Mohammad Al-Qahtani, Heba MY El-Basatiny, Faii AlQahtani, Shahad A. AlHazzaa, Mohammed Hamdan Hashem, Rana A. Al Balwi, Amani K. Alrowished, Abdullah A Yousef, Ala’a A. Aldajani, B. Awary, M. A. Ghamdi, Yara Hejazi, F. M. Alfayez
{"title":"Correlation Between Hand Grip Strength and Glycemic Control Among Saudi Children with Chronic Type 1 Diabetes Mellitus (T1DM)","authors":"Mohammad Al-Qahtani, Heba MY El-Basatiny, Faii AlQahtani, Shahad A. AlHazzaa, Mohammed Hamdan Hashem, Rana A. Al Balwi, Amani K. Alrowished, Abdullah A Yousef, Ala’a A. Aldajani, B. Awary, M. A. Ghamdi, Yara Hejazi, F. M. Alfayez","doi":"10.1900/RDS.2023.19.86","DOIUrl":"https://doi.org/10.1900/RDS.2023.19.86","url":null,"abstract":"Objectives We aimed to study the correlation between the hand grip strength as an indicator of the musculoskeletal affection and the degree of glycemic control in Type 1 Diabetic pediatric patients. Methods Cross-sectional interventional study conducted among children having chronic T1DM recruited from the pediatric diabetes clinic at King Fahd hospital of the University, Saudi Arabia, they were divided into 3 groups according to their HbA1c level to well controlled, fairly controlled and poorly controlled. Anthropometrics measure taken then handgrip strength for both dominant and nondominant hands were measured using valid and reliable digital JAMAR PLUS hand dynamometer, data collection was performed according to the American Society of Hand Therapists (ASHT) guidelines. Results Total of 150 patients, aged 5-18 years, with 56% females and 44% males, two third of them were poorly controlled. Well controlled group showed better hand grip strength than the other 2 groups however it was not statistically significant. Conclusions The handgrip strength in Type 1 DM children is affected by the degree of the glycemic control and it might give a clue of early musculoskeletal functional derangement by the effect of chronic hyperglycemia in these affected children.","PeriodicalId":34965,"journal":{"name":"Review of Diabetic Studies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89159137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Budiyati, Dyah Purnamasari, H. Wibowo, I. Widyahening, P. Soewondo
{"title":"Metabolic and immune response to high-fat diet in healthy urban Indonesian males with family history of type 2 diabetes mellitus","authors":"A. Budiyati, Dyah Purnamasari, H. Wibowo, I. Widyahening, P. Soewondo","doi":"10.1900/RDS.2023.19.51","DOIUrl":"https://doi.org/10.1900/RDS.2023.19.51","url":null,"abstract":"Objectives Non-diabetic first-degree relatives (FDR) of type 2 diabetes mellitus (T2DM) patients have been reported to have relatively higher insulin resistance and inflammatory markers compared to population without family history of T2DM. We investigated whether healthy FDR T2DM of Indonesian males living in urban area are more susceptible to the adverse effects of high-fat diet (HFD) than non-FDR subjects. Methods Twentyseven normoglycemic and normotensive FDR males and 28 ageand- body-mass-index-(BMI)-matched healthy non-FDR males underwent a 5-days HFD challenge. Dietary intake before and after HFD were collected by 24-hours food recall. Metabolic profiles and plasma cytokine levels were assessed before and after the HFD intervention. Results Within similar BMI profile between groups, FDR subjects showed significantly bigger waist circumference (p=0.001) and higher triglyceride (p=0,03) than those of non-FDR. Despite similar HOMA-IR and IL-6 responses to 5-days HFD, significant increase of plasma TNF-α/IL-10 ratio found in FDR subjects, while in contrary, TNF-α/IL-10 ratio significantly decreased in non-FDR group (p<0.001), resulting an OR of 7.1 (95% CI 2.2-23.4) for FDR to develop elevated plasma TNF-α/IL-10 ratio in response to HFD. The tendency was as high as 24.8 (95% CI 2.3-262.6) in FDR subjects with BMI ≥25 compared to the corresponding non-FDR subjects. Conclusions High-fat diet induced insulin resistance and increase of IL-6 plasma in healthy adult Indonesian males. Immune response polarization favouring proinflammatory environment was predominantly occurred in FDR subjects when compared to those of non- FDR subjects. Alteration of lipid accumulation was highly likely contributed to greater HFD-inflammation effects on FDR than non-FDR subjects.","PeriodicalId":34965,"journal":{"name":"Review of Diabetic Studies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86634773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Faka, Louzela-Marina Ntafla, C. Chalkias, D. Panagiotakos
