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Digitally augmented learning: a qualitative study on the perception of nurses and midwives in the Master's degree during the SARS-CoV-2 pandemic in Italy. 数字增强学习:意大利SARS-CoV-2大流行期间硕士学位护士和助产士认知的定性研究
Professioni infermieristiche Pub Date : 2022-07-01 DOI: 10.7429/pi.2022.752075
Francesca Soro, Elena Cristofori, Maria Rosaria Spedicato, Ida Ginosa, Silvana Paoletti, Caterina Galletti
{"title":"Digitally augmented learning: a qualitative study on the perception of nurses and midwives in the Master's degree during the SARS-CoV-2 pandemic in Italy.","authors":"Francesca Soro,&nbsp;Elena Cristofori,&nbsp;Maria Rosaria Spedicato,&nbsp;Ida Ginosa,&nbsp;Silvana Paoletti,&nbsp;Caterina Galletti","doi":"10.7429/pi.2022.752075","DOIUrl":"https://doi.org/10.7429/pi.2022.752075","url":null,"abstract":"<p><strong>Background: </strong>The SARS-CoV-2 pandemic has necessitated a rapid transition to digitally augmented education, generating a phenomenon that is unprecedented in the history of university education of healthcare professionals. The purpose of this study is to understand the effects of online teaching on the learning of students of the Master's Degree, to collect the significant elements of their experience and stimulate reflection on teaching practices.</p><p><strong>Objective: </strong>To describe perceptions and experiences of nurses and midwives in the Master's degree on digitally augmented learning during the SARS-CoV-2 pandemic.</p><p><strong>Methods: </strong>A descriptive qualitative study was performed on a proactive sample of 34 nurse practitioners, pediatric nurses and midwives. The data was collected in January-February 2021 through an online form, built ad hoc. The answers were analyzed with deductive content analysis.</p><p><strong>Results: </strong>4 main categories emerge from the analysis of the texts: educational impact, time management, disadvantages of online teaching, distance learning-teaching. The results partly confirm what is reported in the literature about virtual learning, with better time management and the usefulness of video recordings. However, learning is strongly conditioned by the difficulties of interaction and communication between the students and between the teachers and the students.</p><p><strong>Conclusion: </strong>The digitally augmented learning allowed the continuation of the training course of health professionals engaged during the SARS-CoV-2 emergency. However, distance learning if used exclusively for a long time is a limited tool as it modifies the didactic processes preventing the development of meaningful relationships, dialogue and educational relationships which are important and essential outcomes in the master's course.</p>","PeriodicalId":34911,"journal":{"name":"Professioni infermieristiche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9188376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic pain in in survivors of critical illness: prevalence and associated psychological disorders. 危重疾病幸存者的慢性疼痛:患病率和相关心理障碍。
Professioni infermieristiche Pub Date : 2022-07-01
Vincenzo Damico, Liana Murano, Alberto Dal Molin
{"title":"Chronic pain in in survivors of critical illness: prevalence and associated psychological disorders.","authors":"Vincenzo Damico,&nbsp;Liana Murano,&nbsp;Alberto Dal Molin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the prevalence and characteristics of chronic postICU pain in survivors of critical illness and to examine the association between pain and psychological disorders.</p><p><strong>Methods: </strong>The study was carried out in an Italian ICU. Six months after ICU discharge, patients were called back for an interview for assessed chronic pain (CP), pain intensity, pain location and interference of pain with activities of daily living. During the interview a battery of psychometric test was administered for evaluate anxiety, depression, insomnia, fatigue and posttraumatic stress disorder (PTSD).</p><p><strong>Results: </strong>A total of 143 patients were interviewed and 34 patients (23.8%) reported pain. Nearly 70.6% of respondents suffering from CP were females (p<.001). The most common sites of pain were the shoulder (16.1%), lower limb (11.9%) and the lumbar spine (11.2%). The largest number of CP patients (n= 14) had pain at 4 or more anatomical regions. The prevalence for chronic pain, anxiety, depression, insomnia, fatigue and PTSD were 23.8%, 9.1%, 13.3%, 4.2%, 5.6% and 2.1% respectively. The multivariable analysis indicated significant associations between chronic pain and anxiety (p= .003), depression (p=.015) and insomnia (p= .027). There was a great use of analgesics and nonsteroidal antiinflammatory drugs (NSAIDs) for the pain treatment in 19 patients (55.9%).</p><p><strong>Discussion: </strong>Cronic pain seems associated with some psychological disorders observed 6 months after an ICU stay. In future, studies that investigate interventions to prevent chronic postICU pain are needed.</p>","PeriodicalId":34911,"journal":{"name":"Professioni infermieristiche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9188373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Customer Satisfaction relating to the vaccination campaign aimed at extremely vulnerable people in the Asl of Latina. 针对拉丁美洲极度脆弱人群的疫苗接种活动的客户满意度分析。
