Medycyna wieku rozwojowego最新文献

{"title":"The Role of Perinatal Cardiology in Saving the Life and Its Quality of Fetuses, Newborns and Children (on the Basis of Own Experience and Review of The Literature)","authors":"M. Respondek-Liberska","doi":"10.34763/devperiodmed.20182203.270279","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182203.270279","url":null,"abstract":"Abstract The role of prenatal cardiology and the organization of perinatal cardiological centers in early diagnostics and early therapeutic procedures in fetuses and newborns with cardiac malformations and circulatory disturbances was discussed on the basis of the literature and own experience. The possibilities of an early perinatal diagnosis and early therapeutic approaches to cardiac defects were presented. It was stressed that there is a necessity to broaden the educational aims in these areas and in the near future to prepare multidisciplinary teams working together in specialist centers.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 1","pages":"270 - 279"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49194941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pani Profesor Zw. Dr Hab. n. Med. Krystyna Bożkowa - Redaktor Naczelny Developmental Period Medicine Medycyna Wieku Rozwojowego Zmarła w Dn. 29. Lipca 2018 Roku","authors":"Ewa Helwich","doi":"10.34763/devperiodmed.20182203.217218","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182203.217218","url":null,"abstract":"","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 1","pages":"217 - 218"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49557403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Vitamin D Supplementation on Vitamin D Level, Urinary Calcium Excretion and Bone Density in Patients with Hypercalciuria and Vitamin D Deficiency − Preliminary Report","authors":"J. Milart, K. Jobs, M. Tłustochowicz, Milena Pogonowska, B. Kalicki","doi":"10.34763/devperiodmed.20182202.144152","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182202.144152","url":null,"abstract":"Abstract Aim To study the impact of vitamin D supplementation on vitamin D concentration in plasma, calcium urinary excretion and bone density in patients with urolithiasis in the course of idiopathic hypercalciuria and with a low vitamin D level. Materials and method Prospective analysis concerning 28 patients (16 boys, 12 girls) aged 6-14 years (average 10.4) in terms of urinary calcium excretion (mg/kg/day and Ca/Creatinine ratio in morning urine sample), 25OHD blood level after 3, 6, 9 and 12 months of individually recommended doses of vitamin D supplementation (400 IU or 800 IU). The doses were determined on the basis of 25 (OH) D deficiency. The children were on a normocalcemic diet. The bone mineral density of the patients was assessed before and after 12 months of vitamin D use at the aforementioned doses. Results There was no statistically significant correlation between 25 (OH) D plasma concentration and urinary calcium excretion measured on Ca /Creatinine ratio in daily urine collection and Ca/Creatinine ratio in the morning urine sample. No statistically significant change in calcium excretion was noted (measured by calciuria in daily urine collection and the calcium to creatinine ratio in the morning urine sample). A statistically significant increase in vitamin D plasma concentration was observed. Improvement in bone mineral density was not statistically significant. Conclusions Supplementation of vitamin D in the children with idiopathic hypercalciuria and urolithiasis who were examined seems to be safe. The decision to start treatment and the selection of the vitamin D dose should be considered individually. Patients with urolithiasis should be carefully monitored for calcium/phosphate metabolism parameters and the activity of the disease. Supplementation of low doses vitamin D in the children examined did not improve bone mineral density.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 1","pages":"144 - 152"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43916889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diet Structure and Body Mass Index Among Polish Preschool Children in Relation To Their Place of Residence","authors":"A. Potocka, Aleksandra Jacukowicz","doi":"10.34763/devperiodmed.20182202.153159","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182202.153159","url":null,"abstract":"Abstract Introduction and aim Proper nutritional status in early childhood makes it possible for children to achieve their genetically-determined growth potential and intelligence. A child’s nutritional status is due to economic, cultural, psychosocial and geographic factors. The present study aims to check whether the nutritional status of preschoolers differs depending on their place of residence. Materials and methods In order to achieve this goal we used 24-h dietary recalls to assess the children’s diet based on interviews with 530 mothers of preschool children from five different regions of Poland. Moreover, the