Obesity associated hypertension: new insights into mechanism.

Q3 Medicine
Electrolyte and Blood Pressure Pub Date : 2013-12-01 Epub Date: 2013-12-31 DOI:10.5049/EBP.2013.11.2.46
Young Sun Kang
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引用次数: 124

Abstract

With excess nutrition, the burden of obesity is a growing problem worldwide. The imbalance between energy intake and expenditure leads to variable disorders as all major risk factors for cardiovascular disease. There are many hypothetical mechanisms to explain obesity-associated hypertension. Activation of the RAAS is a key contributing factor in obesity. Particularly, the RAAS in adipose tissue plays a crucial role in adipose tissue dysfunction and obesity-induced inflammation. The phenotypic changes of adipocytes occur into hypertrophy and an inflammatory response in an autocrine and paracrine manner to impair adipocyte function, including insulin signaling pathway. Adipose tissue produce and secretes several molecules such as leptin, resistin, adiponectin, and visfatin, as well as cytokines such as TNF-α, IL-6, MCP-1, and IL-1. These adipokines are stimulated via the intracellular signaling pathways that regulate inflammation of adipose tissue. Inflammation and oxidative stress in adipose tissue are important to interact with the microvascular endothelium in the mechanisms of obesity-associated hypertension. Increased microvascular resistance raises blood pressure. Therefore, a regulatory link between microvascular and perivascular adipose tissue inflammation and adipokine synthesis are provided to explain the mechanism of obesity-associated hypertension.

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肥胖相关高血压:机制的新见解
随着营养过剩,肥胖负担在世界范围内成为一个日益严重的问题。能量摄入和消耗之间的不平衡导致各种疾病成为心血管疾病的所有主要危险因素。有许多假设的机制来解释肥胖相关的高血压。激活RAAS是肥胖的一个关键因素。特别是脂肪组织中的RAAS在脂肪组织功能障碍和肥胖引起的炎症中起着至关重要的作用。脂肪细胞的表型改变发生自分泌和旁分泌方式的肥大和炎症反应,损害脂肪细胞功能,包括胰岛素信号通路。脂肪组织产生并分泌瘦素、抵抗素、脂联素和脂肪素等分子,以及TNF-α、IL-6、MCP-1和IL-1等细胞因子。这些脂肪因子通过调节脂肪组织炎症的细胞内信号通路受到刺激。脂肪组织中的炎症和氧化应激在肥胖相关性高血压的机制中与微血管内皮相互作用是重要的。微血管阻力增加,血压升高。因此,微血管和血管周围脂肪组织炎症和脂肪因子合成之间的调节联系可以解释肥胖相关性高血压的机制。
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来源期刊
Electrolyte and Blood Pressure
Electrolyte and Blood Pressure Medicine-Internal Medicine
CiteScore
2.10
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