Professioni infermieristiche Pub Date : 2022-04-01 DOI: 10.7429/pi.2022.751039
Anna Rita Cacciotti, Sergio Parrocchia, Debora Sorbara, Giulio Battisti, Ombretta D'Onofrio, Federico Ruta
{"title":"Analysis of Customer Satisfaction relating to the vaccination campaign aimed at extremely vulnerable people in the Asl of Latina.","authors":"Anna Rita Cacciotti,&nbsp;Sergio Parrocchia,&nbsp;Debora Sorbara,&nbsp;Giulio Battisti,&nbsp;Ombretta D'Onofrio,&nbsp;Federico Ruta","doi":"10.7429/pi.2022.751039","DOIUrl":"https://doi.org/10.7429/pi.2022.751039","url":null,"abstract":"<p><strong>Introduction: </strong>Customer Satisfaction is a tool for assessing the effectiveness and efficiency of the service offered and related corrective measures to improve the quality of services provided by hospitals Collection and analysis of data regarding customer satisfaction during the vaccination campaign was estremely important.</p><p><strong>Method: </strong>A specific analisys on extremely vulnerable people during the vaccination campaign. An observational study was conducted through a survey on a List of extremely vulnerable people provided by specialists to the Medical Management.</p><p><strong>Results: </strong>There was good feedback with the return of most of the questionnaires administered and above all a good degree of satisfaction and protection on the part of the user.</p><p><strong>Conclusion: </strong>The analysis carried out found that by placing the centrality of the person, \"patient-oriented\" in the foreground, with listening, the \"taken care of\", creates an empathic relationship between the healthcare professional and the user. This humanization makes the user feel satisfied and above all protected even during such a particular path as vaccination.</p>","PeriodicalId":34911,"journal":{"name":"Professioni infermieristiche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9243888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New frontiers in e-health. Policies and the Doctor@Home case study. 电子卫生的新领域。政策和Doctor@Home案例研究。
Professioni infermieristiche Pub Date : 2022-04-01 DOI: 10.7429/pi.2022.751044
Helena Biancuzzi, Francesca Dal Mas, Carlo Drago, Matteo Ruggeri, Nelso Trua, Giulio Menegazzi, Alessandro Rizzardo, Lorenzo Cobianchi, Federico Ruta, Rym Bednarova, Luca Miceli
{"title":"New frontiers in e-health. Policies and the Doctor@Home case study.","authors":"Helena Biancuzzi,&nbsp;Francesca Dal Mas,&nbsp;Carlo Drago,&nbsp;Matteo Ruggeri,&nbsp;Nelso Trua,&nbsp;Giulio Menegazzi,&nbsp;Alessandro Rizzardo,&nbsp;Lorenzo Cobianchi,&nbsp;Federico Ruta,&nbsp;Rym Bednarova,&nbsp;Luca Miceli","doi":"10.7429/pi.2022.751044","DOIUrl":"https://doi.org/10.7429/pi.2022.751044","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, and even more following the need for social distancing generated by the global COVID-19 pandemic, e-health has become an increasingly widespread reality in clinical practice, especially for those clinicians operating in the front-line, like nurses. Its growing importance has been followed by increasing attention both by the literature as well as in the generation of specific rules aimed at regulating the phenomenon.</p><p><strong>Methods: </strong>A regulatory review of the literature aims to outline the current regulatory framework relating to telemedicine. Telemedicine, especially in a pandemic context, calls for regulation that runs parallel to the rapid evolution of the phenomenon itself. The paper traces the European, Italian, and Regional legislation, focusing then on a practical experience of telemedicine, called Doctor @ Home, active at the IRCCS National Cancer Center in Aviano (Italy).</p><p><strong>Discussion: </strong>First, the need for regulatory harmonization emerges. Secondly, the potential of co-production and co-learning processes for healthcare professionals and patients arises to adapt to the outpatient needs of patients in a post-pandemic \"new normal,\" exploiting the new technological tools made available by the National Health Service.</p>","PeriodicalId":34911,"journal":{"name":"Professioni infermieristiche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9187993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advanced Nursing practice and the wave of the future]. 【高级护理实践与未来潮流】。
