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2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)最新文献

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Nanofabrication of High Aspect Ratio Aerosol Particles for Deposition Studies in a Model Human Airway 高纵横比气溶胶颗粒的纳米制造及其在人体气道模型中的沉积研究
2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI: 10.1109/ICMENS.2004.107
K. Gilbertson, W. Finlay, C. Lange, M. Brett, D. Vick
{"title":"Nanofabrication of High Aspect Ratio Aerosol Particles for Deposition Studies in a Model Human Airway","authors":"K. Gilbertson, W. Finlay, C. Lange, M. Brett, D. Vick","doi":"10.1109/ICMENS.2004.107","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.107","url":null,"abstract":"The ability to produce high aspect ratio particle aerosols (airborne fibres) is required in order to develop a thorough understanding of the parameters that affect the deposition of fibres in the mouth and throat. Such an ability is currently being developed. In this work, we produce monodisperse fibres from porous thin films by releasing small structures from a substrate. The development of a means to assay for these fibres is also discussed.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"196 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123274919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Improved Diagnosis and Monitoring of Cancer Using Portable Microfluidics Platforms 利用便携式微流体平台改进癌症诊断和监测
2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI: 10.1109/ICMENS.2004.79
L. Pilarski, Sophia Adamia, P. Pilarski, R. Prakash, J. Lauzon, C. Backhouse
{"title":"Improved Diagnosis and Monitoring of Cancer Using Portable Microfluidics Platforms","authors":"L. Pilarski, Sophia Adamia, P. Pilarski, R. Prakash, J. Lauzon, C. Backhouse","doi":"10.1109/ICMENS.2004.79","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.79","url":null,"abstract":"Microfluidics chips offer the promise of fast and accurate diagnostic and monitoring tools that are inexpensive and automated. Tests that otherwise require expensive instrumentation and consume valuable reagents can be implemented on microfluidic chips for a fraction of the cost with dramatic improvement in speed. Minaturization offers multiple benefits, enabling multiple tests on one chip, requiring tiny tissue samples and fast reaction times for picoliter volumes. More complex microfluidics chips will be able to carry out sample processing followed by cell or molecule fractionation, molecular analysis and readout of the test result. Integrated platforms incorporating microfluidics offer portable testing devices for \"point of concern\" testing in health care facilities, in remote areas or in the home. These devices are likely to increase access to sophisticated testing within the health system while decreasing costs and improving the quality of care.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123153271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Delivery of Hydrophobic Drugs through Self-Assembling Nanostructures 通过自组装纳米结构递送疏水药物
2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI: 10.1109/ICMENS.2004.47
G. Gaucher, E. Fournier, D. Garrec, M. Khalid, D. Hoarau, V. Sant, J. Leroux
{"title":"Delivery of Hydrophobic Drugs through Self-Assembling Nanostructures","authors":"G. Gaucher, E. Fournier, D. Garrec, M. Khalid, D. Hoarau, V. Sant, J. Leroux","doi":"10.1109/ICMENS.2004.47","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.47","url":null,"abstract":"Many potent therapeutic agents possess a high degree of hydrophobicity which can greatly impede their solubilization in aqueous media and thus hamper their oral or parenteral administration. In order to circumvent this limitation, novel drug delivery systems, such as polymeric micelles and lipid-based nanocapsules, are being developed. In general, these nano-sized carriers contain a hydrophobic core which provides the necessary environment to solubilize poorly water-soluble drugs. In addition, when administered intravenously, they can passively target inflamed or cancerous tissues due to the enhanced permeation and retention (EPR) effect, potentially improving the therapeutic efficacy of the drug while reducing its toxicity. Alternatively, the limited oral bioavailability of hydrophobic agents can be improved by selectively releasing the drug in its molecular form close to the absorption site. Polymeric micelles containing pH-sensitive moieties and loaded with a poorly water-soluble drug can dissociate and release their payload in the intestine. This presentation will focus on injectable polymeric and lipidic vectors for hydrophobic anti-cancer agents and on pH-sensitive polymeric micelles as promoters of the oral bioavailability of poorly water-soluble drugs [1].","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122651848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Surface Oriented Self Assembled Growth of Carbon Nanotubes 碳纳米管表面自组装生长研究
