{"title":"The Egg Muffin Technique-A Novel Bipatch Enfolding Repair for Membranous Ventricular Septal Aneurysm with Aortic Valve Replacement: A Case Report.","authors":"Kensuke Kobayashi, Yusuke Mizuno, Hiroaki Yusa","doi":"10.5090/jcs.25.069","DOIUrl":"10.5090/jcs.25.069","url":null,"abstract":"<p><p>A 70-year-old man with severe aortic stenosis was referred to our department for surgery. Echocardiography revealed a peak/mean pressure gradient of 101/61 mm Hg and a membranous ventricular septal aneurysm protruding into the right ventricular outflow tract without shunt flow. Right heart catheterization demonstrated right ventricular outflow tract obstruction with a peak pressure gradient of 11 mm Hg. Aortic valve replacement using a bioprosthetic valve and enfolding repair of the membranous ventricular septal aneurysm were performed. The folded aneurysmal tissue was compressed and reinforced with double-applied patches from both the left and right ventricular sides via aortotomy and right atriotomy, respectively. The postoperative course was uneventful. This novel Bi-Patch Enfolding Repair, termed the \"egg muffin technique,\" provides a simple and effective method for volume reduction of aneurysmal tissue. Unlike aneurysm resection with defect closure, it mitigates the risk of iatrogenic shunt formation and atrioventricular block.</p>","PeriodicalId":34499,"journal":{"name":"Journal of Chest Surgery","volume":" ","pages":"177-180"},"PeriodicalIF":1.5,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13351388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Floating Intercostal Port Technique for Single-Port Robotic Resection of Posterior Mediastinal Schwannomas: A Case Report.","authors":"Kyung Soo Kim","doi":"10.5090/jcs.26.063","DOIUrl":"10.5090/jcs.26.063","url":null,"abstract":"<p><p>Single-port (SP) robotic thoracic surgery is a minimally invasive option for mediastinal tumor resection; however, intercostal access remains challenging due to narrow intercostal spaces and the risk of postoperative neuralgia. This report describes 2 cases of posterior paravertebral mediastinal schwannoma resected using a floating intercostal port technique with the da Vinci SP system. In each case, a small uniportal incision was made at the lowest feasible intercostal space without rib spreading, and the SP metal port was positioned in a floating configuration above the intercostal space to reduce nerve compression while allowing safe instrument deployment. Complete tumor resection was achieved in both patients without intraoperative complications. Postoperative recovery was uneventful, with minimal pain and no intercostal neuralgia. The floating intercostal port technique may facilitate safe and effective SP robotic resection of selected posterior mediastinal tumors while preserving the advantages of intercostal access and supporting early recovery.</p>","PeriodicalId":34499,"journal":{"name":"Journal of Chest Surgery","volume":"59 4","pages":"181-185"},"PeriodicalIF":1.5,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13351390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pleural Sealants in Pneumothorax Surgery: A Step Forward or Added Expense?","authors":"Aliza Ahmed, Muhammad Hassan Saeed","doi":"10.5090/jcs.26.032","DOIUrl":"10.5090/jcs.26.032","url":null,"abstract":"","PeriodicalId":34499,"journal":{"name":"Journal of Chest Surgery","volume":" ","pages":"186-187"},"PeriodicalIF":1.5,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13351391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sujeong Kim, Se Eun Park, Chanwoo Kim, Jae Yeon Kim, Sang Hyeon Han, Eunkyung Park, Jung Eun Kim, Dohun Kim
{"title":"Organoids in Cancer Research: Current Applications, Limitations, and Technological Advances.","authors":"Sujeong Kim, Se Eun Park, Chanwoo Kim, Jae Yeon Kim, Sang Hyeon Han, Eunkyung Park, Jung Eun Kim, Dohun Kim","doi":"10.5090/jcs.25.169","DOIUrl":"10.5090/jcs.25.169","url":null,"abstract":"<p><p>Organoids are 3-dimensional cell culture systems derived from stem cells through self-organization. They recapitulate key aspects of tissue architecture and organ-specific functions, providing a powerful preclinical platform for cancer research. In particular, patient-derived tumor organoids preserve the pathological and genetic features of primary tumors. These models support the prediction of patient-specific drug responses and thereby advance precision medicine. Despite these advantages, several challenges remain, including incomplete reconstruction of the tumor microenvironment-particularly immune components- and insufficient vascularization. Recent advances have sought to address these limitations through innovative approaches, including immune cell co-culture systems and organoid-on-a-chip technologies. This mini-review summarizes recent progress in tumor organoid research and highlights emerging strategies aimed at improving physiological relevance. It also discusses future perspectives, emphasizing the expanding roles of organoids in precision oncology and regenerative medicine.</p>","PeriodicalId":34499,"journal":{"name":"Journal of Chest Surgery","volume":" ","pages":"141-149"},"PeriodicalIF":1.5,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13351377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joon Young Chang, Chansop Hwang, Beatrice Chia-Hui Shih, Du-Young Kang, Duk Hwan Moon, Sungsoo Lee
