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MALDI-TOF mass spectrometry in the 21st century 21世纪的MALDI-TOF质谱
Biochemist Pub Date : 2022-10-27 DOI: 10.1042/bio_2022_130
M. E. Dueñas, Matthias Trost
{"title":"MALDI-TOF mass spectrometry in the 21st century","authors":"M. E. Dueñas, Matthias Trost","doi":"10.1042/bio_2022_130","DOIUrl":"https://doi.org/10.1042/bio_2022_130","url":null,"abstract":"This year marks the 20th anniversary of Koichi Tanaka securing the Nobel Prize in chemistry, shared with John Fenn and Kurt Wüthrich, for demonstrating the applicability of laser technology to analyze biological macromolecules. The principle of laser desorption is fundamental for many of today’s analytical methods such as matrix-assisted laser desorption/ionization (MALDI). In this article, we provide an overview of MALDI and highlight the power, versatility and range of applications within the biochemistry community.","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48425835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Eight steps to facilitating more equitable education in undergraduate sciences 促进本科科学教育更加公平的八个步骤
Biochemist Pub Date : 2022-10-26 DOI: 10.1042/bio_2022_123
Gintarė Lübeck, M. Seery, Barry J. Ryan
{"title":"Eight steps to facilitating more equitable education in undergraduate sciences","authors":"Gintarė Lübeck, M. Seery, Barry J. Ryan","doi":"10.1042/bio_2022_123","DOIUrl":"https://doi.org/10.1042/bio_2022_123","url":null,"abstract":"Pedagogical practices can influence students’ confidence and ability beliefs and affect their ambition to persevere in science. Given the continuing need to diversify science and retain students in scientific programmes, science education must be tailored to cater to the needs of varied student groups. Since early experience in university programmes can be decisive in determining students’ further academic and professional choices, pedagogies employed in undergraduate science courses can be particularly influential in supporting science careers. Undergraduate science instructors are therefore encouraged to consider their approaches to teaching and learning from a variety of perspectives that could help empower students from under-represented groups.","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42283802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet our new President: interview with Professor Dame Julia Goodfellow 见见我们的新校长:采访茱莉亚·古德费罗教授
Biochemist Pub Date : 2022-10-26 DOI: 10.1042/bio_2022_129
{"title":"Meet our new President: interview with Professor Dame Julia Goodfellow","authors":"","doi":"10.1042/bio_2022_129","DOIUrl":"https://doi.org/10.1042/bio_2022_129","url":null,"abstract":"","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47569483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Krebs Memorial Fund 2022 awardees 克雷布斯纪念基金2022获奖者
Biochemist Pub Date : 2022-10-19 DOI: 10.1042/bio_2022_128
Lucy Ollett
{"title":"Krebs Memorial Fund 2022 awardees","authors":"Lucy Ollett","doi":"10.1042/bio_2022_128","DOIUrl":"https://doi.org/10.1042/bio_2022_128","url":null,"abstract":"","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45152584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondria – expanding the role of the powerhouse 线粒体——扩大发电厂的作用
Biochemist Pub Date : 2022-08-30 DOI: 10.1042/bio_2022_124
Heather Doran
{"title":"Mitochondria – expanding the role of the powerhouse","authors":"Heather Doran","doi":"10.1042/bio_2022_124","DOIUrl":"https://doi.org/10.1042/bio_2022_124","url":null,"abstract":"","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49432828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dyspraxia & why I can’t eat spaghetti 运动障碍&为什么我不能吃意大利面条
Biochemist Pub Date : 2022-08-11 DOI: 10.1042/bio_2022_121
George M. Neville
{"title":"Dyspraxia & why I can’t eat spaghetti","authors":"George M. Neville","doi":"10.1042/bio_2022_121","DOIUrl":"https://doi.org/10.1042/bio_2022_121","url":null,"abstract":"Speaking at a conference for the first time can be daunting for anyone. For as long as I can remember, I’ve wanted to be a biochemist… No, really – I was a keen kid. So hours away from giving my first talk at the European SMALP conference, organized by the Biochemical Society, it would appear that I had achieved my life’s goal. Yet, peering out of my hotel window at the busy morning skyline, a downpour of worries started to cloud the day.","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43903719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondria and Us: from exploration to global collective 线粒体与人类:从探索到全球集体
Biochemist Pub Date : 2022-08-04 DOI: 10.1042/bio_2022_122
E. Caccavale, M. P. Johnson, Sonya Brijbassi, A. Andreazza, K. Tokatlidis
