Electrolyte and Blood Pressure最新文献_第9页

Adrenergic genetic mechanisms in hypertension and hypertensive kidney disease. 高血压和高血压肾病的肾上腺素能遗传机制。

Electrolyte and Blood Pressure Pub Date : 2013-06-01 Epub Date: 2013-06-30 DOI: 10.5049/EBP.2013.11.1.24

Sun Woo Kang

{"title":"Adrenergic genetic mechanisms in hypertension and hypertensive kidney disease.","authors":"Sun Woo Kang","doi":"10.5049/EBP.2013.11.1.24","DOIUrl":"https://doi.org/10.5049/EBP.2013.11.1.24","url":null,"abstract":"Catecholamine secretory traits were significantly heritable, as were stress-induced blood pressure changes. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. In the tyrosine hyroxylase promoter, significant associations were found for urinary catecholamine excretion and for blood pressure response to stress. TH promoter haplotype 2 (TGGG) showed pleiotropy, increasing both norepinephrine excretion and blood pressure during stress. In hypertension, 2 independent case-control studies (1,266 subjects with 53% women and 927 subjects with 24% women) replicated the effect of C-824T in the determination of blood pressure. Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Changes in the storage and release of CHGA in clinical and experimental hypertension prompted us to study whether genetic variation at the CHGA locus might contribute to alterations in autonomic function, and hence hypertension and its target organ consequences such as hypertensive kidney disease (nephrosclerosis). Systematic polymorphism discovery across the human CHGA locus revealed such regulatory regions as the proximal promoter and 3'-UTR. In chromaffin cell-transfected CHGA 3'-UTR and promoter/luciferase reporter plasmids, the functional consequences of the regulatory/non-coding allelic variants were documented. Variants in both the proximal promoter and the 3'-UTR displayed statistical associations with hypertension and hypertensive end stage renal disease. Therefore, I would like to review the common genetic variation in TH and CHGA as a cause of inter-individual variation in sympathetic activity, and ultimately blood pressure and hypertensive kidney disease. ","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"11 1","pages":"24-8"},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2013.11.1.24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31658307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Paranoid Adipsia-induced Severe Hypernatremia and Uremia treated with Hemodialysis. 血液透析治疗重度高钠血症和尿毒症。

Electrolyte and Blood Pressure Pub Date : 2013-06-01 Epub Date: 2013-06-30 DOI: 10.5049/EBP.2013.11.1.29

Jae-Hyun Choi, Hee Seung Lee, Sun Moon Kim, Hye-Young Kim, Soon Kil Kwon

引用次数: 5

The role of v2 receptor antagonists in the treatment of hyponatremia. v2受体拮抗剂在治疗低钠血症中的作用。

Electrolyte and Blood Pressure Pub Date : 2013-06-01 Epub Date: 2013-06-30 DOI: 10.5049/EBP.2013.11.1.1

Biff F Palmer

引用次数: 10

Pharmacologic Management of the Cardio-renal Syndrome. 心肾综合征的药物治疗。

Electrolyte and Blood Pressure Pub Date : 2013-06-01 Epub Date: 2013-06-30 DOI: 10.5049/EBP.2013.11.1.17

Chang Seong Kim

{"title":"Pharmacologic Management of the Cardio-renal Syndrome.","authors":"Chang Seong Kim","doi":"10.5049/EBP.2013.11.1.17","DOIUrl":"https://doi.org/10.5049/EBP.2013.11.1.17","url":null,"abstract":"Cardio-renal syndromes are disorders of the heart and kidney wherein acute or long-term dysfunction in one organ may induce acute or long-term dysfunction of the other. Because of this complex organ interaction, management of cardiorenal syndrome must be tailored to the underlying pathophysiology. Clinical guidelines exist for the treatment of heart failure or renal failure as separate conditions. Thus far, however, there has been no consensus about managing patients with cardio-renal and reno-cardiac syndromes. Pharmacologic treatment remains a controversial subject. Standard cardiac drugs such as diuretics and inotropes may have limited effect because resistance often develops after long-term use. Recent studies of patients with acute cardio-renal syndromes have focused on newer therapies, including phosphodiesterase inhibitors, vasopressin antagonists, adenosine A1 receptor antagonists, and renal protective dopamine. Initial clinical trials of these agents have shown encouraging results in some patients with heart failure, but have failed to demonstrate a clear superiority over more conventional treatments. Similarly, the benefits of diuretics, aspirin, erythropoietin agents, and iron supplements for management of chronic cardiorenal syndromes are unknown. ","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"11 1","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2013.11.1.17","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31658306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Potassium balances in maintenance hemodialysis. 维持性血液透析中的钾平衡。

