Malaysian Journal of Paediatrics and Child Health最新文献_第2页

Neonatal Hospital-Acquired Bloodstream Infection in a Single-Centre in Malaysia: Clinical Presentations, Pathogens and Immediate Outcome 马来西亚单中心新生儿医院获得性血流感染：临床表现、病原体和直接后果

Malaysian Journal of Paediatrics and Child Health Pub Date : 2023-11-20 DOI: 10.51407/mjpch.v29i3.254

Mohd Nizam Mat Bah, E. Alias, Sim Yeo Ting, H. Razak, Foo Fang Han, Noor Azlina Mustafa, Azirawati Johari, N Al Abdullah

{"title":"Neonatal Hospital-Acquired Bloodstream Infection in a Single-Centre in Malaysia: Clinical Presentations, Pathogens and Immediate Outcome","authors":"Mohd Nizam Mat Bah, E. Alias, Sim Yeo Ting, H. Razak, Foo Fang Han, Noor Azlina Mustafa, Azirawati Johari, N Al Abdullah","doi":"10.51407/mjpch.v29i3.254","DOIUrl":"https://doi.org/10.51407/mjpch.v29i3.254","url":null,"abstract":"Objectives: To determine the epidemiology, clinical characteristics, pathogen, and outcome of hospital-acquired bloodstream infection (HABSI). Methods: This observational, retrospective cohort study of neonates with HABSI between 2013 and 2019 was retrieved from the Infection Surveillance System. The main outcome measure was mortality. Binary logistic regression was used to identify risk factors associated with mortality. Results: There were 278 neonates (27% < 1000gm birth weight and 26% < 29 weeks gestation) with 316 episodes of HABSI documented. The overall incidence of HABSI was 3.79 (95% CI: 3.35 to 4.24) per 1000 admissions and 1.9 per 1000 patients. HABSI was diagnosed at 18.5 days (IQR 11, 36) of hospitalization and 38% presented with severe signs and symptoms of sepsis. The most common pathogens were Klebsiella pneumoniae (29.4%), followed by coagulase-negative staphylococcus (13.9%) and Acinetobacter baumannii (10.1%). Multidrug-resistant (MDR) organisms were noted in 173 (54.7%) with a significant increase over time of extended-spectrum beta-lactamase-producing organisms. Gram-negative resistance to carbapenem was noted in 45% and associated with high mortality. The overall mortality was 25.5% (95% CI:19.6 to 31.5) with no significant changes over time. HABSI due to gram-negative, presented with severe sepsis and prolonged ventilation were associated with poor outcomes. Conclusion: Multidrug resistance is rising and has high mortality in our centre. Factors associated with high mortality were gram-negative organisms, severe sepsis, and prolonged ventilation. Hence, infection and prevention control programs need to be enhanced.","PeriodicalId":356217,"journal":{"name":"Malaysian Journal of Paediatrics and Child Health","volume":"116 1-2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139257450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Uncommon: A Paediatric Case of Influenza-Related Atrioventricular Block 揭示不寻常:流感相关房室传导阻滞的儿科病例

Malaysian Journal of Paediatrics and Child Health Pub Date : 2023-07-27 DOI: 10.51407/mjpch.v29i2.259

Qu Lun, Nurjannah Hanim Mohd Yasin, Farah Fareesha A’idrus, Mohd Assyakir Shamsuddin, Mohd Hazman Kamaruzaman, M. A. R. Mohd Radzi

