IF 2.7

BioTech Pub Date : 2025-03-06 DOI: 10.3390/biotech14010015

Sandeep Nair, Gerald H Lushington, Mohan Purushothaman, Bernard Rubin, Eldon Jupe, Santosh Gattam

{"title":"Prediction of Lupus Classification Criteria via Generative AI Medical Record Profiling.","authors":"Sandeep Nair, Gerald H Lushington, Mohan Purushothaman, Bernard Rubin, Eldon Jupe, Santosh Gattam","doi":"10.3390/biotech14010015","DOIUrl":"https://doi.org/10.3390/biotech14010015","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a complex autoimmune disease that poses serious long-term patient burdens. (1) Background: SLE patient classification and care are often complicated by case heterogeneity (diverse variations in symptoms and severity). Large language models (LLMs) and generative artificial intelligence (genAI) may mitigate this challenge by profiling medical records to assess key medical criteria. (2) Methods: To demonstrate genAI-based profiling, ACR (American College of Rheumatology) 1997 SLE classification criteria were used to define medically relevant LLM prompts. Records from 78 previously studied patients (45 classified as having SLE; 33 indeterminate or negative) were computationally profiled, via five genAI replicate runs. (3) Results: GenAI determinations of the \"Discoid Rash\" and \"Pleuritis or Pericarditis\" classification criteria yielded perfect concurrence with clinical classification, while some factors such as \"Immunologic Disorder\" (56% accuracy) were statistically unreliable. Compared to clinical classification, our genAI approach achieved a 72% predictive success rate. (4) Conclusions: GenAI classifications may prove sufficiently predictive to aid medical professionals in evaluating SLE patients and structuring care strategies. For individual criteria, accuracy seems to correlate inversely with complexities in clinical determination, implying that improvements in AI patient profiling tools may emerge from continued advances in clinical classification efficacy.","PeriodicalId":34490,"journal":{"name":"BioTech","volume":"14 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytohormonal Regulation of Abiotic Stress Tolerance, Leaf Senescence and Yield Response in Field Crops: A Comprehensive Review. 作物非生物胁迫、叶片衰老和产量响应的激素调控综述

IF 2.7

BioTech Pub Date : 2025-02-27 DOI: 10.3390/biotech14010014

Anna Panozzo, Pranay Kumar Bolla, Giuseppe Barion, Alessandro Botton, Teofilo Vamerali

{"title":"Phytohormonal Regulation of Abiotic Stress Tolerance, Leaf Senescence and Yield Response in Field Crops: A Comprehensive Review.","authors":"Anna Panozzo, Pranay Kumar Bolla, Giuseppe Barion, Alessandro Botton, Teofilo Vamerali","doi":"10.3390/biotech14010014","DOIUrl":"https://doi.org/10.3390/biotech14010014","url":null,"abstract":"Field crops are expected to be increasingly threatened by climate change, which will negatively impact plant development, growth and yield. Phytohormones play a crucial role in regulating specific signalling pathways to induce rapid adaptive responses to environmental stresses. Exogenous phytohormone application alters hormonal balance, thereby enhancing plant adaptation to adverse conditions. While several studies have advanced our understanding of the use of phytohormones in field crops, yield responses and species-specific application strategies remain inconsistent and rarely assessed under field conditions. The application of cytokinins (CKs), abscisic acid (ABA), and gibberellic acid (GA) has been shown to maintain prolonged photosynthetic activity, stabilize plasma membrane, and reduce lipid peroxidation and ion accumulation under salinity stress in wheat. Additionally, inhibitors of ethylene synthesis and receptors can mitigate stress symptoms under drought and heat stress, which typically accelerates senescence and shortens the grain-filling period in cereal crops. In this way, exogenous application of CKs, GA, and ethylene inhibitors can delay senescence by sustaining leaf photosynthetic activity and postponing nutrient remobilization. However, these benefits may not consistently translate into improvements in grain yield and quality. This review explores the molecular mechanisms of phytohormones in abiotic stress tolerance, delineates their specific functions and evaluates experimental findings from field applications. It also summarizes the potential of phytohormone applications in field crops, emphasizing the need for species-specific investigations on application timing and dosages under open-field conditions to optimize their agronomic potential.","PeriodicalId":34490,"journal":{"name":"BioTech","volume":"14 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-Based Modeling of the Gut Bacteria-Host Interactome Through Statistical Analysis of Domain-Domain Associations Using Machine Learning. 利用机器学习对域-域关联进行统计分析，建立基于结构的肠道细菌-宿主相互作用组模型。