{"title":"Outcomes of Pleural Sealant Application in Pneumothorax Surgery: A Comparative Analysis.","authors":"Joon Young Chang, Chansop Hwang, Beatrice Chia-Hui Shih, Du-Young Kang, Duk Hwan Moon, Sungsoo Lee","doi":"10.5090/jcs.25.118","DOIUrl":"10.5090/jcs.25.118","url":null,"abstract":"<p><strong>Background: </strong>Recurrence after video-assisted thoracoscopic surgery (VATS) bullectomy for primary spontaneous pneumothorax (PSP) remains a major clinical concern. Pleural reinforcement has been proposed to reduce recurrence; however, comparative evidence between fibrin sealant (FS) patches and polyglycolic acid (PGA) sheets is limited.</p><p><strong>Methods: </strong>We retrospectively reviewed 188 patients with PSP who underwent VATS bullectomy with pleural reinforcement between 2015 and 2025 (FS group, n=42; PGA group, n=146). Perioperative outcomes and recurrence-free survival (RFS) were compared. Baseline imbalances were adjusted using inverse probability of treatment weighting. Survival outcomes were evaluated using Kaplan-Meier analysis and restricted mean survival time (RMST). Predictors of recurrence were assessed with Firth's penalized Cox regression.</p><p><strong>Results: </strong>The FS group showed significantly shorter operative time (29.6 minutes vs. 39.6 minutes, p<0.001) and a reduced length of hospital stay (3.4 days vs. 4.2 days, p=0.042) compared with the PGA group, whereas chest tube duration was comparable between groups. Overall recurrence was 11.7%. Kaplan-Meier analysis demonstrated no significant difference in RFS (p=0.174), but RMST analysis indicated significantly fewer recurrences with FS (p=0.038). Multivariable Cox regression identified female sex as an independent protective factor against recurrence (hazard ratio, 0.117; p=0.028).</p><p><strong>Conclusion: </strong>FS patches showed a trend toward lower recurrence, achieving statistical significance in RMST analysis. FS appears to be a safe and effective option for pleural reinforcement following VATS bullectomy in patients with PSP.</p>","PeriodicalId":34499,"journal":{"name":"Journal of Chest Surgery","volume":" ","pages":"159-164"},"PeriodicalIF":1.5,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13351407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When Survival Is Not Enough: Rethinking Mechanical Mitral Valve Replacement in Young Children.","authors":"Khaled Ebrahim Al Ebrahim","doi":"10.5090/jcs.25.170","DOIUrl":"10.5090/jcs.25.170","url":null,"abstract":"","PeriodicalId":34499,"journal":{"name":"Journal of Chest Surgery","volume":" ","pages":"139-140"},"PeriodicalIF":1.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chansop Hwang, Beatrice Chia-Hui Shih, Duk Hwan Moon, Sungsoo Lee
{"title":"A Giant Traumatic Pneumatocele Manifesting as Hemoptysis in an Adolescent: A Case Report.","authors":"Chansop Hwang, Beatrice Chia-Hui Shih, Duk Hwan Moon, Sungsoo Lee","doi":"10.5090/jcs.25.034","DOIUrl":"10.5090/jcs.25.034","url":null,"abstract":"<p><p>Traumatic pneumatocele (TP) is a rare, benign pulmonary lesion that primarily affects children and young adults following blunt chest trauma. We present the case of a 16-year-old male judo athlete who developed persistent hemoptysis. Imaging identified a large hydropneumothorax. During video-assisted thoracoscopic surgery, a cystic lesion was discovered in the left lower lobe, and intraoperative bronchofibroscopy revealed a minor bronchopleural fistula. A wedge resection was performed, resulting in an uncomplicated recovery; the patient was discharged on postoperative day 2. This case underscores the rarity of complicated TP necessitating surgical intervention and highlights the importance of considering TP in young patients with blunt chest trauma.</p>","PeriodicalId":34499,"journal":{"name":"Journal of Chest Surgery","volume":" ","pages":"129-131"},"PeriodicalIF":1.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary: Salvage Resection for Local Failure after Stereotactic Ablative Radiotherapy for Pulmonary Malignancies: A Retrospective, Single-Center Study.","authors":"Yong Won Seong","doi":"10.5090/jcs.26.072","DOIUrl":"10.5090/jcs.26.072","url":null,"abstract":"","PeriodicalId":34499,"journal":{"name":"Journal of Chest Surgery","volume":"59 3","pages":"115-116"},"PeriodicalIF":1.