Recent advanced development of calcium phosphate in spherical form: syntheses and applications

Abstract

The advantages of calcium phosphate in biomedical applications such as drug delivery, bone regeneration and tissue engineering have been recognized. An overview of calcium phosphate in spherical form including spherical particles, spherical core and spherical shell was carried out in this work. Advanced spheres manufacturing as well as characterisation methodologies by biomimic remineralisation, seawater and hydrothermal methods was investigated. Their use in dental and vaccine applications was focused and presented in this review. Finally, a brief conclusion of the existing challenges and future perspective are presented.