Interdisciplinary Approaches to Medicine最新文献_第6页

Polymorphism Of Osteoarticular Manifestation Of Brucellosis Infection. A Review 布鲁氏菌病感染骨关节表现的多态性。回顾

Interdisciplinary Approaches to Medicine Pub Date : 2020-01-01 DOI: 10.26577/IAM.2020.V1.I1.03

Yu Khaidarova, M. Masoodi, G. Kurmanova, B. Seizhanova

引用次数: 0

The Current Treatments Of Pulmonary Arterial Hypertension 肺动脉高压的治疗现状

Interdisciplinary Approaches to Medicine Pub Date : 2020-01-01 DOI: 10.26577/IAM.2020.V1.I1.02

G. Butrous

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Serotoninergic System Contribution To The Development Of Early Onset Childhood Schizophrenia 血清素能系统对早期儿童精神分裂症发展的贡献

Interdisciplinary Approaches to Medicine Pub Date : 2020-01-01 DOI: 10.26577/IAM.2020.V1.I1.08

K. Saduakasova, G. Svyatova

{"title":"Serotoninergic System Contribution To The Development Of Early Onset Childhood Schizophrenia","authors":"K. Saduakasova, G. Svyatova","doi":"10.26577/IAM.2020.V1.I1.08","DOIUrl":"https://doi.org/10.26577/IAM.2020.V1.I1.08","url":null,"abstract":"Relevance. In recent years, active research on the relation rs6313 polymorphism with response and side effects of taking antipsychotics and antidepressants established ability of these receptors to bind some antipsychotic drugs, in particular, slowing down the development of negative symptoms in patients with schizophrenia. Thus, when studying the antipsychotic effect of clozapine, its relationship to 5NTR2A receptors was found, therefore, the functional variability of the gene encoding these receptors may affect the clinical effect of clozapine. It was shown that the frequency of rs6313 5NT2A is higher in the group of patients who are resistant to treatment with atypical antipsychotic drugs [17,18,19]. The article does not cover the history of studying the genetic polymorphism 5NT2A, hypotheses “for” and “against” its participation in the pathogenesis of mental diseases. Analysis of the current available scientific literature has shown that our study on the search for associations of the rs6313 genetic polymorphism of the 5NTR2A gene with the development of schizophrenia is the first conducted not in an adult, but in a child population. Clinical and psychopathological features were studied and the genetic contribution of the 102t/S polymorphism of the 5NTR2A gene to the development of child and adolescent schizophrenia was determined.","PeriodicalId":34543,"journal":{"name":"Interdisciplinary Approaches to Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69016640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advices On Search And Critical Appraisal Of Biomedical Literature Part I, General Workflow 对生物医学文献检索与评价的几点建议第一部分，一般工作流程

Interdisciplinary Approaches to Medicine Pub Date : 2020-01-01 DOI: 10.26577/IAM.2020.V1.I1.01

Nurlan Dauletbayev

{"title":"Advices On Search And Critical Appraisal Of Biomedical Literature Part I, General Workflow","authors":"Nurlan Dauletbayev","doi":"10.26577/IAM.2020.V1.I1.01","DOIUrl":"https://doi.org/10.26577/IAM.2020.V1.I1.01","url":null,"abstract":"Both physician-scientists and practicing physicians regularly experience the need to browse, select, and critically appraise the current biomedical literature. There have been many useful reviews on each of the aforementioned topics. Still, having a unified and coherent workflow, feasible to fit into a busy clinical routine, would surely be appreciated by physicians. In addition, many of the aforementioned reviews have been written to target the audience in developed countries. In contrast, particularities of the access to the literature in developing countries (or economies in transition) have been addressed less frequently. Finally, new computational approaches, including machine translation and automated text mining, are rapidly emerging. These are indeed worthy addressing as the initiatives that could provide a great help to practicing physicians for rapid, yet comprehensive literature appraisals. The present review aims to provide physicians with the workflow and methodological recommendation on browsing, selecting, and critical appraisal of the biomedical literature, with the specific focus on patient- and disease-oriented publications. The review further aims to overcome the aforementioned limitations of the previously published literature on this subject.","PeriodicalId":34543,"journal":{"name":"Interdisciplinary Approaches to Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69016553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pulmonary Arterial Hypertension Associated With Ventricular Septal Defects: A Single-Centre Experience In The Republic Of Kazakhstan. 肺动脉高压与室间隔缺损:哈萨克斯坦共和国的单中心经验。

Interdisciplinary Approaches to Medicine Pub Date : 2020-01-01 DOI: 10.26577/IAM.2020.V1.I1.05

Aigerim Mullen, K. Abzaliyev, G. Butrous

{"title":"The Pulmonary Arterial Hypertension Associated With Ventricular Septal Defects: A Single-Centre Experience In The Republic Of Kazakhstan.","authors":"Aigerim Mullen, K. Abzaliyev, G. Butrous","doi":"10.26577/IAM.2020.V1.I1.05","DOIUrl":"https://doi.org/10.26577/IAM.2020.V1.I1.05","url":null,"abstract":". The aim of this study was to evaluate the impact of pulmonary arterial hypertension on outcomes following surgical or transcatheter repair of isolated ventricular septal defect in the Republic of Kazakhstan.Echocardiography and catheterisation reports of children with isolated ventricular septal defect complicated pulmonary arterial hypertension surgical or transcatheter repair between 2012 and 2016. Amongst 38 children ventricular septal defect mean size was 10.92 ± 6.38mm. The mean systolic pressure in the right ventricle on Echocardiography was 55.42 ± 18.47 mmHg. Mean pulmonary arterial pressure by right heart catheterisation was 52.12 ± 29.44 mmHg. The mean end diastolic index for all children was registered as 76.78±19.58ml. Cardiac output was preserved in all children. In the preoperative period, 9 of these children were treated with sildenafil. One week after the operation, mean right ventricle systolic pressure decreased as for children who did not receive preoperative sildenafil (from 55.5±14.8mmHg to 32.2±14.4mmHg) (p <0.01), as for children who did (from 81.4±10.3mmHg. to 48.1±12.4mmHg (p value < 0.01)). End diastolic index normalized in 92.5% of cases. Right ventricle systolic pressure decreased >40% in all children a month after the surgery. surgery has no effect on the effectiveness of surgical treatment of ventricular septal defect. We had had no early postoperative mortality.","PeriodicalId":34543,"journal":{"name":"Interdisciplinary Approaches to Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69016610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0