Precise morphology control of phosphate-based nanospheres via magnesium and application in drug delivery

Advanced Applied Materials Pub Date : 2021-01-10 DOI:10.36822//adv.app.mater.202101

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Abstract

The present work investigates a template-free and rapid synthesis of phosphate-based porous nanospheres via magnesium. The study reveals the magnesium plays a guide role in the formation of amorphous porous magnesium substituted nanospheres, including calcium phosphate (CaP), strontium phosphate (SrP) and barium phosphate (BaP). Cell viabilities of three kinds of particles were evaluated and CaP nanospheres indicated best biocompatibility. Thus, amorphous magnesium substituted CaP nanospheres were chosen as doxorubicin (DOX) carrier for drug delivery in cancer treatment and pH-responsive magnesium substitution can switch on under tumour acidic microenvironment and facilitate controlled sustained DOX release. The CaP nanospheres gave a sustainable release within 150 minutes. The results showed free DOX has better efficiency at killing cancer cells than CaP/DOX at 4 h. However, CaP/DOX systems effectively suppressed the cell proliferation comparing with free DOX at 36 h. Collectively, this simple and templet-free method for synthesis of amorphous porous nanospheres could serve as a promising chemo-therapeutics delivery system and effectively inhibition of cancer cell growth.

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镁基磷酸盐纳米球的精确形貌控制及其在药物传递中的应用

本工作研究了一种无模板、通过镁快速合成磷酸盐基多孔纳米球的方法。研究表明，镁在非晶多孔镁取代纳米球的形成中起着引导作用，包括磷酸钙(CaP)、磷酸锶(SrP)和磷酸钡(BaP)。结果表明，CaP纳米微球具有最佳的生物相容性。因此，选择无定形镁取代的CaP纳米球作为阿霉素(DOX)在癌症治疗中的药物载体，在肿瘤酸性微环境下，ph响应性镁取代可以开启，促进DOX的可控持续释放。CaP纳米球可以在150分钟内持续释放。结果表明，游离DOX在4 h时比CaP/DOX杀死癌细胞的效率更高。然而，与游离DOX相比，CaP/DOX系统在36 h时有效抑制了细胞增殖。总的来说，这种简单且无模板的合成非晶多孔纳米球的方法可以作为一种有前途的化学治疗递送系统，有效抑制癌细胞的生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advanced Applied Materials

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