{"title":"[DIAGNOSIS AND MANAGEMENT OF SEVERE CUTANEOUS ADVERSE DRUG REACTIONS].","authors":"Yoshiko Mizukawa","doi":"10.15036/arerugi.75.73","DOIUrl":"https://doi.org/10.15036/arerugi.75.73","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 2","pages":"73-83"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A CASE OF ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS THAT DEVELOPED FROM DE NOVO SENSITIZATION IN A STABLE NON-ATOPIC ASTHMA, DIAGNOSED BY COMPUTED TOMOGRAPHY].","authors":"Rina Harigane, Mami Rikimaru, Hiroaki Kume","doi":"10.15036/arerugi.75.153","DOIUrl":"10.15036/arerugi.75.153","url":null,"abstract":"<p><p>A 76-year-old woman was diagnosed with asthma at 40 years of age because of chest tightness and wheezing. She was considered to have non-atopic asthma, because total and specific IgE values were normal. Combination therapy with inhaled corticosteroid and long-acting β<sub>2</sub>-adrenergic agonist was effective. Thereafter, the patient remained asymptomatic. Chest radiograph and pulmonary function test were normal, excluding mild elevation of peripheral blood eosinophil counts (maximum value of 670/μL) during this period. At 73 years of age, the chest computed tomography (CT) performed during this stable phase showed mucoid impaction, including a high-attenuation area in the left lower lobar bronchi (B<sup>8</sup>, B<sup>9</sup>) with central bronchiectasis. These high-attenuation mucus (HAM) plugs were not visible in chest radiograph. Re-examination of the blood test revealed elevated total IgE and specific IgE to Aspergillus. Moreover, Aspergillus IgG antibody titer was positive. Therefore, the patient was diagnosed with allergic bronchopulmonary aspergillosis (ABPA). Oral corticosteroids effectively removed HAM plugs. However, HAM plugs recurred in the same bronchi after 16 months. This non-atopic patient acquired de novo sensitization to Aspergillus during a long, stable period of asthma, with HAM plugs initially identified via chest CT, which made early detection difficult.</p>","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 2","pages":"153-158"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hideaki Kouzaki, Hiroki Nakayoshi, Koji Matsumoto, Emiko Noguchi, Atsushi Yuta
{"title":"[INTEGRATED ANALYSIS OF BIOMARKERS IN ALLERGEN IMMUNOTHERAPY BASED ON PATIENT-DERIVED SAMPLES -EVALUATION OF PRE- AND POST-TREATMENT CHANGES AND IDENTIFICATION OF NOVEL PREDICTORS].","authors":"Hideaki Kouzaki, Hiroki Nakayoshi, Koji Matsumoto, Emiko Noguchi, Atsushi Yuta","doi":"10.15036/arerugi.75.278","DOIUrl":"https://doi.org/10.15036/arerugi.75.278","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 4","pages":"278-282"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[PATHOPHYSIOLOGICAL AND CLINICAL SIGNIFICANCE OF NUCLEAR IL-33 IN SKIN BARRIER DYSFUNCTION IN ATOPIC DERMATITIS].","authors":"Jun Muto","doi":"10.15036/arerugi.75.359","DOIUrl":"https://doi.org/10.15036/arerugi.75.359","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 5","pages":"359-366"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[MANAGEMENT OF ANAPHYLAXIS TO HYMENOPTERA VENOM].","authors":"Hisanori Hirokawa, Hirokuni Hirata","doi":"10.15036/arerugi.75.243","DOIUrl":"https://doi.org/10.15036/arerugi.75.243","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 4","pages":"243-249"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[RESEARCH AND DEVELOPMENT STRATEGY FOR THE NEXT GENERATION OF MUCOSAL VACCINES].","authors":"Morio Nagira, Hiroshi Kiyono","doi":"10.15036/arerugi.75.258","DOIUrl":"https://doi.org/10.15036/arerugi.75.258","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 4","pages":"258-262"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}