Lancet Healthy Longevity最新文献

{"title":"Addressing the growing burden of musculoskeletal diseases in the ageing US population: challenges and innovations","authors":"Andrew Nguyen BS ,&nbsp;Philip Lee BS ,&nbsp;Edward K Rodriguez MD, PhD ,&nbsp;Karen Chahal MD ,&nbsp;Benjamin R Freedman PhD ,&nbsp;Ara Nazarian PhD","doi":"10.1016/j.lanhl.2025.100707","DOIUrl":"10.1016/j.lanhl.2025.100707","url":null,"abstract":"<div><div>The prevalence of musculoskeletal diseases such as osteoarthritis, osteoporosis, sarcopenia, and rheumatoid arthritis is rising sharply with global ageing, increasing disability rates among older adults (aged ≥60 years), diminishing quality of life, and burdening health-care systems. Current musculoskeletal care for older adults faces multiple limitations, including comorbidities, frailty, and fragmented care. High osteoarthritis prevalence in individuals older than 55 years, the mounting economic burden of osteoporotic fractures, the growing concern of muscle mass decline, and insufficient guideline implementation collectively underscore these challenges. In the USA, musculoskeletal diseases affect over 121 million people and account for the highest rate of disability among all disease groups, underscoring the need for targeted strategies. Although promising solutions encompassing advanced pharmacological therapies, regenerative medicine, and digital health technologies (including artificial intelligence) are available, they remain underutilised in existing care models. This Personal View discusses the need for personalised, multidisciplinary approaches to address these issues, advocating for collaboration among the orthopaedic, geriatric, and health-care sectors in the USA. We propose that prevention of musculoskeletal diseases is key to its effective management in ageing populations, alongside a holistic, scalable approach that integrates diagnostics, therapy, and telemedicine. Early intervention, interdisciplinary collaboration, and personalised care are essential to improving patient outcomes and addressing the growing musculoskeletal disease burden in the USA.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 5","pages":"Article 100707"},"PeriodicalIF":13.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"War-related trauma and displacement in Gaza: the impact on the health and longevity of older adults","authors":"Bilal Irfan ,&nbsp;Abdulwhhab Abu Alamrain ,&nbsp;Abdallah Abu Shammala","doi":"10.1016/j.lanhl.2025.100713","DOIUrl":"10.1016/j.lanhl.2025.100713","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 5","pages":"Article 100713"},"PeriodicalIF":13.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Area-level socioeconomic inequalities in activities of daily living disability-free life expectancy in England: a modelling study","authors":"Laurie E Davies PhD ,&nbsp;David R Sinclair PhD ,&nbsp;Prof Christopher Todd PhD ,&nbsp;Prof Barbara Hanratty MD ,&nbsp;Prof Fiona E Matthews PhD ,&nbsp;Andrew Kingston PhD","doi":"10.1016/j.lanhl.2025.100700","DOIUrl":"10.1016/j.lanhl.2025.100700","url":null,"abstract":"<div><h3>Background</h3><div>More evidence of socioeconomic inequalities in disability-free life expectancy (DFLE) is needed to help develop approaches to narrow the gap between the most and least socioeconomically deprived people. Activities of daily living (ADL) disability represents the most severe and expensive disablement stage. Using combined longitudinal data, we aimed to quantify area-level socioeconomic inequalities in ADL-DFLE and the total person-years lived with ADL disability, in older men and women in England.</div></div><div><h3>Methods</h3><div>In this modelling study, we harmonised data on ADL disability, area deprivation, age, and self-reported gender for individuals aged 50 years or older from three longitudinal studies in England: the English Longitudinal Study of Ageing (n=11 337), the Cognitive Function and Ageing Study II (n=7469), and the Newcastle 85+ Study (n=847). We used multistate modelling, and calculated the remaining life expectancy with and without ADL disability by gender and area-level socioeconomic status (&lt;20%, 20–80%, and &gt;80% of Index of Multiple Deprivation). From these data and Office for National Statistics population figures for the year 2024, we estimated the extra person-years lived with ADL disability by those aged 65 years from the most socioeconomically deprived areas.