Current Immunology Reviews最新文献

Forecasting of COVID-19 Cases in India: A Predictive Study 印度新冠肺炎病例预测：一项预测研究

Current Immunology Reviews Pub Date : 2020-11-12 DOI: 10.2174/1573395516999201112092152

P. Sharma, Tanu Sharma, K. Veer

引用次数: 0

Can Mandated BCG Vaccine Promote herd Immunity against Novel Coronavirus? A Potential Solution at Hand to Tackle Covid-19 Pandemic 强制接种卡介苗能提高群体对新型冠状病毒的免疫力吗?应对Covid-19大流行的潜在解决方案

Current Immunology Reviews Pub Date : 2020-11-12 DOI: 10.2174/1573395516999201112092557

Ashok Arasu, P. Balakrishnan, T. Velusamy, T. Ramesh

{"title":"Can Mandated BCG Vaccine Promote herd Immunity against Novel Coronavirus? A Potential Solution at Hand to Tackle Covid-19 Pandemic","authors":"Ashok Arasu, P. Balakrishnan, T. Velusamy, T. Ramesh","doi":"10.2174/1573395516999201112092557","DOIUrl":"https://doi.org/10.2174/1573395516999201112092557","url":null,"abstract":"\u0000\u0000The 2019 novel coronavirus (2019-nCoV) infection is an emerging pandemic that poses\u0000a severe threat to global public health. This pandemic started from the Wuhan City of Hubei\u0000Province in China, and is speculated to have originated from bats and spread among humans with\u0000an unknown intermediate transmitter. The virus binds to angiotensin-converting enzyme 2 (ACE2),\u0000which is abundantly expressed on various human cells, including lung epithelial and intestinal\u0000cells, thereby entering into these cells and causing infection. It is transmitted to other humans\u0000through airborne droplets from infected patients. Presently there are no specific treatments or\u0000vaccines that are available to curtail the spread of this disease. There are few indirect reports that\u0000explain the potential importance of the mandated BCG vaccine as a protective factor against\u0000COVID-19. There is a speculation that a live attenuated vaccine (BCG vaccine) can be beneficial\u0000against COVID-19 to develop the initial immune response, and can also spread in the community,\u0000thereby boosting herd immunity to fight against COVID-19. This review summarizes the conclusions\u0000of various reports on the BCG vaccine, and is an attempt to establish BCG-vaccination mediated\u0000herd immunity as an effective instant intermediate approach in curbing COVID-19 spread in\u0000highly populous countries.\u0000","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47141367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Interleukin-10 in Oral Lichen Planus – Review and Meta-Analysis 口腔扁平苔藓中白细胞介素-10的研究综述与meta分析

Current Immunology Reviews Pub Date : 2020-11-11 DOI: 10.2174/1573395516999201111162844

F. Agha-Hosseini, N. Rezaei, Mahdieh-Sadat Moosavi

{"title":"Interleukin-10 in Oral Lichen Planus – Review and Meta-Analysis","authors":"F. Agha-Hosseini, N. Rezaei, Mahdieh-Sadat Moosavi","doi":"10.2174/1573395516999201111162844","DOIUrl":"https://doi.org/10.2174/1573395516999201111162844","url":null,"abstract":"\u0000\u0000Interleukin 10 (IL-10) is a powerful anti-inflammatory cytokine capable\u0000of preventing inflammatory and autoimmune diseases. Oral lichen planus (OLP) is an autoimmune,\u0000chronic, inflammatory disease with relapsing nature involving oral mucous membranes. It was prevsiouly\u0000assumed that like other autoimmune diseases, IL-10 may have a role in OLP pathogenesis,\u0000and many studies focused on that. But there are obvious controversies among IL-10 levels in OLP\u0000patients.\u0000\u0000\u0000\u0000In this review with Meta-Analysis, we attempt to assess IL-10 expression in OLP patients.\u0000\u0000\u0000\u0000The search was conducted via Pubmed, Ovid, and Google Scholar, to identify articles\u0000published up to Jun 2020. A meta-Analysis by Revman 5.3 was conducted based on serum levels\u0000of IL-10 in 313 OLPs and 203 controls.\u0000\u0000\u0000\u0000With Meta-Analysis in 313 OLPs and 203 controls, the Mean difference between IL-10 in\u0000OLPs and controls was obtained as 0.26 (95% CI: -0.51-1.03), demonstrating no statistically significant\u0000difference.\u0000\u0000\u0000\u0000 IL-10, in concert with its receptors, has a crucial role in the pathogenesis of various\u0000diseases, including inflammatory, infectious, and autoimmune diseases. Both over-expression, as\u0000well as IL-10 deficiency, have been described in oral lichen planus. With Meta-Analysis on serum\u0000IL-10 levels, it is speculated that no significant relationship exists between IL-10 and OLP pathogenesis.\u0000With respect to the importance of cytokines in the autoimmunity process, performing additional\u0000studies is of necessity to understand the association of other cytokines with OLP predisposition\u0000and its underlying pathological processes.\u0000","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42916348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Thymosin α1; Potential Therapeutic Implications of an Immunoregulatory Drug in the Treatment of Lymphocytopenia Associated with COVID-19 胸腺素α1;免疫调节药物治疗与COVID-19相关的淋巴细胞减少症的潜在治疗意义

