Integrative Medicine in Nephrology and Andrology最新文献_第5页

Mechanisms of Chinese Herbal Medicines for Diabetic Nephropathy Fibrosis Treatment 中药治疗糖尿病肾病纤维化的机制

Integrative Medicine in Nephrology and Andrology Pub Date : 2022-01-01 DOI: 10.4103/2773-0387.353727

Tong Jiang, Yuhang Bao, Hong-xia Su, Ren-dong Zheng, Lin Cao

{"title":"Mechanisms of Chinese Herbal Medicines for Diabetic Nephropathy Fibrosis Treatment","authors":"Tong Jiang, Yuhang Bao, Hong-xia Su, Ren-dong Zheng, Lin Cao","doi":"10.4103/2773-0387.353727","DOIUrl":"https://doi.org/10.4103/2773-0387.353727","url":null,"abstract":"Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus that is one of the main causes of end-stage renal disease, causing considerable health problems as well as significant financial burden worldwide. The pathological features of DN include loss of normal nephrons, massive fibroblast and myofibroblast hyperplasia, accumulation of extracellular matrix proteins, thickening of the basement membrane, and tubulointerstitial fibrosis. Renal fibrosis is a final and critical pathological change in DN. Although progress has been made in understanding the pathogenesis of DN fibrosis, current conventional treatment strategies may not be completely effective in preventing the disease’s progression. Traditionally, Chinese herbal medicines (CHMs) composed of natural ingredients have been used for symptomatic relief of DN. Increasing numbers of studies have confirmed that CHMs can exert a renoprotective effect in DN, and antifibrosis has been identified as a key mechanism. In this review, we summarize the antifibrotic efficacy of CHM preparations, single herbal medicines, and their bioactive compounds based on their effects on diminishing the inflammatory response and oxidative stress, regulating transforming growth factor, preventing epithelial-mesenchymal transition, and modulating microRNAs. We intend to provide patients of DN with therapeutic interventions that are complementary to existing options.","PeriodicalId":349243,"journal":{"name":"Integrative Medicine in Nephrology and Andrology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130653882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applying the guidelines to standardize the behavior of clinicians in the treatment of chronic kidney disease with Chinese patent medicine 应用该指南规范临床医师在中成药治疗慢性肾脏病中的行为

Integrative Medicine in Nephrology and Andrology Pub Date : 2022-01-01 DOI: 10.4103/2773-0387.344230

Q. Cheng, Ping Li

引用次数: 1

Management of Maintenance Hemodialysis Patients under the Coronavirus Disease Pandemic 冠状病毒大流行下维持性血液透析患者的管理

Integrative Medicine in Nephrology and Andrology Pub Date : 2022-01-01 DOI: 10.4103/imna.imna_3_22

Fei Xiong, Can Tu

引用次数: 0

Successful Intervention with Traditional Chinese Medicine for Severe Coronavirus Disease 2019: A Case Report 2019年新型冠状病毒感染症中医药成功干预1例

Integrative Medicine in Nephrology and Andrology Pub Date : 2022-01-01 DOI: 10.4103/2773-0387.348715

W. Lu, Wen Zhang, Xiang-tong Xu, Q. Guo, B. Fang

引用次数: 0

Patients with Chronic Kidney Disease Have Higher Acute Kidney Injury Morbidity than those without after SARS-CoV-2 Infection 慢性肾脏疾病患者感染SARS-CoV-2后急性肾损伤发生率高于非慢性肾脏疾病患者

Integrative Medicine in Nephrology and Andrology Pub Date : 2021-11-29 DOI: 10.4103/imna.imna_24_21

Yuting Song, D. Mao, R. Zou, Yanglin Hu, Dan Luo, H. Liu, Can Tu, Fei Xiong

{"title":"Patients with Chronic Kidney Disease Have Higher Acute Kidney Injury Morbidity than those without after SARS-CoV-2 Infection","authors":"Yuting Song, D. Mao, R. Zou, Yanglin Hu, Dan Luo, H. Liu, Can Tu, Fei Xiong","doi":"10.4103/imna.imna_24_21","DOIUrl":"https://doi.org/10.4103/imna.imna_24_21","url":null,"abstract":"Background and Objectives: Chronic kidney disease (CKD) and acute kidney injury (AKI) increase the risk of serious disease and mortality in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected patients. This study evaluated the occurrence and outcome of AKI in CKD and non-CKD patients infected with SARS-CoV-2. Subjects and Methods: We retrospectively analyzed the medical records of 845 patients with SARS-CoV-2 infection regarding the occurrence and outcome of AKI in a coronavirus disease-2019 (COVID-19)-designated hospital in Wuhan, China, from December 31, 2019, to March 20, 2020. Results: Of the 845 COVID-19 patients, 91 had CKD and 754 had no CKD (non-CKD), of whom 22 and 14 developed AKI, respectively. Finally, 36 patients were included in the analysis. Older patients and those with cardiovascular or cerebrovascular diseases were more likely to develop AKI. More CKD patients progressed to critical illness (72.73%) than non-CKD patients (57.14%), but the degree of AKI in CKD patients was lesser than that in non-CKD patients. Higher urea nitrogen, creatinine, and proteinuria levels were observed in CKD patients. More non-CKD patients were treated with human albumin than CKD patients. The survival probability of CKD patients was lower than that of non-CKD patients, but it was not statistically significant. Conclusion: There were significant differences in the incidence rate of AKI after SARS-CoV-2 infection between CKD and non-CKD patients, and the clinical manifestations and treatments of AKI also differed. These results highlight the necessity of variable treatment methods for optimal clinical management.","PeriodicalId":349243,"journal":{"name":"Integrative Medicine in Nephrology and Andrology","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128112987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Coronavirus Disease 2019-Associated Acute Kidney Injury Garners More Attention 2019冠状病毒病相关急性肾损伤引起更多关注

