Electrolyte and Blood Pressure最新文献

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Effect of bicarbonate supplementation on renal function and nutritional indices in predialysis advanced chronic kidney disease. 补充碳酸氢盐对透析前晚期慢性肾病患者肾功能和营养指标的影响。
Electrolyte and Blood Pressure Pub Date : 2014-12-01 Epub Date: 2014-12-31 DOI: 10.5049/EBP.2014.12.2.80
Jiwon Jeong, Soon Kil Kwon, Hye-Young Kim
{"title":"Effect of bicarbonate supplementation on renal function and nutritional indices in predialysis advanced chronic kidney disease.","authors":"Jiwon Jeong,&nbsp;Soon Kil Kwon,&nbsp;Hye-Young Kim","doi":"10.5049/EBP.2014.12.2.80","DOIUrl":"https://doi.org/10.5049/EBP.2014.12.2.80","url":null,"abstract":"<p><p>Current practice guidelines recommend alkali therapy in patients with chronic kidney disease (CKD) and metabolic acidosis to prevent complications. This study aims to investigate the effect of oral sodium bicarbonate supplementation on the progression of renal function and nutritional indices in patients with predialysis advanced CKD. Forty patients with predialysis stage 5 CKD(estimated glomerular filtration rate, eGFR <15mL/min per 1.73m(2)) and 40 patients with stage 4 CKD (eGFR 15 to 30mL/min per 1.73m(2)) who had a total CO2 less than 22mEq/L were assigned into the bicarbonate treatment group or control group for 12 months. In stage 4 CKD, there were significant differences in the changes of eGFR during the study between the treatment group and the control group (-2.30±4.49 versus -6.58±6.32mL/min/1.73m(2), p<0.05). However, in stage 5 CKD, there were no significant differences in the change of eGFR during the study between the two groups (-2.10±2.06 versus -3.23±1.95mL/min/1.73 m(2)).There were no significant differences in the changes of nutritional indices such as albumin, prealbumin, transferrin, total lymphocyte count (TLC), and Ondodera's prognostic nutritional index (OPNI) during the study between the two groups. In stage 5 CKD, there were significant differences in the changes of TLC and OPNI between the two groups. In conclusion, our results demonstrate that bicarbonate supplementation slows the rate of decline of renal function in stage 4 CKD and improves nutritional indices in stage 5 CKD. Alkali therapy in advanced CKD may have beneficial effect on renal function and malnutrition. </p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"12 2","pages":"80-7"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2014.12.2.80","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32990413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies. 顺铂所致肾功能障碍及改善治疗策略的展望。
Electrolyte and Blood Pressure Pub Date : 2014-12-01 Epub Date: 2014-12-31 DOI: 10.5049/EBP.2014.12.2.55
Gi-Su Oh, Hyung-Jin Kim, AiHua Shen, Su Bin Lee, Dipendra Khadka, Arpana Pandit, Hong-Seob So
{"title":"Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies.","authors":"Gi-Su Oh,&nbsp;Hyung-Jin Kim,&nbsp;AiHua Shen,&nbsp;Su Bin Lee,&nbsp;Dipendra Khadka,&nbsp;Arpana Pandit,&nbsp;Hong-Seob So","doi":"10.5049/EBP.2014.12.2.55","DOIUrl":"https://doi.org/10.5049/EBP.2014.12.2.55","url":null,"abstract":"<p><p>Cisplatin is one of the most widely used and highly effective drug for the treatment of various solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and nerves. Nephrotoxicity is the most well-known and clinically important toxicity. Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage, and inflammatory responses, are closely associated with cisplatin-induced nephrotoxicity. Even though the establishment of cisplatin-induced nephrotoxicity can be alleviated by diuretics and pre-hydration of patients, the prevalence of cisplatin nephrotoxicity is still high, occurring in approximately one-third of patients who have undergone cisplatin therapy. Therefore it is imperative to develop treatments that will ameliorate cisplatin-nephrotoxicity. In this review, we discuss the mechanisms of cisplatin-induced renal toxicity and the new strategies for protecting the kidneys from the toxic effects without lowering the tumoricidal activity. </p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"12 2","pages":"55-65"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2014.12.2.55","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32990414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 155
