clinical\u0000and x-ray presentation of tumor in this localization can make diagnosis of osteoid osteoma very difficult. A 20-year-old\u0000patient reported pain in the fingertip of his right ring finger persisting for five years. Swelling and redness of the fingertip\u0000combined with nail deformity was also present. X-rays showed osteolysis in the base of distal phalanx. Magnetic resonance\u0000imaging showed suspicion of osteoid osteoma, which was confirmed by computed tomography (CT). We performed\u0000surgical removal of osteoid osteoma in February 2014. The tumor was approached by longitudinal incision on the lateral\u0000side of the distal phalanx of the ring finger and the basal part of distal phalanx was cut with a small chisel to enable access\u0000to cystic change of the bone. Tumor removal with excochleation was performed and the material thus obtained was sent\u0000for histopathologic analysis. After surgery, the ring finger was immobilized in a plaster splint for a three-week period. After\u0000removal of immobilization, the patient was referred to physical therapy consisting of individual exercises in order to obtain\u0000the full range of motion in all joints of the hands and strengthen hand and forearm muscles. After surgical removal of osteoid\u0000osteoma, all symptoms disappeared completely. Histopathologic findings confirmed the diagnosis of osteoid osteoma.\u0000After physical therapy, he returned to daily activities without any problems. On regular follow ups at 3, 6 and 12 months after\u0000surgery, clinical findings were normal and the patient had no pain or discomforts. Full recovery was shown by the result of\u0000the DASH questionnaire three months after the procedure. Preoperative DASH score 54.4 decreased to 0. Distal phalanx of\u0000the finger is a very rare localization of osteoid osteoma, and typical night pain may not be present. In addition, appearance\u0000on x-rays is not typical. Instead of central enlightenment surrounded with sclerosis, x-rays usually show a lytic lesion. For\u0000this reason, it may be difficult to make the diagnosis of osteoid osteoma. The main symptom is permanent pain, swelling\u0000and redness of the finger, with nail deformity. The imaging method of choice is CT, which must be performed with thin layers\u0000of 1 to 2 mm. Furthermore, cooperation of surgeon and radiologist is extremely important to reach the accurate diagnosis.\u0000Many treatment options are described in the literature, such as CT-guided percutaneous thermocoagulation, destruction\u0000of lesions with alcohol, or CT-guided radiofrequency ablation. However, due to the proximity of neurovascular structures,\u0000tendons and joints, the best method for treatment osteoid o","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":" ","pages":"191-5"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39983270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Does Routine Pathology Evaluation of Uterine Content Following Evacuation for Abnormal Early Pregnancy Influence Further Management?] 异常早孕术后子宫内容物的常规病理评价是否影响进一步的处理?]
Acta Medica Croatica Pub Date : 2016-04-01
S Kordić, R Matijević
{"title":"[Does Routine Pathology Evaluation of Uterine Content Following Evacuation for Abnormal Early Pregnancy Influence Further Management?]","authors":"S Kordić,&nbsp;R Matijević","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim was to determine usefulness of routine pathologic evaluation of uterine content after uterine evacuation following\u0000the diagnosis of abnormal early pregnancy. This retrospective descriptive study performed during a one-year period included\u0000all patients diagnosed with abnormal early pregnancy clinically or by ultrasound in the first trimester. All patients had uterine\u0000evacuation. During the study period, 335 women were diagnosed with abnormal early pregnancy and referred for uterine\u0000evacuation. Pathology results were available for 312 women included in the analysis. In 272 (87.2%) women, trophoblast\u0000tissue was found on examination and therefore intrauterine pregnancy was confirmed. In the remaining 40 patients,\u0000trophoblast was not found. In 10 (3.2%) patients, gestational trophoblastic disease was diagnosed, not being suspected\u0000on pre-evacuation assessment. In one patient, suspected molar pregnancy was excluded by pathology evaluation. Based\u0000on 51/312 (16.3 %) patients where pathology examination of uterine content influenced further management and treatment,\u0000we believe that routine pathology examination of uterine content after uterine evacuation in the fi rst trimester following\u0000abnormal early pregnancy is justifiable in clinical practice.</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":"70 2","pages":"97-101"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35183636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hypertrophic Pyloric Stenosis - Five-Year Retrospective Analysis]. [肥厚性幽门狭窄-五年回顾性分析]。
Acta Medica Croatica Pub Date : 2016-04-01
M Bašković, B Župančić, N Lesjak, I Vukasović