Integrative Medicine in Nephrology and Andrology Pub Date : 2021-11-24 DOI: 10.4103/imna.imna_15_21

M. Yan, W. Niu, Ping Li

引用次数: 0

Clinical Analysis of Kidney Injury in Elderly Patients with COVID-19 老年COVID-19肾损伤临床分析

Integrative Medicine in Nephrology and Andrology Pub Date : 2021-11-24 DOI: 10.4103/imna.imna_13_21

Yang Liu, Chao Wang, Q. Ao, Jie-bin Hou, Lei Wei, Fengyan Qi, Wei He, Jia-hui Zhao, Qiang Ma, Xiaohua Wang, Qingqing Cheng, Guang-Lin Yang

{"title":"Clinical Analysis of Kidney Injury in Elderly Patients with COVID-19","authors":"Yang Liu, Chao Wang, Q. Ao, Jie-bin Hou, Lei Wei, Fengyan Qi, Wei He, Jia-hui Zhao, Qiang Ma, Xiaohua Wang, Qingqing Cheng, Guang-Lin Yang","doi":"10.4103/imna.imna_13_21","DOIUrl":"https://doi.org/10.4103/imna.imna_13_21","url":null,"abstract":"Objective: The aim of the study was to analyze the clinical features of elderly patients with coronavirus disease 2019 (COVID-19) and to explore the relationship between COVID-19 patients and kidney injury. Methods: A total of 188 elderly patients with confirmed COVID-19 enrolled in this study were hospitalized for at least 1 week in the Central Theater Command General Hospital of Chinese People's Liberation Army from January 3, 2020 to March 14, 2020. The recorded information included clinical data and results of kidney-related laboratory tests. Retrospective analysis was performed. Results: The median age of the patients was 69 years (interquartile range 65–78, range: 60–97 years); 31.4% were 60–74 years old, and 68.6% were over 75 years old. A total of 12.8% and 18.6% of the patients were in critical and severe stages of COVID-19, respectively. The proportions of patients using mechanical ventilators and deaths were 9.5% and 8.5%, respectively. A total of 26.1% and 8.5% of the patients showed mild elevation of blood urea nitrogen (BUN) and serum creatinine (SCr) levels at admission. A total of 18.6% and 5.9% of the patients had elevated BUN and SCr 1 week after admission, respectively. A total of 3.1% of the patients were diagnosed with acute kidney injury, and 75% of those patients had chronic kidney disease before admission. Compared with the patients aged 60–74 years, those over 75 years exhibited significantly increased proportions of elevated BUN levels, critical illness, use of mechanical ventilated, and death. Multivariate logistic regression analysis revealed that an elevated BUN level at admission and 1 week after admission were independent risk factors for death in the elderly patients with COVID-19. Conclusion: There were more critical cases and a high mortality in elderly patients with COVID-19. An increased BUN level was an independent risk factor for death in elderly patients with COVID-19.","PeriodicalId":349243,"journal":{"name":"Integrative Medicine in Nephrology and Andrology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125866352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 Acute Kidney Injury: Current Knowledge and Barriers of Research COVID-19急性肾损伤:目前的知识和研究障碍

Integrative Medicine in Nephrology and Andrology Pub Date : 2021-09-09 DOI: 10.4103/imna.imna_11_21

Yifei Zhong, J. He

引用次数: 1

COVID-19 and Kidney Involvement – A Systematic Review COVID-19与肾脏受累-一项系统综述

Integrative Medicine in Nephrology and Andrology Pub Date : 2021-09-08 DOI: 10.4103/imna.imna_14_21

Guang Yang, Yang Liu, Jiebin Hou, Q. Cheng

引用次数: 0

Ferroptosis in diabetic nephropathy: A narrative review 糖尿病肾病的上睑下垂:一个叙述性的回顾

Integrative Medicine in Nephrology and Andrology Pub Date : 1900-01-01 DOI: 10.4103/imna.imna_2_22

Haiyong Chen, Y. Wang

引用次数: 1