Lancet Healthy Longevity最新文献

{"title":"Intervention accelerator to prevent and respond to abuse of older people: insights from key promising interventions.","authors":"Laura Campo-Tena, Aresya Farzana, David Burnes, Titus A Chan, Wan Yuen Choo, Mélanie Couture, Fatemeh Estebsari, Minying He, Jeffrey H Herbst, Christelle Sibdou Liliane Kafando, Joshua Lachs, George Rouamba, Marie-Madeleine Simbreni, Louis To, Hau Yan Wan, Elsie Yan, Yongjie Yon, Christopher Mikton","doi":"10.1016/j.lanhl.2024.100647","DOIUrl":"https://doi.org/10.1016/j.lanhl.2024.100647","url":null,"abstract":"<p><p>Globally, abuse of older people (AOP) affects one in six individuals aged 60 years and older every year. Despite the widespread prevalence of AOP, evidence-based interventions for preventing and responding to this issue are insufficient. To address this gap, WHO proposed an initiative to accelerate the development of effective interventions for AOP across all country income levels. In the first phase, the initiative identified 89 promising interventions across a total of 101 evaluations or descriptions, which led to the creation of a public database. Most interventions targeted physical, psychological, and financial abuse and neglect, were implemented in the USA, and focused on victims or potential victims. These interventions were primarily delivered by social workers and nurses, usually in health-care facilities and community centres. Face-to-face delivery was common. Additionally, 28 (28%) of the 101 evaluations used randomised controlled trial designs. The results of this Review can be used to identify interventions that are ready for a rigorous outcome evaluation.</p>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100647"},"PeriodicalIF":13.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between adverse pregnancy outcomes and cognitive impairment and dementia: a systematic review and meta-analysis.","authors":"Eliza C Miller, Patrick Conley, Mohammad Alirezaei, Katrin Wolfova, Mitzi M Gonzales, Zaldy S Tan, Sarah E Tom, Lynn M Yee, Adam M Brickman, Natalie A Bello","doi":"10.1016/j.lanhl.2024.100660","DOIUrl":"https://doi.org/10.1016/j.lanhl.2024.100660","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Individuals with adverse pregnancy outcomes have an increased risk of cerebrovascular disease, but the association between adverse pregnancy outcomes and cognitive impairment and dementia is less well established. We aimed to synthesise, combine, and assess the growing body of data examining the associations between adverse pregnancy outcomes and mild cognitive impairment and dementia in parous women.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this systematic review and meta-analysis, we searched PubMed (MEDLINE), Web of Science, and Embase from database inception up to July 18, 2024, with no language restrictions, for observational studies or clinical trials that reported mild cognitive impairment or dementia as outcomes and included female individuals or women who had an adverse pregnancy outcome, including hypertensive disorders of pregnancy, gestational diabetes, stillbirth, fetal growth restriction, preterm birth, or placental abruption. We excluded studies of men, nulliparous women, women with pre-pregnancy conditions associated with impaired cognition, and studies examining cognitive impairment within 6 months of pregnancy. Database searches were supplemented by manual review of the reference lists of included studies. If studies met eligibility criteria but did not have sufficient data for meta-analysis (ie, did not report a summary statistic or a hazard ratio [HR] for outcome estimation), they were included in the systematic review and excluded from the meta-analysis. After removing duplicates, two investigators independently screened titles and abstracts using Covidence software, with potentially eligible studies undergoing full-text review by the same reviewers, with further review by a third reviewer and disagreements resolved by discussion and group consensus. Study quality was assessed and summary statistics extracted by two reviewers independently. The primary outcomes of our study were mild cognitive impairment, all-cause dementia, Alzheimer's disease, and vascular dementia. Heterogeneity was measured using the Q test and I&lt;sup&gt;2&lt;/sup&gt; statistic, and we used random-effects models with inverse-variance weighting to assess the association between adverse pregnancy outcome and primary outcomes with sufficient meta-analysable data via pooled adjusted HRs and 95% CIs. The study protocol was registered with PROSPERO, CRD42023453511.