Bianca Dorana de Oliveira Souza, B. F. Diaz, Gabriela Guidugli, L. S. Ferraz, M. K. Amarante, S. Rocha, P. Marinello, Milena Menegazzo Miranda Sapla, Francisco José de Abreu Oliveira, M. Watanabe
{"title":"Natural Killer Cells: Prospects in Cancer Immunotherapy","authors":"Bianca Dorana de Oliveira Souza, B. F. Diaz, Gabriela Guidugli, L. S. Ferraz, M. K. Amarante, S. Rocha, P. Marinello, Milena Menegazzo Miranda Sapla, Francisco José de Abreu Oliveira, M. Watanabe","doi":"10.2174/1573395514666180904125809","DOIUrl":"https://doi.org/10.2174/1573395514666180904125809","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180904125809","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47762812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autoimmune Diseases and Infections: A Controversial Relationship","authors":"Mostafa A. Abdel-maksoud and Saleh AL-Quraishy","doi":"10.2174/1573395514666180412154529","DOIUrl":"https://doi.org/10.2174/1573395514666180412154529","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180412154529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48504375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Lara-Reyna, T. Scambler, J. Holbrook, H. Jarosz-Griffiths, D. Peckham, M. McDermott
{"title":"Regulation of the Unfolded Protein Response in Disease: Cellular Stress and microRNAs","authors":"S. Lara-Reyna, T. Scambler, J. Holbrook, H. Jarosz-Griffiths, D. Peckham, M. McDermott","doi":"10.2174/1573395514666180309161144","DOIUrl":"https://doi.org/10.2174/1573395514666180309161144","url":null,"abstract":"Background: The Unfolded Protein Response (UPR) is a well conserved mechanism that mammalian cells use to cope with stress and infections. This mechanism is exquisitely regulated at several levels, including post-transcriptional modifications by microRNAs. These small non-coding RNAs are mainly involved in the degradation of mRNA, thereby blocking protein translation. The finely balanced interplay between the UPR and microRNAs is altered in several disorders, contributing to both disease aetiology and pathology.\u0000\u0000\u0000\u0000Methods: We review and explore alterations in the UPR and microRNAs in several inflammatory conditions, including bone, lung, and neurodegenerative diseases. We also evaluate the impact of these alterations on the disruption of cellular homeostasis and suggest possible therapeutic options to restore this balance.\u0000\u0000\u0000\u0000Results: Several components of the UPR, including IRE1, ATF6, and PERK, are clearly dysregulated in inflammatory bone, lung, and neurodegenerative diseases, contributing to the inflammatory process in these disorders. XBP1s, which is downstream of IRE1, is shown to be dysregulated in several diseases, and significantly contributes to the inflammatory process. MicroRNAs show unique dysregulated signatures in each individual tissue and disorder, suggesting that these small transcripts may regulate different pathways in a cell-dependent manner. Finally, there are functional connections between these dysregulated microRNAs and the UPR, which may underlie important pathological aspects of these disorders.\u0000\u0000\u0000\u0000Conclusion: It is evident that microRNAs regulate several components of the UPR and that these small non-coding RNAs, or other molecules that restore the UPR balance, may represent possible therapeutic options to normalise intracellular homeostasis.","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180309161144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48196767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coenzyme Q10: A Potential Adjunct for Treatment of Antiphospholipid Syndrome and Recurrent Miscarriage","authors":"H. Shankar, P. Verma, D. N. Rao","doi":"10.2174/1573395514666180416155458","DOIUrl":"https://doi.org/10.2174/1573395514666180416155458","url":null,"abstract":"Background: Recurrent Miscarriage (RM) is one of the most frustrating clinical situations wherein most of the cases, neither the engaged obstetrician nor suffering couples know the exact etiology and cause of the disease. About 10-15% of women with RM diagnosed with antiphospholipid syndrome (APS) are characterized by the marked presence of antiphospholipid antibodies (aPLa). There are several scientific reports available on the association between APS and RM; however, scanty data available about the beneficial role of coenzyme Q10 (CoQ10) in APS and APS mediated RM. In the present attempt, we tried to gather information to explain the possible associations between the role of CoQ10 in RM and APS. Methods: We collected peer-reviewed literature using keywords; antiphospholipid syndrome, CoQ10, endothelial dysfunction, oxidative stress and recurrent miscarriage in online electronic databases, such as Web of Science, Science Direct, Google Scholar, PubMed and Medline. The qualitative analysis of content was done by summarizing interventions and findings of included studies, on the basis of which a conceptual framework was prepared for this narrative review. Results: The beneficial role of CoQ10 in diverse pathological conditions has been summarized and the evidence suggests that CoQ10 being a potent antioxidant helps in the amelioration of free radicalmediated aPLa production, endothelial damage and mitochondrial dysfunction. The supplementation of CoQ10 overcomes the immune dysregulation in idiopathic RM and APS; thus could be a possible therapeutic adjunct in such diseases. Conclusion: Based on this review, further comprehensive studies may be conducted to illuminate the beneficial therapeutic effects of supplementing CoQ10 on possible modifiable pathways involved in the progression of RM and APS. A R T I C L E H