IF 2.7

BioTech Pub Date : 2025-02-25 DOI: 10.3390/biotech14010013

Despoina P Kiouri, Georgios C Batsis, Thomas Mavromoustakos, Alessandro Giuliani, Christos T Chasapis

{"title":"Structure-Based Modeling of the Gut Bacteria-Host Interactome Through Statistical Analysis of Domain-Domain Associations Using Machine Learning.","authors":"Despoina P Kiouri, Georgios C Batsis, Thomas Mavromoustakos, Alessandro Giuliani, Christos T Chasapis","doi":"10.3390/biotech14010013","DOIUrl":"https://doi.org/10.3390/biotech14010013","url":null,"abstract":"The gut microbiome, a complex ecosystem of microorganisms, plays a pivotal role in human health and disease. The gut microbiome's influence extends beyond the digestive system to various organs, and its imbalance is linked to a wide range of diseases, including cancer and neurodevelopmental, inflammatory, metabolic, cardiovascular, autoimmune, and psychiatric diseases. Despite its significance, the interactions between gut bacteria and human proteins remain understudied, with less than 20,000 experimentally validated protein interactions between the host and any bacteria species. This study addresses this knowledge gap by predicting a protein-protein interaction network between gut bacterial and human proteins. Using statistical associations between Pfam domains, a comprehensive dataset of over one million experimentally validated pan-bacterial-human protein interactions, as well as inter- and intra-species protein interactions from various organisms, were used for the development of a machine learning-based prediction method to uncover key regulatory molecules in this dynamic system. This study's findings contribute to the understanding of the intricate gut microbiome-host relationship and pave the way for future experimental validation and therapeutic strategies targeting the gut microbiome interplay.","PeriodicalId":34490,"journal":{"name":"BioTech","volume":"14 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Bioactive Compounds and Antioxidant Activity in Germinated Seeds of the New Peanut Variety. 花生新品种发芽种子中生物活性成分和抗氧化活性的增强。

IF 2.7

BioTech Pub Date : 2025-02-25 DOI: 10.3390/biotech14010012

Hwan-Hee Yu, Jong-Suk Park, Sanghyun Lee

{"title":"Enhanced Bioactive Compounds and Antioxidant Activity in Germinated Seeds of the New Peanut Variety.","authors":"Hwan-Hee Yu, Jong-Suk Park, Sanghyun Lee","doi":"10.3390/biotech14010012","DOIUrl":"https://doi.org/10.3390/biotech14010012","url":null,"abstract":"The sprout market in Korea is expanding as consumers seek healthier food options and farmers strive to increase added value and competitiveness. This study examined the changes in the phytochemical composition of Sinpalkwang (SPK), a peanut variety developed in Korea, during germination. Four samples (SPK1, SPK2, SPK3, and SPK4) were collected at different growth stages and analyzed for total polyphenol content (TPC), total flavonoid content (TFC), and antioxidant activities using ABTS+ and DPPH assays. The levels of trans-resveratrol and soyasaponin Bb were quantified using high-performance liquid chromatography (HPLC) with a photo-diode array (PDA). Among the samples, SPK2 exhibited the highest TFC (1.61 mg QE/g ext.) and trans-resveratrol content (0.054 mg/g ext.), while SPK4 showed the highest TPC (29.38 mg TAE/g ext.) and soyasaponin Bb content (6.543 mg/g ext.). In terms of radical scavenging activities, SPK2 and SPK3 performed best in the ABTS+ and DPPH assays, respectively. Germinated samples demonstrated strong results across all analyses, highlighting the benefits of germination in enhancing phytochemical properties. This study provides foundational information on the phytochemical composition of SPK and the effects of germination. Future research will focus on optimizing germination conditions to further enhance the functionality and value of this Korean-bred variety as a source of high-value bioactive ingredients.","PeriodicalId":34490,"journal":{"name":"BioTech","volume":"14 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STXBP1 Syndrome: Biotechnological Advances, Challenges, and Perspectives in Gene Therapy, Experimental Models, and Translational Research. STXBP1综合征：基因治疗、实验模型和转化研究的生物技术进展、挑战和前景。

