Environmental Advances最新文献

{"title":"Occurrence and distribution of glyphosate, polar pesticides and their metabolites in honeybees (Apis mellifera): a monitoring study in six different Italian regions","authors":"Mara Gasparini ,&nbsp;Marialuisa Borgia ,&nbsp;Tommaso Pacini ,&nbsp;Emanuela Verdini ,&nbsp;Serenella Orsini ,&nbsp;Katia Russo ,&nbsp;Tabita Mauti ,&nbsp;Ivan Pecorelli","doi":"10.1016/j.envadv.2025.100657","DOIUrl":"10.1016/j.envadv.2025.100657","url":null,"abstract":"<div><div>The widespread use of agrochemicals has raised concerns about their impact on non-target species, particularly pollinators such as honeybees (<em>Apis mellifera</em>). This study investigates the occurrence and distribution of glyphosate, other polar pesticides, and their metabolites in honeybees across six regions of northern and central Italy: Lombardy, Emilia Romagna, Lazio, Tuscany, Umbria, and Marche. Honeybees serve as effective bioindicators of pesticide contamination, offering insights into environmental and ecosystem health. A total of 314 bee samples were analyzed and categorized into two groups: dead/dying bees and live bees from healthy hives. Advanced analytical techniques, including liquid chromatography-tandem mass spectrometry (LC-MS/MS) and ion chromatography-high resolution mass spectrometry (IC<img>HRMS), were used to detect glyphosate, fosetyl, glufosinate, ethephon, and their metabolites. Results revealed glyphosate contamination in 33.4 % of the samples, predominantly in Lombardy and Emilia Romagna, where herbicide use is highest. Fosetyl residues were also detected but were more localized. Notably, there was no significant difference in glyphosate presence between dead/dying and live bees, suggesting chronic exposure rather than acute toxicity. However, higher pesticide concentrations in dead/dying bees indicate potential sublethal effects contributing to colony distress. This study underscores the importance of monitoring polar pesticides in pollinator populations and advocates for more sustainable agricultural practices. Honeybees can effectively serve as bioindicators of environmental contamination, reinforcing the One Health approach, which links environmental, animal, and human well-being. Continuous surveillance is crucial to mitigating pesticide risks and ensuring pollinator conservation.</div></div>","PeriodicalId":34473,"journal":{"name":"Environmental Advances","volume":"21 ","pages":"Article 100657"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Source-specific multi-pathway human health risk assessment of metals present in clouds over Indian Subcontinent","authors":"Md Abu Mushtaque ,&nbsp;Shahina Raushan Saikh ,&nbsp;Abhishek Biswas ,&nbsp;Gopala Krishna Darbha ,&nbsp;Sanat Kumar Das","doi":"10.1016/j.envadv.2025.100647","DOIUrl":"10.1016/j.envadv.2025.100647","url":null,"abstract":"<div><div>Metal in the cloud is a matter of growing concern due to its adverse impact on human health on a wider scale through continental long-range transport. The present study identifies the toxic metals present in non-precipitating clouds during the onset of monsoon over the Western Ghats and Eastern Himalayas in the Indian subcontinent and quantifies their health risk factors of carcinogenic and non-carcinogenic diseases through inhalation, ingestion, and dermal absorption. Clouds over the Eastern Himalayas are found to have 1.5 times higher pollution levels due to an increase in 40-60% higher loading of toxic metals like Cd, Cu, and Zn emitted from heavy traffic and industrial emissions that cause high health risk factors for carcinogenic diseases. Children are at higher risk of 30% of such toxic metals than adults in India. Inhalation of polluted clouds over Eastern Himalayas containing high concentrations of toxic metals is the most potential route for non-carcinogenic diseases. Health risk for the occurrence of carcinogenic diseases has increased due to inhalation of dissolved Cr present in clouds. Present study highlights that Eastern Himalayas experience higher polluted clouds which contain toxic metals like Cd, Cr, Cu, and Zn coming from vehicular and industrial emissions over foothill regions, and inhalation of such polluted clouds is the potential cause of carcinogenic and non-carcinogenic diseases in India.