Biochemist最新文献_第10页

A beginner’s guide to lipidomics 脂质组学入门指南

Biochemist Pub Date : 2022-01-20 DOI: 10.1042/bio_2021_181

J. Swinnen, J. Dehairs

引用次数: 3

My biochemical journey from a Cambridge undergraduate to the discovery of phosphotyrosine 我从剑桥大学本科生到发现磷酸酪氨酸的生化之旅

Biochemist Pub Date : 2021-12-23 DOI: 10.1042/bio_2021_197

T. Hunter

{"title":"My biochemical journey from a Cambridge undergraduate to the discovery of phosphotyrosine","authors":"T. Hunter","doi":"10.1042/bio_2021_197","DOIUrl":"https://doi.org/10.1042/bio_2021_197","url":null,"abstract":"The most notable moment in my career as a biochemist was the discovery of phosphotyrosine, a somewhat serendipitous finding that turned out to have some very important consequences, notably, in human cancer. My career as a biochemist which has spanned nearly 60 years, began when I was 16. At the time, I was in the sixth form at Felsted School, a boarding school in Essex England, and my biology master, David Sturdy, elected to teach me some extracurricular biochemistry, giving me one-on-one tutorials on glycolysis and the TCA cycle. These early biochemistry lessons turned out to be invaluable because I was able to regurgitate them to answer a question in the University of Cambridge scholarship exam in the autumn of 1960. As a result, I was lucky enough to be awarded an Exhibition at Gonville and Caius College, the college where my father had studied for a medical degree during World War II. When I arrived in Cambridge in October 1962 to read natural sciences (see Figure 1), it was a natural choice to take biochemistry as one of my three required first-year courses. The Part I biochemistry course was taught by a series of excellent lecturers, including Philip Randle (a prominent diabetes researcher who described the Randle Cycle), Brian Chappell (who discovered mitochondrial transporters) and Asher Korner (a pioneer of cell free systems to study protein synthesis). It quickly became clear that biochemistry was an exciting subject, and Brian Chappell, my biochemistry supervisor at Caius, made supervisions a lot of fun. I also took Part I courses in invertebrate zoology and, importantly, organic chemistry, which gave me insights into how the metabolites we were learning about in biochemistry worked as chemicals.","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45965999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sir Dai Rees (28 April 1936 to 10 June 2021) 戴利斯爵士(1936年4月28日至2021年6月10日)

Biochemist Pub Date : 2021-12-23 DOI: 10.1042/bio_2021_200

P. Lillford, Chris Lawson

引用次数: 0

A pandemic in the age of next-generation sequencing 新一代测序时代的大流行

Biochemist Pub Date : 2021-12-16 DOI: 10.1042/bio_2021_187

A. Beckett, K. Cook, S. Robson

{"title":"A pandemic in the age of next-generation sequencing","authors":"A. Beckett, K. Cook, S. Robson","doi":"10.1042/bio_2021_187","DOIUrl":"https://doi.org/10.1042/bio_2021_187","url":null,"abstract":"Since December 2019, the world has found itself rocked by the emergence of a highly contagious novel coronavirus disease, COVID-19, caused by the virus SARS-CoV-2. The global scientific community has rapidly come together to understand the virus and identify potential treatments and vaccine strategies to minimise the impact on public health. Key to this has been the use of cutting-edge technological advances in DNA and RNA sequencing, allowing identification of changes in the viral genome sequence as the infection spreads. This approach has allowed a widespread ‘genomic epidemiology’ approach to infection control, whereby viral transmission (e.g. in healthcare settings) can be detected not only by epidemiological assessment, but also by identifying similarities between viral sub-types among individuals. The UK has been at the forefront of this response, with researchers collaborating with public health agencies and NHS Trusts across the UK to form the COVID-19 Genomics UK (COG-UK) Consortium. Genomic surveillance at this scale has provided critical insight into the virulence and transmission of the virus, enabling near real-time monitoring of variants of concern and informing infection control measures on local, national and global scales. In the future, next-generation sequencing technologies, such as nanopore sequencing, are likely to become ubiquitous in diagnostic and healthcare settings, marking the transition to a new era of molecular medicine.","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48157930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Tales from the lab 实验室的故事

