Infection Epidemiology and Microbiology最新文献_第3页

Isolation and Molecular Identification of Streptomyces spp. Producing Antibacterial Compounds from Iranian Soil 伊朗土壤中产抗菌化合物链霉菌的分离与分子鉴定

Infection Epidemiology and Microbiology Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.25

R. Moravej, Sahar Honarmand Jahromi, peyman Azad

引用次数: 0

Characteristics of Prophage Patterns and Virulence Gene Profiles among Methicillin-Resistant Staphylococcus aureus Isolates from Patients with Diabetic Foot Infections in a Referral Hospital in Tehran, Iran 伊朗德黑兰一家转诊医院糖尿病足感染患者中耐甲氧西林金黄色葡萄球菌原噬菌体模式和毒力基因谱的特征

Infection Epidemiology and Microbiology Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.15

F. Rahimi, Sanaz Khashei

引用次数: 0

Impact of IL-35 and presepsin on immunological, hematological, and biochemical parameters in COVID-19 patients IL-35和蛋白酶对COVID-19患者免疫、血液学和生化指标的影响

Infection Epidemiology and Microbiology Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.35

F. Al-Khikani, Zeytoon Abdulridha Alkhafaji

{"title":"Impact of IL-35 and presepsin on immunological, hematological, and biochemical parameters in COVID-19 patients","authors":"F. Al-Khikani, Zeytoon Abdulridha Alkhafaji","doi":"10.52547/iem.9.1.35","DOIUrl":"https://doi.org/10.52547/iem.9.1.35","url":null,"abstract":"Backgrounds: Immune-inflammatory responses appear to play a key role in severe SARS-CoV-2 infections. Interleukin-35 (IL-35) and presepsin (PSN) are inhibitory cytokine and pro-inflammatory interleukin, which play a crucial role in the immune system modulation, respectively. Therefore, the study of IL-35 and PSN interaction with other parameters may be critical for managing patients with COVID-19. Material(s) and Method(s): A total of 125 severe/critical COVID-19 patients and 60 healthy persons as a control group were enrolled in this work. These patients were admitted to Marjan medical city and Al-Sadeq hospital in Iraq during February to August 2022 and diagnosed as severe cases depending on the SpO2 percentage according to the guidelines released by the National Health World. Anti-and pro-inflammatory cytokines (IL-35 and PSN) were detected by ELISA technique. Finding(s): Presepsin showed a positive correlation with admission to the respiratory care unit (RCU) (r=.022, p=.011). A negative correlation was found between presepsin and C-reactive protein (CRP) (r=.21, p=.018). Both PSN and IL-35 in biochemical tests showed a positive strong effect on glucose levels in COVID-19 patients (r=.234, p=.008 and r=.241, p=.007, respectively). IL-35 had a positive impact on alkaline phosphatase (ALP) (r=.28, p=.002). Hemoglobin (Hb) level showed a positive correlation with presepsin (r=.2, p=.02). Conclusion(s): This study confirms the growing evidence showing the direct role of regulatory pro-inflammatory cytokines in the development and control of COVID-19 through the interaction with other parameters.Copyright © 2023, TMU Press.","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90616269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Review on Phytochemicals and Pharmacological Activities of Syzygium aromaticum 香薷植物化学成分及药理活性研究进展

Infection Epidemiology and Microbiology Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.87

Dr. Yahya Bin Abdullah Alrashdi, Dr. Mohammad Amzad Hossain

引用次数: 0

Diagnostic Role of Platelet-Lymphocyte Ratio and Platelet Parameters in COVID-19 Disease 血小板-淋巴细胞比值及血小板参数在COVID-19中的诊断作用

Infection Epidemiology and Microbiology Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.71

N. Ganesan, E. Thomas, Subba Rao tadury Madhukar, K. S., Lawanya G

{"title":"Diagnostic Role of Platelet-Lymphocyte Ratio and Platelet Parameters in COVID-19 Disease","authors":"N. Ganesan, E. Thomas, Subba Rao tadury Madhukar, K. S., Lawanya G","doi":"10.52547/iem.9.1.71","DOIUrl":"https://doi.org/10.52547/iem.9.1.71","url":null,"abstract":"Backgrounds: This study aimed to analyze the applicability of platelet parameters in assessing the severity of COVID-19 disease. Material(s) and Method(s): Patients with RT-PCR confirmed COVID-19 in the Pathology department of a tertiary care hospital in south India from June to December 2020 were included in this study. Clinical details and laboratory parameters of these patients were obtained. The difference between the studied variables in two groups was assessed using independent t-test. The optimum cut-off value of platelet to lymphocyte ratio (PLR) to differentiate between the tested groups was estimated using ROC (receiver operator curve) analysis. Finding(s): This study was conducted on 218 COVID-19 patients, of whom 17.9% showed thrombocytopenia at the time of admission. Among the hematological parameters, PLR, absolute lymphocyte count (ALC), platelet distribution width (PDW), D-dimer, and erythrocyte sedimentation rate (ESR) were significantly different between the ICU (intensive care unit) and non-ICU groups. Increased PLR values were associated with the disease severity. Conclusion(s): PLR could be used as an additional biomarker in assessing the severity of COVID-19 disease, and a cut-off value of 210.27 is optimal to differentiate severe COVID-19 disease from its mild and moderate forms with 79% specificity.Copyright © 2023, TMU Press.","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73068240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thromboembolic Manifestations in Hospitalized COVID-19 Patients in India- A Single-Centre Retrospective Study 印度住院COVID-19患者的血栓栓塞表现-一项单中心回顾性研究