2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI: 10.1109/ICMENS.2004.137
K. Sivakumar, B. Panchapakesan
{"title":"Surface Oriented Self Assembled Growth of Carbon Nanotubes","authors":"K. Sivakumar, B. Panchapakesan","doi":"10.1109/ICMENS.2004.137","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.137","url":null,"abstract":"We report the self assembled surface oriented growth of single walled carbon nanotubes along the surface of (100), (110) and (111) silicon wafers using thermal CVD. The nanotubes were grown using iron nanoparticles, 10 nm in diameter, as the catalyst. The growth was carried out at 1000oC in a methane atmosphere. The lattice matching of the silicon and iron crystal lattices led to the formation of self aligned silicides at a high temperature which helped orient the nanotubes. SEM, TEM and AFM characterization revealed single wall carbon nanotubes, about 10 nm in diameter and up to 10 μm in length, growing along the <111> direction of the silicon substrate. This process is easy, reliable and may enable the integration of nanotubes with CMOS processing technology.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124828092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
On the Design of an Electrohydrodynamic Ion-Drag Micropump 电流体动力离子拖动微泵的设计研究
2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI: 10.1109/ICMENS.2004.119
M. Badran, M. Moussa
{"title":"On the Design of an Electrohydrodynamic Ion-Drag Micropump","authors":"M. Badran, M. Moussa","doi":"10.1109/ICMENS.2004.119","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.119","url":null,"abstract":"In this paper, several designs of an Electrohydrodynamic (EHD) Ion-Drag Micropump will be investigated. The goal is to determine the effect of several design parameters on the pressure-voltage relationship. The overall dimensions of the micropump channel are 500 µm x 480µm x 60µm. Four designs were tested in simulation with different combinations of the gap between the electrodes (S) and the gap between the electrode pairs (D) to examine their impact on the pumping performance. The design with small gap (S) and large gap (D) was found to have the best pumping performance.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125691751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
By-Pass Transition in Microchannels under EDL Effect EDL效应下微通道的旁路转换
2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI: 10.1109/ICMENS.2004.40
S. Tardu
{"title":"By-Pass Transition in Microchannels under EDL Effect","authors":"S. Tardu","doi":"10.1109/ICMENS.2004.40","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.40","url":null,"abstract":"The effect of the electric double layer (EDL) on the bypass transition mechanism in the linear evolution stage is explored through direct numerical simulations. An initial perturbation velocity field consisting of a pair of counter-rotating vortices is introduced in Poiseuille and EDL flows and the time-space evolution of the perturbed field is analysed for short times at half the critical Reynolds numbers (3000 for Poiseuille and 300 for EDL). The wall normal and spanwise perturbation velocities development are both quantitatively and qualitatively similar in macro and micro flows. The streamwise velocity, which is initially zero and set up by the generation of the wall normal vorticity is twice larger under the EDL effect. Both flows develop inclined strong streamwise shear layers. Overall is the close similarity of the disturbance evolution showing that the three dimensional linear mechanism in EDL flow lead to the structures that are at least as strong as in Poiseuille flow.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134416089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rapid Performance Assessment Method for Microfluidic Chips 一种微流控芯片性能快速评估方法
2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI: 10.1109/ICMENS.2004.21
Rubin Ma, K. Kaler, C. Backhouse
