Lancet Healthy Longevity最新文献

{"title":"Mobility as a pillar for healthy ageing.","authors":"The Lancet Healthy Longevity","doi":"10.1016/j.lanhl.2026.100858","DOIUrl":"https://doi.org/10.1016/j.lanhl.2026.100858","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100858"},"PeriodicalIF":14.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The crucial role of normative ageing in respiratory pathogenesis.","authors":"Caroline M Weight, Amanda L Tatler, Robert T R Huckstepp, Ian M Adcock, Peter J Barnes, Edwin J R van Beek, Gary Christopher, Rachel L Clifford, Devesh J Dhasmana, Simon P Hart, Arshad Hashmat, Simon Noble, Ian Sayers, Emma Short, Rebecca Stinson, Stuart R G Calimport, Barry L Bentley","doi":"10.1016/j.lanhl.2026.100842","DOIUrl":"https://doi.org/10.1016/j.lanhl.2026.100842","url":null,"abstract":"<p><p>Although breathing seems like a simple action, many individuals encounter difficulties under ever-changing and complex circumstances, which can become increasingly problematic as the individuals age. In this Review, we comprehensively assess the ageing respiratory system. We begin with the physiological structural changes and their effect on lung function associated with ageing, before exploring the genetic and molecular factors that contribute to the loss of respiratory function with age. Defining how biological ageing manifests in the respiratory system and understanding disease-driven hallmarks of accelerated ageing conditions will enable the development of interventions to improve health across age groups, which will be crucial to address population health challenges over the coming decades.</p>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100842"},"PeriodicalIF":14.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights of the SIOG Annual Conference 2025","authors":"Aimee Ramgolam","doi":"10.1016/j.lanhl.2026.100822","DOIUrl":"10.1016/j.lanhl.2026.100822","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 3","pages":"Article 100822"},"PeriodicalIF":14.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146198037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of safeguarding hydration for healthy ageing","authors":"The Lancet Healthy Longevity","doi":"10.1016/j.lanhl.2026.100846","DOIUrl":"10.1016/j.lanhl.2026.100846","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 3","pages":"Article 100846"},"PeriodicalIF":14.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines and tools to assess appropriateness of diuretic prescribing and aid deprescribing: a systematic review","authors":"Sofie Jansen PhD ,&nbsp;Jim S van Hees MD ,&nbsp;George Soulis PhD ,&nbsp;Joost Daams MSc ,&nbsp;Marieke J Henstra PhD ,&nbsp;Prof Nathalie van der Velde MD ,&nbsp;Eveline Petra van Poelgeest PhD","doi":"10.1016/j.lanhl.2026.100828","DOIUrl":"10.1016/j.lanhl.2026.100828","url":null,"abstract":"<div><div>Diuretics are widely used as first-line therapy for heart failure and hypertension in older adults, but long-term continuation without a clear indication can increase adverse drug events such as electrolyte disturbances, renal dysfunction, hypotension, syncope, falls, and reduced quality of life—especially in people with multimorbidity, frailty, and polypharmacy. In this systematic review of international clinical practice guidelines and expert tools published up to August, 2025, we identified 41 resources (14 guidelines, 27 tools) and synthesised 184 unique recommendations on inappropriate chronic diuretic use and deprescribing. We searched Ovid MEDLINE and Embase using predefined concepts for heart failure, hypertension, clinical practice guidelines, and deprescribing. We included English-language guidelines and deprescribing tools for adults published after October, 2013, that addressed inappropriate chronic diuretic use or deprescribing. Deprescribing guidance was comparatively sparse and most often framed as prompts to consider stopping rather than practical how-to pathways. Only 16 recommendations offered actionable support (eg, stepwise tapering or discontinuation, monitoring and safety-netting, or usable algorithms or flowcharts). Consolidated, implementation-ready deprescribing guidance is urgently needed to support safer long-term diuretic management and shared decision making.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 3","pages":"Article 100828"},"PeriodicalIF":14.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of frailty and comorbidities in severe infections and the risk of dementia: a prospective, multicohort, observational study","authors":"Pyry N Sipilä MD ,&nbsp;Jaana Pentti MSc ,&nbsp;Philipp Frank PhD ,&nbsp;Michael R Duggan PhD ,&nbsp;Keenan A Walker PhD ,&nbsp;Prof Timo E Strandberg MD ,&nbsp;Joni V Lindbohm MD ,&nbsp;Prof Mika Kivimäki FMedSci","doi":"10.1016/j.lanhl.2026.100826","DOIUrl":"10.1016/j.lanhl.2026.100826","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Severe infections have been linked to an increased risk of dementia, but whether this association reflects pre-existing conditions that predispose individuals to infections and dementia remains unclear. We assessed whether the association between severe infections and dementia risk is explained by pre-existing frailty, comorbidities, or other age-related physical diseases.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This prospective, multicohort, observational study included participants without severe infections or dementia (between Dec 19, 2006, and Oct 1, 2010, from the UK Biobank study and between Oct 8, 2002, and Nov 30, 2004, from the Whitehall II prospective cohort study). The primary analysis was conducted in the UK Biobank cohort. Frailty was assessed at baseline using the widely used phenotypic Fried Frailty Scale and comorbidities were assessed using the Charlson Comorbidity Index and 78 age-related diseases. Incident severe (hospital-treated) infections were identified from linked hospital discharge diagnoses. Follow-up included a 5-year exposure period from baseline, a 2-year washout period; and a final period extending to the end of follow-up. Incident dementia occurring after the exposure and washout periods was ascertained from hospital records and death certificates until 2022 (Oct 31 in England, Sept 30 in Scotland, and May 31 in Wales). Participants with a record of dementia during the exposure period or subsequent washout period were excluded. We repeated the main analyses in the Whitehall II study and conducted several supplementary analyses with follow-up until March 1, 2023.