{"title":"Geographical variation in diabetes mellitus prevalence rates in Greece","authors":"A. Faka, Louzela-Marina Ntafla, C. Chalkias, D. Panagiotakos","doi":"10.1900/RDS.2023.19.62","DOIUrl":"https://doi.org/10.1900/RDS.2023.19.62","url":null,"abstract":"The aim of this study was to investigate the geographical variation of diabetes prevalence in Greece. The database of Diabetes Mellitus Patients Registry of the National Organization for Health Care Services Provision, was used to identify patients of type 1 and type 2 diabetes. Incidence rates were estimated by type of diabetes and sex for each prefecture of Greece and spatial analysis was performed to recognize statistically significant spatial clusters across the country. 424,118 patients of type 1 and type 2 diabetes had been registered in the Diabetes Mellitus Patients Registry. Type 1 diabetes prevalence was 0.24% and type 2 was 3.66%. Mapping diabetes prevalence revealed the highest rates oftype 1 in the Greek islands, whereas the highest rates of type 2 diabetes were identified in northern and eastern prefectures of Greece. Spatial clusters of high values of diabetics were noticed in northwest and northeast Greece, for type 1 and type 2 diabetes respectively. In type 1, men patients prevailed to women in most Greek prefectures, while type 2 men to women ratio highlighted the female predominance in north, central and east Greece. The present study underlines geospatial surveillance as a useful tool by more precisely determining the underlying spatial epidemiology of diabetes.","PeriodicalId":34965,"journal":{"name":"Review of Diabetic Studies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84220223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David A. Duggan, Lynne M Chepulis, N. Brown, Chris Wang, Justina E Wu, Ha Nguyen, R. Paul
{"title":"Suboptimal monitoring of glucose levels and poor glycaemic control is associated with increased mortality and length of stay in adult inpatients with diabetes in a tertiary New Zealand hospital","authors":"David A. Duggan, Lynne M Chepulis, N. Brown, Chris Wang, Justina E Wu, Ha Nguyen, R. Paul","doi":"10.1900/RDS.2023.19.43","DOIUrl":"https://doi.org/10.1900/RDS.2023.19.43","url":null,"abstract":"Objectives We aimed to determine the effectiveness of glycaemic monitoring and control in the inpatient setting of a tertiary New Zealand hospital, and whether suboptimal control and monitoring may be associated with adverse outcomes in both Māori and Non-Māori diabetes patients. Methods Clinical records including all glucose levels (n = 51,680) from inpatients ≥ 15 years old with diabetes who were admitted to Waikato Hospital for > 24 hours between 1st July 2017 to 30th June 2018 were extracted electronically from the hospital database, and the data retrospectively examined (n=3,380 patients and 4,901 admissions). Results Overall 80.8% of diabetes inpatients had their blood glucose levels monitored. Patients experiencing ≥ 1 episode of hypoglycaemia were 1.90 times (CI: 1.37-2.64) and 1.94 times (CI: 1.51-2.49) more likely to die within 60 days and one year respectively, with an increased length of hospital stay by a mean of 3.13 weeks (CI: 2.55-3.85). Māori patients were more likely to experience ≥ 1 episode of hypoglycaemia (OR: 1.46), with a higher one-year mortality (p<0.001) as well as higher readmission rates at 30,60, 90 and 365 days than non-Māori. Blood glucose checks at least once every 24 hours were associated with shorter hospital stays (0.36 weeks) and a lower one-year mortality (Adjusted odds ratios (OR): 0.77, CI: 0.64-0.91). Conclusions At least one episode of inpatient hypoglycaemia was associated with a statistically significant increase in 60-day and one-year mortality as well as notably longer hospital stays, with more frequent hypoglycaemia occurring in Māori patients. Significant hyperglycaemia was associated with an increased one-year mortality, higher readmission rates within one year and longer hospital stays.","PeriodicalId":34965,"journal":{"name":"Review of Diabetic Studies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81679356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Derkaoui, S. Benyakhlef, Imane Rami, O. E. Mehraoui, N. Messaoudi, Hajar Charif, N. Bouichrat, I. Assarrar, A. Tahri, S. Derbel, N. Abda, S. Rouf, H. Latrech
