Chinese Medical Sciences Journal最新文献

{"title":"Duration of Hypothermia is Associated with Postoperative Complications in Patients Undergoing Gynecological Surgery: A Prospective Cohort Study","authors":"Su-Mei Wang ,&nbsp;Li-Jian Pei ,&nbsp;Yue-Lun Zhang ,&nbsp;Jie Yi","doi":"10.24920/004419","DOIUrl":"10.24920/004419","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the relationship between hypothermia duration and postoperative complications in patients undergoing gynecological surgery.</div></div><div><h3>Methods</h3><div>Patients who underwent elective gynecological surgery at our hospital were consecutively enrolled between October 2020 and January 2022. Core temperature was continuously monitored intraoperatively, and early postoperative complications were collected. By adjusting the logistic regression model for potential confounding factors, the association of postoperative complications with the duration of hypothermia, the lowest body temperature below 36°C, and the hypothermia upon admission to postanesthesia care unit (PACU) or intensive care unit (ICU) were analyzed. Additionally, the potential inflection point in the relationship between the duration of hypothermia and the risk of postoperative complications was explored by using cumulative probability scatter plots and moving average sequences.</div></div><div><h3>Results</h3><div>The study included 370 patients, with 193 (52.2%) experiencing hypothermia and 177 (47.8%) not. Among them, 92 (24.9%) developed complications. The duration of hypothermia (adjusted odds ratio [<em>OR</em>] for each one-minute increase: 1.003; 95% confidence interval [<em>CI</em>]: 1.000-1.006, <em>P</em>=0.047) and hypothermia upon admission to PACU or ICU (adjusted <em>OR</em>: 1.980; 95% <em>CI</em>: 1.135-3.454, <em>P</em>=0.016) were associated with early postoperative complications. Notably, the cumulative incidence of postoperative complications tended to rise as the duration of hypothermia increased, with a potential inflection point observed at 120 minutes.</div></div><div><h3>Conclusions</h3><div>In gynecological surgery, the duration of hypothermia as well as hypothermia upon admission to PACU or ICU are associated with postoperative complications. Minimizing the duration of hypothermia may be clinically beneficial.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 4","pages":"Pages 233-240"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End-of-Life Inpatient Palliative Care for Glioblastoma Multiforme: Lessons Learned from One Case","authors":"Zhi-Yuan Xiao ,&nbsp;Yan-Xia Sun ,&nbsp;Dong-Rui Xu ,&nbsp;Xiao-Hong Ning ,&nbsp;Yu Wang ,&nbsp;Yi Zhang ,&nbsp;Wen-Bin Ma","doi":"10.24920/004394","DOIUrl":"10.24920/004394","url":null,"abstract":"<div><div>Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor with a poor prognosis and limited survival. Patients with GBM have a high demand for palliative care. In our present case, a 21-year-old female GBM patient received inpatient palliative care services including symptom management, mental and psychological support for the patient, psychosocial and clinical decision support for her family members, and pre- and post-death bereavement management for the family. Furthermore, we provided the family members with comprehensive psychological preparation for the patient's demise and assisted the patient's family throughout the mourning period. The aim of this study is to provide a reference and insights for the clinical implementation of palliative care for patients with malignant brain tumors.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 4","pages":"Pages 297-302"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication Rules of Hub Herb Pairs for Insomnia and Mechanism of Action: Results of Data Mining, Network Pharmacology, and Molecular Docking","authors":"Wen-Long Guo ,&nbsp;Hui-Juan Jiang ,&nbsp;Yan-Rong Li ,&nbsp;Jin-Long Yang ,&nbsp;Yu-Chan Chen","doi":"10.24920/004384","DOIUrl":"10.24920/004384","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the medication rules of traditional Chinese medicine (TCM) and mechanism of action of hub herb pairs for treating insomnia.