Chinese Medical Sciences Journal最新文献

{"title":"A Case Study of Comprehensive Postoperative Management for Elderly Total Hip Arthroplasty Patients Based on Peplau's Interpersonal Relationship Theory.","authors":"Jing-Han Ai, Chao Huang, Jing-Jin Luo","doi":"10.24920/004485","DOIUrl":"https://doi.org/10.24920/004485","url":null,"abstract":"<p><p>With a growing population of elderly patients undergoing hip arthroplasty, traditional nursing care often faces challenges dus to fragmented services and inadequate continuity. Based on Peplau's interpersonal relationship theory, we explored a comprehensive hospital-home-community management model for an 80-year-old female patient following total hip arthroplasty. This nursing model was structured into four sequential phases (orientation, identification, exploitation, and resolution) and incorporated a structured multidisciplinary team, a stepwise health education system, discharge preparation services, and evidence-based postoperative care. Post-discharge management integrated traditional Chinese medicine-based pain management, intelligent rehabilitation training, and evidence-based constipation management. After six months of intervention, the patient achieved satisfactory wound healing and optimal prosthesis positioning. Significant improvements were observed in pain, constipation, sleep, anxiety, hip function, self-care ability, and self-management competence. This approach established a closed-loop management system encompassing assessment, screening, referral, liaison, home visits, multidisciplinary collaboration, and continuous follow-up. This model bridges hospital-home care gap, enhances care continuity, and improves rehabilitation outcomes, thereby providing a replicable framework for the postoperative management of elderly surgical patients.</p>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"40 4","pages":"315-326"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence Applications in Fangcang Shelter Hospitals: Opportunities and Challenges","authors":"Ming Li ,&nbsp;Xiao-Hu Li ,&nbsp;Kai-Yuan Min ,&nbsp;Jun-Tao Yang","doi":"10.24920/004510","DOIUrl":"10.24920/004510","url":null,"abstract":"<div><div>Fangcang shelter hospitals are modular, rapidly deployable facilities that play a vital role in pandemic response by providing centralized isolation and basic medical care for large patient populations. Artificial intelligence (AI) has the potential to transform Fangcang shelter hospitals into intelligent, responsive systems that are capable of significantly improving emergency preparedness, operational efficiency, and patient outcomes. Key application areas include site selection and design optimization, clinical decision support, AI-assisted clinical documentation and patient engagement, intelligent robotics, and operational management. However, realizing AI's full potential requires overcoming several challenges, including limited data accessibility, privacy and governance concerns, inadequate algorithmic adaptability in dynamic emergency settings, insufficient transparency and accountability in AI-driven decisions, fragmented system architectures due to proprietary formats, high costs disproportionate to the temporary nature of Fangcang shelter hospitals, and hardware reliability in austere environments. Addressing these challenges demands standardized data-sharing frameworks, development of explainable and robust AI algorithms, clear ethical and legal oversight, interoperable modular system designs, and active collaboration among multidisciplinary stakeholders.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"40 3","pages":"Pages 197-202"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthesia Management for Emergency Cesarean Section in a Severely Obese Parturient with Refractory Hypertension: A Case Report","authors":"Qian-Mei Zhu,&nbsp;Qian Shu,&nbsp;Zi-Jia Liu","doi":"10.24920/004412","DOIUrl":"10.24920/004412","url":null,"abstract":"<div><div>Emergency cesarean section has always been a challenge for patients, surgeons, and anesthesiologists, as it endangers the safety of both parturients and fetuses. Obesity and hypertension are common among pregnant women, but severe obesity combined with refractory hypertension is very rare in clinical practice. The optimal anesthetic management