COVID-19:发病机制和治疗策略的最新进展

Q4 Medicine

Current Immunology Reviews Pub Date : 2020-10-01 DOI:10.2174/1573395516999201001154837

R. Chauhan, P. Sharma, S. Srivastava

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引用次数: 0

摘要

新冠肺炎（冠状病毒病）是传染性最强的病毒，已被世界卫生组织定性为全球大流行。新冠肺炎病毒的病理周期可被指定为RNA血症、严重肺炎、地面不透明（GGO）和急性心脏损伤。据报道，冠状病毒的S蛋白参与了病毒进入宿主细胞的过程，这可以通过病毒和质膜之间的直接膜融合来实现。在内质网或高尔基体膜中，新形成的包膜糖蛋白被引入。疾病的传播是由于携带病毒颗粒的囊泡与宿主释放的病毒质膜结合而产生的接触和飞沫。本文描述了新冠肺炎的发病机制和各种治疗策略，包括氯喹和羟氯喹等药物、抗疟疾药物、抗体：SARS-CoV-特异性人单克隆抗体CR3022和促进治疗效果的血浆治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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COVID-19: Update on Pathogenesis and Treatment Strategies

COVID-19 (Coronavirus disease) is the most contagious virus, which has been characterized as a global pandemic by WHO. The pathological cycle of COVID-19 virus can be specified as RNAaemia, severe pneumonia, along with the Ground-glass opacity (GGO), and acute cardiac injury. The S protein of Coronavirus has been reported to be involved in the entry of the virus into the host cell, which can be accomplished by direct membrane fusion between the virus and plasma membrane. In the endoplasmic reticulum or Golgi membrane, the newly formed enveloped glycoproteins are introduced. The spread of disease occurs due to contact and droplets unleashed by the vesicles holding the virus particles combined with the plasma membrane to the virus released by the host. The present manuscript describes the pathogenesis of COVID-19 and various treatment strategies that include drugs such as chloroquine and hydroxychloroquine, an anti-malarial drug, antibodies: SARS-CoV-specific human monoclonal antibody CR3022 and plasma treatment facilitate the therapeutic effect.

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来源期刊

Current Immunology Reviews Medicine-Immunology and Allergy

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期刊介绍： Current Immunology Reviews publishes frontier reviews on all the latest advances in clinical immunology. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in clinical immunology.