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Upstaging Risk and Prognosis of Clinical T2-3N0M0 Esophageal Squamous Cell Carcinoma Patients after a Curative Esophagectomy: A Propensity Score-Matched Analysis.","authors":"Ping-Chung Tsai, Chia Liu, Ling-I Chien, En-Kuei Tang, Chien-Sheng Huang, Chih-Cheng Hsieh, Han-Shui Hsu, Po-Kuei Hsu","doi":"10.5090/jcs.25.111","DOIUrl":"10.5090/jcs.25.111","url":null,"abstract":"<p><strong>Background: </strong>Neoadjuvant chemoradiation therapy (nCRT) has survival benefits for patients with cT1N1 or cT2-3N0-1 esophageal squamous cell carcinoma (ESCC), but heterogeneous disease behavior has been observed in node-negative tumors. This study aimed to investigate the risk of upstaging and the efficacy of upfront esophagectomy compared with nCRT followed by surgery in patients with cT2-3N0 ESCC.</p><p><strong>Methods: </strong>ESCC patients treated at Taipei Veterans General Hospital, Taiwan, between January 2010 and December 2022 were retrospectively reviewed. Patients who underwent upfront surgery (n=72) and those who received neoadjuvant therapy (n=36) were included in this analysis on an intention-to-treat basis after propensity score matching. Comparisons of TNM (tumor, node, and metastasis) classification shifts between patients who underwent upfront surgery and those who received neoadjuvant therapy, as well as primary outcomes including overall survival (OS) and recurrence-free survival (RFS), were analyzed.</p><p><strong>Results: </strong>Among patients who underwent upfront surgery, 6 (16.7%) in the cT2 group and 10 (27.8%) in the cT3 group had occult lymph node (LN) metastasis. Most patients (77.4%) who received neoadjuvant therapy experienced downstaging; however, there were no significant differences in OS (5-year OS: 53.8% vs. 51.6%, p=0.666) or RFS (5-year RFS: 48.6% vs. 44.8%, p=0.864) compared with upfront surgery. No significant differences were observed before propensity score matching for either OS (p=0.809) or RFS (p=0.856).</p><p><strong>Conclusion: </strong>Upfront esophagectomy in patients with cT2-3N0 ESCC provides comparable survival outcomes, despite the higher risk of upstaging and occult LN metastasis.</p>","PeriodicalId":34499,"journal":{"name":"Journal of Chest Surgery","volume":" ","pages":"117-126"},"PeriodicalIF":1.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eun Chae Kim, Samina Park, Eun Ji Hong, Kwon Joong Na, In Kyu Park, Chang Hyun Kang, Young Tae Kim, Hak Jae Kim
{"title":"Salvage Resection for Local Failure after Stereotactic Ablative Radiotherapy for Pulmonary Malignancies: A Retrospective, Single-Center Study.","authors":"Eun Chae Kim, Samina Park, Eun Ji Hong, Kwon Joong Na, In Kyu Park, Chang Hyun Kang, Young Tae Kim, Hak Jae Kim","doi":"10.5090/jcs.25.107","DOIUrl":"10.5090/jcs.25.107","url":null,"abstract":"<p><strong>Background: </strong>Salvage resection after radiotherapy is technically challenging, and patients are vulnerable to postoperative complications. Outcomes of salvage lung resection after stereotactic ablative radiotherapy (SABR) are not well established. We aimed to assess the feasibility and safety of salvage resection for local failure after SABR.</p><p><strong>Methods: </strong>We identified patients treated with SABR for primary or secondary lung malignancies from 2012 to 2018 who subsequently underwent salvage resection for local recurrence at the SABR-treated site. Detailed patient data were retrospectively collected. Short-term postoperative outcomes and mid-term recurrence rates were evaluated.</p><p><strong>Results: </strong>Of 741 patients who received SABR, 16 underwent 17 salvage procedures for local failure. Pulmonary metastasis from colorectal cancer (n=12; 71%) was the most common pathology. The median time from SABR to local recurrence was 15.9 months (interquartile range [IQR], 8.6-21.5 months). Video-assisted thoracoscopic surgery was performed in 13 of 17 operations, and R0 resection was achieved in all cases. Eight lesions required anatomic resection to achieve complete removal. Postoperative bleeding requiring surgical intervention occurred in 1 patient (6%) and was unrelated to prior radiation. No 30- or 90-day mortality was recorded. The median hospital stay was 4 days (IQR, 4-6 days), and the median follow-up duration was 58.1 months (IQR, 31.5-72.1 months). Although 4 patients developed distant metastases after salvage resection, none experienced local failure.</p><p><strong>Conclusion: </strong>Salvage resection can be a safe and effective treatment for local failure after SABR. Careful selection of eligible patients is essential.</p>","PeriodicalId":34499,"journal":{"name":"Journal of Chest Surgery","volume":" ","pages":"109-114"},"PeriodicalIF":1.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}