Effect of dialysate sodium concentration on sodium gradient and hemodialysis parameters. 透析液钠浓度对钠梯度及血液透析参数的影响。
Electrolyte and Blood Pressure Pub Date : 2014-12-01 Epub Date: 2014-12-31 DOI: 10.5049/EBP.2014.12.2.66
Haifeng Jin, Seung Yun Lee, Si Nae Lee, Joon Ho Song, Moon-Jae Kim, Seoung Woo Lee
{"title":"Effect of dialysate sodium concentration on sodium gradient and hemodialysis parameters.","authors":"Haifeng Jin,&nbsp;Seung Yun Lee,&nbsp;Si Nae Lee,&nbsp;Joon Ho Song,&nbsp;Moon-Jae Kim,&nbsp;Seoung Woo Lee","doi":"10.5049/EBP.2014.12.2.66","DOIUrl":"https://doi.org/10.5049/EBP.2014.12.2.66","url":null,"abstract":"<p><p>This retrospective study was performed to determine the ranges of the sodium gradient (SG) between the dialysate sodium concentration (DNa) and serum sodium concentration (SNa) in hemodialysis (HD) patients and to examine the relationships between HD parameters over a 1 year period. Fifty-five clinically stable HD patients, who had been on HD >2 years were enrolled. Monthly HD [ultrafiltration (UF) amount, systolic blood pressure (SBP), frequency of intradialytic hypotension (IDH)] and laboratory data were collected and 12-month means were subjected to analysis. The SG was calculated by subtracting SNa from prescribed DNa. Mean SG values were 1.5±3.3 (range -5.6~9.1). SG was positively related to DNa and the frequency of IDH. A higher SG was associated with larger UF amounts and SBP reduction during HD. The percentages of patients with a SG ≥3mEq/L increased as DNa increased. On the other hand, SG was not found to be associated with SNa or pre-HD SBP. DNa appears to cause a significant increase in SG, and this seems to be related to HD parameters, such as, UF amount and IDH. </p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"12 2","pages":"66-73"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2014.12.2.66","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32990410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Uric Acid Puzzle: Dual Role as Anti-oxidantand Pro-oxidant. 尿酸之谜:抗氧化和促氧化的双重作用。
Electrolyte and Blood Pressure Pub Date : 2014-06-01 Epub Date: 2014-06-30 DOI: 10.5049/EBP.2014.12.1.1
Duk-Hee Kang, Sung-Kyu Ha
{"title":"Uric Acid Puzzle: Dual Role as Anti-oxidantand Pro-oxidant.","authors":"Duk-Hee Kang,&nbsp;Sung-Kyu Ha","doi":"10.5049/EBP.2014.12.1.1","DOIUrl":"https://doi.org/10.5049/EBP.2014.12.1.1","url":null,"abstract":"<p><p>Hyperuricemia is known to be associated with the presence of cardiovascular and metabolic syndrome and with the development of incipient kidney disease and an accelerated renal progression. However, an elevated uric acid level was not generally regarded as a true etiology or mediator, but an indicator of these diseases. Uric acid has recently regained the clinical interest and popularity based on emerging data suggesting the causative role of hyperuricemia in cardiovascular and renal disease. Experimental data demonstrates oxidative stress is one of the earliest phenomena observed in vascular, renal, liver cells and adipocytes exposed to uric acid. Since uric acid is one of the major antioxidants of plasma acting as a free radical scavenger and a chelator of transitional metal ion, uric acid-induced oxidative stress seems paradoxical. Data regarding the clinical implication of hyperuricemia is even more confusing, which defines hyperuricemia as a useless parameter to be eliminated from routine follow-up or a major risk factor to be therapeutic target. With a review of experimental and epidemiologic data, the presence of molecular switch to regulate the role of uric acid as anti- or pro-oxidant in different compartment of our body is suggested, which may shed light on understanding the paradoxical role of uric acid and solving the \"uric acid debate\". </p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"12 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2014.12.1.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32532886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 166