</div></div>","PeriodicalId":34473,"journal":{"name":"Environmental Advances","volume":"21 ","pages":"Article 100647"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual and mixture associations of placental per- and polyfluoroalkyl substance with neurodevelopment at 12 and 24 months of age","authors":"Neha Sehgal ,&nbsp;Stephanie M. Eick ,&nbsp;Kartik Shankar ,&nbsp;Dana Boyd Barr ,&nbsp;Jayne B. Bellando ,&nbsp;Ginger McCorkle ,&nbsp;Clark R. Sims ,&nbsp;Parinya Panuwet ,&nbsp;Volha Yakimavets ,&nbsp;Donald Turner ,&nbsp;Lauren A. Havens ,&nbsp;Andrew J. Morris ,&nbsp;Kevin J. Pearson ,&nbsp;Aline Andres ,&nbsp;Todd M. Everson","doi":"10.1016/j.envadv.2025.100650","DOIUrl":"10.1016/j.envadv.2025.100650","url":null,"abstract":"<div><div>Maternal serum per- and polyfluoroalkyl substances (PFAS) are linked to infant neurodevelopment vulnerabilities. However, the impact of placental PFAS exposure, a more proximal <em>in utero</em> exposure estimate, remains unknown. We hypothesize that elevated placental PFAS levels are associated with delayed neurodevelopment at 12 and 24 months.</div><div>Mother-infant dyads (<em>n</em> = 151) were enrolled in a prospective cohort in Arkansas, US. PFOA, PFOS, PFHxS, PFNA, and PFDA were detected in &gt;65 % of placentas. The Bayley Scales of Infant and Toddler Development (BSID)-III was administered at 12 and 24 months. Individual associations of each placental PFAS on BSID-III scores were examined using linear regressions. Mixture effects were assessed using quantile g-computation and Bayesian Kernel Machine Regression.</div><div>Placental PFAS were jointly associated with lower cognitive (Ψ = -2.6; 95 % CI = -6.0, 0.9) and motor (Ψ = -2.9; 95 % CI = -6.6, 0.9) scores at 12 months and higher social-emotional scores (Ψ = 3.3; 95 % CI = -1.9, 8.5) at 24 months among males. Among females, higher PFAS mixture levels were associated with higher language (Ψ = 3.3; 95 % CI = -1.2, 7.7) and social-emotional (Ψ = 3.7; 95 % CI = -3.3, 10.6) scores at 24 months. Linear regressions showed PFHxS and PFOS were associated with lower cognitive scores at 12 months and PFDA was associated with lower motor scores at 12 months among males, while PFOS and PFNA were associated with higher social-emotional scores at 24 months among females, although confidence intervals included the null. In a matched subset with maternal serum, cord serum and placental PFAS (<em>n</em> = 98), we observed mostly null associations consistently across biomatrices and noted few associations, such as a negative relation of cord PFOA and PFHxS with language scores at 12 months among females.</div><div>Overall, placental PFAS levels were modestly associated with performance on neurodevelopmental assessments in early childhood and these relationships were sex- and compound-specific, and most confidence intervals cross the null.</div></div>","PeriodicalId":34473,"journal":{"name":"Environmental Advances","volume":"21 ","pages":"Article 100650"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Overview of fungal bioleaching of metals” [Environmental Advances Volume 5, October 2021, 100083]","authors":"Leonce Dusengemungu ,&nbsp;George Kasali ,&nbsp;Cousins Gwanama ,&nbsp;Benjamin Mubemba","doi":"10.1016/j.envadv.2025.100658","DOIUrl":"10.1016/j.envadv.2025.100658","url":null,"abstract":"","PeriodicalId":34473,"journal":{"name":"Environmental Advances","volume":"21 ","pages":"Article 100658"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critical review of artificial destratification systems for mitigating water stratification","authors":"Khin July Win Thant ,&nbsp;Peter Thew ,&nbsp;Joe Pera ,&nbsp;Lee J. Baumgartner ,&nbsp;Lalantha Seneviratha","doi":"10.1016/j.envadv.2025.100649","DOIUrl":"10.1016/j.envadv.2025.100649","url":null,"abstract":"<div><div>Thermal stratification (ThS) in water bodies, particularly during warmer seasons, severely degrades water quality by reducing oxygen levels, leading to detrimental ecological impacts. Artificial destratification technologies have emerged as potential solutions to mitigate these effects and improve water quality. This systematic review examines 194 studies from databases such as Web of Science, Scopus, MDPI, and ASCE, covering research from 1990 to 2024. The review evaluates various destratification methods, including mechanical mixers, bubble aerators, floating intakes, suspended curtains, multi-level