Integrative Medicine in Nephrology and Andrology最新文献_第6页

Treatment of membranoproliferative glomerulonephritis with traditional chinese medicine and rituximab: A case report 中药联合利妥昔单抗治疗膜增生性肾小球肾炎1例

Integrative Medicine in Nephrology and Andrology Pub Date : 1900-01-01 DOI: 10.4103/IMNA.IMNA_10_21

Yaohong Wang, Q. Zeng, R. Yu

引用次数: 4

Integrative Medicine in Nephrology and Andrology is welcoming a fresh start 肾脏学和男科的结合医学迎来了一个新的开始

Integrative Medicine in Nephrology and Andrology Pub Date : 1900-01-01 DOI: 10.4103/IMNA.IMNA_31_21

Yangang Ren, Renhuan Yu, Huiyao Lan, Ping Li

引用次数: 0

Traditional chinese medicine in ameliorating diabetic kidney disease via modulating gut microbiota 中药通过调节肠道菌群改善糖尿病肾病

Integrative Medicine in Nephrology and Andrology Pub Date : 1900-01-01 DOI: 10.4103/IMNA.IMNA_28_21

Ya-nan Yang, Chongming Wu

{"title":"Traditional chinese medicine in ameliorating diabetic kidney disease via modulating gut microbiota","authors":"Ya-nan Yang, Chongming Wu","doi":"10.4103/IMNA.IMNA_28_21","DOIUrl":"https://doi.org/10.4103/IMNA.IMNA_28_21","url":null,"abstract":"Diabetic kidney disease (DKD), a major microvascular complication of diabetes mellitus, has become the second cause of end-stage renal disease enhancing the mortality rate of diabetes. However, there are still few treatment approaches to combat it. Traditional Chinese medicine (TCM) has been applied for a long time to treat DKD. However, there is a lack of research on how does TCM plays the role in treating DKD due to the complex of composition of TCM. In recent decade, gut microbiota is increasingly recognized for its contributions to host health, and the occurrence of gut–kidney axis also attracts many interests about microbiota in kidney injury. Some of the studies have already revealed that TCM can alleviate the symptoms of DKD through regulating gut microbiota and ameliorate a vicious circle caused by imbalance of gut–kidney axis. However, the problems of which specific species mediates the efficacy of TCM and how gut microbiota influences the process of DKD are urgent to solve. Therefore, this review systematically summarized the application of TCM and the importance of gut microbiota in DKD. More importantly, the review provided a new insight to find biomarkers for diagnosis and treatment of DKD. In future study, targeted manipulation of the gut microbiota will be progressively recognized as a way to enhance human health.","PeriodicalId":349243,"journal":{"name":"Integrative Medicine in Nephrology and Andrology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126507479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

New insights into the immunity and podocyte in glomerular health and disease: From pathogenesis to therapy in proteinuric kidney disease 免疫和足细胞在肾小球健康和疾病中的新认识:从蛋白尿肾病的发病机制到治疗

Integrative Medicine in Nephrology and Andrology Pub Date : 1900-01-01 DOI: 10.4103/IMNA.IMNA_26_21

P. X. M. Rangel, A. Priyadarshini, Xuefei Tian

引用次数: 13

Xiaochaihu decoction in diabetic kidney disease: A study based on network pharmacology and molecular docking technology 小柴胡汤治疗糖尿病肾病:基于网络药理学和分子对接技术的研究

Integrative Medicine in Nephrology and Andrology Pub Date : 1900-01-01 DOI: 10.4103/imna.imna_21_21

Tingting Zhao, Ping Li, Ying Wang, Xuefeng Zhou, Minjing Luo

引用次数: 5

JUN amino terminal kinase in cell death and inflammation in acute and chronic kidney disease JUN氨基末端激酶在急慢性肾脏疾病的细胞死亡和炎症中的作用

Integrative Medicine in Nephrology and Andrology Pub Date : 1900-01-01 DOI: 10.4103/imna.imna_35_21

D. Nikolic-Paterson, K. Grynberg, F. Ma

引用次数: 3

Effects and Prospects of the Integration of Traditional Chinese Medicine with Western Biomedical Approach for Premature Ejaculation 中西医结合治疗早泄的疗效及展望

Integrative Medicine in Nephrology and Andrology Pub Date : 1900-01-01 DOI: 10.4103/2773-0387.345766

E. Jannini, E. Colonnello, Fu Wang, J. Guo

引用次数: 1

Tangshen formula attenuates renal fibrosis by downregulating transforming growth factor β1/Smad3 and LncRNA-MEG3 in rats with diabetic kidney disease 糖参方通过下调糖尿病肾病大鼠转化生长因子β1/Smad3和LncRNA-MEG3减轻肾纤维化

Integrative Medicine in Nephrology and Andrology Pub Date : 1900-01-01 DOI: 10.4103/IMNA.IMNA_22_21

Xuefeng Zhou, Ying Wang, Minjing Luo, Tingting Zhao, Ping Li

{"title":"Tangshen formula attenuates renal fibrosis by downregulating transforming growth factor β1/Smad3 and LncRNA-MEG3 in rats with diabetic kidney disease","authors":"Xuefeng Zhou, Ying Wang, Minjing Luo, Tingting Zhao, Ping Li","doi":"10.4103/IMNA.IMNA_22_21","DOIUrl":"https://doi.org/10.4103/IMNA.IMNA_22_21","url":null,"abstract":"Background and Objective: The traditional Chinese Tangshen formula (TSF) has been reported to ameliorate diabetic kidney disease (DKD) in humans and animals. However, the effect of TSF on renal fibrosis remains unclear. Transforming growth factor-β1 (TGF-β1)/Smad3 signaling and lncRNA MEG3 are important in renal fibrosis. In this study, we examined the therapeutic effect of TSF on renal fibrosis and explored whether it was related to the modulation of TGFβ1/Smad3 signaling and lncRNA MEG3 expression. Materials and Methods: Experiments were performed in rats in vivo and in the HK2 cells in vitro. DKD was induced in rats by uninephrectomy combined with a single streptozotocin injection. The HK2 cells were stimulated by high glucose (HG) to explore the mechanism of TSF effects in vitro. Results: TSF significantly attenuated renal injury by lowering proteinuria and renal histological damage in DKD rats. TSF reduced collagen deposition by decreasing the expression of the fibrotic indicators collagen I, collagen IV, and fibronectin at the protein and mRNA levels, which suggested that TSF ameliorated DKD by decreasing renal fibrosis. Furthermore, TSF decreased TGF-β1 expression and suppressed the levels of phosphorylated Smad3 and Smad2/3 in vivo. Moreover, TSF downregulated the lncRNA MEG3 level in DKD rats. TSF reversed the upregulation of collagen I and fibronectin expression and downregulated Smad2/3 phosphorylation in the HK2 cells stimulated with HG. Conclusions: TSF ameliorates renal fibrosis in rats with DKD by suppressing TGF-β1/Smad3 signaling and lncRNA MEG3 expression.","PeriodicalId":349243,"journal":{"name":"Integrative Medicine in Nephrology and Andrology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126163116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The yin and yang role of transforming growth factor-β in kidney disease 转化生长因子-β在肾脏疾病中的阴阳作用

Integrative Medicine in Nephrology and Andrology Pub Date : 1900-01-01 DOI: 10.4103/IMNA.IMNA_17_21

Huiyao Lan

引用次数: 6