children’s BMIs were calculated. Results We found differences in the level of anthropometric indicators, diet structure and what percentage of the estimated average requirement for energy was met depending on the region where the children live. Youngsters from the western region of Poland had significantly higher BMIs than those from other regions. What is more, the percentage of meeting the estimated average requirement for energy and the percentage of calories from carbohydrates was higher among children from the western region, as compared with preschoolers from other areas of the country. The amount of fats and protein in the diet of children from western Poland, in turn, was significantly lower as compared with the diet of their peers from other regions. Conclusions The present study provides evidence that the nutritional status of children should be analyzed in the context of their place of residence. Thus, the differences between regions and their impact on the health status of their inhabitants should be taken into account when designing preventive or corrective measures.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 1","pages":"153 - 159"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69886276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging Results, Short-term Assessment of Psychomotor Development and the Risk of Autism Spectrum Disorder in Extremely Premature Infants (≤28 GA) - a Prospective Cohort Study (preliminary Report)","authors":"M. Rutkowska, M. Bekiesińska-Figatowska, G. Kmita, I. Terczyńska, Katarzyna Polak, M. Kalisiak, Dorota Prażmowska, E. Kiepura, Sylwia Szkudlińska-Pawlak, M. Seroczyńska, E. Helwich","doi":"10.34763/devperiodmed.20182201.3948","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182201.3948","url":null,"abstract":"Abstract Infants ≤28 GA are at particular risk of psychomotor and neurological developmental disorder. They also remain at a higher risk of developing autism spectrum disorder (ASD), characterized by persistent deficits in communication/social interactions and restricted, repetitive behaviors, activities and interests. Monitoring their development by a team of specialists (a neurologist, psychologist, psychiatrist) allows us to make an early diagnosis and to implement appropriate therapy. Neuroimaging studies during the neonatal period may be helpful in clarifying diagnosis and prognosis. Objective The aim of the study was to search for the interrelation between the results of neuroimaging and the neurological, psychological and psychiatric evaluation at the age of 2. Material and methods Neonates born at ≤28 weeks between 01.06.2013 and 31.12.2015 and hospitalized at NICU were enrolled. We present the results of the first 12 children who have attained 2 years of corrected age and have undergone both neuroimaging, and neurological, psychological and psychiatric assessments. Transfontanel ultrasound was performed according to general standards, MRI between 38 and 42 weeks of corrected age. Neurological examination based on the Denver scale, ASD screening with use of the STAT test and psychological DSR assessment were performed at 2 years of corrected age. Results Median GA was 26 weeks and median weight 795 g. The ultrasound examination was normal in 9 cases (75%) and MRI in 4 (33%). Abnormalities in the cerebellum were the main additional information found in MRI as compared to US. Neurological examination was normal in 8 infants (67%), in 4 of whom neuroimaging was normal. In 4 (33%) infants the neurological examination was abnormal. Psychomotor development at an average level or above was found in seven (58%) children. In 4 of them neuroimaging was normal, whereas 3 had ventricular dilatation and haemorrhagic infarct. There were no abnormalities within the cerebellum in this group. In the remaining 5 children (42%) psychomotor development was rated as delayed. All of them had cerebellar haemorrhage. An increased risk of ASD was observed in 4 children who developed cerebellar hemorrhage. Conclusions 1. The use of MRI at a term-equivalent age may contribute to the prognosis of neurodevelopmental outcomes in extremely premature infants, allowing risk stratification and thus enhancing early monitoring of a child’s development and functional status 2. There is a clear tendency towards abnormal psychomotor development and positive screening for ASD to co-occur with abnormal MRI findings in the cerebellum.