IF 2.7

BioTech Pub Date : 2025-02-20 DOI: 10.3390/biotech14010011

Silvestre Ruano-Rodríguez, Mar Navarro-Alonso, Benito Domínguez-Velasco, Manuel Álvarez-Dolado, Francisco J Esteban

{"title":"STXBP1 Syndrome: Biotechnological Advances, Challenges, and Perspectives in Gene Therapy, Experimental Models, and Translational Research.","authors":"Silvestre Ruano-Rodríguez, Mar Navarro-Alonso, Benito Domínguez-Velasco, Manuel Álvarez-Dolado, Francisco J Esteban","doi":"10.3390/biotech14010011","DOIUrl":"https://doi.org/10.3390/biotech14010011","url":null,"abstract":"STXBP1 syndrome is a severe early-onset epileptic encephalopathy characterized by developmental delay and intellectual disability. This review addresses key challenges in STXBP1 syndrome research, focusing on advanced therapeutic approaches and experimental models. We explore gene therapy strategies, including CRISPR-Cas9, adeno-associated viral (AAV) vectors, and RNA therapies such as antisense oligonucleotides (ASOs), aimed at correcting STXBP1 genetic dysfunctions. This review presents in vivo and in vitro models, highlighting their contributions to understanding disease mechanisms. Additionally, we provide a proposal for a detailed bioinformatic analysis of a Spanish cohort of 41 individuals with STXBP1-related disorders, offering insights into specific mutations and their biological implications. Clinical and translational perspectives are discussed, emphasizing the potential of personalized medicine approaches. Future research directions and key challenges are outlined, including the identification of STXBP1 interactors, unexplored molecular pathways, and the need for clinically useful biomarkers. This comprehensive review underscores the complexity of STXBP1-related infantile epileptic encephalopathy and opens new avenues for advancing the understanding and treatment of this heterogeneous disease.","PeriodicalId":34490,"journal":{"name":"BioTech","volume":"14 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Live-Cell Imaging-Based Fluorescent SARS-CoV-2 Neutralization Assay by Antibody-Mediated Blockage of Receptor Binding Domain-ACE2 Interaction. 抗体介导阻断受体结合域- ace2相互作用的基于活细胞成像的SARS-CoV-2荧光中和试验