{"title":"Unveiling the Uncommon: A Paediatric Case of Influenza-Related Atrioventricular Block","authors":"Qu Lun, Nurjannah Hanim Mohd Yasin, Farah Fareesha A’idrus, Mohd Assyakir Shamsuddin, Mohd Hazman Kamaruzaman, M. A. R. Mohd Radzi","doi":"10.51407/mjpch.v29i2.259","DOIUrl":"https://doi.org/10.51407/mjpch.v29i2.259","url":null,"abstract":"This case report highlights a 5-year-old child who developed a first-degree atrioventricular (AV) block during an influenza B infection. Influenza is a common viral illness that can cause severe morbidity and mortality, especially in children with underlying medical conditions. The case emphasizes the potential cardiac complications of influenza and the need for prompt recognition in paediatric patients. The child presented with bradycardia and a prolonged PR interval on the electrocardiogram, indicating AV block. The child had no other symptoms and was discharged in stable condition after two days of observation. Prompt recognition and evaluation of cardiac manifestations in influenza-infected patients, including thorough medical history and diagnostic workup, are crucial for the timely management and prevention of long-term sequelae. This case underscores the importance of considering cardiac complications in severe cases of influenza, especially in the paediatric population, and emphasizes the need for healthcare providers to be vigilant in identifying potential cardiac manifestations during influenza outbreaks.","PeriodicalId":356217,"journal":{"name":"Malaysian Journal of Paediatrics and Child Health","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133194360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retropharyngeal Abscess as an Uncommon Cause of Torticollis in a Child 咽后脓肿是儿童斜颈的罕见病因

Malaysian Journal of Paediatrics and Child Health Pub Date : 2023-07-24 DOI: 10.51407/mjpch.v29i2.255

Anura Aman, Nik Mohd Syukra Nik Abd Ghani, A. Mohamad, S. Yusuf, Khairul Azhar M. Rajet, I. Mohamad

引用次数: 0

Common Variable Immunodeficiency: A Paradox of Immunodeficiency and Autoimmunity 共同变量免疫缺陷:免疫缺陷与自身免疫的悖论

Malaysian Journal of Paediatrics and Child Health Pub Date : 2023-07-23 DOI: 10.51407/mjpch.v29i2.231

Anis Fatini Shamsul Bahrain, Noor Faralina Zainul Fadziruddin, I. J. Abd Hamid, I. Hashim, Z. Zainudeen

引用次数: 0

Aggressive Aortic Disease with Marfan-like Phenotype in Malaysian Patients with Loeys-Dietz Syndrome 马来西亚Loeys-Dietz综合征患者伴有marfan样表型的侵袭性主动脉疾病

Malaysian Journal of Paediatrics and Child Health Pub Date : 2023-07-17 DOI: 10.51407/mjpch.v29i2.242

M. Haniffa, G. Kandavello, J. Sivabalakrishnan

{"title":"Aggressive Aortic Disease with Marfan-like Phenotype in Malaysian Patients with Loeys-Dietz Syndrome","authors":"M. Haniffa, G. Kandavello, J. Sivabalakrishnan","doi":"10.51407/mjpch.v29i2.242","DOIUrl":"https://doi.org/10.51407/mjpch.v29i2.242","url":null,"abstract":"\u0000\u0000\u0000\u0000Loeys- Dietz Syndrome (LDS, pronounced LOH-eez-DEETS) is a connective tissue disorder that was first described in 2005. In the past, many patients were misdiagnosed clinically as Marfan Syndrome (MFS) due to their overlapping phenotype. Distinguishing craniofacial features of LDS include hypertelorism, bifid uvula, cleft palate and absence of lens dislocation. Unlike MFS, aortic root dilatation with or without arterial tortuosity elsewhere are almost always present. Patient 1 was a 7-year- old boy, diagnosed with MFS at 4 years of age. Echocardiogram showed aortic root dilatation with no lens dislocation on eye assessment. He was initially started on β-blocker by the cardiologist, losartan was added on subsequently due to the increasing size of his aortic root diameter. Patient 2 was a 14-year-old boy, followed up for severe aortic root dilatation. He had a stormy neonatal period; diagnosed with tracheobronchomalacia, multiple joint dislocation, feeding intolerance, scoliosis and squint. He was followed up for many years as possible MFS. Genetic testing performed showed mutation at TGFBR2 gene, confirming a diagnosis of LDS in both patients. In addition to these families, another 6 families under our aortopathy clinic follow up have had their diagnosis of LDS confirmed molecularly. LDS is increasingly being described in patients with a more severe aortic disease and Marfan-like phenotype. The difference in disease severity highlights the importance of genetic testing in patients with suspected aortopathy, enabling timely implementation of therapeutic strategies.\u0000\u0000\u0000\u0000","PeriodicalId":356217,"journal":{"name":"Malaysian Journal of Paediatrics and Child Health","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121041116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanotic Neuroectodermal Tumour of Infancy: A Benign but Locally Destructive Growth 婴儿期黑色素神经外胚层肿瘤:良性但局部破坏性的生长