</div></div><div><h3>Findings</h3><div>Those living in the least deprived areas had a reduced risk of ADL disability compared with those in the most deprived areas (hazard ratio [HR] 0·61 [95% CI 0·55–0·69]; p&lt;0·0001), as did those in the middle area-level socioeconomic group (HR 0·76 [0·69–0·84]; p&lt;0·0001). Increasing area-level socioeconomic disadvantage was associated with reduced life expectancy and more time spent with ADL disability, particularly for women. Living in the most disadvantaged areas was associated with people having ADL disability 11·0 years earlier for men and 12·0 years earlier for women, compared with living in the least deprived areas. An extra 59 000 person-years for men and 88 000 person-years for women were lived with ADL disability by those in the most deprived areas, at the population level, compared with the least deprived areas.</div></div><div><h3>Interpretation</h3><div>Targeted policies to address underlying socioeconomic inequalities in health are likely to be the long-term definitive solution.</div></div><div><h3>Funding</h3><div>National Institute for Health and Care Research Policy Research Unit in Healthy Ageing.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 4","pages":"Article 100700"},"PeriodicalIF":13.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of China’s Integrated Medical and Social Care Policy on functional dependency and care deficits in older adults: a nationwide quasi-experimental study","authors":"Wenjian Zhou PhD ,&nbsp;Muqi Guo PhD ,&nbsp;Bo Hu PhD ,&nbsp;Yuling Jiang MSc ,&nbsp;Yao Yao MD","doi":"10.1016/j.lanhl.2025.100697","DOIUrl":"10.1016/j.lanhl.2025.100697","url":null,"abstract":"<div><h3>Background</h3><div>With population ageing, the development and implementation of pragmatic care strategies for older people with functional dependencies have become critical issues. In alliance with WHO’s Integrated Care for Older People framework, China implemented the Integrated Medical and Social Care Policy (IMSCP) in several cities in 2016. This study aims to evaluate whether and to what extent the IMSCP has achieved its primary objectives of reducing functional dependency and addressing care needs in Chinese older adults aged 65 years and older.</div></div><div><h3>Methods</h3><div>The IMSCP was initiated in 2016 in several pilot cities from various provinces. We did a quasi-experimental study with a difference-in-differences analysis by using the data collected in the 2014 and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey. Participants from pilot cities constituted the intervention group, whereas participants from non-pilot cities were assigned into the control group. Functional dependency was measured based on activities of daily living and instrumental activities of daily living. Care deficits were recorded for those who were functionally dependent, and for whom care needs were unmet. We used fixed-effects models to examine between-group differences in functional dependency and care deficits.</div></div><div><h3>Findings</h3><div>3080 individuals who participated in both the 2014 and 2018 surveys were included (mean age 81·7 years [SD 9·1] in 2014; 1621 [52·6%] were female and 1459 [47·4%] were male). Of these, 1146 (37·2%) were in the intervention group and 1934 (62·8%) were in the control group. Implementing the IMSCP was associated with a reduced risk of functional dependency (odds ratio [OR] 0·72 [95% CI 0·58–0·89], p=0·0024). Among those who were functionally dependent, the IMSCP was also associated with less care deficits (0·62 [0·41–0·95], p=0·029). We also examined the relatively long-term impact of the IMSCP with duration from 2014 to 2021; the influence of the IMSCP on mitigating functional dependency remained in male participants (OR 0·45 [95% CI 0·23–0·87], p=0·017) but not in female participants (0·85 [0·52–1·39], p=0·524); while its association with bridging care deficits remained among the total participants.</div></div><div><h3>Interpretation</h3><div>Implementing integrated medical and social care policy could reduce the risk of both functional dependency in older adults and care deficits in those who need care. These findings support the continued and expanded implementation of the IMSCP to address the growing care needs of China’s ageing population.