Current Immunology Reviews Pub Date : 2020-11-11 DOI: 10.2174/1573395516999201111163304

Milad Shirvaliloo

引用次数: 0

COVID-19: Update on Pathogenesis and Treatment Strategies COVID-19:发病机制和治疗策略的最新进展

Current Immunology Reviews Pub Date : 2020-10-01 DOI: 10.2174/1573395516999201001154837

R. Chauhan, P. Sharma, S. Srivastava

引用次数: 0

Immunomodulation in Multiple Sclerosis by Phytotherapy 植物疗法对多发性硬化症的免疫调节作用

Current Immunology Reviews Pub Date : 2020-09-30 DOI: 10.2174/1573395516999200930122850

M. Bahrami, G. Mosayebi, A. Ghazavi, A. Ganji

引用次数: 1

Seroprevalence of Hepatitis B, Hepatitis C, and Human Immunodeficiency Viruses in End-Stage Renal Disease Patients, Southern Iran 伊朗南部终末期肾病患者乙型肝炎、丙型肝炎和人类免疫缺陷病毒的血清阳性率

Current Immunology Reviews Pub Date : 2020-08-19 DOI: 10.2174/1573395516999200819164045

Nahid Tavakoli Movaghar, S. Mojarrad, H. Shahraki, M. Nazari, M. Hadadi, M. Motamedifar

{"title":"Seroprevalence of Hepatitis B, Hepatitis C, and Human Immunodeficiency Viruses in End-Stage Renal Disease Patients, Southern Iran","authors":"Nahid Tavakoli Movaghar, S. Mojarrad, H. Shahraki, M. Nazari, M. Hadadi, M. Motamedifar","doi":"10.2174/1573395516999200819164045","DOIUrl":"https://doi.org/10.2174/1573395516999200819164045","url":null,"abstract":"Hemodialysis [HD] patients are more prone to blood-borne viruses, such\u0000as hepatitis B virus [HBV], hepatitis C virus [HCV], and, to a lesser extent, Human Immunodeficiency\u0000Virus [HIV]. Chronic HBV and HCV infections are associated with liver cirrhosis, hepatocellular\u0000carcinoma, and early graft failure after kidney transplantation. As there was no recent information,\u0000this study aimed to evaluate the prevalence of HBV, HCV, and HIV infection in HD patients\u0000in Fars province, southern Iran. This could help health policymakers to run more effective infection\u0000control practices for reducing such blood-borne virus infections, if necessary.\u0000\u0000\u0000\u0000This cross-sectional study was performed on 906 HD patients in Fars province, southern\u0000Iran. A total of 906 blood samples were obtained from patients and diagnostic tests of HBV, HCV,\u0000and HIV were done. Demographic data and some other information, such as duration of dialysis,\u0000were extracted from the patients’ medical records. Data were analyzed in SPSS, version 18.\u0000\u0000\u0000\u0000Out of the patients enrolled in the study, 547 [60.4%] were male and 359 [39.6%] female.\u0000The mean ± SD age of the patients was 58.0 ± 15.8 years. The prevalence of HBV, HCV, and HIV\u0000infection was 0.88%, 0.55% and 0.44%, respectively. HIV-infected subjects were significantly\u0000younger than the HIV-negative group [P <0.017].\u0000\u0000\u0000\u0000 It seems that Fars is among the provinces with low HBV and HCV prevalence in HD\u0000patients in comparison to other provinces of Iran. On the other hand, HIV prevalence here is higher\u0000than other provincial studies. Strict adherence to preventive infection control measures is recommended\u0000in HD centers.","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42426485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Warm Reactive Anti-A1 Agglutinin in an A2B individual: A Rare Case with Review of Literature A2B个体的温反应性抗a1凝集素:一例罕见病例并复习文献

Current Immunology Reviews Pub Date : 2020-08-07 DOI: 10.2174/1573395516999200807162612

M. Raturi, A. Kusum

{"title":"Warm Reactive Anti-A1 Agglutinin in an A2B individual: A Rare Case with Review of Literature","authors":"M. Raturi, A. Kusum","doi":"10.2174/1573395516999200807162612","DOIUrl":"https://doi.org/10.2174/1573395516999200807162612","url":null,"abstract":"\u0000\u0000The prevalence of the major subgroup of A as A1 in almost 80% of the A group population\u0000is a known fact. A2 and the remaining subgroups such as Aend, Am, Ax etc comprise the remaining\u0000population, based on erythrocyte agglutinability and various serological reactions. These A subgroups\u0000can often result in an ABO typing discrepancy. Anti-A1 antibody often appears as an irregular\u0000cold agglutinin in the sera of A2 or A2B individuals who lack the corresponding antigen. Rather\u0000notably, the literature suggests that 1% to 8% of A2 and 22% to 35% of A2B individuals possess an\u0000allo-anti-A1 in their sera, which reacts at a temperature below 25°C. Although routinely, it does not\u0000pose any problem either during or post blood transfusion, however, the literature reports of hemolysis\u0000happening in procedures that are performed at lower temperatures, particularly in hypothermic\u0000situations. We report herein, a case of a massively bleeding A2B Indian lady after the expulsion of\u0000her dead fetus and an underlying uterine fibroid having a warm reactive allo-anti-A1 agglutinin that\u0000warranted an urgent blood transfusion management.\u0000","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43593794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Is Immune Response Relevant in Interstitial Lung Disease? 免疫反应与间质性肺病有关吗?