strategy for obese pregnant women with a difficult airway and poorly controlled hypertension remains debatable. This report presents a 32-year-old woman with severe obesity and refractory hypertension at 36 weeks and 6 days of pregnancy. Owing to fetal heart rate abnormalities, she was scheduled for emergency cesarean section. Given the urgency of the fetal condition and the challenges posed by the patient's obesity for epidural puncture, the anesthesiologist opted for rapid sequence induction and tracheal intubation instead of intervertebral anesthesia. Shortacting antihypertensive medications were adminstrated preoperatively to control elevated blood pressure, and vasopressor agents were continuously infused during surgery to prevent severe hypotension induced by anesthetic drugs. The entire anesthesia and surgical procedure proceeded uneventfully, with no major adverse events observed. Both the patient and fetus achieved favorable outcomes. This case indicates that early anesthetic risk assessment and meticulous pre-delivery planning are paramount, necessitating personalized management of airway and hemodynamics to optimize outcomes in obese parturients.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"40 3","pages":"Pages 232-236"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Risk Factors of Coronary Artery Disease in Patients with Hypertension and Persistent Atrial Fibrillation","authors":"Jia-Qi Bai ,&nbsp;Yi-Ning Liu ,&nbsp;Rui-Zhe Li ,&nbsp;Zong-Bin Li","doi":"10.24920/004480","DOIUrl":"10.24920/004480","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Hypertension (HT) and atrial fibrillation (AF) are highly prevalent cardiovascular conditions that frequently coexist. Coronary artery disease (CAD) is a major global cause of mortality. The co-occurrence of HT, AF, and CAD presents significant management challenges. This study aims to explore the clinical characteristics and risk factors associated with CAD in patients with HT and persistent AF (HT-AF).</div></div><div><h3>Methods</h3><div>In this retrospective cross-sectional study, data were collected from 384 hospitalized HT-AF patients at the People's Liberation Army General Hospital between January 2010 and December 2019. CAD diagnosis was confirmed by coronary angiography or computed tomography angiography. Clinical characteristics and comorbidities were compared between patients with and without CAD. Multivariate logistic regression analyses were performed to identify independent risk factors associated with CAD development.</div></div><div><h3>Results</h3><div>The prevalence of CAD among HT-AF patients was 66.41% (255/384). Cardiovascular complications, particularly heart failure (44.7% <em>vs</em> 25.6%, <em>P</em> &lt; 0.05), were significantly more prevalent in the CAD group than in the non-CAD group. Only age was identified as an independent risk factor for CAD (adjusted <em>OR</em>: 1.047; 95% <em>CI</em>: 1.022–1.073; <em>P</em> = 0.000). Of all HT-AF patients, 54.7% had a CHA₂DS₂-VASc score of ≥4, indicating high stroke risk. There was a slightly higher anticoagulant usage rate in the CAD group than those without CAD (8.6% <em>vs</em> 4.7%, <em>P</em> = 0.157), and the overall anticoagulant usage remained low.</div></div><div><h3>Conclusion</h3><div>There is a high prevalence of CAD among hospitalized HT-AF patients, among whom age is the sole independent risk factor for CAD. Despite a high stroke risk, the utilization of oral anticoagulants is alarmingly low.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"40 3","pages":"Pages 171-179"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Ready Competency Framework for Biomedical Scientific Data Literacy","authors":"Zhe Wang ,&nbsp;Zhi-Gang Wang ,&nbsp;Wen-Ya Zhao ,&nbsp;Wei Zhou ,&nbsp;Sheng-Fa Zhang ,&nbsp;Xiao-Lin Yang","doi":"10.24920/004522","DOIUrl":"10.24920/004522","url":null,"abstract":"<div><div>With the rise of data-intensive research, data literacy has become a critical capability for improving scientific data quality and achieving artificial intelligence (AI) readiness. In the biomedical domain, data are characterized by high complexity and privacy sensitivity, calling for robust and systematic data management skills. This paper reviews current trends in scientific data governance and the evolving