</div></div><div><h3>Methods</h3><div>Totally 104 prescriptions were statistically analyzed. The association rule algorithm was applied to mine the hub herb pairs. Network pharmacology was utilized to analyze the mechanism of the hub herb pairs, while molecular docking was applied to simulate the interaction between receptors and herb molecules, thereby predicting their binding affinities.</div></div><div><h3>Results</h3><div>The most frequently used herbs in TCM prescriptions for treating insomnia included <em>Semen Ziziphi Spinosae</em>, <em>Radix Glycyrrhizae</em>, <em>Radix et Rhizoma Ginseng</em>, and <em>Poria cum Radix Pini</em>. Among them, the most commonly used were the supplementing herbs, followed by heat-clearing, mind-calming, and exterior-releasing ones, with their properties of warm and cold, flavors of sweet, Pungent, and bitter, and meridian tropisms of liver, lungs, spleen, kidneys, heart, and stomach. The hub herb pairs based on the association rules included <em>Radix Astragali</em>-<em>Radix et Rhizoma Ginseng</em>, <em>Rhizoma Chuanxiong</em>-<em>Radix Glycyrrhizae</em>, <em>Seman Platycladi</em>-<em>Semen Ziziphi Spinosae</em>, <em>Pericarpium Citri Reticulatae</em>-<em>Radix Glycyrrhizae</em>, <em>Radix Polygalae</em>-<em>Semen Ziziphi Spinosae</em>, and <em>Radix Astragali</em>-<em>Semen Ziziphi Spinosae</em>. Network pharmacology revealed that the cAMP signaling pathway might play a key role in treating insomnia synergistically with HIF-1 signaling pathway, prolactin signaling pathway, chemical carcinogenesis receptor activation, and PI3K-Akt signaling pathway. Molecular docking indicated that there was good binding between the active ingredients of the hub herb pairs and the hub targets.</div></div><div><h3>Conclusions</h3><div>This study identified six hub herb pairs for treating insomnia in TCM. These hub herb pairs may synergistically treat insomnia with HIF-1 signaling pathway, prolactin signaling pathway, chemical carcinogenesis receptor activation, and PI3K-Akt signaling pathway through the cAMP signaling pathway.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 4","pages":"Pages 249-260"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video Feedback Improves Anesthesia Residents’ Communication Skill and Performance on Showing Empathy During Preoperative Interviews","authors":"Di Xia,&nbsp;Ya-Hong Gong,&nbsp;Xia Ruan,&nbsp;Li Xu,&nbsp;Li-Jian Pei,&nbsp;Xu Li,&nbsp;Rui-Ying Wang","doi":"10.24920/004379","DOIUrl":"10.24920/004379","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the impact of scenario-based lecture and personalized video feedback on anesthesia residents’ communication skills during preoperative visits.</div></div><div><h3>Methods</h3><div>A total of 24 anesthesia residents were randomly divided into a video group and a control group. Residents in both groups took part in a simulated interview and received a scenario-based lecture on how to communicate with patients during preoperative visits. Afterwards, residents in the video group received personalized video feedback recorded during the simulated interview. One week later all the residents undertook another simulated interview. The communication skills of all the residents were assessed using the Consultation and Relational Empathy measure (CARE) scale by two examiners and one standardized patient (SP), both of whom were blinded to the group allocation.</div></div><div><h3>Results</h3><div>CARE scores were comparable between the two groups before training, and significantly improved after training in both groups (all <em>P</em> &lt; 0.05). The video group showed significantly greater increase in CARE score after the training than the control group, especially assessed by the SP (<em>t</em> = 6.980, <em>P</em> &lt; 0.001). There were significant correlations between the examiner-assessed scores and SP-assessed scores (both <em>P</em> = 0.001).</div></div><div><h3>Conclusion</h3><div>Scenario-based lectures with simulated interviews provide a good method for training communication skills of anesthesia residents, and personalized video feedback can enhance their performance on showing empathy during preoperative interview.