</div></div><div><h3>Funding</h3><div>National Natural Science Foundation of China, National Key Research and Development Project of China, and National Science and Technology Major Project of China.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 4","pages":"Article 100697"},"PeriodicalIF":13.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined mind–body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment in primary care: a three-arm randomised controlled trial","authors":"Zijun Xu PhD ,&nbsp;Dexing Zhang PhD ,&nbsp;Benjamin Hon-Kei Yip PhD ,&nbsp;Eric Kam-Pui Lee MSc ,&nbsp;Paul Kwok-Ming Poon MBChB ,&nbsp;Ruth Peters PhD ,&nbsp;Zuyao Yang PhD ,&nbsp;Allen Ting-Chun Lee MD ,&nbsp;Maria Kwan-Wa Leung MFM Clin ,&nbsp;Eliza Lai-Yi Wong PhD ,&nbsp;Vincent Chung-Tong Mok MD ,&nbsp;Linda Chiu-Wa Lam MD ,&nbsp;Samuel Yeung-Shan Wong MD","doi":"10.1016/j.lanhl.2025.100706","DOIUrl":"10.1016/j.lanhl.2025.100706","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Mild cognitive impairment is a cognitive state that is worse than that of healthy older adults but less severe than dementia. The effectiveness of a nurse-led risk factor modification (RFM) intervention for older adults with mild cognitive impairment is unclear. The study aimed to compare the effects of: (1) a multi-component intervention: combined cognitive training, mind–body physical exercise, and nurse-led RFM (CPR), (2) nurse-led RFM alone, and (3) health advice alone on cognitive function among older adults with mild cognitive impairment in primary care.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We did a 15-month, three-arm, open-label, blinded-endpoint, randomised controlled trial in older adults with mild cognitive impairment at a university-affiliated research and training clinic of the Lek Yuen Health Centre in Hong Kong. Inclusion criteria were age 60–80 years, a Hong Kong Montreal Cognitive Assessment score of 19–25 (defined as mild cognitive impairment), and a physically stable condition. Participants were randomly assigned (1:1:1) via computer-generated allocation sequencing to receive either CPR, RFM, or health advice. Assessors and data analysts were masked to group allocation. Participants randomly assigned to the CPR and RFM groups met the nurse quarterly and the primary care physician every 6 months. The CPR group also received Tai Chi and cognitive training three times a week for 3 months. The health advice group received booklets with general health advice. Assessments were conducted at baseline, 6 months, 12 months, and 15 months. The primary outcome was the Alzheimer’s Disease Assessment Scale-Cognitive section (ADAS-Cog) Z score at 15 months. The analysis followed the modified intention-to-treat principle that included participants completing at least one follow-up assessment. A linear mixed model was used for the analysis, with adjustments for multiple comparisons made using Bonferroni’s correction. The trial was preregistered at the Chinese Clinical Trial Registry (ChiCTR 1900026857), and is completed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;Between Oct 28, 2019, and Dec 1, 2022, 3122 registrations were received, 1104 were excluded (declined to participate, duplicate registrations, or unable to be contacted), and 2018 were assessed for eligibility. A further 1562 participants were excluded, and 456 participants were randomly assigned to an intervention. 152 participants were assigned to the CPR group, 152 to the RFM group, and 152 to the health advice group. 423 participants who completed at least one follow-up assessment were included in the analysis (139 in the CPR group, 144 in the RFM group, and 140 in the health advice group). 118 (28%) participants were male and 305 (72%) were female. The mean age of participants was 70·1 years (SD 4·9). No significant difference between the three groups in ADAS-Cog was found at the primary endpoint at 15 months (CPR &lt;em&gt;vs&lt;/em&gt; health advice, β= –0·04 [95% CI","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 4","pages":"Article 100706"},"PeriodicalIF":13.