IF 2.7

BioTech Pub Date : 2025-02-14 DOI: 10.3390/biotech14010010

Jorge L Arias-Arias, Laura Monturiol-Gross, Eugenia Corrales-Aguilar

{"title":"A Live-Cell Imaging-Based Fluorescent SARS-CoV-2 Neutralization Assay by Antibody-Mediated Blockage of Receptor Binding Domain-ACE2 Interaction.","authors":"Jorge L Arias-Arias, Laura Monturiol-Gross, Eugenia Corrales-Aguilar","doi":"10.3390/biotech14010010","DOIUrl":"10.3390/biotech14010010","url":null,"abstract":"Neutralization assays have become an important tool since the beginning of the COVID-19 pandemic for testing vaccine responses and therapeutic antibodies as well as for monitoring humoral immunity to SARS-CoV-2 in epidemiological studies. The spike glycoprotein (S) present on the viral surface contains a receptor binding domain (RBD) that recognizes the angiotensin-converting enzyme 2 receptor (ACE2) in host cells, allowing virus entry. The gold standard for determining SARS-CoV-2 neutralizing antibodies is the plaque reduction neutralization test (PRNT), which relies on live-virus replication performed exclusively in biosafety level 3 (BSL-3) laboratories. Here, we report the development of a surrogate live-cell imaging-based fluorescent SARS-CoV-2 neutralization assay, applicable to BSL-1 or BSL-2 laboratories, by antibody-mediated blockage of the interaction between recombinant RBD with overexpressed ACE2 receptor in a genetically modified HEK 293T stable cell line. Our approach was able to detect neutralizing antibodies both in COVID-19-positive human serum samples and polyclonal equine formulations against SARS-CoV-2. This new cell-based surrogate neutralization assay represents a virus-free fluorescence imaging alternative to the reported approaches, which can be used to detect antibody-neutralizing capabilities toward SARS-CoV-2. This assay could also be extrapolated in the future to other established and emergent viral agents.","PeriodicalId":34490,"journal":{"name":"BioTech","volume":"14 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinformatics Tools for NGS-Based Identification of Single Nucleotide Variants and Large-Scale Rearrangements in Mitochondrial DNA. 基于 NGS 的线粒体 DNA 单核苷酸变异和大规模重排鉴定的生物信息学工具。

IF 2.7

BioTech Pub Date : 2025-02-12 DOI: 10.3390/biotech14010009

Marco Barresi, Giulia Dal Santo, Rossella Izzo, Andrea Zauli, Eleonora Lamantea, Leonardo Caporali, Daniele Ghezzi, Andrea Legati

{"title":"Bioinformatics Tools for NGS-Based Identification of Single Nucleotide Variants and Large-Scale Rearrangements in Mitochondrial DNA.","authors":"Marco Barresi, Giulia Dal Santo, Rossella Izzo, Andrea Zauli, Eleonora Lamantea, Leonardo Caporali, Daniele Ghezzi, Andrea Legati","doi":"10.3390/biotech14010009","DOIUrl":"10.3390/biotech14010009","url":null,"abstract":"The unique features of mitochondrial DNA (mtDNA), including its circular and multicopy nature, the possible coexistence of wild-type and mutant molecules (i.e., heteroplasmy) and the presence of nuclear mitochondrial DNA segments (NUMTs), make the diagnosis of mtDNA diseases particularly challenging. The extensive deployment of next-generation sequencing (NGS) technologies has significantly advanced the diagnosis of mtDNA-related diseases. However, the vast amounts and diverse types of sequencing data complicate the interpretation of these variants. From sequence alignment to variant calling, NGS-based mtDNA sequencing requires specialized bioinformatics tools, adapted for the mitochondrial genome. This study presents the use of new bioinformatics approaches, optimized for short- and long-read sequencing data, to enhance the accuracy of mtDNA analysis in diagnostics. Two recent and emerging free bioinformatics tools, Mitopore and MitoSAlt, were evaluated on patients previously diagnosed with single nucleotide variants or large-scale deletions. Analyses were performed in Linux-based environments and web servers implemented in Python, Perl, Java, and R. The results indicated that each tool demonstrated high sensitivity and specific accuracy in identifying and quantifying various types of pathogenic variants. The study suggests that the integrated and parallel use of these tools offers a significant advantage over traditional methods in interpreting mtDNA genetic variants, reducing the computational demands, and provides an accurate diagnostic solution.","PeriodicalId":34490,"journal":{"name":"BioTech","volume":"14 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Scaling up Bioelectrochemical Systems: A Review. 生物电化学系统规模化研究进展综述。