{"title":"Mitochondria and Us: from exploration to global collective","authors":"E. Caccavale, M. P. Johnson, Sonya Brijbassi, A. Andreazza, K. Tokatlidis","doi":"10.1042/bio_2022_122","DOIUrl":"https://doi.org/10.1042/bio_2022_122","url":null,"abstract":"The ‘Mitochondria and Us’ project embodies our ambition to break new ground by working across traditionally siloed disciplines and by co-creating innovative approaches to impact research and societal awareness. Our vision is to provide a paradigm shift of knowledge integration at all levels adopting a pandisciplinary cooperation in a crucial and emerging area of medicine impacting several incurable human diseases. We describe our efforts on this journey through a series of ‘Crossover’ workshops and webinars supported by the Biochemical Society and the Royal Society of Edinburgh, by bringing together mitochondria experts from the University of Glasgow and the University of Toronto together with designers from the Innovation School of the Glasgow School of Art, artists, patient groups, social scientists and bioethicists. The global Mitochondria Collective initiative has the vision to unite research, community voices and stakeholders to bring mitochondria to the forefront of medicine as a means of sustained impact on improved healthcare and quality of life.","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46033640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the road to open scholarship in 2022 2022年开放奖学金之路
Biochemist Pub Date : 2022-08-04 DOI: 10.1042/bio_2022_116
Malavika Legge, Ciaran Hoogendoorn
{"title":"On the road to open scholarship in 2022","authors":"Malavika Legge, Ciaran Hoogendoorn","doi":"10.1042/bio_2022_116","DOIUrl":"https://doi.org/10.1042/bio_2022_116","url":null,"abstract":"The Biochemical Society and Portland Press are committed to open scholarship. In 2020 we launched our Unlimited Read & Publish programme. This article summarizes the progress that has been made since then and explores the effect that our transitioning sales offerings have had on paywalls to published content. The share of content in our transitioning (hybrid) journals published open access (OA) is the highest it has ever been and continues to increase as more institutions take up transformative agreements with us each year. Open data and clear communication are key parts of the on-going transition, and progress with publishing workflows and data availability have been made. With over 40% of 2021’s published content in hybrid journals converted to OA, the Biochemical Society and Portland Press are also actively scoping future models. For this, we are seeking sustainable and collaborative pathways to completing our transition in a way that is globally equitable and inclusive.","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45907108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Energy transduction and the mind–mitochondria connection 能量转导与脑线粒体连接
Biochemist Pub Date : 2022-08-01 DOI: 10.1042/bio_2022_118
M. Picard
{"title":"Energy transduction and the mind–mitochondria connection","authors":"M. Picard","doi":"10.1042/bio_2022_118","DOIUrl":"https://doi.org/10.1042/bio_2022_118","url":null,"abstract":"The body and mind are fuelled by energy. But where does the energy come from? The sun beams energy through space as photons that are captured by plants, which store that energy in the improbable separation of carbon and oxygen. By reuniting carbon and oxygen in their mitochondria, breathing animals power their warm bodies, thoughts, feelings, minds and consciousness. Thus, the life-giving flow of energy proceeds from light, through chemistry, into life. Mapping the mechanisms of energy transformation among mind-imbued organisms is the challenge for the field of mitochondrial psychobiology. Emerging evidence positions energy as the substrate of the mind–body connection, linking the molecular processes in the organism and the subjective experiences in our mind. Building a bioenergetic psychobiology framework can stimulate the health sciences in three main ways: it provides an empirical foundation to examine the interconnectedness of people and their environment, highlights health as a dynamic process, and may eventually illuminate new approaches and strategies to optimize the energetic mind–body crosstalk that is the basis of human health.","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41525719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Fixing the powerhouse: genetic engineering of mitochondrial DNA 修复发电厂：线粒体DNA的基因工程
Biochemist Pub Date : 2022-07-27 DOI: 10.1042/bio_2022_120
C. Mutti, Pedro Silva-Pinheiro, M. Minczuk
{"title":"Fixing the powerhouse: genetic engineering of mitochondrial DNA","authors":"C. Mutti, Pedro Silva-Pinheiro, M. Minczuk","doi":"10.1042/bio_2022_120","DOIUrl":"https://doi.org/10.1042/bio_2022_120","url":null,"abstract":"Mitochondria are complex factories that provide our cells with most of the energy we need to survive and perform daily tasks. They comprise their own small genome, mitochondrial DNA (mtDNA), which contains genes for parts of the energy-producing machinery. Mutations in mtDNA can lead to mitochondrial diseases, which are a devastating group of heterogenous inheritable diseases that can develop at any stage of life. Despite rapid developments in genome engineering for nuclear DNA, the incompatibility of certain techniques in mitochondria has meant that the field of mitochondrial genome modification has been impeded for many years. However, recent advances in mtDNA engineering techniques, such as programmable nucleases and base editors, will allow for a deeper understanding of the processes taking place in mitochondria and improve the prospects of developing treatments for mitochondrial diseases.","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41771714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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