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Findings: &lt;/strong&gt;Of 11 251 publications identified, 15 studies (including 7 347 202 participants) met inclusion criteria for the systematic review, and 11 studies (6 263 431 participants) had sufficient data for meta-analysis. A history of any adverse pregnancy outcome was associated with higher risk of all-cause dementia (adjusted HR 1·32 [95% CI 1·17-1·49]; I&lt;sup&gt;2&lt;/sup&gt;= 80%), Alzheimer's disease (1·26 [1·04-1·53]; I&lt;sup&gt;2&lt;/sup&gt;=63%), and vascular dementia (1·94 [1·70-2·21]; I&lt;sup&gt;2&lt;/sup&gt;=0%). A history of any hypertensive disorder of pregnancy was significantly ass","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100660"},"PeriodicalIF":13.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatricians-on-the-Move for sustainable ageing.","authors":"Anton De Spiegeleer, Bart De Spiegeleer","doi":"10.1016/j.lanhl.2024.100661","DOIUrl":"https://doi.org/10.1016/j.lanhl.2024.100661","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100661"},"PeriodicalIF":13.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights of the SIOG Annual Conference 2024.","authors":"Sophie Raeder","doi":"10.1016/j.lanhl.2024.100667","DOIUrl":"https://doi.org/10.1016/j.lanhl.2024.100667","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100667"},"PeriodicalIF":13.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Midlife matters: metabolic syndrome and the risk of dementia.","authors":"Michal Schnaider Beeri, Yian Gu","doi":"10.1016/j.lanhl.2024.100659","DOIUrl":"https://doi.org/10.1016/j.lanhl.2024.100659","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100659"},"PeriodicalIF":13.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of age and exposure duration in the association between metabolic syndrome and risk of incident dementia: a prospective cohort study.","authors":"Danial Qureshi, Robert Luben, Shabina Hayat, Robert Talarico, Naomi E Allen, Elżbieta Kuźma, Thomas J Littlejohns","doi":"10.1016/j.lanhl.2024.100652","DOIUrl":"https://doi.org/10.1016/j.lanhl.2024.100652","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Metabolic syndrome could be a modifiable risk factor for dementia. However, the effects of age and duration of exposure to metabolic syndrome on dementia risk remains underexplored. The aim of this study was to determine whether the association between metabolic syndrome and risk of dementia differs across mid-life versus late-life, and to explore how duration of metabolic syndrome affects this risk.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted a population-based prospective study using data from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) cohort. Metabolic syndrome was defined as having at least three of the following: elevated waist circumference, triglycerides, blood pressure, or glycated haemoglobin, or reduced HDL cholesterol. Incident all-cause dementia was ascertained through hospital inpatient, death, and mental health-care records. In full-cohort analyses, we studied 20 150 adults without dementia aged 50-79 years who attended baseline assessments. Cox proportional hazards models were used to estimate the association between metabolic syndrome and dementia in the full sample, and in mid-life (50-59 years and 60-69 years) and late-life (70-79 years). To assess duration of metabolic syndrome, group-based trajectory analysis was performed on 12 756 participants who attended at least two health assessments over 20 years.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Findings: &lt;/strong&gt;The mean age of participants was 62·6 years (SD 7·5), and 10 857 (54%) were female. Over 25 years of follow-up (mean 18·8 years [SD 6·3]), 2653 (13%) participants developed dementia. In the full cohort, metabolic syndrome was associated with an increased risk of dementia (hazard ratio 1·11, 95% CI 1·01-1·21). In age-specific analyses, the association was similar for participants in late mid-life (age 60-69 years: 1·21, 1·05-1·39) and, although non-significant, in early mid-life (age 50-59 years: 1·12, 0·87-1·43), but attenuated for participants in late-life (age 70-79 years: 0·96, 0·81-1·14). A linear trend was observed between the number of metabolic syndrome components and dementia risk in those aged 60-69 years (p&lt;sub&gt;trend&lt;/sub&gt;=0·0040), but not in other age groups. In trajectory analysis, a prolonged duration of metabolic syndrome was associated with a significantly increased risk of developing dementia (1·26, 1·13-1·40) when compared to those with consistently low metabolic syndrome. No association was found for increasing metabolic syndrome (1·01, 0·88-1·17).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Interpretation: &lt;/strong&gt;These findings provide insights into how certain age windows and time periods might differentially affect dementia risk in the context of metabolic syndrome, and highlight the importance of considering age and duration of exposure to metabolic syndrome when devising dementia prevention strategies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Funding: &lt;/strong&gt;Canadian Institutes of Health Research-Institute of Aging, Oxford Population Health, and the Nicolaus","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100652"},"PeriodicalIF":13.