Serotoninergic System Contribution To The Development Of Early Onset Childhood Schizophrenia

Relevance. In recent years, active research on the relation rs6313 polymorphism with response and side effects of taking antipsychotics and antidepressants established ability of these receptors to bind some antipsychotic drugs, in particular, slowing down the development of negative symptoms in patients with schizophrenia. Thus, when studying the antipsychotic effect of clozapine, its relationship to 5NTR2A receptors was found, therefore, the functional variability of the gene encoding these receptors may affect the clinical effect of clozapine. It was shown that the frequency of rs6313 5NT2A is higher in the group of patients who are resistant to treatment with atypical antipsychotic drugs [17,18,19]. The article does not cover the history of studying the genetic polymorphism 5NT2A, hypotheses “for” and “against” its participation in the pathogenesis of mental diseases. Analysis of the current available scientific literature has shown that our study on the search for associations of the rs6313 genetic polymorphism of the 5NTR2A gene with the development of schizophrenia is the first conducted not in an adult, but in a child population. Clinical and psychopathological features were studied and the genetic contribution of the 102t/S polymorphism of the 5NTR2A gene to the development of child and adolescent schizophrenia was determined.