{"title":"[TYPICAL COLD URTICARIA EASILY TRIGGERED BY EXERCISE IN A 13-YEAR-OLD GIRL].","authors":"Yuma Onagawa, Kei Kubota, Yuko Horikawa, Ayako Goto, Shinichiro Nagamitsu","doi":"10.15036/arerugi.75.142","DOIUrl":"https://doi.org/10.15036/arerugi.75.142","url":null,"abstract":"<p><p>Typical cold urticaria is a form of physical urticaria triggered by exposure to cold, which can lead to anaphylaxis, particularly after full immersion in cold water or exposure to cold air. While it is a rare cause of anaphylaxis in Japan, the association between cold urticaria and exercise remains unclear. We report a case of the 13-year-old girl with typical cold urticaria, whose symptoms were easily triggered during exercise. In January X, she experienced recurrent episodes of loss of consciousness, facial swelling, and wheals in her limbs during morning exercise after eating bread for breakfast. Wheat-dependent exercise-induced anaphylaxis was initially suspected; however, allergy testing showed no sensitization to wheat or ω-5 gliadin. The patient was referred to our department in February. The patient continued to experience facial and limb swelling during exercise under cold conditions, even wheat consumption. The exercise challenge test following wheat ingestion, and aspirin pre-administration, did not provoke allergic symptoms. The ice cube test result was positive, confirming the diagnosis of typical cold urticaria. After initiating oral antihistamine therapy, her winter urticaria symptoms improved, and she had no further episodes of anaphylaxis. Her symptoms were provoked exclusively during exercise in everyday situation, suggesting that exercise played a significant role in triggering her symptoms. Typical cold urticaria should be considered a potential cause of anaphylaxis during exercise under winter conditions.</p>","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 2","pages":"142-146"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[ORAL IMMUNOTHERAPY FOR SEVERE FOOD ALLERGY PATIENTS: ISSUES TO BE ADDRESSED AND NOVEL APPROACHES THROUGH LONG-TERM OUTCOMES].","authors":"Ken-Ichi Nagakura, Motohiro Ebisawa","doi":"10.15036/arerugi.75.18","DOIUrl":"https://doi.org/10.15036/arerugi.75.18","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 1","pages":"18-21"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[DIAGNOSIS OF ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-NEGATIVE EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS BASED ON RENAL PATHOLOGICAL FINDINGS WITHOUT ASTHMA].","authors":"Masamichi Itoga, Shintaro Oyama, Yasuhito Nunomura, Takashi Fukushima, Takahiro Akita, Hiroaki Sakamoto, Tomonori Makiguchi, Hisashi Tanaka, Kageaki Taima, Sadatomo Tasaka","doi":"10.15036/arerugi.75.147","DOIUrl":"https://doi.org/10.15036/arerugi.75.147","url":null,"abstract":"<p><strong>Background: </strong>Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of necrotizing vasculitis typically accompanied by asthma and eosinophilia. Only a small number of cases lacking asthma symptoms have been reported.</p><p><strong>Case presentation: </strong>A man in his fifties with no history of asthma, allergic rhinitis, or eosinophilic sinusitis was admitted with fever, shortness of breath, and a rash. Peripheral blood eosinophilia and multi-organ dysfunction were also observed. Myocardial and gastrointestinal tract biopsies revealed eosinophil-predominant inflammatory infiltrates. Renal biopsy revealed pauci-immune necrotizing crescentic glomerulonephritis with eosinophilic interstitial nephritis. Although anti-neutrophil cytoplasmic antibodies (ANCA) were negative, the patient was diagnosed with EGPA based on the classification criteria.</p><p><strong>Treatment and clinical course: </strong>Systemic corticosteroid therapy was initiated, followed by the administration of intravenous cyclophosphamide and immunoglobulin. The patient achieved remission and was discharged from the hospital.</p><p><strong>Conclusion: </strong>Even in ANCA-negative patients without asthma, the presence of eosinophilia and characteristic renal pathological findings provides important diagnostic clues. EGPA should be included in the differential diagnosis of renal impairment with eosinophilia, and an early renal biopsy should be considered.</p>","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 2","pages":"147-152"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[UNCONVENTIONAL T CELLS IN ALLERGIC DISEASES].","authors":"Hiroshi Wakao","doi":"10.15036/arerugi.75.84","DOIUrl":"https://doi.org/10.15036/arerugi.75.84","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"75 2","pages":"84-90"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[ELUCIDATION OF PATHOGENESIS IN HUMAN INFLAMMATORY SKIN DISEASES USING SINGLE-CELL RNA-SEQ ANALYSIS].","authors":"Satoshi Nakamizo","doi":"10.15036/arerugi.74.107","DOIUrl":"https://doi.org/10.15036/arerugi.74.107","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 3","pages":"107-113"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}