Lancet Healthy Longevity最新文献

{"title":"Effect of an exercise intervention or combined exercise and diet intervention on health-related quality of life-physical functioning after kidney transplantation: the Active Care after Transplantation (ACT) multicentre randomised controlled trial","authors":"Tim J Knobbe MD ,&nbsp;Daan Kremer MD ,&nbsp;Dorien M Zelle MD PhD ,&nbsp;Gerald Klaassen MSc ,&nbsp;Desie Dijkema MSc ,&nbsp;Iris M Y van Vliet PhD ,&nbsp;Paul B Leurs MD PhD ,&nbsp;Prof Frederike J Bemelman ,&nbsp;Prof Maarten H L Christiaans ,&nbsp;Prof Stefan P Berger MD PhD ,&nbsp;Prof Gerjan Navis MD PhD ,&nbsp;Prof Stephan J L Bakker MD PhD ,&nbsp;Eva Corpeleijn PhD","doi":"10.1016/j.lanhl.2024.07.005","DOIUrl":"10.1016/j.lanhl.2024.07.005","url":null,"abstract":"<div><h3>Background</h3><p>Robust evidence for interventions to improve health-related quality of life (HRQoL) in people who receive a kidney transplant is scarce. We aimed to assess the effects of a lifestyle intervention in this context.</p></div><div><h3>Methods</h3><p>We conducted a multicentre, open-label, parallel-group, randomised controlled trial among people who have received a kidney transplant. Participants from six hospitals across the Netherlands were randomly assigned 1:1:1 by an independent company into: usual care, exercise, and exercise plus diet. The exercise intervention encompassed two phases, a 3-month supervised exercise programme (twice weekly) followed by 12 months of lifestyle coaching, with 15 months of additional dietary counselling (12 sessions) for the exercise plus diet group. The primary outcome was HRQoL-domain physical functioning, assessed using the 36-item Short Form Survey at 15 months.</p></div><div><h3>Findings</h3><p>From Oct 12, 2010 to Nov 18, 2016, 221 participants who had received a kidney transplant (138 [62%] male and 83 [38%] female, with a mean age of 52·5 [SD 13·5] years, who were a median of 5·5 [IQR 3·6–8·4] months post-transplant) were included and randomly assigned to usual care (n=74), exercise intervention (n=77), and exercise plus diet intervention (n=70). In the intention-to-treat analyses, at 15 months post-baseline, no significant differences in HRQoL-domain physical functioning were found for the exercise group (5·3 arbitrary units, 95% CI –4·2 to 14·9; p=0·27), and the exercise plus diet group (5·9 arbitrary units, –4·1 to 16·0; p=0·25) compared with control. Safety outcomes showed no safety concerns. After 3 months of supervised exercise intervention, HRQoL-domain physical functioning improved in the exercise group (7·3 arbitrary units, 95% CI 1·2 to 13·3; p=0·018) but not in the exercise plus diet group (5·8 arbitrary units, –0·5 to 12·1; p=0·072).</p></div><div><h3>Interpretation</h3><p>A lifestyle intervention is safe and feasible in people who have received kidney transplants, paving the way for lifestyle intervention studies in other multimorbid populations with polypharmacy. However, improving HRQoL for people who have received a kidney transplant is challenging. The lifestyle interventions in the current study did not show significant improvements in HRQoL at the end of the study at the total group level.</p></div><div><h3>Funding</h3><p>Dutch Kidney Foundation, Innovation Fund of the Dutch Medical Insurance Companies, and University Medical Center Groningen.</p></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 9","pages":"Article 100622"},"PeriodicalIF":13.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666756824001387/pdfft?md5=458089fe15d2e09b2eea98693510e45f&pid=1-s2.0-S2666756824001387-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reserve and resilience: the cumulative risk of surgery on cognition and neurodegeneration in older individuals","authors":"Tammy T Hshieh","doi":"10.1016/j.lanhl.2024.08.003","DOIUrl":"10.1016/j.lanhl.2024.08.003","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 9","pages":"Article 100634"},"PeriodicalIF":13.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666756824001600/pdfft?md5=df4ef66c7ed43cea96a9eb3bdd33238d&pid=1-s2.0-S2666756824001600-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life-course financial mobility shapes later-life memory function","authors":"Xiaolin Xu ,&nbsp;Mika Kivimäki","doi":"10.1016/j.lanhl.2024.07.011","DOIUrl":"10.1016/j.lanhl.2024.07.011","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 9","pages":"Article 100628"},"PeriodicalIF":13.