policy landscape, highlighting persistent challenges such as inconsistent standards, semantic misalignment, and limited awareness of compliance. These issues are largely rooted in the lack of structured training and practical support for researchers. In response, this study builds on existing data literacy frameworks and integrates the specific demands of biomedical research to propose a comprehensive, lifecycle-oriented data literacy competency model with an emphasis on ethics and regulatory awareness. Furthermore, it outlines a tiered training strategy tailored to different research stages—undergraduate, graduate, and professional, offering theoretical foundations and practical pathways for universities and research institutions to advance data literacy education.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"40 3","pages":"Pages 203-210"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Assessment Scales in Palliative Care for Glioma: A Systematic Review","authors":"Zhi-Yuan Xiao ,&nbsp;Tian-Rui Yang ,&nbsp;Ya-Ning Cao ,&nbsp;Wen-Lin Chen ,&nbsp;Jun-Lin Li ,&nbsp;Ting-Yu Liang ,&nbsp;Ya-Ning Wang ,&nbsp;Yue-Kun Wang ,&nbsp;Xiao-Peng Guo ,&nbsp;Yi Zhang ,&nbsp;Yu Wang ,&nbsp;Xiao-Hong Ning ,&nbsp;Wen-Bin Ma","doi":"10.24920/004416","DOIUrl":"10.24920/004416","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Patients with glioma experience a high symptom burden and have diverse palliative care needs. However, the assessment scales used in palliative care remain non-standardized and highly heterogeneous. To evaluate the application patterns of the current scales used in palliative care for glioma, we aim to identify gaps and assess the need for disease-specific scales in glioma palliative care.</div></div><div><h3>Methods</h3><div>We conducted a systematic search of five databases including PubMed, Web of Science, Medline, EMBASE, and CINAHL for quantitative studies that reported scale-based assessments in glioma palliative care. We extracted data on scale characteristics, domains, frequency, and psychometric properties. Quality assessments were performed using the Cochrane ROB 2.0 and ROBINS-I tools.</div></div><div><h3>Results</h3><div>Of the 3,405 records initially identified, 72 studies were included. These studies contained 75 distinct scales that were used 193 times. Mood (21.7%), quality of life (24.4%), and supportive care needs (5.2%) assessments were the most frequently assessed items, exceeding half of all scale applications. Among the various assessment dimensions, the Distress Thermometer (DT) was the most frequently used tool for assessing mood, while the Short Form-36 Health Survey Questionnaire (SF-36) was the most frequently used tool for assessing quality of life. The Mini Mental Status Examination (MMSE) was the most common tool for cognitive assessment. Performance status (5.2%) and social support (6.8%) were underrepresented. Only three brain tumor-specific scales were identified. Caregiver-focused scales were limited and predominantly burden-oriented.</div></div><div><h3>Conclusions</h3><div>There are significant heterogeneity, domain imbalances, and validation gaps in the current use of assessment scales for patients with glioma receiving palliative care. The scale selected for use should be comprehensive and user-friendly.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"40 3","pages":"Pages 211-218"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Complications and 30-day Readmission in Patients Older than 80 Years with Chronic Kidney Disease after Hip Fracture","authors":"Hua-Wen Zhang,&nbsp;Lu-Lu Ma,&nbsp;Xue-Rong Yu","doi":"10.24920/004446","DOIUrl":"10.24920/004446","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the impact of chronic kidney disease (CKD) on prognosis of patients older than 80 years after hip fracture.</div></div><div><h3>Methods</h3><div>This retrospective, observational, single-center study included patients older than 80 years who underwent hip fracture operations between Feburary 2013 to June 2021 at our hospital. Patients were divided into CKD and non-GKD groups based on the estimated glomerular filtration rate (eGFR) &lt; 60 mL/(min·1.73m2)] or not. Outcomes were the incidence of in-hospital postoperative infectious and non-infectious complications, 30-day readmission, and in-hospital death. Logistic regression analysis was used to calculate the odds ratio (<em>OR</em>) of CKD on these outcomes.