{"title":"A Rapid Performance Assessment Method for Microfluidic Chips","authors":"Rubin Ma, K. Kaler, C. Backhouse","doi":"10.1109/ICMENS.2004.21","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.21","url":null,"abstract":"We present a method to assess microchip performance for on-chip electrophoretic separations. The assessment is realized through electrophoretic manipulation of a DNA size standard using specially designed electric voltage programs. Results achieved from the assessment could be used as an indicator of microchip \"aging\" in terms of lowered resolutions and fluctuations in electro-osmotic flow (EOF).","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129723693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Finite Element-Based Analysis of Single-Crystal Si Contour-Mode Electromechanical RF Resonators 单晶硅等高线模机电射频谐振器的有限元分析
2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI: 10.1109/ICMENS.2004.71
C. Maxey, S. Raman
{"title":"Finite Element-Based Analysis of Single-Crystal Si Contour-Mode Electromechanical RF Resonators","authors":"C. Maxey, S. Raman","doi":"10.1109/ICMENS.2004.71","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.71","url":null,"abstract":"Micron-scale electromechanical disk-shaped resonators have exhibited operational frequencies above 1 GHz and quality factors exceeding 1,500 at these frequencies. Additionally, such disk resonators can be potentially realized in current silicon CMOS and BiCMOS integrated circuit processes, making them attractive alternatives to traditional high-Q off-chip components. Accurate modeling of these devices is critical to predicting the mode-shape and, most importantly, the vibration frequency. This paper presents a finite element-based approach to modeling higher-order effects in disk-shaped resonators using ANSYS 7.0. An in-depth study of the mode-shapes for disk resonators of various sizes, and the effects of substrate anchors attached to the disks at various locations, is included. Effects on resonator operation due to metal layers, such as electroless plated copper, deposited on the disks are also simulated. All simulations are performed in a fully coupled electrical-mechanical environment so as to incorporate as many process and excitation variables as possible.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123738978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Cytotoxicity of Drug-Loaded Nanoparticles and Liposomes Carried by Aerosol "Cluster Bombs" in Lung Cancer Cells 气溶胶“集束炸弹”携带的载药纳米颗粒和脂质体在肺癌细胞中的细胞毒性
2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI: 10.1109/ICMENS.2004.46
X. Tao, Hua Chen, Zhao-quan Wang, W. Finlay, R. Löbenberg, W. Roa
{"title":"Cytotoxicity of Drug-Loaded Nanoparticles and Liposomes Carried by Aerosol \"Cluster Bombs\" in Lung Cancer Cells","authors":"X. Tao, Hua Chen, Zhao-quan Wang, W. Finlay, R. Löbenberg, W. Roa","doi":"10.1109/ICMENS.2004.46","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.46","url":null,"abstract":"This study aims to identify the intracellular locations of nanoparticles and liposomes carried by aerosol \"cluster bomb\", and investigated the relative efficiencies of such drug delivery systems to kill cancer cells in vitro.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"160 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124891418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Lattice Boltzmann Simulations of Bubble Dynamics in Microchannels 微通道气泡动力学的晶格玻尔兹曼模拟
2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04) Pub Date : 2004-08-25 DOI: 10.1109/ICMENS.2004.86
Junfeng Zhang, D. Kwok
{"title":"Lattice Boltzmann Simulations of Bubble Dynamics in Microchannels","authors":"Junfeng Zhang, D. Kwok","doi":"10.1109/ICMENS.2004.86","DOIUrl":"https://doi.org/10.1109/ICMENS.2004.86","url":null,"abstract":"The moving contact line problem of liquid-vapor interfaces on solid surfaces was studied using a mean-field free-energy lattice Boltzmann method recently proposed [Zhang et al., Phys. Rev. E, 69, 032602, 2004]. We have examined the static and dynamic interfacial behaviors by means of the bubble and capillary wave tests and found that both the Laplace equation of capillarity and the dispersion relation were satisfied. Dynamic contact angles followed the general trend of contact line velocity observed experimentally and can be described by Blake's theory. The velocity fields near the interface were also obtained and are in good agreement with fluid mechanics and molecular dynamics studies. Our simulations demonstrated that incorporating interfacial effects into the lattice Boltzmann model can be a valuable and powerful alternative in interfacial studies.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122250436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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