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 1","pages":"39 - 48"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45881553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mutation Responsible for Torsion Dystonia Type 1 Shows the Ability To Stimulate Intracellular Aggregation of Mutant Huntingtin","authors":"M. Jurek, E. Obersztyn, M. Milewski","doi":"10.34763/devperiodmed.20182201.3338","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182201.3338","url":null,"abstract":"Abstract Introduction Torsion dystonia type 1 is the most common form of early-onset primary dystonia. Previous reports have suggested that torsin 1A, a protein mutated in this disease, might function as a chaperone that prevents the toxic aggregation of misfolded polypeptides. The aim of the study The aim of this study was to verify the chaperone function of torsin 1A by investigating its ability to prevent the aggregation of huntingtin model peptides. Materials and methods N-terminal mutant huntingtin fragments of different length were co-expressed in neuronal HT-22 and non-neuronal HeLa cells with either the wild-type or mutant (ΔE302/303) torsin 1A protein. The transfected cells were immunostained and analyzed for the presence of huntingtin aggregates using fluorescence microscopy. Results The immunofluorescence analysis of huntingtin subcellular distribution within the transfected cells showed no significant difference between the huntingtin aggregation levels in cells co-expressing the wild-type torsin 1A and in control cells co-transfected with an empty vector. Instead, it was the increased level of huntingtin aggregation in the presence of the torsion dystonia-causing ΔE302/303 mutant that reached statistical significance in both neuronal and non-neuronal cells. Conclusions Either torsin 1A does not function as a chaperone protein or huntingtin is not an efficient substrate for such a hypothetical chaperone activity. However, the ability of mutant torsin 1A to stimulate the accumulation of aggregation-prone polypeptides might constitute an important source of ΔE302/303 pathogenicity and thus a potential target for future therapy.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 1","pages":"33 - 38"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44090937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of Topical Steroid Application in Children with Non-retractile Prepuce","authors":"D. Makhija, H. Shah, Charu Tiwari, Pankaj Dwiwedi, Suraj Gandhi","doi":"10.34763/devperiodmed.20182201.7174","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182201.7174","url":null,"abstract":"Abstract True phimosis is overdiagnosed due to the failure to distinguish it from physiological phimosis, which is a normal developmental non retractability of the foreskin. The non-retractile prepuce in children is a cause of parental anxiety and concern. This leads to the majority of the children undergoing surgical procedures. Pathological phimosis needs to be differentiated from physiologic phimosis to avoid unnecessary circumcision. In recent years, topical steroid application use in cases of non-retractile prepuce has shown a good success rate and is well accepted by the parents. It has low risks, is cost effective and avoids anaesthetic and surgical complications. This is an observational study of 100 children with non-retractile foreskin who were managed by local application of topical steroid cream (0.1% Mometasone) over a period of 6 weeks. The non-retractibility was classified according to Kikiro’s classification. These patients were analyzed on the basis of age at presentation, complaints at the first presentation, grade of phimosis at first presentation (as per Kikiro’s classification), results of the topical steroid application as assessed at 6 weeks after starting application and after stopping of the steroid administered for 6 weeks. The results were analyzed on the basis of the resolution of symptoms and the decrease in Kikiro’s grade. Those patients in whom there was no response to treatment or who developed recurrence after stopping steroid treatment underwent circumcision. A total of 19 patients required surgical intervention in the form of circumcision. The use of topical steroids yields satisfactory results in patients with a non-retractile prepuce. It could be a first-line treatment for management in such cases and is an effective alternative designed to avoid unnecessary circumcision.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 1","pages":"71 - 74"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45733773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Treatment Methods of Urolithiasis in the Pediatric Population","authors":"J. Samotyjek, B. Jurkiewicz, A. Krupa","doi":"10.34763/devperiodmed.20182201.8893","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182201.8893","url":null,"abstract":"Abstract Urolithiasis in the pediatric population represents a major challenge associated with both the diagnosis and therapy of the condition. Over the past 25 years, the incidence has increased. The average age of pediatric patients with stones is about 7-8 years and the recurrence rate is 24%-50%. More than 80% of the stones are eliminated spontaneously. The remaining ones require conservative or surgical treatment. Choosing the most appropriate treatment depends on many factors. Surgical procedures in children are the same as in adults. These include extracorporeal shockwave lithotripsy (ESWL), ureterolithotripsy (URSL), retrograde intrarenal surgery (RIRS), percutaneous nephrolithotomy (PCNL) and laparoscopic or open surgery. ESWL is a method of choice for the treatment of stones with a diameter of ≤20 mm located in the upper urinary tract, while PCNL is used in the treatment of deposits ≥1.5 cm located in the upper pole of the kidney, deposits of ≥1.0 cm located in the lower pole of the kidney, as well as hard stones such as cystic or struvite ones. URSL/RIRS is a method for ureteral and renal stones. Open surgery is indicated in cases when anatomical anomalies coexist with urolithiasis, or when the use of PCNL or ESWL is impossible. The ideal procedure should be effective, safe and allow the complete evacuation of the stones after the 1st procedure.