Professioni infermieristiche Pub Date : 2022-04-01 DOI: 10.7429/pi.2022.751001
De Caro Walter
{"title":"[Advanced Nursing practice and the wave of the future].","authors":"De Caro Walter","doi":"10.7429/pi.2022.751001","DOIUrl":"https://doi.org/10.7429/pi.2022.751001","url":null,"abstract":"","PeriodicalId":34911,"journal":{"name":"Professioni infermieristiche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9210314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal pain assessment scales: review of the literature. 新生儿疼痛评估量表:文献综述。
Professioni infermieristiche Pub Date : 2022-04-01 DOI: 10.7429/pi.2022.751017
Emanuele Castagno, Giada Fabiano, Virna Carmellino, Roberto Cerchio, Barbara De Vito, Barbara Lauria, Giancarlo Mercurio, Alessandra Coscia, Giulia Ponte, Claudia Bondone
{"title":"Neonatal pain assessment scales: review of the literature.","authors":"Emanuele Castagno,&nbsp;Giada Fabiano,&nbsp;Virna Carmellino,&nbsp;Roberto Cerchio,&nbsp;Barbara De Vito,&nbsp;Barbara Lauria,&nbsp;Giancarlo Mercurio,&nbsp;Alessandra Coscia,&nbsp;Giulia Ponte,&nbsp;Claudia Bondone","doi":"10.7429/pi.2022.751017","DOIUrl":"https://doi.org/10.7429/pi.2022.751017","url":null,"abstract":"<p><strong>Introduction: </strong>The measurement of pain is the fundamental prerequisite for its proper management. Since newborns are unable to communicate verbally, neonatal algometric scales have been developed. However, no gold standard has been identified yet.</p><p><strong>Objective: </strong>To identify and classify the most suitable and effective scales for different kinds of pain for term and preterm newborns in different clinical settings.</p><p><strong>Method: </strong>The review was carried out between December 2019 and November 2020 by consulting the PubMed and CINAHL Database, combining Mesh terms and free text with appropriate inclusion and exclusion filters. The references reported in the articles found in the first part of the research were also analyzed, in order to identify further relevant studies.</p><p><strong>Results: </strong>:Out of 2442 papers initially identified, we included 45 articles, describing 50 pain assessment scales (34 for acute pain, 12 for procedural pain, 24 for prolonged/chronic pain and 19 for pain after surgery). Scales with higher evidence are N-PASS, NFCS, BIIP and PIPP for acute and procedural pain, N-PASS, ALPS-Neo, EDIN and EDIN6 for prolonged/chronic pain, and PIPP, CRIES and COMFORT for pain after surgery.</p><p><strong>Discussion: </strong>There is no unanimously accepted gold standard scale for neonatal pain. However, some are more suitable and effective: PIPP, NFCS, N-PASS and BIIP for acute pain; N-PASS, ALPS-Neo and EDIN/EDIN6 for chronic and prolonged pain; PIPP, CRIES and COMFORT for postoperative pain. Among all, N-PASS scale is the most complete and fits to different settings.</p>","PeriodicalId":34911,"journal":{"name":"Professioni infermieristiche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9243885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Impact of COVID-19 outbreak on ICU nurses' mental health. An Italian multicenter study. 新冠肺炎疫情对ICU护士心理健康的影响意大利多中心研究。
Professioni infermieristiche Pub Date : 2022-04-01 DOI: 10.7429/pi.2022.751058
Vincenzo Damico, Giuseppe Demoro, Stefano Bolgi, Antonella Chirino, Francesco Molina, Antonella D'alessandro, Liana Murano, Giuseppe Russello, Giusy Cataldi
{"title":"Impact of COVID-19 outbreak on ICU nurses' mental health. An Italian multicenter study.","authors":"Vincenzo Damico,&nbsp;Giuseppe Demoro,&nbsp;Stefano Bolgi,&nbsp;Antonella Chirino,&nbsp;Francesco Molina,&nbsp;Antonella D'alessandro,&nbsp;Liana Murano,&nbsp;Giuseppe Russello,&nbsp;Giusy Cataldi","doi":"10.7429/pi.2022.751058","DOIUrl":"https://doi.org/10.7429/pi.2022.751058","url":null,"abstract":"<p><strong>Aim: </strong>AIM: The aim of this study was to evaluate variations in ICU nurses ' mental health status over the COVID-19 outbreak by quantifying the extent of symptoms of depression, anxiety and PTSD over time.</p><p><strong>Methods: </strong>METHODS: This study was an Italian multicenter prospective cohort study assessing caseness of anxiety, depression and PTSD at 6 and 12 months from the beginning of the COVID-19 outbreak in Italy.