I S T O R Y Received: December 29, 2017 Revised: April 06, 2018 Accepted: April 14, 2018 DOI: 10.2174/1573395514666180416155458","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180416155458","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43295645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chikungunya Infection and Immunity: An Overview","authors":"P. Verma, Alpana Sharma, H. Shankar, D. N. Rao","doi":"10.2174/1573395514666180417143739","DOIUrl":"https://doi.org/10.2174/1573395514666180417143739","url":null,"abstract":"Background: Chikungunya infections are a major concern because of their persistent recurrence in the last few decades. Chikungunya virus (CHIKV) is a mosquito borne alpha virus that causes an acute febrile illness accompanied by body rashes, myalgia and polyarthralgia; which may persists for years. Chikungunya fever, affect millions of people in Africa, Asia, including the Indian subcontinent and lately in several regions of the Americas. No specific antivirals and vaccines are currently available to treat or prevent the disease. Methods: Understanding the mechanisms of host immune responses to CHIKV and the immunopathology of the disease is essential for the development of vaccines and diagnostics. Many studies have demonstrated the role of the immune response in the immunopathology of the disease and in the host’s incapability to clear the virus efficiently. In this review the excellence of the referenced papers were evaluated using standard tools. Results: Total seventy-four papers were included in the review. Majority of them were highlighted the importance of understanding the immunopathology of virus, contributing factor and control measures of the epidemics. Nineteen papers were provided the current occurrence and re-emergence of the disease. The diagnostic importance (sensitivity and specificity) of developed diagnostics for the early detection were also provided in eight papers. Conclusion: In the current review we highlighted the importance of conceptual mechanism of the host immune responses to CHIKV and the immunopathology of this alpha virus. The presented review provides an update on the infection, its vector, and the disease transmission, research development, and administration for avoidance of Chikungunya disease. A R T I C L E H I S T O R Y Received: August 16, 2017 Revised: January 12, 2018 Accepted: April 14, 2018 DOI: 10.2174/1573395514666180417143739","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180417143739","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44280739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Rezaei, S. Aslani, M. Marashi, F. Rezaei, E. Sharif-Paghaleh
{"title":"Immunomodulatory Effects of Vitamin D in Influenza Infection","authors":"R. Rezaei, S. Aslani, M. Marashi, F. Rezaei, E. Sharif-Paghaleh","doi":"10.2174/1573395513666171031162100","DOIUrl":"https://doi.org/10.2174/1573395513666171031162100","url":null,"abstract":"Background: Vitamin D has mainly been described in the literature beyond its skeletal functions, including an influence on the immune responses against infections. Observational and interventional studies have represented evidence that Vitamin D deficiency may cause increased risk of seasonal influenza and pulmonary tract infection. Methods: A structured search of EMBASE, Medline, and Web of Science databases was fulfilled to extract all eligible articles published prior to September 2017. Results: In this review, our goal is to define the possible mechanisms that link influenza-mediated immune responses to Vitamin D. Herein, we first briefly describe the role of Vitamin D in the immune responses and then elucidate three immunological processes that connect Vitamin D to influenza infection. Finally, we describe randomized controlled trials and observational studies exploring the effect of Vitamin D supplementation on seasonal influenza infections and vaccinations. Conclusion: Our literature review suggests that treatment of influenza-infected individuals with Vitamin D supplements or cathelicidin-derived agents may provide appreciable protection against natural influenza infection. Moreover, Vitamin D given at appropriate doses may facilitate protection against seasonal flu. A R T I C L E H I S T O R Y Received: May 06, 2017 Revised: June 29, 2017 Accepted: October 12, 2017 DOI: 10.2174/1573395513666171031162100","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395513666171031162100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42037353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Angeletti, G. Iannella, A. Ciofalo, M. Re, R. Plateroti, P. Plateroti, B. Pasquariello, A. Manno, D. Didona, G. Magliulo
{"title":"Otorhinolaryngological Manifestations in Sjogren Syndrome","authors":"D. Angeletti, G. Iannella, A. Ciofalo, M. Re, R. Plateroti, P. Plateroti, B. Pasquariello, A. Manno, D. Didona, G. Magliulo","doi":"10.2174/1573395514666180118103149","DOIUrl":"https://doi.org/10.2174/1573395514666180118103149","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180118103149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42779655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Tuttolomondo, Anna Cirrincione, Valerio Vassallo, M. Daidone, A. Pinto
{"title":"Endothelial Function and Pathogenesis of Endothelial Dysfunction","authors":"A. Tuttolomondo, Anna Cirrincione, Valerio Vassallo, M. Daidone, A. Pinto","doi":"10.2174/1573395513666170502130828","DOIUrl":"https://doi.org/10.2174/1573395513666170502130828","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"13 1","pages":"115-131"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44325963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