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666756824001442/pdfft?md5=ca8acc97c1fb119304778c034b0eb9fe&pid=1-s2.0-S2666756824001442-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 inhibitors and GLP-1 receptor agonists: which is the best anti-frailty drug?","authors":"Pasquale Mone ,&nbsp;Michele Ciccarelli ,&nbsp;Stanislovas S Jankauskas ,&nbsp;Germano Guerra ,&nbsp;Carmine Vecchione ,&nbsp;Valeria Visco ,&nbsp;Gaetano Santulli","doi":"10.1016/j.lanhl.2024.08.001","DOIUrl":"10.1016/j.lanhl.2024.08.001","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 9","pages":"Article 100632"},"PeriodicalIF":13.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666756824001582/pdfft?md5=a738d8d237a2880177d0a896f7b64a1c&pid=1-s2.0-S2666756824001582-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life course financial mobility and later-life memory function and decline by gender, and race and ethnicity: an intersectional analysis of the US KHANDLE and STAR cohort studies","authors":"Lindsay C Kobayashi PhD ,&nbsp;Rachel L Peterson PhD ,&nbsp;Xuexin Yu PhD ,&nbsp;Justina Avila-Rieger PhD ,&nbsp;Priscilla A Amofa-Ho MS ,&nbsp;Clara Vila-Castelar PhD ,&nbsp;Erika Meza PhD ,&nbsp;C Elizabeth Shaaban PhD ,&nbsp;Prof Rachel A Whitmer PhD ,&nbsp;Paola Gilsanz PhD ,&nbsp;Elizabeth Rose Mayeda","doi":"10.1016/S2666-7568(24)00129-6","DOIUrl":"10.1016/S2666-7568(24)00129-6","url":null,"abstract":"<div><h3>Background</h3><p>Intersectionality has rarely been considered in research studies of cognitive ageing. We investigated whether life-course financial mobility is differentially associated with later-life memory function and decline across intersectional identities defined by gender, and race and ethnicity.</p></div><div><h3>Methods</h3><p>Data were from two harmonised multiethnic cohorts (the Kaiser Healthy Aging and Diverse Life Experiences cohort and the Study of Healthy Aging in African Americans cohort) in northern California, USA (n=2340). Life-course financial mobility, measured using a combination of self-reported financial capital measures in childhood (from birth to age 16 years) and later adulthood (at the cohort baseline) was defined as consistently high, upwardly mobile, downwardly mobile, or consistently low. We clustered individuals into 32 strata representing intersectional identities defined by life-course financial mobility combined with gender, and race and ethnicity. Verbal episodic memory was assessed using the Spanish and English Neuropsychological Assessment Scales over four waves from 2017 to 2023. Adjusted mixed-effects linear regression models were estimated with and without fixed effects of gender, race and ethnicity, and financial mobility, to evaluate whether the random effects of the intersectional identity strata contributed variance to memory beyond individual fixed effects.</p></div><div><h3>Findings</h3><p>Mean age was 73·6 years (SD 8·1). Of 2340 individuals, 1460 (62·4%) were women, 880 (37·6%) were men, 388 (16·6%) were Asian, 1136 (48·5%) were Black, 334 (14·3%) were Latinx, and 482 (20·6%) were White. Consistently low and downwardly mobile financial capital were strongly negatively associated with later-life memory at baseline (–0·162 SD units [95% CI –0·273 to –0·051] for consistently low and –0·171 [–0·250 to –0·092] for downwardly mobile), but not rate of change over time. Intersectional identities contributed 0·2% of memory variance after accounting for the fixed effects of gender, race and ethnicity, and financial mobility.</p></div><div><h3>Interpretation</h3><p>Consistently low and downward life-course financial mobility are associated with lower later-life memory function. Intersectional identities defined by financial mobility in addition to gender, and race and ethnicity, contribute negligible additional variance to later-life memory in this study setting.</p></div><div><h3>Funding</h3><p>US National Institute on Aging, US National Institutes of Health.</p></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 9","pages":"Article 100613"},"PeriodicalIF":13.