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in reducing long-term care needs: insights from China","authors":"Pablo Villalobos Dintrans ,&nbsp;Beatrice Fabiani deLeva","doi":"10.1016/j.lanhl.2025.100705","DOIUrl":"10.1016/j.lanhl.2025.100705","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 4","pages":"Article 100705"},"PeriodicalIF":13.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential interactions of community-based acute care teams on the frequency of acute contacts with health-care systems: an interrupted time series analysis","authors":"Stine Emilie Junker Udesen MScPH ,&nbsp;Prof Annmarie Touborg Lassen MD ,&nbsp;Prof Jens Søndergaard MD ,&nbsp;Nina Andersen RN ,&nbsp;Prof Søren Mikkelsen MD ,&nbsp;Søren Bie Bogh PhD","doi":"10.1016/j.lanhl.2025.100694","DOIUrl":"10.1016/j.lanhl.2025.100694","url":null,"abstract":"<div><h3>Background</h3><div>Ageing populations necessitate innovative approaches to health-care services. In 2018, Denmark introduced statutory municipal acute nursing care as part of community-based health care to improve care for adults with complex health needs. We evaluated the potential interactions of the acute care team Odense (ATO) on (1) acute hospital contacts; (2) acute hospital contacts caused by specific infection diagnoses, hypernatraemia, delirium, or confusion; and (3) acute ambulance transports.</div></div><div><h3>Methods</h3><div>In this retrospective, population-based, longitudinal study, we employed interrupted time series analysis to evaluate the association of ATO on adults in Odense Municipality from Jan 1, 2015, to Feb 28, 2019. Subgroup analyses were used to examine the data of people aged 80 years or older, nursing home residents, and people living at home with home or nursing care.</div></div><div><h3>Findings</h3><div>The people treated by ATO were older, had more comorbidities, and were more dependent on municipal health care than the average population. The implementation of ATO was not statistically significantly associated with the monthly rate of acute hospital contacts but associated with a substantial reduction of the monthly rates of acute hospital contacts caused by specific infection diagnoses, hypernatraemia, delirium, or confusion (−2·8 [95% CI −5·5 to −0·1]), and acute ambulance transports (−9·5 [−16·2 to −2·9]). For nursing home residents, the monthly rates decreased for acute hospital contacts caused by specific infection diagnoses, hypernatraemia, delirium, or confusion (−0·8 [−1·7 to 0·0]), and acute ambulance transports (−2·1 [−3·7 to −0·4]). Among those aged 80 years or older, acute ambulance transports decreased monthly (−3·8 [−6·6 to −0·9]).</div></div><div><h3>Interpretation</h3><div>This framework shows potential in minimising transitions between sectors, particularly in the context of acute ambulance transports and acute hospital contacts caused by specific infection diagnoses, hypernatraemia, delirium, or confusion. These findings could offer valuable insights for policy makers on the role of municipal acute nursing care. According to acute hospital contacts, a proportion of numbers might fall beyond the scope of what this framework can prevent, making it valuable to focus on specific groups.</div></div><div><h3>Funding</h3><div>Østifterne, Region of Southern Denmark, Odense University Hospital, and Odense Municipality.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 4","pages":"Article 100694"},"PeriodicalIF":13.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunisation: reaching older adults","authors":"The Lancet Healthy Longevity","doi":"10.1016/j.lanhl.2025.100714","DOIUrl":"10.1016/j.lanhl.2025.100714","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 4","pages":"Article 100714"},"PeriodicalIF":13.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of acute care trajectories for older people: impact of a community-based acute care team","authors":"Lone Winther Lietzen ,&nbsp;Thomas Johannesson Hjelholt","doi":"10.1016/j.lanhl.2025.100704","DOIUrl":"10.1016/j.lanhl.2025.100704","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 4","pages":"Article 100704"},"PeriodicalIF":13.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Lancet Healthy Longev 2025; 6: 100689","authors":"","doi":"10.1016/j.lanhl.2025.100712","DOIUrl":"10.1016/j.lanhl.2025.100712","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 4","pages":"Article 100712"},"PeriodicalIF":13.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}