A Case of Post-radiotherapy Urethral Stricture with Spontaneous Bladder Rupture, Mimicking Obstructive Uropathy due to Cancer Metastasis. 放疗后尿道狭窄并发自发性膀胱破裂1例,模拟肿瘤转移致梗阻性尿路病变。
Electrolyte and Blood Pressure Pub Date : 2014-06-01 Epub Date: 2014-06-30 DOI: 10.5049/EBP.2014.12.1.26
Jun Young Shin, Sang Min Yoon, Hyuck Jae Choi, Si Nae Lee, Hai Bong Kim, Woo Chul Joo, Joon Ho Song, Moon-Jae Kim, Seoung Woo Lee
{"title":"A Case of Post-radiotherapy Urethral Stricture with Spontaneous Bladder Rupture, Mimicking Obstructive Uropathy due to Cancer Metastasis.","authors":"Jun Young Shin,&nbsp;Sang Min Yoon,&nbsp;Hyuck Jae Choi,&nbsp;Si Nae Lee,&nbsp;Hai Bong Kim,&nbsp;Woo Chul Joo,&nbsp;Joon Ho Song,&nbsp;Moon-Jae Kim,&nbsp;Seoung Woo Lee","doi":"10.5049/EBP.2014.12.1.26","DOIUrl":"https://doi.org/10.5049/EBP.2014.12.1.26","url":null,"abstract":"<p><p>Non-traumatic, spontaneous urinary bladder rupture is a rare complication of urethral stricture. Furthermore, its symptoms are often nonspecific, and misdiagnosis is common. The authors experienced a case of urethral stricture with spontaneous bladder rupture and bilateral hydronephrosis, mimicking obstructive uropathy attributed to cancer metastasis. A 55-year-old woman was admitted with abdominal pain and distension, oliguria, and an elevated serum creatinine level. She had undergone radical hysterectomy for uterine cervical cancer and received post-operative concurrent chemoradiation therapy 13 years previously. Non-contrast enhanced computed tomography showed massive ascites and bilateral hydronephrosis. The initial diagnosis was acute kidney injury due to obstructive uropathy caused by malignant disease. After improvement of her renal function by bilateral percutaneous nephrostomy catheterization, contrast-enhanced computed tomography and a cytologic examination of ascites showed no evidence of malignancy. However, during retrograde pyelography, a severe urethral stricture was found, and subsequent cystography showed leakage of contrast into the peritoneal cavity and cystoscopy revealed a defect of the posterior bladder wall. After urethral dilatation and primary closure of the bladder wall, acute kidney injury and ascites were resolved. </p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"12 1","pages":"26-9"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2014.12.1.26","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32534324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Dietary salt intake and hypertension. 食盐摄入与高血压的关系
Electrolyte and Blood Pressure Pub Date : 2014-06-01 Epub Date: 2014-06-30 DOI: 10.5049/EBP.2014.12.1.7
Sung Kyu Ha
{"title":"Dietary salt intake and hypertension.","authors":"Sung Kyu Ha","doi":"10.5049/EBP.2014.12.1.7","DOIUrl":"https://doi.org/10.5049/EBP.2014.12.1.7","url":null,"abstract":"<p><p>Over the past century, salt has been the subject of intense scientific research related to blood pressure elevation and cardiovascular mortalities. Moderate reduction of dietary salt intake is generally an effective measure to reduce blood pressure. However, recently some in the academic society and lay media dispute the benefits of salt restriction, pointing to inconsistent outcomes noted in some observational studies. A reduction in dietary salt from the current intake of 9-12 g/day to the recommended level of less than 5-6 g/day will have major beneficial effects on cardiovascular health along with major healthcare cost savings around the world. The World Health Organization (WHO) strongly recommended to reduce dietary salt intake as one of the top priority actions to tackle the global non-communicable disease crisis and has urged member nations to take action to reduce population wide dietary salt intake to decrease the number of deaths from hypertension, cardiovascular disease and stroke. However, some scientists still advocate the possibility of increased risk of CVD morbidity and mortality at extremes of low salt intake. Future research may inform the optimal sodium reduction strategies and intake targets for general populations. Until then, we have to continue to build consensus around the greatest benefits of salt reduction for CVD prevention, and dietary salt intake reduction strategies must remain at the top of the public health agenda. </p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"12 1","pages":"7-18"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2014.12.1.7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32532887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 219