{"title":"[Hypertrophic Pyloric Stenosis - Five-Year Retrospective Analysis].","authors":"M Bašković,&nbsp;B Župančić,&nbsp;N Lesjak,&nbsp;I Vukasović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although the etiology of the disease has not yet been fully clarified in the 21st century, clinical significance of the disease\u0000is huge because it is frequent in the neonatal period compared with other diseases. Today, owing to advanced diagnostic\u0000possibilities, hypertrophic pyloric stenosis is easily distinguished from other differential diagnoses that are manifested by\u0000vomiting as the main symptom. At Department of Pediatric Surgery, Zagreb Children’s Hospital, efforts have been invested\u0000to successfully manage this and a number of other conditions that affect newborns. We retrospectively analyzed data on\u000040 hospitalized children retrieved from the hospital information system for the 2010-2015 period and present them as a\u0000basis for the respective algorithms and future research. Reviewing a range of parameters, we have come to some concrete\u0000conclusions. On average, the disease started manifesting on 28th day after birth; 63% of the children developed metabolic\u0000alkalosis. Thickness of the muscle wall verified by ultrasound ranged from 3.1 mm to 7 mm. Surgery was performed seven\u0000days after hospitalization and correction of metabolic condition. The average duration of surgery was 48 minutes. The mean\u0000length of hospital stay was 11.64 days, of which 2 days in the intensive care unit. Complications occurred in two patients.</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":"70 2","pages":"103-6"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35183637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[What General/Family Medicine Practitioner should Know about Viral Hepatitis]. 【全科医生/家庭医生应了解的病毒性肝炎】。
Acta Medica Croatica Pub Date : 2016-04-01
J Vučak, E Vučak
{"title":"[What General/Family Medicine Practitioner should Know about Viral Hepatitis].","authors":"J Vučak,&nbsp;E Vučak","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Viral hepatitis is a systemic disease that predominantly affects the liver. The most common causes of viral hepatitis are fi ve\u0000hepatotropic viruses A, B, C, D and E; according to duration, it can be acute or chronic. Although clinical course of all viral\u0000hepatitides is similar, particular problem is predisposition of hepatitis B and hepatitis C to cause chronic forms of illness\u0000with severe outcome such as cirrhosis, hepatocellular carcinoma and liver failure. Clinical features include malaise, nausea,\u0000anorexia, low grade fever, aversion to smoking, and in clinical status usually we can fi nd hepatomegaly, and seldom\u0000splenomegaly with adenopathy and jaundice. Generally, symptoms are very variable, from usually asymptomatic to fulminant,\u0000which in most cases have lethal outcome. There are three stages in acute phase of viral hepatitis: prodromal, icteric and\u0000convalescence. Standard laboratory tests show elevated values of aspartate aminotransferase, alanine aminotransferase\u0000and alkaline phosphatase in acute phase of hepatitis and elevated lactate dehydrogenase in chronic phase. Serum protein\u0000electrophoresis usually shows decreased albumin fraction and albumin/globulin ratio, as well as increased bilirubin level,\u0000positive urobilinogen and disturbance in coagulability factors, i.e. marked prolongation of prothrombin time. For etiology of\u0000each virus, series of serologic tests are used. In hepatitis A, acute phase of disease is characterized by IgM anti-HAV and\u0000presence of IgG anti-HAV indicates previous exposure. In hepatitis B, appearance of HBsAg in serum is the fi rst evidence\u0000of infection and recovery is connected with appearance of anti-HBsAg along with IgG anti HBcAg. Active forms of chronic\u0000hepatitis B are characterized by active virus replication, which can be measured with polymerase chain reaction (PCR)\u0000HBV DNA. Diagnosis of hepatitis C is based on detection of antibodies to HCV (anti-HCV). Generally, it signifi es that HCV\u0000infection is present but that diagnostic tool is poor for the phase of disease. In these circumstances, diagnosis of hepatitis\u0000C may be confi rmed by using an assay for HCV RNA. First line therapy in acute phase is mostly supportive, i.e. bed rest,\u0000appropriate diet including palatable meals as tolerated, without overfeeding. Alcohol and hepatotoxic agents (for example,\u0000paracetamol, amoxicillin, ketoconazole) should be avoided. In cases with increased tendency of developing chronic forms\u0000of hepatitis and complications (cirrhosis, hepatocellular carcinoma), immunomodulators should be administered, e.g.,\u0000interferon and/or antiviral agents. The role of family physician/general practitioner is in maintaining preventive measures\u0000(vaccination) and education of general population. Special attention needs to be paid to screening and educating high risk\u0000patients with respect to proper diagnostics, laboratory and serologic tests. After establishing the diagnosis, all relevant\u0000measures should be taken to avoid chronifi cation o","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":"70 2","pages":"87-95"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35181112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Carotid Endarterectomy in Patients with Antiaggregation Therapy]. 抗聚集治疗患者颈动脉内膜切除术。
