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Precise morphology control of phosphate-based nanospheres via magnesium and application in drug delivery 镁基磷酸盐纳米球的精确形貌控制及其在药物传递中的应用
Advanced Applied Materials Pub Date : 2021-01-10 DOI: 10.36822//adv.app.mater.202101
{"title":"Precise morphology control of phosphate-based nanospheres via magnesium and application in drug delivery","authors":"","doi":"10.36822//adv.app.mater.202101","DOIUrl":"https://doi.org/10.36822//adv.app.mater.202101","url":null,"abstract":"The present work investigates a template-free and rapid synthesis of phosphate-based porous nanospheres via magnesium. The study reveals the magnesium plays a guide role in the formation of amorphous porous magnesium substituted nanospheres, including calcium phosphate (CaP), strontium phosphate (SrP) and barium phosphate (BaP). Cell viabilities of three kinds of particles were evaluated and CaP nanospheres indicated best biocompatibility. Thus, amorphous magnesium substituted CaP nanospheres were chosen as doxorubicin (DOX) carrier for drug delivery in cancer treatment and pH-responsive magnesium substitution can switch on under tumour acidic microenvironment and facilitate controlled sustained DOX release. The CaP nanospheres gave a sustainable release within 150 minutes. The results showed free DOX has better efficiency at killing cancer cells than CaP/DOX at 4 h. However, CaP/DOX systems effectively suppressed the cell proliferation comparing with free DOX at 36 h. Collectively, this simple and templet-free method for synthesis of amorphous porous nanospheres could serve as a promising chemo-therapeutics delivery system and effectively inhibition of cancer cell growth.","PeriodicalId":353210,"journal":{"name":"Advanced Applied Materials","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131921827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug delivery systems for Intra⁃articular injection in the Osteoarthritis treatment 关节内注射给药系统治疗骨关节炎
Advanced Applied Materials Pub Date : 2020-11-20 DOI: 10.36822/adv.app.mater.202011
{"title":"Drug delivery systems for Intra⁃articular injection in the Osteoarthritis treatment","authors":"","doi":"10.36822/adv.app.mater.202011","DOIUrl":"https://doi.org/10.36822/adv.app.mater.202011","url":null,"abstract":"Intra⁃articular injection is one of the most important treatment for osteoarthritis (OA) drug administration. It would improve the pharmacotherapy efficacy and reduce the adverse drug reaction and toxic effect of drugs. In the last decades, the microspheres, nanoparticles, hydrogels, and other drug delivery systems have been extensively studied in OA therapy. This paper reviews the late research development on OA treated via IA drug delivery systems.","PeriodicalId":353210,"journal":{"name":"Advanced Applied Materials","volume":"660 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134063050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on bone grafts materials for bone defect repair 骨缺损修复骨移植材料研究进展
Advanced Applied Materials Pub Date : 2020-06-30 DOI: 10.36822/adv.app.mater.202006
{"title":"Update on bone grafts materials for bone defect repair","authors":"","doi":"10.36822/adv.app.mater.202006","DOIUrl":"https://doi.org/10.36822/adv.app.mater.202006","url":null,"abstract":"","PeriodicalId":353210,"journal":{"name":"Advanced Applied Materials","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117127828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress on Exosome Application in Drug Delivery 外泌体在药物传递中的应用研究进展
Advanced Applied Materials Pub Date : 2019-10-18 DOI: 10.36822/adv.app.mater.201910
{"title":"Research Progress on Exosome Application in Drug Delivery","authors":"","doi":"10.36822/adv.app.mater.201910","DOIUrl":"https://doi.org/10.36822/adv.app.mater.201910","url":null,"abstract":"cell-to-cell communication. The most studied extracellular vesicles are exosomes. Exosomes are discoid vesicles with diameters between 30 and 150 nm. They have good delivery abilities, and many studies have shown that as novel drug delivery systems exosome have low immunogenicity, high biocompatibility, and are a powerful and novel delivery platform for disease treatment. In this review, exosome drug-loading methods and the latest research results for their use in drug delivery are summarized to facilitate expansion of exosome applications in cancer treatment.","PeriodicalId":353210,"journal":{"name":"Advanced Applied Materials","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121666758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesoporous silica nanoparticles for drug delivery—Recent advances 介孔二氧化硅纳米颗粒给药研究进展
Advanced Applied Materials Pub Date : 2019-06-25 DOI: 10.36822/adv.app.mater.201903
{"title":"Mesoporous silica nanoparticles for drug delivery—Recent advances","authors":"","doi":"10.36822/adv.app.mater.201903","DOIUrl":"https://doi.org/10.36822/adv.app.mater.201903","url":null,"abstract":"Mesoporous silica nanoparticles (MSNs) have been attracting great attention for the potential biomedical applications in the last decades. Due to the unique properties, such as tunable mesoporous structure, huge surface area, large pore volume, as well as the functional ability of surface, MSNs exhibit high loading capacity for therapeutic active pharmaceutical ingredients (APIs) and controllable release behavior. In this review, the applications of MSNs in pharmaceutics improving the bioavailability, reducing toxicity of loaded drugs, increasing cellular targeted delivery ability and recent advances in drug delivery are summarized.","PeriodicalId":353210,"journal":{"name":"Advanced Applied Materials","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124471244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advanced development of calcium phosphate in spherical form: syntheses and applications 球形磷酸钙的合成及应用研究进展
Advanced Applied Materials Pub Date : 2018-12-10 DOI: 10.36822/adv.app.mater.20180202
{"title":"Recent advanced development of calcium phosphate in spherical form: syntheses and applications","authors":"","doi":"10.36822/adv.app.mater.20180202","DOIUrl":"https://doi.org/10.36822/adv.app.mater.20180202","url":null,"abstract":"The advantages of calcium phosphate in biomedical applications such as drug delivery, bone regeneration and tissue engineering have been recognized. An overview of calcium phosphate in spherical form including spherical particles, spherical core and spherical shell was carried out in this work. Advanced spheres manufacturing as well as characterisation methodologies by biomimic remineralisation, seawater and hydrothermal methods was investigated. Their use in dental and vaccine applications was focused and presented in this review. Finally, a brief conclusion of the existing challenges and future perspective are presented.","PeriodicalId":353210,"journal":{"name":"Advanced Applied Materials","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133820951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-situ facile deposition of TiO2 hole blocking layers for efficienthole-conductor-free perovskite solar cells 高效无孔-无导体钙钛矿太阳能电池中TiO2空穴阻挡层的原位快速沉积
Advanced Applied Materials Pub Date : 2018-12-10 DOI: 10.36822/adv.app.mater.20180201
{"title":"In-situ facile deposition of TiO2 hole blocking layers for efficient\u0000hole-conductor-free perovskite solar cells","authors":"","doi":"10.36822/adv.app.mater.20180201","DOIUrl":"https://doi.org/10.36822/adv.app.mater.20180201","url":null,"abstract":"A compact hole blocking layer is necessary for high efficient perovskite solar cell, which was usually fabricated by spin coating or spray pyrolysis with the followed annealing process, or vacuum deposition. Here, we deposited TiO2 compact layers by an in-situ room-temperature solvent method, which were applied as an effective hole blocking layer for hole-conductor-free perovskite solar cells with carbon electrodes. The thickness of the TiO2 compact layer can be easily regulated by the depositing time. By optimizing the TiO2 depositing time, the power conversion efficiency of hole-conductor-free perovskite solar cells was up to 10.66%.","PeriodicalId":353210,"journal":{"name":"Advanced Applied Materials","volume":"161 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132950580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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