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 1","pages":"88 - 93"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44850697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Levels of Bone Alkaline Phosphatase (BALP) and Soluble Epidermal Growth Factor Receptor-2 (ECD/HER-2) in Pediatric Patients with Osteosarcoma During Clinical Treatment","authors":"M. Rychłowska-Pruszyńska, J. Gajewska, J. Ambroszkiewicz, M. Karwacki, K. Szamotulska","doi":"10.34763/devperiodmed.20182201.5864","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182201.5864","url":null,"abstract":"Abstract Aim The aim of this study was to assess the usefulness of bone-specific alkaline phosphatase (BALP) and the extracelluar domain of human epidermal growth factor receptor 2 (ECD/HER-2) measurements in pediatric patients with osteosarcoma as prospective prognostic and predictive markers for monitoring the treatment and early detection of disease recurrence. Material and methods We studied 22 patients (5 girls, 17 boys) aged 7-20 years with osteosarcoma (OS) treated at the Institute of Mother and Child in Warsaw. All the patients were evaluated for the serum levels of BALP and ECD/HER-2 before treatment, during pre- and postoperative chemotherapy and after the completion of treatment. Healthy children (n=22) were the reference group. The levels of BALP and ECD/HER-2 were measured using immunoenzymatic methods. Results The values of BALP and ECD/HER-2 proteins were higher (p<0.01; p<0.05, respectively) in patients with osteosarcoma at the time of diagnosis compared with the control group. The values of both markers significantly decreased during chemotherapy in most patients with remission. In contrast to ECD/HER-2, the value of BALP after therapy was higher in patients with progression than with remission (p<0.001). Conclusions Our results demonstrate the different pattern of BALP and ECD/HER-2 proteins during clinical treatment in patients with osteosarcoma. Higher values of BALP may characterize the progression of the disease and unfavourable prognosis. Further longitudinal studies are necessary to confirm the prognostic values of BALP and ECD/HER-2 proteins in this group of patients.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 1","pages":"58 - 64"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45193474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"the Safety of Pulmonary Ultrasonography in the Neonatal Intensive Care Unit","authors":"M. Jagła, Olga Krzeczek, Aleksandra Buczyńska, Z. Zakrzewska, P. Kwinta","doi":"10.34763/devperiodmed.20182201.7580","DOIUrl":"https://doi.org/10.34763/devperiodmed.20182201.7580","url":null,"abstract":"Abstract Introduction Due to specific anatomy of children are more vulnerable to the carcinogenic effects of ionizing radiation from chest X-rays. Lung ultrasound (LUS) is a validated procedure which can easily be used in diagnosing pathologies of the neonatal lung. However, experimental studies have shown that low frequency ultrasound may induce pulmonary capillary hemorrhage (PCH). Aim of the study To evaluate the potential relationship between lung ultrasound and pulmonary hemorrhage in very low birth weight infants. Patients and methods We analysed the medical records of very low birth weight infants admitted to our neonatal tertiary centre between 2008 and 2011 (group 1), when CXR was the main procedure used to evaluate the respiratory system, and between 2013 and 2016 (group 2), when LUS became a routine procedure, replacing the chest X-ray. Results 297 infants were enrolled in the first group and 286 in the second group, respectively. There was no difference in the frequency of pulmonary hemorrhages between the two groups (p=1). In the first group there was only one episode of PCH and in the second group no PCH was seen. Statistically significant differences were seen in a number of patients with pulmonary hemorrhage risk factors: surfactant administration (p<0.001), mechanical ventilation (p=0.0003), and hemodynamically significant patent ductus arteriosus (p=0.025). Conclusions Routine lung ultrasound appears to be safe in very low birth weight infants; there were no episodes of pulmonary hemorrhage.","PeriodicalId":35058,"journal":{"name":"Medycyna wieku rozwojowego","volume":"22 1","pages":"75 - 80"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43714085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}