Current Immunology Reviews Pub Date : 2020-03-31 DOI: 10.2174/1573395516999200914143054

Manzoor M. Khan

{"title":"Is Immune Response Relevant in Interstitial Lung Disease?","authors":"Manzoor M. Khan","doi":"10.2174/1573395516999200914143054","DOIUrl":"https://doi.org/10.2174/1573395516999200914143054","url":null,"abstract":"\u0000\u0000Interstitial lung disease, a term for a group of disorders, causes lung fibrosis, is mostly\u0000refractory to treatments and has a high death rate. After diagnosis the survival is up to 3 years but\u0000in some cases the patients live much longer. It involves a heterogenous group of lung diseases that\u0000exhibit progressive and irreversible destruction of the lung due to the formation of scars. This results\u0000in lung malfunction, disruption of gas exchange, and eventual death because of respiratory\u0000failure. The etiology of lung fibrosis is mostly unknown with a few exceptions. The major characteristics\u0000of the disease are comprised of injury of epithelial type II cells, increased apoptosis, chronic\u0000inflammation, monocytic and lymphocytic infiltration, accumulation of myofibroblasts, and inability\u0000to repair damaged tissue properly. These events result in abnormal collagen deposition and\u0000scarring. The inflammation process is mild, and the disease is primarily fibrotic driven. Immunosuppressants\u0000do not treat the disease but the evidence is evolving that both innate and acquired immune\u0000responses a well as the cytokines contribute to at least early progression of the disease. Furthermore,\u0000mediators of inflammation including cytokines are involved throughout the process of\u0000lung fibrosis. The diverse clinical outcome of the disease is due to different pattern of inflammatory\u0000markers. Nonetheless, the development of novel therapeutic strategies requires better understanding\u0000of the role of the immune response. This review highlights the role of the immune response in\u0000interstitial lung disease and considers the therapeutic strategies based on these observations. For\u0000this review several literature data sources were used to assess the role of the immune response in interstitial\u0000lung disease and to evaluate the possible therapeutic strategies for the disease.\u0000","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48345305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Potential Prognostic Performance of Neutrophil CD64 and Monocyte HLA-DR in Patients with Complicated Intra-abdominal Infections 中性粒细胞CD64和单核细胞HLA-DR对复杂腹腔感染患者的潜在预后影响

Current Immunology Reviews Pub Date : 2020-03-12 DOI: 10.2174/1573395516666200312111456

E. Dimitrov, K. Halacheva, E. Enchev, G. Minkov, Y. Yovtchev

{"title":"The Potential Prognostic Performance of Neutrophil CD64 and Monocyte HLA-DR in Patients with Complicated Intra-abdominal Infections","authors":"E. Dimitrov, K. Halacheva, E. Enchev, G. Minkov, Y. Yovtchev","doi":"10.2174/1573395516666200312111456","DOIUrl":"https://doi.org/10.2174/1573395516666200312111456","url":null,"abstract":"\u0000\u0000Complicated intra-abdominal infections are still associated with a high risk of\u0000an unfavorable outcome. Despite the equal treatment, the mortality rates in some patients’ populations\u0000remain significant, especially when the impaired immune response is present.\u0000\u0000\u0000\u0000The object of this research is to analyze the impact of pro-inflammatory neutrophil CD64 and\u0000anti-inflammatory monocyte HLA-DR on the final outcome.\u0000\u0000\u0000\u0000We have searched in the PubMed database, the literature relating the prognostic value of two\u0000biomarkers - nCD64 and mHLA-DR in patients with complicated intra-abdominal infections and/or\u0000sepsis.\u0000\u0000\u0000\u0000Eighteen original studies with 2960 patients fulfilled our inclusion criteria. The data about\u0000nCD64 that we found was contradictory, whereas low mHLA-DR expression showed good prognostic\u0000value.\u0000\u0000\u0000\u0000Our review showed heterogeneous data about nCD64 survival prediction. Further investigations\u0000with surgical patients exclusively are needed to evaluate its prognostic value in cIAIs. However,\u0000we observed a good prognostic performance of low mHLA-DR expression. After a validation in\u0000larger multicentre studies, mHLA-DR could be used as promising prognostic biomarker in cIAIs.\u0000","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44804375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1