Malaysian Journal of Paediatrics and Child Health Pub Date : 2023-07-06 DOI: 10.51407/mjpch.v29i2.258

Benjamin Wei Liang Ng, S. Kazakydasan, L. Wong, Betty Lee-Sue Ho

{"title":"Melanotic Neuroectodermal Tumour of Infancy: A Benign but Locally Destructive Growth","authors":"Benjamin Wei Liang Ng, S. Kazakydasan, L. Wong, Betty Lee-Sue Ho","doi":"10.51407/mjpch.v29i2.258","DOIUrl":"https://doi.org/10.51407/mjpch.v29i2.258","url":null,"abstract":"\u0000\u0000\u0000\u0000Melanotic Neuroectodermal Tumour of Infancy (MNTI) is a rare neoplasm typically reported in infancy, involving the head and neck regions. Although described as a benign tumour, the growth is rapid and has a high local recurrence rate. Due to the rapid and locally destructive growth, it can easily be misdiagnosed as a malignant tumour, leading to unwarranted and potentially harmful interventions. Therefore, histopathological assessment is pertinent in confirming the diagnosis. Early surgical resection is critical to limiting cosmetic disfigurement but is challenging as it requires prompt and careful planning to ensure optimal clearance. Therefore, it is crucial to approach anterior maxillary swellings in an infant with an index of suspicion and to consider MNTI as a rare but important differential diagnosis to ensure a timely diagnosis and plan for appropriate early intervention. We report a case of an infant presenting with a rapidly growing and locally destructive intra-oral swelling who underwent tumour excision and was later confirmed to be MNTI. We discuss the clinical, radiological, and histological features and the challenges in diagnosing and managing this rare childhood tumour.\u0000\u0000\u0000\u0000","PeriodicalId":356217,"journal":{"name":"Malaysian Journal of Paediatrics and Child Health","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115925613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pamidronate as treatment of severe hypercalcemia in SCFN of the newborn: A case report 帕米膦酸钠治疗新生儿SCFN严重高钙血症1例

Malaysian Journal of Paediatrics and Child Health Pub Date : 2023-07-06 DOI: 10.51407/mjpch.v29i2.257

Raiwathy Krishnasamy, A. Wan, Nalini M Selveindran

{"title":"Pamidronate as treatment of severe hypercalcemia in SCFN of the newborn: A case report","authors":"Raiwathy Krishnasamy, A. Wan, Nalini M Selveindran","doi":"10.51407/mjpch.v29i2.257","DOIUrl":"https://doi.org/10.51407/mjpch.v29i2.257","url":null,"abstract":"\u0000\u0000\u0000\u0000Subcutaneous fat necrosis of newborn (SCFN) is an uncommon entity that occurs in neonates who experienced perinatal stress. We report use of pamidronate, to control persistent hypercalcemia in a 5- week-old infant with SCFN not responding to initial treatment. A term male neonate was born by emergency LSCS due to non-reassuring fetal status. Antenatally mother had gestational diabetes mellitus, group B streptococcus carrier and an antenatal scan at 29 weeks detected a fetus with dilated small bowel. Baby was born vigorous but complicated with bowel perforation requiring fluid resuscitation and a bedside glove drain. He underwent laparotomy for small bowel perforation secondary to ileal atresia and required TPN postoperatively. At 1 month of life, he had palpable purplish lumps at his trunk and limbs associated with severe hypercalcemia supporting the diagnosis of subcutaneous fat necrosis. Despite receiving initial treatment of hyperhydration and frusemide for two weeks, the patient's hypercalcemia peaked to 4.11mmol/L. His renal ultrasound showed nephrocalcinosis with renal and bladder calculi. He was given IV Pamidronate. Post single dose of IV Pamidronate, calcium levels reduced ranging 2.2-3 mmol/L and frusemide was discontinued. On discharge he was maintained on low calcium milk. During his first follow up the calcium level remained stable and repeated ultrasound showed resolution of the renal pelvis and bladder calculi with persistence of the medullary nephrocalcinosis. SCFN has a potentially life-threatening complication due to development of severe hypercalcemia. For patients with severe hypercalcemia not responding to hydration, and low calcium intake, pamidronate is an effective and safe treatment. Good supportive management is very important and should be done prior to pamidronate.\u0000 \u0000\u0000\u0000\u0000","PeriodicalId":356217,"journal":{"name":"Malaysian Journal of Paediatrics and Child Health","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130993519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Relationship between Family Functioning and Parental Health-Related Quality of Life among Parents with Down Syndrome Children in Kelantan, Malaysia 马来西亚吉兰丹唐氏综合症儿童父母家庭功能与父母健康相关生活质量的结构关系

