发布求助
文献互助 智能选刊 最新文献

Current Immunology Reviews最新文献

筛选
英文 中文
Intestinal CD4 Depletion in HIV / SIV Infection. HIV / SIV感染中的肠道CD4耗竭。
Current Immunology Reviews Pub Date : 2019-01-01 DOI: 10.2174/1573395514666180605083448
Ronald S Veazey
{"title":"Intestinal CD4 Depletion in HIV / SIV Infection.","authors":"Ronald S Veazey","doi":"10.2174/1573395514666180605083448","DOIUrl":"10.2174/1573395514666180605083448","url":null,"abstract":"<p><p>Among the most significant findings in the pathogenesis of HIV infection was the discovery that almost total depletion of intestinal CD4+ T cells occurs rapidly after SIV or HIV infection, regardless of the route of exposure, and long before CD4+ T cell losses occur in blood or lymph nodes. Since these seminal discoveries, we have learned much about mucosal and systemic CD4+ T cells, and found several key differences between the circulating and intestinal CD4+ T cell subsets, both in phenotype, relative proportions, and functional capabilities. Further, specific subsets of CD4+ T cells are selectively targeted and eliminated first, especially cells critically important for initiating primary immune responses, and for maintenance of mucosal integrity (Th1, Th17, and Th22 cells). This simultaneously results in loss of innate immune responses, and loss of mucosal integrity, resulting in mucosal, and systemic immune activation that drives proliferation and activation of new target cells throughout the course of infection. The propensity for the SIV/HIV to infect and efficiently replicate in specific cells also permits viral persistence, as the mucosal and systemic activation that ensues continues to damage mucosal barriers, resulting in continued influx of target cells to maintain viral replication. Finally, infection and elimination of recently activated and proliferating CD4+ T cells, and infection and dysregulation of Tfh and other key CD4+ T cell results in hyperactive, yet non-protective immune responses that support active viral replication and evolution, and thus persistence in host tissue reservoirs, all of which continue to challenge our efforts to design effective vaccine or cure strategies.</p>","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"15 1 1","pages":"76-91"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43235978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucosal Vaccine Approaches for Prevention of HIV and SIV Transmission. 预防HIV和SIV传播的粘膜疫苗方法。
Current Immunology Reviews Pub Date : 2019-01-01 DOI: 10.2174/1573395514666180605092054
Pamela A Kozlowski, Anna Aldovini
{"title":"Mucosal Vaccine Approaches for Prevention of HIV and SIV Transmission.","authors":"Pamela A Kozlowski, Anna Aldovini","doi":"10.2174/1573395514666180605092054","DOIUrl":"10.2174/1573395514666180605092054","url":null,"abstract":"<p><p>Optimal protective immunity to HIV will likely require that plasma cells, memory B cells and memory T cells be stationed in mucosal tissues at portals of viral entry. Mucosal vaccine administration is more effective than parenteral vaccine delivery for this purpose. The challenge has been to achieve efficient vaccine uptake at mucosal surfaces, and to identify safe and effective adjuvants, especially for mucosally administered HIV envelope protein immunogens. Here, we discuss strategies used to deliver potential HIV vaccine candidates in the intestine, respiratory tract, and male and female genital tract of humans and nonhuman primates. We also review mucosal adjuvants, including Toll-like receptor agonists, which may adjuvant both mucosal humoral and cellular immune responses to HIV protein immunogens.</p>","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"15 1 1","pages":"102-122"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44559068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diet Matters, But Heterogeneity Looms: Altered Fatty Acid Profiles and Mental Status in Health and Disease 饮食很重要，但异质性隐现:健康和疾病中脂肪酸谱和精神状态的改变
Current Immunology Reviews Pub Date : 2018-11-15 DOI: 10.2174/157339551402181017144417
Cody Cissom, Z. Shariat-Madar
{"title":"Diet Matters, But Heterogeneity Looms: Altered Fatty Acid Profiles and Mental Status in Health and Disease","authors":"Cody Cissom, Z. Shariat-Madar","doi":"10.2174/157339551402181017144417","DOIUrl":"https://doi.org/10.2174/157339551402181017144417","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47743477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board Member 会见我们的编辑委员会成员