offtakes (MLOs), and gradual entrainment level inverters (GELs), for their effectiveness in improving oxygenation and reducing nutrient buildup. It highlights that bubble aerators perform best in smaller water bodies, while mechanical mixers, though less common, offer cost-effective solutions for larger systems. However, mixers alone show limited effectiveness in large reservoirs, and their combination with bubble aerators can enhance system performance at increased operational costs. This review fills a critical gap in the literature by synthesizing available data on destratification technologies and their role in restoring ecological balance in stratified waters. The findings provide valuable insights for improving water pollution control strategies, supporting ecosystem health, and guiding future research and policy development to address the real-world challenges posed by ThS.</div></div>","PeriodicalId":34473,"journal":{"name":"Environmental Advances","volume":"21 ","pages":"Article 100649"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the spatial variability of airborne bacterial and fungal communities: A comparative study across five central Mediterranean areas","authors":"Mattia Fragola ,&nbsp;Salvatore Romano ,&nbsp;Dalila Peccarrisi ,&nbsp;Leke Pepkolaj ,&nbsp;Ivano Ammoscato ,&nbsp;Roberta Claudia Calidonna ,&nbsp;Luana Malacaria ,&nbsp;Giorgia De Benedetto ,&nbsp;Mark M. Scerri ,&nbsp;Anastasios Kalimeris ,&nbsp;Adamantia Kampioti ,&nbsp;Lucio Maruccio ,&nbsp;Pietro Alifano ,&nbsp;Adelfia Talà ,&nbsp;Gianluca Quarta ,&nbsp;Lucio Calcagnile","doi":"10.1016/j.envadv.2025.100660","DOIUrl":"10.1016/j.envadv.2025.100660","url":null,"abstract":"<div><div>In this study the distribution of airborne bacterial and fungal communities was investigated in five different areas of the Central Mediterranean (Salento Peninsula and Lamezia Terme in South Italy, Albania, Malta, and Zakynthos in Greece). Advanced DNA-based approaches and compositional data analysis (CoDa) were used to explore microbial community compositions and their spatial variability associated with the different types of sampling site (urban, rural, and coastal). Analytical results revealed distinct patterns of the airborne microbial community mainly shaped by geographic and environmental features. Among the identified airborne bacterial genera, <em>Sphingomonas</em> was found in all the selected sites, while <em>Brevundimonas, Geodermatophilus</em>, and <em>Rubrobacter</em> were prevalent in coastal and rural locations. Among the airborne fungal genera, <em>Cladosporium</em> and <em>Alternaria</em> were abundant in rural and coastal areas. The clustering of detected samples by geographic characteristics and monitoring site type was further highlighted by the Aitchison distance-based dendrograms and principal component analysis biplots by utilizing singular value decomposition. This statistical approach allowed proving that some specific microbial genera were associated with different environmental characteristics related to the selected sampling areas. Therefore, this study points out the complex relationship between spatial variability and microbial distributions, underlining that environmental and geographic variations can significantly contribute to microbial community composition.</div></div>","PeriodicalId":34473,"journal":{"name":"Environmental Advances","volume":"21 ","pages":"Article 100660"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and trend analysis of satellite-derived surface water temperature observations over adirondack lakes","authors":"Marzi Azarderakhsh ,&nbsp;Carolien Mossel ,&nbsp;Abdou Rachid Bah ,&nbsp;Aisha Malik ,&nbsp;Fahmeda Khanom ,&nbsp;Jonathan Borrelli ,&nbsp;Pete McIntyre ,&nbsp;Hamid Norouzi ,&nbsp;Kevin Rose","doi":"10.1016/j.envadv.2025.100662","DOIUrl":"10.1016/j.envadv.2025.100662","url":null,"abstract":"<div><div>This study aims to validate and evaluate satellite remote sensing observations from the Landsat series over 135 lakes in the Adirondack State Park, located in upstate New York, and to examine their surface temperature trends over the past 40 years. It utilizes data from the Moderate Resolution Imaging Spectroradiometer (MODIS), along with Landsat 5 and 7. Park-scale results were derived by extracting MODIS surface temperatures within the park boundary, while lake-scale