International Journal of Electronic Marketing and Retailing最新文献

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Calcium-Sensing Receptor and Transient Receptor Ankyrin-1 Mediate Emesis Induction by Deoxynivalenol (Vomitoxin). 钙传感受体和瞬时受体Ankyrin-1介导脱氧雪腐镰刀菌素（呕吐毒素）的催吐作用

IF 3.8

International Journal of Electronic Marketing and Retailing Pub Date : 2017-01-01 Epub Date: 2016-09-25 DOI: 10.1093/toxsci/kfw191

Wenda Wu, Hui-Ren Zhou, Steven J Bursian, Jane E Link, James J Pestka

{"title":"Calcium-Sensing Receptor and Transient Receptor Ankyrin-1 Mediate Emesis Induction by Deoxynivalenol (Vomitoxin).","authors":"Wenda Wu, Hui-Ren Zhou, Steven J Bursian, Jane E Link, James J Pestka","doi":"10.1093/toxsci/kfw191","DOIUrl":"10.1093/toxsci/kfw191","url":null,"abstract":"The common foodborne mycotoxin deoxynivalenol (DON, vomitoxin) can negatively impact animal and human health by causing food refusal and vomiting. Gut enteroendocrine cells (EECs) secrete hormones that mediate DON's anorectic and emetic effects. In prior work utilizing a cloned EEC model, our laboratory discovered that DON-induced activation of calcium-sensing receptor (CaSR), a G-coupled protein receptor (GPCR), and transient receptor ankyrin-1 (TRPA1), a transient receptor potential (TRP) channel, drives Ca2+-mediated hormone secretion. Consistent with these in vitro findings, CaSR and TRPA1 mediate DON-induced satiety hormone release and food refusal in the mouse, an animal model incapable of vomiting. However, the roles of this GPCR and TRP in DON's emetic effects remain to be determined. To address this, we tested the hypothesis that DON triggers emesis in mink by activating CaSR and TRPA1. Oral gavage with selective agonists for CaSR (R-568) or TRPA1 (allyl isothiocyanate; AITC) rapidly elicited emesis in the mink in dose-dependent fashion. Oral pretreatment of the animals with the CaSR antagonist NPS-2143 or the TRP antagonist ruthenium red (RR), respectively, inhibited these responses. Importantly, DON-induced emesis in mink was similarly inhibited by oral pretreatment with NPS-2143 or RR. In addition, these antagonists suppressed concurrent DON-induced elevations in plasma peptide YY3-36 and 5-hydroxytryptamine-hormones previously demonstrated to mediate the toxin's emetic effects in mink. Furthermore, antagonist co-treatment additively suppressed DON-induced emesis and peptide YY 3-36 release. To summarize, the observations here strongly suggest that activation of CaSR and TRPA1 might have critical roles in DON-induced emesis.","PeriodicalId":35056,"journal":{"name":"International Journal of Electronic Marketing and Retailing","volume":"1 1","pages":"32-42"},"PeriodicalIF":3.8,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88878083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the impact of corporate credibility and technology acceptance on online shopping 评估企业信誉和技术接受度对网上购物的影响

International Journal of Electronic Marketing and Retailing Pub Date : 2007-04-09 DOI: 10.1007/978-3-319-11779-9_6

Esther Swilley, R. Goldsmith

引用次数: 7

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