Biochemist Pub Date : 2021-12-16 DOI: 10.1042/bio_2021_189

Andrew N Holding

引用次数: 0

The algae revolution 2.0: the potential of algae for the production of food, feed, fuel and bioproducts – why we need it now 藻类革命2.0:藻类在食品、饲料、燃料和生物产品生产中的潜力——为什么我们现在需要它

Biochemist Pub Date : 2021-12-15 DOI: 10.1042/bio_2021_190

S. Mayfield, M. Burkart

{"title":"The algae revolution 2.0: the potential of algae for the production of food, feed, fuel and bioproducts – why we need it now","authors":"S. Mayfield, M. Burkart","doi":"10.1042/bio_2021_190","DOIUrl":"https://doi.org/10.1042/bio_2021_190","url":null,"abstract":"Algae made our world possible, and it can help us make the future more sustainable; but we need to change the way we live and adopt new more efficient production systems, and we need to do that now. When the world was new, the atmosphere was mainly carbon dioxide, and no animal life was possible. Along came algae with the process of photosynthesis, and things began to change. Ancient cyanobacteria algae turned carbon dioxide into enormous sums of lipids, proteins and carbohydrates, while they secreted oxygen into the atmosphere. Over a billion years, as oxygen filled the air and algae filled the seas, animal life became possible. Eventually all that algae biomass became petroleum and natural gas, which for eons sat undisturbed in vast underground reservoirs, holding enormous sums of untapped energy. Less than 200 years ago humans learned to tap these energy reserves to create the world we know today, but in so doing, we have released millions of years of stored CO2 back into the atmosphere. Algae can again help make the world a better place, but this will require new thinking and new ways of producing our food, feed and fuels. We need an algae revolution 2.0.","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46486451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycans for the greater good 为了更大的利益

Biochemist Pub Date : 2021-12-15 DOI: 10.1042/bio_2021_186

J. Lloyd

{"title":"Glycans for the greater good","authors":"J. Lloyd","doi":"10.1042/bio_2021_186","DOIUrl":"https://doi.org/10.1042/bio_2021_186","url":null,"abstract":"Carbohydrates are ubiquitous in nature and present across all kingdoms of life – bacteria, fungi, viruses, yeast, plants, animals and humans. They are essential to many biological processes. However, due to their complexity and heterogeneous nature they are often neglected, sometimes referred to as the ‘dark matter’ of biology. Nevertheless, due to their extensive biological impact on health and disease, glycans and the field of glycobiology have become increasingly popular in recent years, giving rise to glycan-based drug development and therapeutics. Forecasting of communicable diseases predicts that we will see an increase in pandemics of humans and livestock due to global loss of biodiversity from changes to land use, intensification of agriculture, climate change and disruption of ecosystems. As such, the development of point-of-care devices to detect pathogens is vital to prevent the transmission of infectious disease, as we have seen with the COVID-19 pandemic. So, can glycans be exploited to detect COVID-19 and other infectious diseases? And is this technology sensitive and accurate? Here, I discuss the structure and function of glycans, the current glycan-based therapeutics and how glycan binding can be exploited for detection of infectious disease, like COVID-19.","PeriodicalId":35334,"journal":{"name":"Biochemist","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46452012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR systems: what’s new, where next? CRISPR系统：有什么新的，下一步在哪里？

Biochemist Pub Date : 2021-12-15 DOI: 10.1042/bio_2021_194

Ashley Parkes, Fiona E Kemm, Liu He, Tom Killelea

引用次数: 0

Opportunities for early-career researchers to engage with science policy through the Biochemical Society 早期职业研究人员通过生物化学学会参与科学政策的机会

Biochemist Pub Date : 2021-12-13 DOI: 10.1042/bio_2021_182

Byron Carpenter

引用次数: 0

The benefits of an open-science approach in student research projects 开放科学方法在学生研究项目中的好处

Biochemist Pub Date : 2021-12-13 DOI: 10.1042/bio_2021_198

Emma MacKenzie, Sophie M. Winterbourne, Felicity Anderson, Edward Wallace

引用次数: 0