Electrolyte and Blood Pressure Pub Date : 2013-06-01 Epub Date: 2013-06-30 DOI: 10.5049/EBP.2013.11.1.9

Hoon Young Choi, Sung Kyu Ha

{"title":"Potassium balances in maintenance hemodialysis.","authors":"Hoon Young Choi, Sung Kyu Ha","doi":"10.5049/EBP.2013.11.1.9","DOIUrl":"https://doi.org/10.5049/EBP.2013.11.1.9","url":null,"abstract":"Potassium is abundant in the ICF compartment in the body and its excretion primarily depends on renal (about 90%), and to a lesser extent (about 10%) on colonic excretion. Total body potassium approximated to 50mmol/kg body weight and 2% of total body potassium is in the ECF compartment and 98% of it in the intracellular compartment.Dyskalemia is a frequent electrolyte imbalance observed among the maintenance hemodialysis patients. In case of hyperkalemia, it is frequently \"a silent and a potential life threatening electrolyte imbalance\" among patients with ESRD under maintenance hemodialysis. The prevalence of hyperkalemia in maintenance HD patients was reported to be about 8.7-10%. Mortality related to the hyperkalemia has been shown to be about 3.1/1,000 patient-years and about 24% of patients with HD required emergency hemodialysis due to severe hyperkalemia. In contrast to the hyperkalemia, much less attention has been paid to the hypokalemia in hemodialysis patients because of the low prevalence under maintenance hemodialysis patients. Severe hypokalemia in the hemodialysis patients usually was resulted from low potassium intake (malnutrition), chronic diarrhea, mineralocorticoid use, and imprudent use of K-exchange resins. Recently, the numbers of the new patients with advanced chronic kidney disease undergoing maintenance hemodialysis are tremendously increasing worldwide. However, the life expectancy of these patients is still much lower than that of the general population. The causes of excess mortality in these patients seem to various, but dyskalemia is a common cause among the patients with ESRD undergoing hemodialysis. ","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"11 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2013.11.1.9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31658305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

A case of syndrome of inappropriate scretion of anti-diuretic hormone associated with sodium valproate. 丙戊酸钠所致抗利尿激素分泌不当综合征1例。

Electrolyte and Blood Pressure Pub Date : 2012-12-01 Epub Date: 2012-12-31 DOI: 10.5049/EBP.2012.10.1.31

Hong Joo Lee, Jung Kook Wi, Ju Young Moon, Kyung Hwan Jeong, Chun Gyoo Ihm, Sang Ho Lee, Tae Won Lee

引用次数: 0

Novel Biomarkers for Cardio-renal Syndrome. 心肾综合征的新生物标志物。

Electrolyte and Blood Pressure Pub Date : 2012-12-01 Epub Date: 2012-12-31 DOI: 10.5049/EBP.2012.10.1.12

Sul Ra Lee, Kyung Hwan Jeong

{"title":"Novel Biomarkers for Cardio-renal Syndrome.","authors":"Sul Ra Lee, Kyung Hwan Jeong","doi":"10.5049/EBP.2012.10.1.12","DOIUrl":"https://doi.org/10.5049/EBP.2012.10.1.12","url":null,"abstract":"Cardio-renal syndrome (CRS) is a frequent and life-threatening syndrome. It is a disorder of the heart and kidneys in which acute or chronic dysfunction in one organ may induce acute or chronic dysfunction in the other organ. Acute kidney injury (AKI) is strongly associated with increased morbidity and mortality in patients with CRS. Early detection of renal dysfunction is not possible using the traditional marker, serum creatinine, and therefore efforts to explore possible biomarkers for early detection of AKI are being made. Apart from predicting AKI, several biomarker studies also identified predictors for poor prognosis such as the need for renal replacement therapy (RRT) or death. It is possible that biomarkers can become risk factors in an improvement of clinical outcomes of CRS. Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with renal dysfunction and the treatment for this disease can be modified based on cardiac biomarkers. In addition to natriuretic peptides, which are established cardiac markers, several new biomarkers have been identified and may play important roles in CRS. In this review, we will briefly summarize the literature on novel renal and cardiac biomarkers and discuss their potential roles in the clinical outcome of CRS.","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"10 1","pages":"12-7"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2012.10.1.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31318950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Etiology of hypokalemic paralysis in Korea: data from a single center. 韩国低钾血症性麻痹的病因学:来自单一中心的数据。