{"title":"Effectiveness of a new smartphone application on type 1 diabetes control and self-management in times of Covid-19: Randomized controlled trial","authors":"N. Derkaoui, S. Benyakhlef, Imane Rami, O. E. Mehraoui, N. Messaoudi, Hajar Charif, N. Bouichrat, I. Assarrar, A. Tahri, S. Derbel, N. Abda, S. Rouf, H. Latrech","doi":"10.1900/RDS.2023.19.71","DOIUrl":"https://doi.org/10.1900/RDS.2023.19.71","url":null,"abstract":"Background Self-management for type1 diabetes mellitus patients is a real challenge especially in a time of a spreading pandemic. “Ana wa Soukari” is a smartphone application for therapeutic education and insulin doses management. Objectives Our study evaluated the effectiveness of “Ana wa Soukari” on clinical and biological outcomes of type1 diabetes self-management. Methods This is a randomized controlled trial including 62 patients. Groupe “A” (Application users) and Group “B” (without application). Primary endpoint was HbA1c after three months’ follow-up. Secondary endpoints were number of hypoglycaemic events and treatment satisfaction which was assessed using the Arabic version of DTSQs questionnaire. Results Sixty-two patients were included. Their mean age was 15±6,41 years. Sex ratio M/F=1,1. Mean diabetes duration was 4,9±4,3 years. All patients declared using the application at least twice a day. Mean HbA1c levels in Group A and Group B dropped from 8,3%±2,3 and 8,2%±2 respectively at baseline to 7,4%±1,5 and 8%±1,8 at three months’ follow-up. Change in hypoglycaemic episodes was –1,8±2,0(P< 0,001) for Group A and –1,2±1,5(P< 0,001) for Group B. DTSQs scores were significantly higher in group(A) than group(B). Conclusions Self-management smartphone apps appear to be effective on glycaemic control and should be considered an adjuvant intervention to standard diabetes care.","PeriodicalId":34965,"journal":{"name":"Review of Diabetic Studies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88630926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fredrik Drews Mellbye, K. Hermansen, P. Jeppesen, S. Gregersen
{"title":"Acute effects of the coffee diterpene cafestol on glucose metabolism in non-diabetic subjects with abdominal obesity","authors":"Fredrik Drews Mellbye, K. Hermansen, P. Jeppesen, S. Gregersen","doi":"10.1900/RDS.2023.19.34","DOIUrl":"https://doi.org/10.1900/RDS.2023.19.34","url":null,"abstract":"Objectives Coffee consumption is associated with a reduced risk of Type-2 Diabetes. A bioactive compound in coffee, cafestol, has shown potential preventive effects for Type-2 Diabetes in cell and animal studies, but its potential benefits in humans have not been examined. Methods In this randomized, double- blinded crossover intervention study, 15 healthy participants with increased waist circumference and thus elevated risk of developing Type-2 Diabetes underwent three oral glucose tolerance tests one week apart, with placebo, 7 mg- or 14 mg cafestol capsules ingested with the glucose load. Results There were no substantial differences in area under the curve (AUC) for glucose, insulin, glucagon-like peptide 1 (GLP-1) or gastric inhibitory peptide (GIP) on placebo or cafestol intervention study days. Among participants with impaired glucose tolerance and/or elevated fasting glucose (n=8, 53%), ingestion of 14 mg of cafestol resulted in an 11% larger AUC for GIP (p=0.046) and a 5% smaller AUC for glucose (p=0.14), compared to placebo. Conclusions Our results suggest that cafestol may contribute to coffee's inverse association with risk of Type-2 Diabetes, particularly in subjects with impaired glucose tolerance, possibly through increased GIP secretion. Further studies are needed to confirm these novel findings in participants with impaired glucose metabolism, both after acute and longer-term cafestol intervention.","PeriodicalId":34965,"journal":{"name":"Review of Diabetic Studies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81891550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health-Related