results were estimated using Landsat 5 (1984-2012) and Landsat 7 (1999-2023) observations. In addition, field observations were utilized to perform a comprehensive validation and evaluation of satellite-based surface temperature data. The findings indicate that satellite-derived temperatures are within a reasonable range of in situ measurements, with RMSEs ranging from 1.97 to 2.08°C and correlation coefficients between 0.64 and 0.75. Comprehensive trend analyses conducted on an annual and monthly basis reveal that temperature values during the Landsat 5 period exhibited higher warming rates compared to the Landsat 7 period, which showed seasonal variations and even some cooling months. Monthly MODIS-derived park-wide trends ranged from −1.57 °C to 1.2 °C (March to November) and were generally lower in magnitude than those estimated from Landsat data. On average, lakes in the Adirondack lakes demonstrated a warming trend of about 0.89°C per decade. The seasonal analyses revealed an expansion of the summer season, with higher warming rates in May and October/September. These findings highlight the critical role of satellite observations in monitoring climate change impacts on lake ecosystems, especially in regions with limited ground-based data.</div></div>","PeriodicalId":34473,"journal":{"name":"Environmental Advances","volume":"21 ","pages":"Article 100662"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated spatial analysis of drought risk factors using agglomerative hierarchical clustering and correlation","authors":"Saowanee Wijitkosum","doi":"10.1016/j.envadv.2025.100646","DOIUrl":"10.1016/j.envadv.2025.100646","url":null,"abstract":"<div><div>Drought results from the complex interplay between climatic variability and human activities, further intensified by hydro-meteorological and socio-economic interactions. This study investigates the interrelationships among climatic, geographic, soil, and anthropogenic factors influencing drought risk in the Upper Phetchaburi River Basin. Ten key drought risk factors—precipitation, aridity index, slope, elevation, soil texture, drainage, fertility, erosion, land use, and land cover—were spatially analyzed using Agglomerative Hierarchical Clustering and Pearson Product-Moment Correlation. The analysis revealed both direct and inverse relationships among these variables, underscoring the compounded effects of climate, land use, and soil dynamics on drought vulnerability. A particularly strong correlation between climatic and anthropogenic variables suggests a spatial-temporal alignment that intensifies drought conditions. Additional significant correlations—including precipitation–aridity index, aridity index–land use, and slope–soil fertility—further emphasize the integrated nature of environmental processes regulating drought susceptibility. Clustering analysis identified three distinct groups: (1) precipitation, aridity index, and soil erosion, illustrating how reductions in precipitation and aridity index accelerate soil degradation; (2) soil properties—texture, drainage, and fertility—are crucial in highlighting their roles in water retention, nutrient availability, and vegetation resilience, particularly in slope terrain; and (3) elevation, land use, and land cover, demonstrating the combined effects of topography and anthropogenic activities on drought dynamics. These findings underscore the urgent need for sustainable land management, targeted ecosystem restoration, and climate-adaptive policies to mitigate drought risks. By elucidating localized drought drivers within broader environmental contexts, this study offers a transferable framework for informing proactive, cross-disciplinary drought mitigation strategies.