Severe hypernatremia by excessive bamboo salt ingestion in healthy young woman. 健康青年妇女摄入过量竹盐致严重高钠血症。
Electrolyte and Blood Pressure Pub Date : 2013-12-01 Epub Date: 2013-12-31 DOI: 10.5049/EBP.2013.11.2.53
Hyun Jun Ju, Hong Jin Bae, Dae Eun Choi, Ki Ryang Na, Kang Wook Lee, Young Tai Shin
{"title":"Severe hypernatremia by excessive bamboo salt ingestion in healthy young woman.","authors":"Hyun Jun Ju,&nbsp;Hong Jin Bae,&nbsp;Dae Eun Choi,&nbsp;Ki Ryang Na,&nbsp;Kang Wook Lee,&nbsp;Young Tai Shin","doi":"10.5049/EBP.2013.11.2.53","DOIUrl":"https://doi.org/10.5049/EBP.2013.11.2.53","url":null,"abstract":"<p><p>Severe hypernatremia is an important electrolyte disorder that has serious effects. The patient had no medical history. A. 20-year-old ingested bamboo salt for digestion and weight reduction according to the folk remedies posted on an internet website. She presented with vomiting and diarrhea over ten times per day. Her initial serum sodium concentration was 174mEq/L. Her symptoms improved rapidly with hypotonic saline infusion. She recovered completely without any sequelae in three days. Severe hypernatremia in a normal young adult with clear consciousness and normal renal function has not been reported in Korea yet. So we report a case of severe hypernatremia by excessive bamboo salt ingestion in healthy young woman. </p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"11 2","pages":"53-5"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2013.11.2.53","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32173912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Obesity associated hypertension: new insights into mechanism. 肥胖相关高血压:机制的新见解
Electrolyte and Blood Pressure Pub Date : 2013-12-01 Epub Date: 2013-12-31 DOI: 10.5049/EBP.2013.11.2.46
Young Sun Kang
{"title":"Obesity associated hypertension: new insights into mechanism.","authors":"Young Sun Kang","doi":"10.5049/EBP.2013.11.2.46","DOIUrl":"https://doi.org/10.5049/EBP.2013.11.2.46","url":null,"abstract":"<p><p>With excess nutrition, the burden of obesity is a growing problem worldwide. The imbalance between energy intake and expenditure leads to variable disorders as all major risk factors for cardiovascular disease. There are many hypothetical mechanisms to explain obesity-associated hypertension. Activation of the RAAS is a key contributing factor in obesity. Particularly, the RAAS in adipose tissue plays a crucial role in adipose tissue dysfunction and obesity-induced inflammation. The phenotypic changes of adipocytes occur into hypertrophy and an inflammatory response in an autocrine and paracrine manner to impair adipocyte function, including insulin signaling pathway. Adipose tissue produce and secretes several molecules such as leptin, resistin, adiponectin, and visfatin, as well as cytokines such as TNF-α, IL-6, MCP-1, and IL-1. These adipokines are stimulated via the intracellular signaling pathways that regulate inflammation of adipose tissue. Inflammation and oxidative stress in adipose tissue are important to interact with the microvascular endothelium in the mechanisms of obesity-associated hypertension. Increased microvascular resistance raises blood pressure. Therefore, a regulatory link between microvascular and perivascular adipose tissue inflammation and adipokine synthesis are provided to explain the mechanism of obesity-associated hypertension. </p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"11 2","pages":"46-52"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2013.11.2.46","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32173911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 124
Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. 肾素-血管紧张素-醛固酮系统在高血压发病中的最新进展。
Electrolyte and Blood Pressure Pub Date : 2013-12-01 Epub Date: 2013-12-31 DOI: 10.5049/EBP.2013.11.2.41
Ju-Young Moon