Fitness of Adolescent Boys with Type 1 Diabetes Mellitus After Recreational Football Exercise with Caloric Control","authors":"M. Mohammed, Mohammad Al-Qahtani, T. Takken","doi":"10.1900/RDS.2023.19.77","DOIUrl":"https://doi.org/10.1900/RDS.2023.19.77","url":null,"abstract":"Objective The current study investigated the influence of recreational football exercise integrated with caloric control on the health-related fitness in adolescent males with type 1 diabetes mellitus (T1DM). Methods We divided the participants into four distinct groups. The first group played football and followed a diet plan (FDG), while the second group played only football (FG), meanwhile, the third group had only a diet plan (DG), and the fourth group represented the control group (CG). Every group consisted of 10 male participants. The FDG and FG played twice weekly 90 minutes of football for 12 weeks. Body mass, body mass index (BMI), abdominal endurance, explosive strength, handgrip strength, trunk flexibility, and estimated VO2 max were measured before and after the 12 weeks. Changes in these variables were considered significant if p ≤ 0.050 and the value of effect size (ES) ≤ 42 % or ES ≥ 58 %. Results Both the DG and FDG experienced a significant decrease in both body mass and BMI. Moreover, only the FDG experienced significant increases in all muscular fitness parameters and an increase in estimated VO2 max. The FG experienced significant increases in explosive strength and handgrip strength. Conclusion An intervention of 12 weeks of integrated football with caloric control offers the highest improvements in musculoskeletal and cardiovascular fitness in adolescent boys with T1DM, thus improving their overall healthrelated fitness.","PeriodicalId":34965,"journal":{"name":"Review of Diabetic Studies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88625473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hernando Vargas-Uricoechea, Juan Pablo Frias, Hernando David Vargas-Sierra
{"title":"Fixed-ratio Combinations (basal Insulin Plus GLP-1RA) In Type 2 Diabetes. an Analytical Review Of Pivotal Clinical Trials.","authors":"Hernando Vargas-Uricoechea, Juan Pablo Frias, Hernando David Vargas-Sierra","doi":"10.1900/RDS.2023.19.14","DOIUrl":"https://doi.org/10.1900/RDS.2023.19.14","url":null,"abstract":"<p><p>In type 2 diabetes, therapeutic failure to the oral anti diabetics is frequent, the use of schemes with basal insulin or with multiple doses of insulin (basal insulin and short-acting insulins) are a widely accepted way to intensify therapy. The use of GLP-1 receptor agonists is another intensification strategy. The fixedratio combinations with molecules such as insulin degludec + liraglutide, and insulin glargine + lixisenatide have proven useful in intensifying treatment of individuals with type 2 diabetes. The purpose of this review was to evaluate and analyze the results of pivotal studies with both fixed-ratio combinations in individuals with type 2 diabetes, finding that, they are capable of achieving better glycemic control when compared with each of its components separately (with a lower risk of hypoglycemia vs basal insulin and lower risk of gastrointestinal adverse effects vs GLP-1 receptor agonists) in various clinical scenarios, especially in individuals who do not achieve control with oral antidiabetics or who do not achieve control with basal insulin (associated with oral antidiabetics) or in those under management with GLP-1RA plus oral antidiabetics.</p>","PeriodicalId":34965,"journal":{"name":"Review of Diabetic Studies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9613626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Waleed H Albuali, Abdullah A Yousef, Mohammad H Al-Qahtani, Faisal O AlQurashi, Hamad W Albuali, Haneen A Yousef, Ala'a A Aldajani, Mohammed A Al Ghamdi, Bassam N AlBassam