</div></div><div><h3>Results</h3><div>A total of 498 patients were included, 165 in the CKD group and 333 in the non-CKD group. Eighty-seven (52.7%) CKD patients experienced 140 episodes of postoperative complications. In comparison, 114 (34.2%) non-CKD patients had 158 episodes of postoperative complications. CKD patients were more likely to have postoperative complications than non-CKD patients (<em>OR</em> = 2.143, 95% <em>CI</em>: 1.465–3.134, <em>P</em> &lt; 0.001). CKD increased the risk of cardiovascular complications (<em>OR</em> = 2.044, 95% <em>CI</em>: 1.245–3.356, <em>P</em> = 0.004), acute kidney injury (<em>OR</em> = 3.401, 95% <em>CI</em>: 1.905–6.072, <em>P</em> &lt; 0.001), delirium (<em>OR</em> = 2.276, 95% <em>CI</em>: 1.140–4.543, <em>P</em> = 0.024), and gastrointestinal bleeding (<em>OR</em> = 4.151, 95% <em>CI</em>: 1.025–16.812, <em>P</em> = 0.031). The transfusion rate (<em>OR</em> = 2.457, 95% <em>CI</em>: 1.668–3.618, <em>P</em> &lt; 0.001) and incidence of 30-day readmission (<em>OR</em> = 2.426, 95% <em>CI</em>: 1.203–4.892, <em>P</em> = 0.011) in CKD patients were significantly higher than those in patients without CKD.</div></div><div><h3>Conclusion</h3><div>CKD is associated with poor postoperative outcomes in geriatric hip fracture patients. Special attention should be paid to patients with CKD.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"40 3","pages":"Pages 188-196"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Introversion Personality and Social Media Usage-Related Social Anxiety Among Chinese College Students: Chain Mediating Effects of Interaction Anxiousness and Mobile Phone Addiction","authors":"Su-Yan Wang ,&nbsp;Wen-Hui Li ,&nbsp;Hong-Liang Dai","doi":"10.24920/004397","DOIUrl":"10.24920/004397","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Social anxiety arising from intensive social media usage (SMU) among adolescents and youth has gained extensive attention in recent years due to its negative influence on mental health and academic performance. In spite of that, there is a dearth regarding the etiology of SMU-related social anxiety. This study aims to further clarify the influence of introversion personality on SMU-related social anxiety and the mechanism underlying such an association and provide a new perspective for developing effective intervention strategies for the highly prevailing SMU-related anxiety among Chinese college students.</div></div><div><h3>Methods</h3><div>A cohort of 979 college students (266 males and 713 females) aged 20.90 ± 1.91 years was enrolled in this cross-sectional study. Four measures including the “extroversion” domain of Eysenck Personality Questionnaire Revised, Short Scale (EPQ-R-S E), Interaction Anxiousness Scale (IAS), Mobile Phone Addiction Index (MPAI), and Social Anxiety Scale for Social Media Users (SAS-SMU) were used to evaluate the influence of introversion personality on SMU-related social anxiety that was potentially mediated sequentially by interaction anxiousness and mobile phone addiction. Hayes PROCESS was used for correlation and mediation analysis.</div></div><div><h3>Results</h3><div>Interaction anxiousness (indirect effect = –1.331, 95% <em>CI</em> : –1.559 – –1.122) partially mediated the association between introversion personality and SMU-related social anxiety. Besides, a sequential mediation of interaction anxiousness and mobile phone addiction in the link between introversion personality and SMU-related social anxiety was revealed (indirect effect = –0.308, 95% <em>CI</em> : –0.404 – –0.220). No significant mediating effect was found with mobile phone addiction in the association between introversion personality and SMU-related social anxiety.</div></div><div><h3>Conclusion</h3><div>Targeting interaction anxiousness and mobile phone addiction may represent an efficient strategy alleviating SMU-related social anxiety among Chinese college students with introversion personality.