IF 2.7

BioTech Pub Date : 2025-01-31 DOI: 10.3390/biotech14010008

Diego A Corona-Martínez, Silvia Y Martínez-Amador, José A Rodríguez-De la Garza, Elan I Laredo-Alcalá, Pedro Pérez-Rodríguez

引用次数: 0

The Use of Biologics for Targeting GPCRs in Metastatic Cancers. 靶向gpcr的生物制剂在转移性癌症中的应用。

IF 2.7

BioTech Pub Date : 2025-01-30 DOI: 10.3390/biotech14010007

Cian McBrien, David J O'Connell

{"title":"The Use of Biologics for Targeting GPCRs in Metastatic Cancers.","authors":"Cian McBrien, David J O'Connell","doi":"10.3390/biotech14010007","DOIUrl":"10.3390/biotech14010007","url":null,"abstract":"A comprehensive review of studies describing the role of G-protein coupled receptor (GPCR) behaviour contributing to metastasis in cancer, and the developments of biotherapeutic drugs towards targeting them, provides a valuable resource toward improving our understanding of the opportunities to effectively target this malignant tumour cell adaptation. Focusing on the five most common metastatic cancers of lung, breast, colorectal, melanoma, and prostate cancer, we highlight well-studied and characterised GPCRs and some less studied receptors that are also implicated in the development of metastatic cancers. Of the approximately 390 GPCRs relevant to therapeutic targeting, as many as 125 of these have been identified to play a role in promoting metastatic disease in these cancer types. GPCR signalling through the well-characterised pathways of chemokine receptors, to emerging data on signalling by orphan receptors, is integral to many aspects of the metastatic phenotype. Despite having detailed information on many receptors and their ligands, there are only thirteen approved therapeutics specifically for metastatic cancer, of which three are small molecules with the remainder including synthetic and non-synthetic peptides or monoclonal antibodies. This review will cover the existing and potential use of monoclonal antibodies, proteins and peptides, and nanobodies in targeting GPCRs for metastatic cancer therapy.","PeriodicalId":34490,"journal":{"name":"BioTech","volume":"14 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aromatic Amino Acids: Exploring Microalgae as a Potential Biofactory. 芳香氨基酸：微藻作为潜在生物工厂的探索。

IF 2.7

BioTech Pub Date : 2025-01-29 DOI: 10.3390/biotech14010006

Archana Niraula, Amir Danesh, Natacha Merindol, Fatma Meddeb-Mouelhi, Isabel Desgagné-Penix

{"title":"Aromatic Amino Acids: Exploring Microalgae as a Potential Biofactory.","authors":"Archana Niraula, Amir Danesh, Natacha Merindol, Fatma Meddeb-Mouelhi, Isabel Desgagné-Penix","doi":"10.3390/biotech14010006","DOIUrl":"10.3390/biotech14010006","url":null,"abstract":"In recent times, microalgae have emerged as powerful hosts for biotechnological applications, ranging from the production of lipids and specialized metabolites (SMs) of pharmaceutical interest to biofuels, nutraceutical supplements, and more. SM synthesis through bioengineered pathways relies on the availability of aromatic amino acids (AAAs) as an essential precursor. AAAs, phenylalanine, tyrosine, and tryptophan are also the building blocks of proteins, maintaining the structural and functional integrity of cells. Hence, they are crucial intermediates linking the primary and specialized metabolism. The biosynthesis pathway of AAAs in microbes and plants has been studied for decades, but not much is known about microalgae. The allosteric control present in this pathway has been targeted for metabolic engineering in microbes. This review focuses on the biosynthesis of AAAs in eukaryotic microalgae and engineering techniques for enhanced production. All the putative genes involved in AAA pathways in the model microalgae Chlamydomonas reinhardtii and Phaeodactylum tricornutum are listed in this review.","PeriodicalId":34490,"journal":{"name":"BioTech","volume":"14 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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