摩洛哥糖尿病儿童和青少年的维生素D状况:一项病例对照研究

Q3 Medicine
Nisrine Bouichrat, Salma Benyakhef, Imane Assarrar, Najat Draoui, Youssef Lazreg, Naima Abda, Siham Rouf, Hanane Latrech
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引用次数: 0

摘要

背景:1型糖尿病(T1DM)的发病率目前在全球范围内呈上升趋势,不同的环境因素以及遗传易感性可能是该疾病发病的强大触发因素。在这项研究中,我们的目标是阐明25OHD缺乏与T1DM之间的关系。患者与方法:采用病例对照研究比较T1DM患者与对照组血清25OHD水平。2014年10月至2019年12月,我们从内分泌-糖尿病与营养科招募了147名年龄在19岁以下的T1DM患者。从我中心临床生化实验室随机招募对照147例,经仔细配对。测定T1DM患者和非糖尿病对照组血清中25OHD水平。结果:两组患者血清25OHD平均浓度均成立;与病程无关,对照组为19.29±6.13 ng/ml, T1DM组为15.02±6.48 ng/ml。然而,两组T1DM患者的平均血清25OHD浓度在糖尿病病程≤5年和≥5年之间无显著差异,且25OHD浓度在冬季和夏季均较低。在T1DM患者中,HbA1c与血清25ohd浓度呈负相关,且具有统计学意义(p结论:维生素D状态的重要性的关键信息,特别是在糖尿病儿童和青少年中,应该广泛传播,以便开始适当的维生素补充,并建立适当推荐剂量的时间指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Vitamin D Status in Diabetic Moroccan Children And Adolescents: a Case-control Study.

Vitamin D Status in Diabetic Moroccan Children And Adolescents: a Case-control Study.

Vitamin D Status in Diabetic Moroccan Children And Adolescents: a Case-control Study.

Background: Type 1 diabetes mellitus (T1DM) incidence is currently increasing worldwide, and different environmental players along with genetic predisposition, could be involved as powerful triggers of this disease onset. In this study, we aim to shed the light on the relationship between 25OHD deficiency and T1DM. Patients and methods: A case-control study was laid out to compare serum 25OHD level between T1DM patients and controls. A total of 147 T1DM patients aged under 19 years old were recruited from our Endocrinology-Diabetology and Nutrition department between October 2014 and December 2019. A total of 147 controls were randomly enlisted from clinical biochemistry laboratory of our center, and were carefully matched. The levels of 25OHD in the serum were determined in T1DM patients and nondiabetic controls. Results: Average serum 25OHD concentration was established in both groups; reaching 19,29 ±6,13 ng/ml in the control arm and 15,02 ± 6,48 ng/ml in the selected group with T1DM independently of the disease duration. However, the mean serum 25OHD concentration was not significantly different between the two T1DM subgroups according to diabetes duration below or above 5 years, and 25OHD concentration remained lower either in winter or summer months. A negative correlation was noticed between HbA1c and serum 25 OHD concentration in T1DM patients and was statistically significant (p<0,05). Conclusion: Key messages on the importance of vitamin D status, particularly in diabetic children and adolescents, should be spread widely in order to start a suitable vitamin supplementation, and establish guidelines regarding its timing at adequate recommended doses..

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来源期刊
Review of Diabetic Studies
Review of Diabetic Studies Medicine-Internal Medicine
CiteScore
1.80
自引率
0.00%
发文量
28
期刊介绍: The Review of Diabetic Studies (RDS) is the society"s peer-reviewed journal published quarterly. The purpose of The RDS is to support and encourage research in biomedical diabetes-related science including areas such as endocrinology, immunology, epidemiology, genetics, cell-based research, developmental research, bioengineering and disease management.
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