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 4","pages":"Pages 282-287"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Systemic Immune Inflammation Index, Aggregate Index of Systemic Inflammation, and Systemic Inflammation Response Index in Lower Extremity Deep Venous Thrombosis Following Severe Trauma","authors":"Peng-Fei Li,&nbsp;Xin Lu,&nbsp;Yu-Qian Zhou,&nbsp;Ke Wang,&nbsp;Peng Yang,&nbsp;Xiong-Hui Chen,&nbsp;Feng Xu","doi":"10.24920/004411","DOIUrl":"10.24920/004411","url":null,"abstract":"<div><h3>Objective</h3><div>Venous thromboembolism is a highly prevalent condition after polytrauma, and recognized as an important factor contributing to poor prognosis. The aim of this study was to investigate the risk factors for lower extremity deep venous thrombosis (LEDVT) in a severely traumatized population and to evaluate their predictive value for LEDVT.</div></div><div><h3>Methods</h3><div>This was a retrospective, single-center observational study. All subjects were severely traumatized patients who were admitted to the Traumatic Intensive Care Unit from January 2021 to May 2024. Based on Doppler ultrasound findings of both lower extremities from the time of injury to 30 days post-injury, patients who developed LEDVT were enrolled in the LEDVT group, and those who did not develop LEDVT were enrolled in the NLEDVT group. Demographic, clinical, and laboratory data were collected upon admission. Multivariable logistic regression analysis was performed to identify risk factors for LEDVT. Receiver operating characteristic (ROC) curve was used to evaluate the overall fit of the final model.</div></div><div><h3>Results</h3><div>There were 56 patients enrolled in the LEDVT group and 81 patients in the NLEDVT group. Age, Aggregate Index of Systemic Inflammation (AISI), Systemic Inflammation Response Index (SIRI), ICU length of stay, and albumin were identified as independent risk factors for LEDVT (all <em>P</em> &lt; 0.05). The area under their ROC curves were 0.604, 0.657, 0.694, 0.668, and 0.405, respectively. Combined model for early clinical prediction of LEDVT in severely traumatized patients by age, SIRI, AISI, and albumin resulted in an area under the ROC curve of 0.805 (95%<em>CI</em>: 0.73-0.88, <em>SE</em> = 0.037).</div></div><div><h3>Conclusion</h3><div>The combination of age, SIRI, AISI, and albumin has a predictive value for LEDVT in severely traumatized patients.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 4","pages":"Pages 241-248"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BILL Strategy: Points to Consider During the Performance and Interpretation of Critical Care Echocardiography","authors":"Hong-Min Zhang ,&nbsp;Hui Lian ,&nbsp;Xiao-Ting Wang","doi":"10.24920/004357","DOIUrl":"10.24920/004357","url":null,"abstract":"<div><div>The growing utilization of critical care echocardiography (CCE) by clinicians necessitates a meticulous review of clinical conditions in critically ill patients, both before and during the examination. The reviewing process of clinical conditions minimizes the risk of overlooking or misinterpreting crucial findings. This article proposes a comprehensive strategy, namely BILL strategy, to integrate into the CCE protocol, where “B” represents baseline respiratory and hemodynamic support, “I” signifies information gleaned from invasive monitoring, including central venous pressure and thermodilution-derived cardiac output, the first “L” denotes laboratory results such as central venous oxygen saturation, troponin, and brain natriuretic peptide, and the second “L” refers to lung ultrasound data. Combining the BILL strategy with CCE can enhance comprehensive understanding of critical conditions, potentially leading to improved diagnostic accuracy and patient outcomes.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 3","pages":"Pages 226-232"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypyrimidine Tract-Binding Protein Enhances Zika Virus Translation by Binding to the 5’UTR of Internal Ribosomal Entry Site","authors":"Moliduer Hamiti ,&nbsp;Xin-Tian Zhang ,&nbsp;Rui-Min Zhu ,&nbsp;Yun-Peng Liu ,&nbsp;Bin Yin ,&nbsp;Peng-Cheng Shu ,&nbsp;Xiao-Zhong Peng","doi":"10.24920/004393","DOIUrl":"10.24920/004393","url":null,"abstract":"<div><h3>Objectives</h3><div>To identify the 5’ untranslated region of Zika virus (ZIKV 5’UTR) RNA-binding proteins and to investigate the impact of the binding protein on the activity of internal ribosomal entry site (IRES) located in ZIKV 5’UTR and virus production.