{"title":"[DWI MAGNETIC RESONANCE IN CHARACTERIZATION OF FOCAL LIVER LESIONS].","authors":"E Jahić, A Sofić, A Husić-Selimović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this study was to examine the possibilities of measuring ADC/DWI values with the ROI method for precise\u0000differentiation of focal liver lesions from normal liver parenchyma. The study included 100 liver lesions sized ≥1 cm, previously\u0000detected in patients by ultrasound and computed tomography. It is done by measuring the diffusion coefficient ADC folder\u0000(MRI 3T), setting the ROI on the periphery of hepatic lesions, on the liver parenchyma around the focal hepatic lesions and\u0000on liver parenchyma that is distant to hepatic lesions. In our study, difference between the average ADC value of focal\u0000liver lesions (1.24 x10(-3) mm(2)/s) and normal liver parenchyma around focal liver lesions (1.001x10(-3) mm(2)/s) was statistically\u0000confirmed. There was statistically proven difference in the average ADC values between normal liver parenchyma around\u0000focal lesions and liver parenchyma located distant from focal lesions of (1.003x10-3 mm2/s). Wilcoxon rank test yielded\u0000differences in the average (median) ADC values between total lesions in patients and liver parenchyma directly around\u0000focal lesions (p<0.0005). Wilcoxon rank test showed no differences in the average (median) ADC between liver parenchyma\u0000directly around focal lesions and distant of focal hepatic lesions (p<0.0005). The results obtained for each focal liver lesion\u0000were compared with histopathology findings obtained by puncture or surgery, and for cystic lesions radiological follow up\u0000was sufficient. For all liver lesions, the resulting overall DWI/ADC sensitivity was 92% and specificity 77%. Kendall’s tau-b\u0000coefficient of concordance showed a statistically significant correlation between our DWI diagnosis and histopathology\u0000verification for all liver lesions (p<0.0005). He mangiomas and cysts showed greatest difference in ADC values as compared\u0000with healthy liver. ADC values of hepatocellular carcinoma (HCC) and the surrounding normal liver parenchyma were not\u0000statistically different, which can be explained by similarities in their cell structure. Related articles conclude that DWI has\u0000inadequate sensitivity in detecting HCC, explaining this minimal difference in cellularity of well differentiated HCC and liver\u0000parenchyma. DWI/ADC has the potential to differentiate and reliably define the limits of focal lesions of the normal liver\u0000parenchyma. ADC delimitation of focal lesions of the liver parenchyma is most reliable for hemangiomas and cysts, while\u0000ADC delimitation of HCC can pose diagnostic difficulties.</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":" ","pages":"179-84"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39983251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V Nesek Adam, M Matolić, E Grizelj Stojčić, V Mršić, Ž Rašić
{"title":"[ACUTE PAIN MANAGEMENT IN PATIENT ON OPIOID SUBSTITUTION THERAPY WITH\u0000METHADONE OR BUPRENORPHINE].","authors":"V Nesek Adam, M Matolić, E Grizelj Stojčić, V Mršić, Ž Rašić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The result of the increase in drug abuse is a growing number of patients receiving methadone or buprenorphine\u0000substitution therapy. Physicians are increasingly confronted with patients on substitution therapy at the time when they\u0000are developing acute pain conditions or when they need surgery. Although pain has sensory qualities, it is a very personal\u0000and complex experience. The intensity and duration of pain are influenced by numerous factors. Poorly controlled pain\u0000leads to unnecessary suffering of the patients with the possibility of permanent changes in behavior and reduced quality\u0000of life. Efficacious pain treatment is considered a basic right of every patient. Because of the complex mechanisms of the\u0000emergence and transmission of pain and the emotional components that are involved in the experience of pain, appropriate\u0000pain relief in patients on substitution therapy is a major challenge for both the physicians and the patients. The article gives\u0000an overview of issues related to the treatment of acute pain and perioperative treatment in patients on substitution therapy\u0000with methadone and buprenorphine. The article highlights the wrong common misconception about pain treatment in these\u0000patients, which also are the most common cause of their inadequate treatment.</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":" ","pages":"173-8"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39983750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}