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;We included 449 223 participants without severe infection or dementia from the UK Biobank study and 6106 from the Whitehall II study. Most participants were White (424 405 [94·5%] in UK Biobank and 5616 [92·0%] in the Whitehall II study). In UK Biobank, the mean age of participants was 56·5 years (SD 8·1), of whom 245 139 (54·6%) were female and 204 084 (45·4%) were male. Of 435 957 participants with dementia follow-up, 23 860 (5·5%) had a record of severe infection during the 5-year exposure period. After a 2-year washout period, the remaining follow-up for dementia occurred for a mean of 6·5 years (SD 1·2). 6756 participants developed incident dementia, corresponding to an incidence of 2·37 (95% CI 2·31–2·43) per 1000 person-years. Adjustment for frailty resulted in no statistically significant attenuation of the infection and dementia association (adjusted hazard ratio [HR] 1·54 [95% CI 1·43–1·67] for presence &lt;em&gt;vs&lt;/em&gt; absence of severe infections before adjustment for frailty and 1·49 [1·37–1·61] after adjustment). The association was also evident within a subgroup of non-frail participants (1·34 [1·18–1·53]). Pre-frail and frail participants had a higher corresponding adjusted HR (1·62 [1·47–1·79]). In the Whitehall II study, the mean age of participants was 60·6 years (SD 6·0), of whom","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 3","pages":"Article 100826"},"PeriodicalIF":14.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended use of point-of-care technology by acute community nurses during in-home assessment of older adults with potential acute respiratory conditions: a parallel-group, open-label, randomised controlled trial","authors":"Siri Aas Smedemark PhD ,&nbsp;Dorte Ejg Jarbøl PhD ,&nbsp;Christian B Laursen PhD ,&nbsp;Jørgen T Lauridsen PhD ,&nbsp;Flemming S. Rosenvinge MD ,&nbsp;Karen Andersen-Ranberg PhD","doi":"10.1016/j.lanhl.2026.100830","DOIUrl":"10.1016/j.lanhl.2026.100830","url":null,"abstract":"<div><h3>Background</h3><div>Diagnosing acute respiratory conditions in adults older than 65 years is challenging due to age-related physiological changes, which increase diagnostic complexity and the risk of hospital admission. We investigated whether extended point-of-care technology (POCT), used at home by acute community nurses, reduced hospital admissions in older adults.</div></div><div><h3>Methods</h3><div>In this parallel-group, open-label, randomised controlled trial, conducted in a primary care setting in Denmark, adults aged 65 years and older with potential respiratory symptoms were randomly assigned (1:1) using computer-generated allocation, with blocked randomisation (variable block sizes of two, four, and six) stratified by gender, to standard nurse-led care (clinical assessment, vital signs, and C-reactive protein and haemoglobin) or standard nurse-led care with extended POCT (additional blood tests, focused lung ultrasound, and tele-ultrasound). Participants and clinicians were not masked to assignment. The primary outcome was hospital admission within 30 days. Mortality was assessed as a prespecified safety outcome. Analyses were done on an intention-to-treat basis. The trial is registered with <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>, <span><span>NCT05546073</span><svg><path></path></svg></span>.</div></div><div><h3>Findings</h3><div>Between Oct 14, 2022, and Nov 18, 2023, 623 participants were randomly assigned. 313 (50%) of 623 participants were assigned usual care and 310 (50%) were assigned the intervention. No difference was observed in hospital admissions within 30 days (112 [38%] participants in the usual care group <em>vs</em> 119 [40%] participants in the intervention group; risk ratio [RR] 1·06, 95% CI 0·86–1·30). 30-day mortality was lower in the intervention group (25 [8%] deaths in the usual care group <em>vs</em> 11 [4%] deaths in the intervention group; RR 0·44, 95% CI 0·22–0·88). No intervention-related harms were observed.</div></div><div><h3>Interpretation</h3><div>Compared with standard nurse-led community care including basic POCT, extended POCT did not reduce hospital admissions among older adults with potential acute respiratory conditions. These findings suggest that the added value of extended diagnostic technology in community-based acute care might have little impact on admission decisions and warrant further evaluation focusing on clinical decision making and patient trajectories.</div></div><div><h3>Funding</h3><div>Region of Southern Denmark, Karen Elise Jensen Foundation, AP Moeller Foundation, Hartmann Foundation, Gangsted Foundation, and Odense University Hospital Innovation Foundation.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 3","pages":"Article 100830"},"PeriodicalIF":14.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From blueprint to budget: health economics as the compass for China’s National Dementia Action Plan","authors":"Yao Yao ,&nbsp;Qi Qin ,&nbsp;Yi Tang","doi":"10.1016/j.lanhl.2026.100836","DOIUrl":"10.1016/j.lanhl.2026.100836","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 3","pages":"Article 100836"},"PeriodicalIF":14.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe infections consistently linked to dementia?","authors":"Janet Janbek","doi":"10.1016/j.lanhl.2026.100839","DOIUrl":"10.1016/j.lanhl.2026.100839","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 3","pages":"Article 100839"},"PeriodicalIF":14.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Lancet Healthy Longevity 2025; 6: 100749","authors":"","doi":"10.1016/j.lanhl.2026.100825","DOIUrl":"10.1016/j.lanhl.2026.100825","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 3","pages":"Article 100825"},"PeriodicalIF":14.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147533145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}