</div></div>","PeriodicalId":34473,"journal":{"name":"Environmental Advances","volume":"21 ","pages":"Article 100646"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passive sampling in brackish waters: Monitoring metals and organic pollutants in the Camargue and its application to phytoremediation","authors":"Emmanuelle Boisard ,&nbsp;Amiel Boullemant ,&nbsp;Guillaume Boisard ,&nbsp;Christophe Armand ,&nbsp;Arnaud Bretecher ,&nbsp;Fiorella Lucarini ,&nbsp;Davide Staedler","doi":"10.1016/j.envadv.2025.100656","DOIUrl":"10.1016/j.envadv.2025.100656","url":null,"abstract":"<div><div>The Camargue region in southern France, characterized by its unique brackish water ecosystems, faces significant contamination from agricultural runoff, introducing organic pollutants and metals into the environment. This study presents a four-seasonal monitoring program comprising nine sampling campaigns, using Polar Organic Chemical Integrative Samplers (POCIS) and Diffusive Gradients in Thin Films (DGT) to explore the temporal and spatial dynamics of contaminants. A comprehensive analysis was conducted on 483 organic pollutants, encompassing a broad spectrum of herbicides, fungicides, their degradation products, and a comprehensive list of heavy metals. By providing time-weighted average concentrations, these techniques allowed to track seasonal variations driven by agricultural cycles and hydrological processes. The results revealed persistent organic pollutants, such as 2-methyl-4-chlorophenoxyacetic acid (MCPA), atrazine metabolites, and metolachlor ethanesulfonic acid (ESA), exhibiting clear seasonal peaks aligned with crop applications. Heavy metals, including copper and barium, displayed temporal fluctuations influenced by both anthropogenic activities and natural geochemical processes. To demonstrate the applicability of this monitoring approach, passive samplers were also deployed within an existing phytoremediation system based on <em>Phragmites australis</em>, allowing to assess its effectiveness in contaminant removal. While organic pollutants were reduced by up to 95 %, metal removal remained variable. This study underscores the high suitability of passive sampling for long-term environmental monitoring in brackish water ecosystems, offering a robust methodology to track pollutant dynamics, support regulatory assessments, and evaluate remediation strategies. The findings provide critical insights for future monitoring programs aimed at balancing agricultural productivity with the protection of fragile aquatic environments.</div></div>","PeriodicalId":34473,"journal":{"name":"Environmental Advances","volume":"21 ","pages":"Article 100656"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human adipose tissue gene expression signatures indicate an inflammatory response and retinoic receptor activation under persistent organic pollutants exposure","authors":"Tobias Hagemann ,&nbsp;Ulrike Rolle-Kampczyk ,&nbsp;Kristin Schubert ,&nbsp;Arne Dietrich ,&nbsp;Martin von Bergen ,&nbsp;Matthias Blüher ,&nbsp;Anne Hoffmann","doi":"10.1016/j.envadv.2025.100655","DOIUrl":"10.1016/j.envadv.2025.100655","url":null,"abstract":"<div><div>Adipose tissue (AT) is subject to permanent accumulation of persistent organic pollutants (POP) due to their hydrophobic nature. Therefore, AT can be considered as interface between the body and an increasingly complex exposure to the chemical environment. As endocrinologically activate tissue, AT itself secretes adipokines regulating inflammation, insulin sensitivity and energy expenditure among others which are known to be dysfunctional in obesity. This study examined the impact of accumulated POPs 4,4-Diisoopropylbiphenyl (DIPB) and Ethyltetradecanoate (ETD) on human AT function. RNA-sequencing based gene expression analysis was conducted within the Leipzig Obesity Biobank (LOBB) between individuals (<em>N</em> = 43) with positive concentrations of DIPB and ETD in body fat against negative controls in subcutaneous (SAT) and visceral AT (VAT) in a sex-specific manner independent of their obesity status. Our study reveals sex- and AT-depot-specific gene expression profiles associated with immune responses, NF-κB signaling, and PPARγ pathways, highlighting POP interaction with immunological reactions in AT independent of obesity. Notably, our findings suggest altered retinoid acid receptor activity, which may influence AT browning. This research provides novel insights into the molecular mechanisms underlying the impact of POP exposure on human AT function. Importantly, our results indicate that POP exposure can contribute to AT dysfunction independently of obesity, suggesting that external environmental factors, such as POPs, should be considered as potential drivers of AT dysfunction in future obesity-related studies.</div></div>","PeriodicalId":34473,"journal":{"name":"Environmental Advances","volume":"21 ","pages":"Article 100655"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}