</p><p><strong>Results: </strong>RESULTS: A total of 359 nurses, 233 (64.9%) were males and 126 (35.1%) were females were enrolled. At 6 months the caseness prevalence for anxiety, depression and PTSD were 31.3%, 32.1% and 18.7% respectively. At 12 months the caseness prevalence for anxiety, depression and PTSD were 34.8%, 36.4% and 24.1 % respectively. No statistically significant increase between 6 and 12 months was recorded for the caseness prevalence anxiety (p= .29) and depression (p= .19). However, an increase for the caseness prevalence PTSD at 12 months was observed (p= .049). The significant risk factors for the 221 patients with at least one disorders were age 31-40 (RR= 1.44, IC= 1.25-1.89; p < .001), female gender (RR= 1.31, IC= 1.02-1.51; p=. 042) and had 0-5 years of professional experience (RR= 1.36, IC= 1.02-1.63; p = .031).</p><p><strong>Conclusion: </strong>The results of our study may provide support for the implementation of some interventions for well-being in COVID-19 outbreak condition.</p>","PeriodicalId":34911,"journal":{"name":"Professioni infermieristiche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9187999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Review of literature on instruments measuring health professionals' knowledges, attitudes, and perceptions of antimicrobial stewardship programs. 关于测量卫生专业人员对抗菌药物管理计划的知识、态度和看法的仪器的文献综述。
Professioni infermieristiche Pub Date : 2022-04-01 DOI: 10.7429/pi.2022.751003
Irene Zainaghi, Maura Lusignani, Silvia Cilluffo
{"title":"Review of literature on instruments measuring health professionals' knowledges, attitudes, and perceptions of antimicrobial stewardship programs.","authors":"Irene Zainaghi,&nbsp;Maura Lusignani,&nbsp;Silvia Cilluffo","doi":"10.7429/pi.2022.751003","DOIUrl":"https://doi.org/10.7429/pi.2022.751003","url":null,"abstract":"<p><strong>Introduction: </strong>The establishment of multi-disciplinary antimicrobial stewardship programmes means that there is a need to study how well healthcare personnel are able to deal with the problem on a daily basis. This study therefore aimed to identify and critically examine existing tools to measure knowledge, attitudes and practices with respect to antimicrobial stewardship among physicians and nurses.</p><p><strong>Methods: </strong>After a literature review of biomedical databases such as PUBMED, EMBASE, SCOPUS, CINAHL, a total of 14 instruments were identified between May and November 2021, the purpose, theoretical framework and statistical validity of which were analysed and described.</p><p><strong>Results: </strong>The theoretical framework and validation process vary widely between instruments and are not described in all of them. The pilot study was not always conducted or well detailed. The questionnaires varied in length and were mostly answered on a 5-7 point Likert scale. The work of Baraka et al 2019 together with that of Ashiru-Oredope et al 2021 appear to be the best from the point of view of statistical validity. Baraka has the high number of questions.</p><p><strong>Conclusion: </strong>The literature review and the use of already existing instruments, even by the same author, are the basis of all the identified studies even if the explanation with respect to the reason for this choice is missing. The validation process was not described for all instruments. When selecting and adapting instruments, attention should be paid to the domains within the scale, the number of items and the theoretical-cultural fit.</p>","PeriodicalId":34911,"journal":{"name":"Professioni infermieristiche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9539579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethical challenges in acute and long-term care of the elderly: a scoping review. 老年人急性和长期护理的伦理挑战:范围审查。
Professioni infermieristiche Pub Date : 2022-03-31 DOI: 10.7429/pi.2022.75159
Federico Pennestrì, Giannetta Noemi, Villa Giulia, Manara Duilio Fiorenzo, Sala Roberta, Mordacci Roberto
{"title":"Ethical challenges in acute and long-term care of the elderly: a scoping review.","authors":"Federico Pennestrì,&nbsp;Giannetta Noemi,&nbsp;Villa Giulia,&nbsp;Manara Duilio Fiorenzo,&nbsp;Sala Roberta,&nbsp;Mordacci Roberto","doi":"10.7429/pi.2022.75159","DOIUrl":"https://doi.org/10.7429/pi.2022.75159","url":null,"abstract":"<p><strong>Introduction: </strong>The discontinuity between the high ideals of nursing education and real-world practice is a major cause of frustration, moral distress and burnout among the youngest, and pushes up to half nurses to change career within two years. These conditions are accentuated in the care of elderly patients with multiple chronic needs.