Infection Epidemiology and Microbiology Pub Date : 2023-03-01 DOI: 10.52547/iem.9.1.79

Y. Chidambaram, C. J. Jenil Dhas, N. Abilash, Velammal Petchiappan, M. Alagesan

引用次数: 0

Using Single Multiplex PCR Reaction to Identify Candida Species in Vaginal isolates: Comparison between Phenotypic and Molecular Methods 用单次多重PCR反应鉴定阴道分离念珠菌种类:表型方法与分子方法的比较

Infection Epidemiology and Microbiology Pub Date : 2022-12-01 DOI: 10.52547/iem.8.4.337

Majid Zare-Bidaki, F. Ghasemi, N. Ghanbarzadeh, F. Noferesti, F. Nikoomanesh

引用次数: 0

Development of a New Epitope Immunogenic Structure Based on the Coronavirus Membrane Glycoprotein M Using Immunoinformatics Tools 利用免疫信息学工具构建冠状病毒膜糖蛋白M抗原表位免疫原性结构

Infection Epidemiology and Microbiology Pub Date : 2022-12-01 DOI: 10.52547/iem.8.4.365

S. Pirmoradi

{"title":"Development of a New Epitope Immunogenic Structure Based on the Coronavirus Membrane Glycoprotein M Using Immunoinformatics Tools","authors":"S. Pirmoradi","doi":"10.52547/iem.8.4.365","DOIUrl":"https://doi.org/10.52547/iem.8.4.365","url":null,"abstract":"Backgrounds: Although conventional therapies have played an essential role in the treatment of many diseases, emerging diseases require new treatment methods with less complications. Therefore, it is important to develop an effective vaccine for infections caused by the coronavirus to prevent mortality and create immunity the community. Material(s) and Method(s): In this research bioinformatics tools were used to design a vaccine against the M membrane protein of SARS-CoV-2. A total of 27 epitopes confined to B cells and MHC I and II alleles were structurally constructed in M protein for immune stimulation and antibody recognition which were used in the construction of a chimeric peptide vaccine. Finding(s): The vaccine was predicted to be a stable, antigenic, and non-allergenic compound. TRL5/vaccine complex analysis and docking simulation indicated a sufficiently stable binding with appropriated receptor activation. The immune response simulation following hypothetical immunization indicated the potential of this vaccine to stimulate the production of active and memory B cells, CD8 + T and, CD4 + T cells, and effective immunological responses induced by Th2 and Th1. Conclusion(s): The analysis of in-silico processes showed that the vaccine structure induced high antigenicity and good cellular immunity in the host body and stimulates various immune receptors such as TLR5, MHC I, and MHC II. Vaccine function was also associated with an increase in IgM and IgG antibodies and a set of Th1 and Th2 cytokines. But the final confirmation of the effectiveness of the designed vaccine requires clinical processes.Copyright © 2022, TMU Press.","PeriodicalId":34545,"journal":{"name":"Infection Epidemiology and Microbiology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84367546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Resistance and Virulence Potential of Avian Colibacillosis-Causing Escherichia coli Isolates 禽大肠杆菌病病原菌分离株的耐药性和毒力潜力

Infection Epidemiology and Microbiology Pub Date : 2022-12-01 DOI: 10.52547/iem.8.4.307

Z. Pourhossein, L. Asadpour, H. Habibollahi, Seyedeh Tooba Shafighi

引用次数: 0

Evaluating the Genetic Diversity of Helicobacter pylori Isolates in Patients Suffering from Gastritis 胃炎患者幽门螺杆菌分离株遗传多样性评价

Infection Epidemiology and Microbiology Pub Date : 2022-12-01 DOI: 10.52547/iem.8.4.297

Sanaz Mami, Saeedeh Khaleghnezhad, M. Mami, M. Dadashi, M. Goudarzi, Hossein Ghahremanpour, Bahareh Hajikhani

引用次数: 0