Current Immunology Reviews Pub Date : 2018-11-15 DOI: 10.2174/157339551402181017142844
P. Ohashi
{"title":"Meet Our Editorial Board Member","authors":"P. Ohashi","doi":"10.2174/157339551402181017142844","DOIUrl":"https://doi.org/10.2174/157339551402181017142844","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/157339551402181017142844","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45177078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteoarthritis: Potential for Herbal Medicines as Therapies in the Management of Chronic Inflammatory Damage 骨关节炎：草药治疗慢性炎症损伤的潜力
Current Immunology Reviews Pub Date : 2018-07-31 DOI: 10.2174/1573395514666180530093702
D. R. Mickle
{"title":"Osteoarthritis: Potential for Herbal Medicines as Therapies in the Management of Chronic Inflammatory Damage","authors":"D. R. Mickle","doi":"10.2174/1573395514666180530093702","DOIUrl":"https://doi.org/10.2174/1573395514666180530093702","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180530093702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45168547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Computational Analysis of Specific IgE Epitopes Responsible for Allergy to Fish 鱼类变态反应特异性IgE表位的计算分析
Current Immunology Reviews Pub Date : 2018-07-31 DOI: 10.2174/1573395514666180622121750
M. Mohammadi, R. Falak, R. Z. Emameh, S. Maleki, G. Kardar
{"title":"Computational Analysis of Specific IgE Epitopes Responsible for Allergy to Fish","authors":"M. Mohammadi, R. Falak, R. Z. Emameh, S. Maleki, G. Kardar","doi":"10.2174/1573395514666180622121750","DOIUrl":"https://doi.org/10.2174/1573395514666180622121750","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49424992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Approach to Systemic Autoinflammatory Disorders: Classification, Disease Phenotypes and Management 系统性自身炎症性疾病的临床治疗方法：分类、疾病表型和治疗
Current Immunology Reviews Pub Date : 2018-07-31 DOI: 10.2174/1573395514666180621152753
T. Borges
{"title":"Clinical Approach to Systemic Autoinflammatory Disorders: Classification, Disease Phenotypes and Management","authors":"T. Borges","doi":"10.2174/1573395514666180621152753","DOIUrl":"https://doi.org/10.2174/1573395514666180621152753","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48751108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Immune Checkpoint Inhibitor Therapy and Risk of Myocarditis: A Review of the Literature 免疫检查点抑制剂治疗与心肌炎风险：文献综述
Current Immunology Reviews Pub Date : 2018-07-31 DOI: 10.2174/1573395514666180723162753
Matthew Kelling, M. Dimza, S. Dalia
{"title":"Immune Checkpoint Inhibitor Therapy and Risk of Myocarditis: A Review of the Literature","authors":"Matthew Kelling, M. Dimza, S. Dalia","doi":"10.2174/1573395514666180723162753","DOIUrl":"https://doi.org/10.2174/1573395514666180723162753","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47865246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine Gene Polymorphisms in Cancer and Inflammatory Disorders 肿瘤和炎性疾病中的细胞因子基因多态性
Current Immunology Reviews Pub Date : 2018-07-31 DOI: 10.2174/1573395514666180724121419
H. K. Norhalifah, N. Mat, H. A. Edinur
{"title":"Cytokine Gene Polymorphisms in Cancer and Inflammatory Disorders","authors":"H. K. Norhalifah, N. Mat, H. A. Edinur","doi":"10.2174/1573395514666180724121419","DOIUrl":"https://doi.org/10.2174/1573395514666180724121419","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46972863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Lambert-Eaton Myasthenic Syndrome: A Very Rare and Tortuously Exasperating Facet of Pre-Synaptic Disorder of Neuromuscular Junction Lambert-Eaton肌无力综合征：一种非常罕见且令人痛苦的神经肌肉交界处突触前障碍
Current Immunology Reviews Pub Date : 2018-07-31 DOI: 10.2174/1573395514666181005121833
A. K. Saini, S. Chandra, A. Rai
{"title":"Lambert-Eaton Myasthenic Syndrome: A Very Rare and Tortuously Exasperating Facet of Pre-Synaptic Disorder of Neuromuscular Junction","authors":"A. K. Saini, S. Chandra, A. Rai","doi":"10.2174/1573395514666181005121833","DOIUrl":"https://doi.org/10.2174/1573395514666181005121833","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49523700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信