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of oral health on functional disability and mortality in older adults in Japan: a cohort study","authors":"Takafumi Abe PhD ,&nbsp;Kazumichi Tominaga DDS ,&nbsp;Hisaaki Saito DDS ,&nbsp;Jun Shimizu PhD ,&nbsp;Norikuni Maeda DDS ,&nbsp;Ryouji Matsuura PhD ,&nbsp;Yukio Inoue DDS ,&nbsp;Yuichi Ando PhD ,&nbsp;Yuhei Matsuda PhD ,&nbsp;Takahiro Kanno PhD ,&nbsp;Shozo Yano PhD ,&nbsp;Minoru Isomura PhD","doi":"10.1016/j.lanhl.2024.08.005","DOIUrl":"10.1016/j.lanhl.2024.08.005","url":null,"abstract":"<div><h3>Background</h3><div>Oral health has previously shown associations with functional disability and mortality. We aimed to explore the associations of various aspects of oral health status with functional disability and mortality using survival analysis, as well as the relative magnitudes of the impact of these aspects on outcomes.</div></div><div><h3>Methods</h3><div>We obtained data for individuals aged 75 years and older in Shimane, Japan, who had at least one oral health check-up between April 1, 2016, and March 31, 2022 under Japan’s long-life medical care system insurance system. Those with missing data or with functional disability at baseline were excluded. 13 aspects of oral health status were assessed by dentists or dental hygienists as part of the check-up (using protocols provided by the Japan Dental Association and the Japanese Ministry of Health, Labour and Welfare): number of remaining teeth, subjective masticatory performance, objective masticatory performance, periodontal tissue status, functional dysphagia, tongue mobility, articulation, oral hygiene, number of decayed teeth, inadaptation of dentures of the upper jaw and lower jaw (considered separately), oral mucosal disease, and dry mouth. Multivariate Cox proportional hazards models were used to analyse the associations between each aspect of oral health and functional disability and mortality, with fully adjusted models adjusting for sex, age, BMI, medical history, or a propensity score derived from these covariates. Population-attributable fractions (PAFs) were calculated to assess the differential impacts of these oral health status aspects on outcome occurrence.</div></div><div><h3>Findings</h3><div>Of the 24 619 individuals who had an oral health check-up during the study period, 21 881 individuals were included in the analysis of functional disability (9175 [41·93%] men, 12 706 [58·07%] women, mean age 78·31 years [SD 2·88], mean follow-up 41·43 months [20·80]), and 22 747 individuals in the analysis of mortality (9722 [42·74%] men, 13 025 [57·26%] women, mean age 78·34 years [2·89], mean follow-up 42·63 months [20·58]). All 13 aspects of oral health status showed significant associations with the occurrence of mortality, while functional disability was associated with 11 aspects (excluding oral mucosal disease and dry mouth) in the fully adjusted model. Based on PAFs, of all oral health aspects assessed, objective masticatory performance had the greatest impact on both functional disability (PAF 23·10% [95% CI 20·42–25·69] for the lowest and 10·62% [8·18–12·99] for the second-lowest quartile of performance) and mortality (16·47% [13·44–19·40] and 8·90% [5·87–11·82]).</div></div><div><h3>Interpretation</h3><div>Various aspects of oral health are associated with mortality and functional disability. Maintaining good oral health in older adults might help to reduce these outcomes.</div></div><div><h3>Funding</h3><div>None.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 11","pages":"Article 100636"},"PeriodicalIF":13.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating immunisation into a global strategy for healthy ageing","authors":"Anna Odone ,&nbsp;Giacomo Pietro Vigezzi","doi":"10.1016/j.lanhl.2024.100654","DOIUrl":"10.1016/j.lanhl.2024.100654","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 11","pages":"Article 100654"},"PeriodicalIF":13.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caring for our invisible older carers","authors":"The Lancet Healthy Longevity","doi":"10.1016/j.lanhl.2024.100662","DOIUrl":"10.1016/j.lanhl.2024.100662","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 11","pages":"Article 100662"},"PeriodicalIF":13.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating complex care for older women with HIV: role of geriatrician support","authors":"Luxey Sirisegaram ,&nbsp;Kristina Marie Kokorelias ,&nbsp;Alice Zhabokritsky ,&nbsp;Sharon Walmsley","doi":"10.1016/j.lanhl.2024.100649","DOIUrl":"10.1016/j.lanhl.2024.100649","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"5 11","pages":"Article 100649"},"PeriodicalIF":13.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}