{"title":"A Clinical and Biochemical Comparative Study Of Diabetic Ketoacidosis (DKA) in Newly Diagnosed Vs Known Cases of Type 1 Diabetic Children.","authors":"Waleed H Albuali, Abdullah A Yousef, Mohammad H Al-Qahtani, Faisal O AlQurashi, Hamad W Albuali, Haneen A Yousef, Ala'a A Aldajani, Mohammed A Al Ghamdi, Bassam N AlBassam","doi":"10.1900/RDS.2023.19.28","DOIUrl":"https://doi.org/10.1900/RDS.2023.19.28","url":null,"abstract":"<p><p><b>Objectives:</b> We aimed to study the characterizing clinical and biochemical profiles of Diabetic Ketoacidosis (DKA) in children with newly diagnosed Type 1 Diabetes Mellitus (Type 1DM) compared to children with established diagnosis of Type 1DM presenting with DKA admitted to the pediatric intensive care unit of a large university hospital in the eastern region of Saudi Arabia. <b>Methods:</b> We retrospectively reviewed the medical records of 211 patients who were admitted to the pediatric intensive care unit with diabetic ketoacidosis between 2010 and 2019. The diagnosis of diabetic ketoacidosis was based on symptoms of polydipsia, polyurea, weight loss, vomiting, dehydration, abdominal pain, breathing problems, lethargy or coma, biochemical hyperglycemia (blood glucose level of >200 mg/dL), venous pH of <7.3, serum bicarbonate level of ≤15 mEq/L, and ketonemia (blood β -hydroxybutyrate concentration of ≥3 mM) or moderate or severe ketonuria (diagnosed as newly acquired type 1 diabetes). <b>Results:</b> The rate of newly diagnosed Type 1 DM with DKA was 41.7%, out of them who got severe and moderate diabetic ketoacidosis were 61.6% and 38.4%, respectively. We observed significantly increased heart and respiratory rates in patients newly diagnosed with diabetic ketoacidosis and in those with severe diabetic ketoacidosis (p<0.001) compared to known cases with Type 1DM presenting with DKA. We also identified significantly increased biochemical indices including HbA1c, random blood sugar, serum osmolality, blood urea nitrogen, creatinine, chloride, lactate, and anion gap in relation to severe diabetic ketoacidosis and newly diagnosed type 1 diabetes (p ≤ 0.05). <b>Conclusions:</b> We found that the clinical and biochemical profiles of patients with newly diagnosed Type 1 DM children were significantly affected compared to children who were known Type 1DM presenting with DKA.</p>","PeriodicalId":34965,"journal":{"name":"Review of Diabetic Studies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9613627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vitamin D Status in Diabetic Moroccan Children And Adolescents: a Case-control Study.","authors":"Nisrine Bouichrat, Salma Benyakhef, Imane Assarrar, Najat Draoui, Youssef Lazreg, Naima Abda, Siham Rouf, Hanane Latrech","doi":"10.1900/RDS.2023.19.1","DOIUrl":"https://doi.org/10.1900/RDS.2023.19.1","url":null,"abstract":"<p><p><b>Background:</b> Type 1 diabetes mellitus (T1DM) incidence is currently increasing worldwide, and different environmental players along with genetic predisposition, could be involved as powerful triggers of this disease onset. In this study, we aim to shed the light on the relationship between 25OHD deficiency and T1DM. <b>Patients and methods:</b> A case-control study was laid out to compare serum 25OHD level between T1DM patients and controls. A total of 147 T1DM patients aged under 19 years old were recruited from our Endocrinology-Diabetology and Nutrition department between October 2014 and December 2019. A total of 147 controls were randomly enlisted from clinical biochemistry laboratory of our center, and were carefully matched. The levels of 25OHD in the serum were determined in T1DM patients and nondiabetic controls. <b>Results:</b> Average serum 25OHD concentration was established in both groups; reaching 19,29 ±6,13 ng/ml in the control arm and 15,02 ± 6,48 ng/ml in the selected group with T1DM independently of the disease duration. However, the mean serum 25OHD concentration was not significantly different between the two T1DM subgroups according to diabetes duration below or above 5 years, and 25OHD concentration remained lower either in winter or summer months. A negative correlation was noticed between HbA1c and serum 25 OHD concentration in T1DM patients and was statistically significant (p<0,05). <b>Conclusion:</b> Key messages on the importance of vitamin D status, particularly in diabetic children and adolescents, should be spread widely in order to start a suitable vitamin supplementation, and establish guidelines regarding its timing at adequate recommended doses..</p>","PeriodicalId":34965,"journal":{"name":"Review of Diabetic Studies","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9613628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}