{"title":"Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension.","authors":"Ju-Young Moon","doi":"10.5049/EBP.2013.11.2.41","DOIUrl":"https://doi.org/10.5049/EBP.2013.11.2.41","url":null,"abstract":"<p><p>The activation of renin-angiotensin-aldosterine system(RAAS) is one of the main pathogenesis of hypertension. All the components of RAAS are present in the kidneys at higher concentrations compared to plasma levels, and intrarenal formation of angiotensin II (Ang II) is independent of the systemic RAAS. There are some unique features in intrarenal RAAS compared to systemic RAAS. Unlike JG cells where Ang II inhibits renin release via the AngII type 1 (AT1) receptor by negative feedback, in the collecting duct Ang II stimulates renin expression via the AT1 receptor. Upregulated renin produced in the distal nephron may be able to support continued intrarenal Ang II formation leading to amplification or maintenance of the hypertensive state.The recently discovered angiotensin-converting enzyme-related carboxypeptidase 2 (ACE2)-Angiotensin-(1-7) Ang-(1-7)-Mas receptor axis has an opposing function to that of the ACE-Ang II-AT1 receptor axis.The ACE2 deficiency was associated with an increase in blood pressure, and ACE2 knockout mice have highlighted hypertensive response to Ang II infusion associated with exaggerated accumulation of Ang II in the kidney. Recently, several numbers of patients have been evaluated as the activators of ACE2-Ang-(1-7)-Mas receptor axis, which can be divided into two main classes: aimed to increase the activity of ACE2, and directed to stimulate the Ang-(1-7) receptor Mas. In order to investigate new targets for hypertension and kidney disease, further research on the function of the ACE-Ang-(1-7)-Mas receptor axis is required. </p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"11 2","pages":"41-5"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2013.11.2.41","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32173910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 61
Severe Hyponatremia Associated with the Use of Angiotensin II Receptor Blocker/thiazide Combinations. 严重低钠血症与血管紧张素受体阻滞剂/噻嗪类药物联合使用相关
Electrolyte and Blood Pressure Pub Date : 2013-12-01 Epub Date: 2013-12-31 DOI: 10.5049/EBP.2013.11.2.56
Da-Rae Kim, Joo-Hee Cho, Won-Seok Jang, Jin-Sug Kim, Kyung-Hwan Jeong, Tae-Won Lee, Chun-Gyoo Ihm
{"title":"Severe Hyponatremia Associated with the Use of Angiotensin II Receptor Blocker/thiazide Combinations.","authors":"Da-Rae Kim,&nbsp;Joo-Hee Cho,&nbsp;Won-Seok Jang,&nbsp;Jin-Sug Kim,&nbsp;Kyung-Hwan Jeong,&nbsp;Tae-Won Lee,&nbsp;Chun-Gyoo Ihm","doi":"10.5049/EBP.2013.11.2.56","DOIUrl":"https://doi.org/10.5049/EBP.2013.11.2.56","url":null,"abstract":"<p><p>There are several widely used combinations of angiotensin II receptor blocker (ARB)/thiazide. The complimentary mechanism of action for such anti-hypertensive therapies is that, while ARB inhibits the vasoconstricting and aldosterone-secreting effects of angiotensin II, hydrochlorothiazide affects the renal tubular mechanisms of electrolyte reabsorption and increases excretion of sodium and chloride in the distal tubule, consequently promoting water excretion. In addition, hypokalemia, which may be triggered by a hydrochlorothiazide-induced increase in urinary potassium loss, is resisted by the use of ARB. Hence, the ARB/thiazide combination is safe in terms of potassium imbalance. For these reasons, fixed-dose ARB/thiazide combination anti-hypertensive drugs have been widely used for the treatment of hypertension. However, there have not been many studies done regarding cases where patients under such regimens showed severe hyponatremia, even when the amount of thiazide included was low. Here we report two cases in which severe hyponatremia occurred following treatment with the ARB/thiazide combinations. Upon discontinuation of the regimen, both patients showed recovery from hyponatremia. </p>","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"11 2","pages":"56-9"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2013.11.2.56","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32173913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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