Malaysian Journal of Paediatrics and Child Health Pub Date : 2023-07-04 DOI: 10.51407/mjpch.v29i2.256

Muhammad Aiman Shuib, H. Rostenberghe, A. Nasir, N. Yaacob, Khanisa Md Khalid

{"title":"Structural Relationship between Family Functioning and Parental Health-Related Quality of Life among Parents with Down Syndrome Children in Kelantan, Malaysia","authors":"Muhammad Aiman Shuib, H. Rostenberghe, A. Nasir, N. Yaacob, Khanisa Md Khalid","doi":"10.51407/mjpch.v29i2.256","DOIUrl":"https://doi.org/10.51407/mjpch.v29i2.256","url":null,"abstract":"\u0000\u0000\u0000\u0000Caregiving and living with a Down Syndrome (DS) child is distressing and has given a negative impact on the quality of life of parents. The study aims examine the parents with DS children on the health-related quality of life (HRQoL) and family functioning and to identify potential factors affecting them. The cross-sectional study involved 94 parents with DS children from the Paediatric Clinic, Hospital Raja Perempuan Zainab II, Kota Bharu, Malaysia, with a mean age of 46.7 ± 7.0 years. Demographic and socioeconomic data of the parents and DS children were collected, and their quality of life (QoL) was measured based on the self-reported Pediatric Quality of Life Inventory Family Impact Module (PedsQL FIM). Parents of DS children in the current study have shown good HRQoL and family functioning, with scores of 83.2 and 89.3 out of 100, respectively. The family functioning score shown significantly correlated with the parental health-related quality of life (p<0.001). The number of family members was found to have a statistically significant effect on family functioning (p=0.015). The lowest score in the HRQoL was in the domain of ‘worry’. The findings of the current study verify previous reports of relatively good quality of life and family functioning in families with DS children and also with other disabilities.\u0000\u0000\u0000\u0000","PeriodicalId":356217,"journal":{"name":"Malaysian Journal of Paediatrics and Child Health","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123313811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical Thymic Cyst - An Overlooked Entity 宫颈胸腺囊肿-一个被忽视的实体

Malaysian Journal of Paediatrics and Child Health Pub Date : 2023-06-25 DOI: 10.51407/mjpch.v29i2.253

Siti Sarah Che Mohd Razali, Maithrea Suresh Narayana, Nik Khairani Nik Mohd, Suzina sheikh Ab Hamid, Tengku Diana Mariana Tengku Yahya

引用次数: 0

Uncommon Origin of Parotid Swelling 腮腺肿大的罕见原因

Malaysian Journal of Paediatrics and Child Health Pub Date : 2023-06-11 DOI: 10.51407/mjpch.v29i2.252

Eric Tan Jin Wee, Linda Lim Pei Fang, F. Hassan, Suzina Sheikh Ab Hamid

引用次数: 0