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666756824001296/pdfft?md5=e05617b92e985c04bf8be870390e4a3d&pid=1-s2.0-S2666756824001296-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Lancet Healthy Longev 2024; 5: 552–562","authors":"","doi":"10.1016/j.lanhl.2024.08.002","DOIUrl":"10.1016/j.lanhl.2024.08.002","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 9","pages":"Article 100633"},"PeriodicalIF":13.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666756824001594/pdfft?md5=6cdd1adeb80a30dcff492e13d446b578&pid=1-s2.0-S2666756824001594-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combating dementia: the imperative for population-level interventions","authors":"The Lancet Healthy Longevity","doi":"10.1016/j.lanhl.2024.07.014","DOIUrl":"10.1016/j.lanhl.2024.07.014","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 9","pages":"Article 100631"},"PeriodicalIF":13.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666756824001491/pdfft?md5=9b42b7b1b87a4a7b4fa256586232d670&pid=1-s2.0-S2666756824001491-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between surgical admissions, cognition, and neurodegeneration in older people: a population-based study from the UK Biobank","authors":"Jennifer Taylor PhD ,&nbsp;Kristy P Robledo PhD ,&nbsp;Vicente Medel PhD ,&nbsp;Prof Gillian Heller PhD ,&nbsp;Thomas Payne MD ,&nbsp;Jordan Wehrman PhD ,&nbsp;Cameron Casey PhD ,&nbsp;Phillip F Yang MBBS MS ,&nbsp;Bryan M Krause PhD ,&nbsp;Richard Lennertz MD PhD ,&nbsp;Prof Sharon Naismith DPsych ,&nbsp;Prof Armando Teixeira-Pinto PhD ,&nbsp;Prof Robert D Sanders MBBS PhD","doi":"10.1016/j.lanhl.2024.07.006","DOIUrl":"10.1016/j.lanhl.2024.07.006","url":null,"abstract":"<div><h3>Background</h3><p>Previous studies have shown that major surgical and medical hospital admissions are associated with cognitive decline in older people (aged 40–69 years at recruitment), which is concerning for patients and caregivers. We aimed to validate these findings in a large cohort and investigate associations with neurodegeneration using MRI.</p></div><div><h3>Methods</h3><p>For this population-based study, we analysed data from the UK Biobank collected from March 13, 2006, to July 16, 2023, linked to the National Health Service Hospital Episode Statistics database, excluding participants with dementia diagnoses. We constructed fully adjusted models that included age, time, sex, <em>Lancet</em> Commission dementia risk factors, stroke, and hospital admissions with a participant random effect. Primary outcomes were hippocampal volume and white matter hyperintensities, both of which are established markers of neurodegeneration, and exploratory analyses investigated the cortical thickness of Desikan–Killiany–Tourville atlas regions. The main cognitive outcomes were reaction time, fluid intelligence, and prospective and numeric memory. Surgeries were calculated cumulatively starting from 8 years before the baseline evaluation.</p></div><div><h3>Findings</h3><p>Of 502 412 participants in the UK Biobank study, 492 802 participants were eligible for inclusion in this study, of whom 46 706 underwent MRI. Small adverse associations with cognition were found per surgery: reaction time increased by 0·273 ms, fluid intelligence score decreased by 0·057 correct responses, prospective memory (scored as correct at first attempt) decreased (odds ratio 0·96 [95% CI 0·95 to 0·97]), and numeric memory maximum correct matches decreased by 0·025 in fully adjusted models. Surgeries were associated with smaller hippocampal volume (β=−5·76 mm³ [−7·89 to −3·64]) and greater white matter hyperintensities volume (β=100·02 mm³ [66·17 to 133·87]) in fully adjusted models. Surgeries were also associated with neurodegeneration of the insula and superior temporal cortex.</p></div><div><h3>Interpretation</h3><p>This population-based study corroborates that surgeries are generally safe but cumulatively are associated with cognitive decline and neurodegeneration. Perioperative brain health should be prioritised for older and vulnerable patients, particularly those who have multiple surgical procedures.</p></div><div><h3>Funding</h3><p>The Australian and New Zealand College of Anaesthetists (ANZCA) Foundation and the University of Sydney.</p></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 9","pages":"Article 100623"},"PeriodicalIF":13.