{"title":"[CHARACTERISTICS OF ASTHMA PATIENTS WITH A FORCED EXPIRATORY VOLUME IN ONE SECOND/FORCED VITAL CAPACITY OF LESS THAN 70% IN A BRONCHODILATOR INHALATION TEST].","authors":"Shinobu Osanai, Yoshinori Minami, Takaaki Sasaki","doi":"10.15036/arerugi.75.297","DOIUrl":"10.15036/arerugi.75.297","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to investigate the clinical characteristics and bronchodilator inhalation (BDI) responsiveness of asthma patients whose forced expiratory volume in one second to forced vital capacity ratio (FEV<sub>1</sub>/FVC) remained below 70% after BDI.</p><p><strong>Methods: </strong>This retrospective observational study included 130 patients diagnosed with asthma by respiratory specialists who had undergone airway reversibility test, and whose diagnoses could be confirmed from medical records.</p><p><strong>Results: </strong>Among the 130 patients, 91 showed a post-BDI FEV<sub>1</sub>/FVC ≥70% (N group), while 39 showed a post-BDI FEV<sub>1</sub>/FVC <70% (O group). Peripheral blood eosinophil counts were significantly higher in the O group, whereas no other background factors differed between the groups. Before BDI, the percentage predicted FEV<sub>1</sub> (%FEV<sub>1</sub>) and the percentage predicted forced vital capacity (%FVC) were significantly lower in the O group. After BDI, %FEV<sub>1</sub> remained lower in the O group, whereas %FVC did not differ significantly between the two groups. Both the absolute and relative increases in FEV<sub>1</sub> and FVC following BDI were greater in the O group. In the O group, the absolute increases in FEV<sub>1</sub> and FVC were comparable, whereas in the N group, the increase in FVC was smaller than that in FEV<sub>1</sub>. The proportion of patients meeting criteria for airway reversibility (≥10% improvement in either FEV<sub>1</sub> or FVC from predicted values) was significantly higher in the O group.</p><p><strong>Conclusion: </strong>Asthma patients with a post-BDI FEV<sub>1</sub>/FVC <70% had more severe obstructive ventilatory impairment; however, their bronchodilator responsiveness was preserved, with a particularly marked improvement in FVC.</p>","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 4","pages":"297-304"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[PATHOPHYSIOLOGICAL AND CLINICAL SIGNIFICANCE OF IL-31 IN ALLERGIC DISEASES].","authors":"Saeko Nakajima","doi":"10.15036/arerugi.75.22","DOIUrl":"https://doi.org/10.15036/arerugi.75.22","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 1","pages":"22-26"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[EVALUATION OF STEROID SENSITIVITY IN SEVERE ASTHMA: INVOLVEMENT OF THE PI3K PATHWAY AND RESTORATION OF SENSITIVITY BY BIOLOGICS].","authors":"Sekiko Uehara, Keita Hirai","doi":"10.15036/arerugi.75.367","DOIUrl":"https://doi.org/10.15036/arerugi.75.367","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 5","pages":"367-374"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[THE NEED FOR ALLERGISTS TO MOVE BEYOND AN \"ASTHMA-ONLY\" FOCUS: CHANGING DISEASE PATTERNS AND HOW TO RESPOND].","authors":"Yuma Fukutomi","doi":"10.15036/arerugi.75.29","DOIUrl":"https://doi.org/10.15036/arerugi.75.29","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 1","pages":"29-32"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}