</div></div><div><h3>Methods</h3><div>Interacting proteins in U251 cells were captured using tRSA-tagged ZIKV 5’UTR RNA and tRSA-ZIKV 5’UTR RNA-binding proteins were visualized by SDS-PAGE silver staining. Subsequently, liquid chromatographytandem mass spectrometry (LC-MS/MS), bioinformatics analysis, and Western blot were used to identify the candidate proteins binding to ZIKV 5’UTR. Dicistronic expression assay and plaque forming assay were performed to analyze the effect of the binding protein on ZIKV IRES activity and ZIKV production, respecitvely.</div></div><div><h3>Results</h3><div>tRSA RNA pull-down assay, LC-MS/MS, and Western blot analysis showed that polypyrimidine tract-binding protein (PTB) bound to the ZIKV 5’UTR. Furthermore, dual luciferase reporter assay revealed that overexpression of PTB significantly enhanced the IRES activity of ZIKV (<em>t</em> = 10.220, <em>P</em> &lt; 0.001), while PTB knockdown had the opposite effect (<em>t</em> = 4.897, <em>P</em> &lt; 0.01). Additionally, virus plaque forming assay demonstrated that up-regulation of PTB expression significantly enhanced viral titer (<em>t</em> = 6.400, <em>P</em> &lt; 0.01), whereas reducing PTB expression level weakened virus infectivity (<em>t</em> = 5.055, <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>PTB positively interacts with the ZIKV 5’UTR and enhances IRES activity and virus production.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 3","pages":"Pages 162-170"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alignment Techniques in Total Knee Arthroplasty: Where do We Stand Today?","authors":"Hemanta Dhungana,&nbsp;Subhash Jangid,&nbsp;Meghal Goyal","doi":"10.24920/004372","DOIUrl":"10.24920/004372","url":null,"abstract":"<div><div>Achieving optimal alignment in total knee arthroplasty (TKA) is a critical factor in ensuring optimal outcomes and long-term implant survival. Traditionally, mechanical alignment has been favored to achieve neutral postoperative joint alignment. However, contemporary approaches, such as kinematic alignments and hybrid techniques including adjusted mechanical, restricted kinematic, inverse kinematic, and functional alignments, are gaining attention for their ability to restore native joint kinematics and anatomical alignment, potentially leading to enhanced functional outcomes and greater patient satisfaction. The ongoing debate on optimal alignment strategies considers the following factors: long-term implant durability, functional improvement, and resolution of individual anatomical variations. Furthermore, advancements of computer-navigated and robotic-assisted surgery have augmented the precision in implant positioning and objective measurements of soft tissue balance. Despite ongoing debates on balancing implant longevity and functional outcomes, there is an increasing advocacy for personalized alignment strategies that are tailored to individual anatomical variations. This review evaluates the spectrum of various alignment techniques in TKA, including mechanical alignment, patient-specific kinematic approaches, and emerging hybrid methods. Each technique is scrutinized based on its fundamental principles, procedural techniques, inherent advantages, and potential limitations, while identifying significant clinical gaps that underscore the need for further investigation.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 3","pages":"Pages 217-225"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting Causal Relationships Between Plasma Metabolites and Osteoporosis: A Bidirectional Mendelian Randomization Study","authors":"Hao Lv ,&nbsp;Ge Zhang ,&nbsp;Zhi-Mu Hu ,&nbsp;Qing-Song Chu ,&nbsp;Jiu-Xiang Wang ,&nbsp;Ting Jiang","doi":"10.24920/004356","DOIUrl":"10.24920/004356","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the causal relationships between plasma metabolites and osteoporosis <em>via</em> Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Bidirectional MR was used to analyze pooled data from different genome-wide association studies (GWAS). The causal effect of plasma metabolites on osteoporosis was estimated using the inverse variance weighted method, intersections