Acta Medica Croatica Pub Date : 2016-04-01
I Cvjetko, I Dovžak Bajs, M Bezjak
{"title":"[Carotid Endarterectomy in Patients with Antiaggregation Therapy].","authors":"I Cvjetko,&nbsp;I Dovžak Bajs,&nbsp;M Bezjak","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Carotid endarterectomy is a common way of surgical treatment of extracranial carotid artery disease caused by\u0000atherosclerosis. Patients are often operated on under local anesthesia with intraoperative application of heparin.\u0000Postoperative bleeding occurs in up to 8% of cases, and up to 4.7% of patients need reoperation due to bleeding. TachoSil\u0000is a medical sponge consisting of collagen with added human coagulation factors (fibrinogen and thrombin). In contact with\u0000water, blood or bodily fluids, it forms a clot that adheres to the surface. The hypothesis and aim of our study was to show\u0000that TachoSil could be topically administered during surgery on carotid arteries in order to prevent minor bleeding, without\u0000causing any local signs of inflammation or infection. The study included a prospective series of consecutive patients that\u0000underwent surgery for extracranial carotid stenosis with concomitant antiplatelet therapy at Department of Vascular Surgery,\u0000Merkur University Hospital in Zagreb. All patients received antiplatelet therapy with aspirin or aspirin and clopidogrel until\u0000the day before surgery. From April 2, 2012 to February 8, 2013, a total of 24 patients with extracranial carotid artery stenosis\u0000were operated on, along with receiving antiplatelet therapy. All patients received 100 mg of acetylsalicylic acid and/or 75\u0000mg of clopidogrel until one day prior to surgery. Patients had been treated with antiplatelet drugs for at least six months\u0000prior to carotid endarterectomy. Four patients had been on dual antiplatelet therapy (aspirin 100 mg and clopidogrel 75 mg)\u0000because of percutaneous transluminal angioplasty (PTA) and a stent placed in pelvic arteries or superficial femoral artery.\u0000Due to speech disturbances following clamping of carotid arteries in two study patients a temporary intraluminal shunt was\u0000created. These two patients underwent longitudinal arteriotomy and longitudinal endarterectomy. Arteriotomy was closed\u0000by direct suture without a patch. Following arteriotomy and partial conversion of heparin with protamine, six patients needed\u0000additional individual sutures. Then, protamine was added again to up to the full dose of conversion (50 mg). In 19 patients,\u0000only one TachoSil medical sponge (9.5 cm x 4.8 cm) was placed, whereas in fi ve patients two sponges were placed. None\u0000of the patients (24 of them operated on between April 2, 2012 and February 8, 2013) with TachoSil placed intraoperatively\u0000had any signs of postoperative wound infection. Carotid artery stenosis is a very common disease the incidence of which\u0000increases proportionally with age of the population observed. Bleeding is a relatively common and significant complication\u0000following surgical treatment, particularly in case of arterial bleeding. Bleeding and other complications in the neck can be\u0000very serious and challenging for surgical treatment. With the present guidelines for the administration of clopidogrel in the\u0000evening before surgery, in some circumstances a","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":"70 2","pages":"131-8"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35183642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Historical Review of Cesarean Section at King's Maternity Hospital and Midwifery School Zagreb 1908-1918]. [萨格勒布国王妇产医院和助产学校1908-1918年剖宫产的历史回顾]。
Acta Medica Croatica Pub Date : 2016-04-01
D Habek, V Kruhak
{"title":"[Historical Review of Cesarean Section at King's Maternity Hospital and Midwifery School Zagreb 1908-1918].","authors":"D Habek,&nbsp;V Kruhak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article presents a historical review of the performance of 23 cesarean sections at the King’s Maternity Hospital and\u0000Midwifery School in Zagreb during the 1908-1918 period. Following prenatal screening by midwives and doctors in the\u0000hospital, deliveries in high risk pregnant women were performed at maternity hospitals, not at home. The most common\u0000indication for cesarean section was narrowed pelvis in 65.2% of women, while postpartum febrile condition was the most\u0000common complication in the puerperium. Maternal mortality due to sepsis after the procedure was 8.69% and overall\u0000perinatal mortality was 36.3% (stillbirths and early neonatal deaths).</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":"70 2","pages":"107-10"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35183638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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