Electrolyte and Blood Pressure Pub Date : 2012-12-01 Epub Date: 2012-12-31 DOI: 10.5049/EBP.2012.10.1.18

Jung-Kook Wi, Hong Joo Lee, Eun Young Kim, Joo Hee Cho, Sang Ouk Chin, Sang Youl Rhee, Ju-Young Moon, Sang-Ho Lee, Kyung-Hwan Jeong, Chun-Gyoo Ihm, Tae-Won Lee

{"title":"Etiology of hypokalemic paralysis in Korea: data from a single center.","authors":"Jung-Kook Wi, Hong Joo Lee, Eun Young Kim, Joo Hee Cho, Sang Ouk Chin, Sang Youl Rhee, Ju-Young Moon, Sang-Ho Lee, Kyung-Hwan Jeong, Chun-Gyoo Ihm, Tae-Won Lee","doi":"10.5049/EBP.2012.10.1.18","DOIUrl":"https://doi.org/10.5049/EBP.2012.10.1.18","url":null,"abstract":"Recognizing the underlying causes of hypokalemic paralysis seems to be essential for the appropriate management of affected patients and their prevention of recurrent attacks. There is, however, a paucity of documented reports on the etiology of hypokalemic paralysis in Korea. We retrospectively analyzed 34 patients with acute flaccid weakness due to hypokalaemia who were admitted during the 5-year study period in order to determine the spectrum of hypokalemic paralysis in Korea and to identify the differences in clinical parameters all across the causes of hypokalemic paralysis. We divided those 34 patients into 3 groups; the 1(st) group, idiopathic hypokalemic periodic paralysis (HPP), the 2(nd), thyrotoxic periodic paralysis (TPP), and the 3rd group, secondary hypokalemic paralysis (HP) without TPP. Seven of the patients (20.6%) were diagnosed as idiopathic HPP considered the sporadic form, and 27 patients (79.4%) as secondary HP. Among the patients diagnosed as secondary HP, 16 patients (47.1%) had TPP. Patients of secondary hypokalemic paralysis without TPP required a longer recovery time compared with those who had either idiopathic HPP or TPP. This is due to the fact that patients of secondary HP had a significantly negative total body potassium balance, whereas idiopathic HPP and TPP were only associated with intracellular shift of potassium. Most of the TPP patients included in our study had overt thyrotoxicosis while 3 patients had subclinical thyrotoxicosis. This study shows that TPP is the most common cause of hypokalemic paralysis in Korea. And we suggest that doctors should consider the presence of TPP in patients of hypokalemic paralysis even if they clinically appear to be euthyroid state.","PeriodicalId":35352,"journal":{"name":"Electrolyte and Blood Pressure","volume":"10 1","pages":"18-25"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5049/EBP.2012.10.1.18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31411381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

A new technical approach to monitor the cellular physiology by atomic force microscopy. 原子力显微镜监测细胞生理的新技术方法。

Electrolyte and Blood Pressure Pub Date : 2012-12-01 Epub Date: 2012-12-31 DOI: 10.5049/EBP.2012.10.1.7

Kyung Hwan Jeong, Sang Ho Lee

引用次数: 1

Polyuria with the Concurrent manifestation of Central Diabetes Insipidus (CDI) & Type 2 Diabetes Mellitus (DM). 多尿伴中枢性尿崩症(CDI)和2型糖尿病(DM)。

Electrolyte and Blood Pressure Pub Date : 2012-12-01 Epub Date: 2012-12-31 DOI: 10.5049/EBP.2012.10.1.26

Hyun-Jong Shin, Jae-Ha Kim, Joo-Hark Yi, Sang-Woong Han, Ho-Jung Kim

引用次数: 18