of statistically significant metabolites obtained from different sources of osteoporosis-related GWAS aggregated data was determined, and then sensitivity analysis was performed on these metabolites. Heterogeneity between single nucleotide polymorphisms was evaluated by Cochran's Q test. Horizontal pleiotropy was assessed through the application of the MR-Egger intercept method and the MRPRESSO method. The causal effect of osteoporosis on plasma metabolites was also evaluated using the inverse variance weighted method. Additionally, pathway analysis was conducted to identify potential metabolic pathways involved in the regulation of osteoporosis.</div></div><div><h3>Results</h3><div>Primary analysis and sensitivity analysis showed that 77 and 61 plasma metabolites had a causal relationship with osteoporosis from the GWAS data in the GCST90038656 and GCST90044600 datasets, respectively. Five common metabolites were identified <em>via</em> intersection. X-13684 levels and the glucose-to-maltose ratio were negatively associated with osteoporosis, whereas glycoursodeoxycholate levels and arachidoylcarnitine (C20) levels were positively associated with osteoporosis (all <em>P</em> &lt; 0.05). The relationship between X-11299 levels and osteoporosis showed contradictory results (all <em>P</em> &lt; 0.05). Pathway analysis indicated that glycine, serine, and threonine metabolism, valine, leucine, and isoleucine biosynthesis, galactose metabolism, arginine biosynthesis, and starch and sucrose metabolism pathways were participated in the development of osteoporosis.</div></div><div><h3>Conclusion</h3><div>We found a causal relationship between plasma metabolites and osteoporosis. These results offer novel perspectives with important implications for targeted metabolite-focused interventions in the management of osteoporosis.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 3","pages":"Pages 182-188"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Evidence for Causal Association Between Hypertension and Chronic Pain: A Bidirectional Two-Sample Mendelian Randomization Study","authors":"Shuai-Lei Wang,&nbsp;Wei-Yun Chen,&nbsp;Zi-Jia Liu,&nbsp;Yu-Guang Huang","doi":"10.24920/004380","DOIUrl":"10.24920/004380","url":null,"abstract":"<div><h3>Objective</h3><div>The extent to which the association between hypertension and chronic pain in observational studies is either causally linked or influenced by other shared risk factors has not been substantially addressed. In the present study, Mendelian randomization (MR) was employed to examine the potential causal relationship between hypertension and risk of chronic pain.</div></div><div><h3>Methods</h3><div>The study data were derived from the pooled dataset of the genome-wide association study (GWAS), enabling the evaluation of the causal effects of hypertension on various types of chronic pain including chronic headache as well as chest, abdominal, joint, back, limb, and multisite chronic pain. We performed a bidirectional two-sample MR analysis using random effect inverse variance weighting (IVW), MR-Egger, weighted median, and weighted mode, quantified by odds ratio (OR).</div></div><div><h3>Results</h3><div>Genetically predicted essential hypertension was associated with an increased risk of chronic headache (<em>OR</em> = 1.007, 95% <em>CI</em>: 1.003–1.011, <em>P</em> = 0.002) and limb pain (<em>OR</em> = 1.219, 95% <em>CI</em>: 1.033–1.439, <em>P</em> = 0.019). No potential causal associations were identified between chronic pain and essential hypertension in the reverse direction MR (<em>P</em> &gt; 0.05). In addition, there was no potential causal association between secondary hypertension and chronic pain (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study provided genetic evidence that a unidirectional causal relationship exists between essential hypertension and the increased risks of chronic headache and limb pain, and no causal relationship was found between secondary hypertension and chronic pain. These findings offer theoretical underpinnings for future research on managing hypertension and chronic pain.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"39 3","pages":"Pages 155-161"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}