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"40 3","pages":"Pages 180-187"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Phase Contrast-Enhanced CT Clinical-Radiomics Model for Predicting Prognosis of Extrahepatic Cholangiocarcinoma After Surgery: A Single-Center Retrospective Study","authors":"Shen-Bo Zhang ,&nbsp;Zheng Wang ,&nbsp;Ge Hu ,&nbsp;Si-Hang Cheng ,&nbsp;Zhi-Wei Wang ,&nbsp;Zheng-Yu Jin","doi":"10.24920/004458","DOIUrl":"10.24920/004458","url":null,"abstract":"<div><h3>Objective</h3><div>To develop and validate a preoperative clinical-radiomics model for predicting overall survival (OS) and disease-free survival (DFS) in patients with extrahepatic cholangiocarcinoma (eCCA) undergoing radical resection.</div></div><div><h3>Methods</h3><div>In this retrospective study, consecutive patients with pathologically-confirmed eCCA who underwent radical resection at our institution from 2015 to 2022 were included. The patients were divided into a training cohort and a validation cohort according to the chronological order of their CT examinations. Least absolute shrinkage and selection operator (LASSO)-Cox regression was employed to select predictive radiomic features and clinical variables. The selected features and variables were incorporated into a Cox regression model. Model performance for 1-year OS and DFS prediction was assessed using calibration curves, area under receiver operating characteristic curve (AUC), and concordance index (C-index).</div></div><div><h3>Results</h3><div>This study included 123 patients (mean age 64.0 ± 8.4 years, 85 males/38 females), with 86 in the training cohort and 37 in the validation cohort. The OS-predicting model included four clinical variables and four radiomic features. It achieved a training cohort AUC of 0.858 (C-index = 0.800) and a validation cohort AUC of 0.649 (C-index = 0.605). The DFS-predicting model included four clinical variables and four other radiomic features. It achieved a training cohort AUC of 0.830 (C-index = 0.760) and a validation cohort AUC of 0.717 (C-index = 0.616).</div></div><div><h3>Conclusion</h3><div>The preoperative clinical-radiomics models show promise as a tool for predicting 1-year OS and DFS in eCCA patients after radical surgery.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"40 3","pages":"Pages 161-170"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-Effectiveness of Denosumab for Treating Bone Metastases from Solid Tumors: A Systematic Review (2017-2023)","authors":"Cong Wang ,&nbsp;Jin-Yu Liu ,&nbsp;Min Wan ,&nbsp;Qi Yuan ,&nbsp;Yu Zhang ,&nbsp;Guang-Yi Yu ,&nbsp;Ru-Xu You","doi":"10.24920/004368","DOIUrl":"10.24920/004368","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review examines recent pharmacoeconomic literature on denosumab’ cost-effectiveness for bone metastasis treatment, providing evidence-based insights to guide healthcare policy decisions.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was performed across Cochrane, PubMed, EMBASE (Ovid), CNKI, and Wanfang databases to identify original articles published between 2017 and 2023. Key words consisted of bone metastases, denosumab, and cost-effectiveness in the search strategy. The methodological quality of the included studies was assessed utilizing the revised Consolidated Health Economic Evaluation Reporting Standards (CHEERS 2022). Data was extracted regarding methodological characteristics and cost-effectiveness analyses.</div></div><div><h3>Results</h3><div>A total of 111 studies were retrieved, of which 6 met the inclusion criteria. All included studies were based on clinical trials and published literature data and exhibited high methodological quality. Up to 83% (5 out of 6) of comparisons demonstrated that denosumab was more cost-effective or dominant compared to zoledronic acid. The adjusted incremental cost-effectiveness ratios varied substantially by tumor type, ranging from CZK 436,339.09 to USD 136,234 per skeletal-related event avoided and from CZK 61,580.95 to USD 118,392.11 per quality-adjusted life year gained.</div></div><div><h3>Conclusions</h3><div>The majority of the included studies support denosumab as a more cost-effective treatment option for bone metastases in solid tumors compared to zoledronic acid. The application of CHEER (2022) enhances the reliability of pharmacoeconomic evaluations.</div></div>","PeriodicalId":35615,"journal":{"name":"Chinese Medical Sciences Journal","volume":"40 3","pages":"Pages 219-231"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}