</p><p><strong>Methods: </strong>A multidisciplinary team of nurses and philosophers investigated the chronic determinants of ethical issues in aged care nursing, building on insightful experiences from different institu-tional settings, in order to provide evidence for contextualized and patient-oriented professio-nal support. A scoping review protocol was employed at this purpose.</p><p><strong>Results: </strong>Most of the environmental and organizational deteminants of chronical ethical issues are out-side the control of nurses, and most of the relational ones follow as a result in both settings. Many of the them have been confirmed and further aggravated by the COVID-19 pandemic.</p><p><strong>Discussion: </strong>Although there are not universal solutions to the issues described, still it is possible to distin-guish which determinants fall within the control of nurses, to help them prevent or manage their occurrence; and what are beyond, to help them avoid self-blame and transfer constructive information to those who can intervene.</p><p><strong>Conclusions: </strong>Education can help exercise critical thinking and communicate properly. However, once maximized team cooperation, orga-nizational efficiency and individual soft skills, diminishing room for improvement will be available at increasing human and financial costs. Improving the condition of nurses is an urgent political responsibility and requires a broader socio-cultural change.</p>","PeriodicalId":34911,"journal":{"name":"Professioni infermieristiche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40488837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Predictors of poor seroconversion and adverse events to SARS-CoV-2 mRNA BNT162b2 vaccine in cancer patients on active treatment. Role of the Research Nurse. 积极治疗的癌症患者对SARS-CoV-2 mRNA BNT162b2疫苗的不良血清转化率和不良事件的预测因素。研究护士的角色。
Professioni infermieristiche Pub Date : 2021-08-09 DOI: 10.2139/ssrn.3901796
Tania Buttiron Webber, N. Provinciali, I. M. Briata, M. Boitano, C. Defferrari, Monica Magnani, Fortuna Paciolla, Emanuela Mercenaro, I. Cevasco, S. Gandini, A. Decensi
{"title":"Predictors of poor seroconversion and adverse events to SARS-CoV-2 mRNA BNT162b2 vaccine in cancer patients on active treatment. Role of the Research Nurse.","authors":"Tania Buttiron Webber, N. Provinciali, I. M. Briata, M. Boitano, C. Defferrari, Monica Magnani, Fortuna Paciolla, Emanuela Mercenaro, I. Cevasco, S. Gandini, A. Decensi","doi":"10.2139/ssrn.3901796","DOIUrl":"https://doi.org/10.2139/ssrn.3901796","url":null,"abstract":"BACKGROUND\u0000Vaccines have shown 95% protection from COVID-19 disease in healthy populations. Initial findings in cancer patients suggest a lower seroconversion and greater toxicity possibly related to myelo-immunosuppressive therapies.\u0000\u0000\u0000AIM\u0000We conducted a prospective study to assess factors predicting poor seroconversion and adverse events following immunization (AEFI) to the BNT162b2 vaccine in cancer patients on active treatment.\u0000\u0000\u0000METHODS\u0000Blood samples were collected by the research nurse at first dose (visit 1), second dose (visit 2), after 42 days (visit 3) and after 6 months (visit 4). At visit 1, 3 and 4 participants received: Hospital Anxiety and Depression Scale (HADS) and Distress Thermometer. Patients who ended treatment >6 months on active surveillance served as controls.\u0000\u0000\u0000RESULTS\u0000Between March and July 2021, 320 subjects were recruited and 291 were assessable. The lack of seroconversion at 21 days from the second dose was 1.6% (95% CI, 0.4-8.7) on active surveillance, 13.9% (8.2-21.6) on chemotherapy, 11.4% (5.1-21.3) on hormone therapy, 21.7% (7.5-43.7) on targeted therapy and 4.8% (0.12-23.8) on immunotherapy. Compared to controls, the risk of no IgG response was greater for chemotherapy (P=0.033), targeted therapy (0.005) and hormonotherapy (P=0.051). Lymphocyte count less than 1x109/L, older age and advanced stage also significantly predicted poor seroconversion. Overall, 43 patients (14.8%) complained of AEFI, mostly of mild grade. Risk of AEFI was greater in females (P=0.001) and younger patients (P=0.009).\u0000\u0000\u0000CONCLUSIONS\u0000A third booster dose and long-term serological testing is required in subjects who have not responded to the vaccine.\u0000\u0000\u0000NURSING IMPLICATIONS\u0000nurses must take responsibility for promoting and protecting the health of cancer patients.","PeriodicalId":34911,"journal":{"name":"Professioni infermieristiche","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42093141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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