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666756824001399/pdfft?md5=bd3cfbe08dfee9f5b21f45c2462307a5&pid=1-s2.0-S2666756824001399-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations of socioeconomic status, social activities, and loneliness with depressive symptoms in adults aged 50 years and older across 24 countries: findings from five prospective cohort studies","authors":"Yaping Wang MD ,&nbsp;Prof Min Liu PhD ,&nbsp;Prof Fude Yang MD ,&nbsp;Prof Hongguang Chen MD ,&nbsp;Prof Yaogang Wang PhD ,&nbsp;Prof Jue Liu PhD","doi":"10.1016/j.lanhl.2024.07.001","DOIUrl":"10.1016/j.lanhl.2024.07.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Depression is the leading cause of mortality among mental health disorders. Evidence about the associations of socioeconomic status, social activities, and loneliness with depression is scarce. We aimed to identify whether social activities and loneliness mediate the association between socioeconomic status and depression, and the extent of interactive or joint relationships between social activities, loneliness, and socioeconomic status on depression.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;In this population-based, cross-national cohort study we used data from five nationally representative surveys across 24 countries between Feb 15, 2008, and Feb 27, 2019: the Health and Retirement Study (HRS); the English Longitudinal Study of Ageing (ELSA); the Survey of Health, Ageing and Retirement in Europe (SHARE); the China Health and Retirement Longitudinal Study (CHARLS); and the Mexican Health and Ageing Study (MHAS). We included participants who were aged 50 years and older with reported information on socioeconomic status, social activities, and loneliness at baseline, and who had been assessed at least twice. We excluded participants with depressive symptoms at baseline; those with missing data on depressive symptoms and covariates; and those lost to follow-up. We defined socioeconomic status as high and low using latent class analysis based on family income, education, and employment status. Depression was assessed using the Center for Epidemiological Studies Depression Scale (CES-D) or EURO-D. We applied Cox proportional hazard models to estimate the association of socioeconomic status with depression. We used random-effects models to obtain pooled results. Joint and interactive effects of socioeconomic status, social activities, and loneliness on depression were explored, and the mediating roles of social activities and loneliness in the association between socioeconomic status and depression were explored using causal mediation analysis.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;p&gt;A total of 69 160 participants were included in our study and, during a median follow-up of 5 years, a total of 20 237 participants developed depression with a pooled incidence of 7·2 (95% CI 4·4–10·0) per 100 person-years. Compared with participants with high socioeconomic status, those with low socioeconomic status had a higher risk of depression (pooled hazard ratio [HR] 1·34; 95% CI 1·23–1·44). The proportion of the associations between socioeconomic status and depression mediated by social activities and loneliness were 6·12% (1·14–28·45) and 5·54% (0·71–27·62), respectively. We only observed a significant multiplicative interaction of socioeconomic status and loneliness with depression (pooled HR 0·84; 0·79–0·90). Compared with participants with high socioeconomic status and who were socially active and not lonely, those with low socioeconomic status and who were socially inactive and lonely had a higher risk of depression (pooled HR 2·45; 2·08–2·82).","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 9","pages":"Article 100618"},"PeriodicalIF":13.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266675682400134X/pdfft?md5=412aa34e9dea043387eb9d7c218215ac&pid=1-s2.0-S266675682400134X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global barriers to hip-fracture care","authors":"Naoko Onizuka ,&nbsp;Carmen Quatman","doi":"10.1016/S2666-7568(24)00088-6","DOIUrl":"10.1016/S2666-7568(24)00088-6","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 8","pages":"Pages e510-e511"},"PeriodicalIF":13.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666756824000886/pdfft?md5=3a9ca6fcefafd061076cf9811ce4cf88&pid=1-s2.0-S2666756824000886-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}