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The new international multidisciplinary histological classification of lung adenocarcinoma and clinical implications for Indian physicians 新的国际多学科肺腺癌组织学分类及其对印度医生的临床意义
Biomedical Research Journal Pub Date : 2014-01-01 DOI: 10.4103/2349-3666.240661
K. Kadota, Ming-Ching Lee, P. Adusumilli
{"title":"The new international multidisciplinary histological classification of lung adenocarcinoma and clinical implications for Indian physicians","authors":"K. Kadota, Ming-Ching Lee, P. Adusumilli","doi":"10.4103/2349-3666.240661","DOIUrl":"https://doi.org/10.4103/2349-3666.240661","url":null,"abstract":"In 2011, a new histologic classification of lung adenocarcinomas (IASLC/ATS/ERS) was proposed based on the recommendations of an international and multidisciplinary panel that included thoracic medical oncologists, pulmonologists, radiologists, molecular biologists, thoracic surgeons and pathologists. This classification proposed a comprehensive histologic subtyping (lepidic, acinar, papillary, micropapillary and solid pattern) and a semi-quantitative assessment of histologic patterns (in 5% increments) in an effort to choose a single, predominant pattern. The prognostic value of this classification has been validated in large, independent cohorts from multiple countries. Patients with adenocarcinomas in situ and minimally invasive adenocarcinomas experienced no recurrence. Patients with micropapillary or solid predominant tumors would be classified as high risk for recurrence or cancer-related death. Patients with acinar and papillary predominant tumors might be classified as an intermediate-risk group, but further investigation is needed for papillary subtype. This classification, coupled with additional prognostic factors (nuclear grade, cribriform pattern, high Ki-67 labeling index, TTF-1 negativity, immune markers and SUVmax on FDG-PET), which we have published on extensively, could further stratify patients into prognostic subgroups that may help with clinical management. This new classification for the most common type of lung cancer is important for oncologists practicing in India, as its implementation would require only hematoxylin and eosin (H&E) histology slides, the most common type of stain used at hospitals. It can be implemented with basic pathologist training and no additional costs. Furthermore, implementation and analyses would identify if this classification is valid for Indian patients or a specific modification is required.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":"14 1","pages":"6 - 22"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84641945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of proliferation by gonadotropin-releasing hormone receptors in breast cancer cells 促性腺激素释放激素受体对乳腺癌细胞增殖的调节
Biomedical Research Journal Pub Date : 2014-01-01 DOI: 10.4103/2349-3666.240662
Sunil Gangadharan, A. Karande
{"title":"Modulation of proliferation by gonadotropin-releasing hormone receptors in breast cancer cells","authors":"Sunil Gangadharan, A. Karande","doi":"10.4103/2349-3666.240662","DOIUrl":"https://doi.org/10.4103/2349-3666.240662","url":null,"abstract":"Gonadotropin-releasing hormone (GnRH) is secreted from hypothalamic neurons and bind to receptors on gonadotrope cells of the pituitary gland, which then synthesize and release luteinizing hormone and follicle-stimulating hormone that regulate gonadal development. The presence of GnRH receptors and the effects of synthetic analogs of GnRH at extrapituitary sites is less clear. Several reports suggest that GnRH/analogues through cognate receptors may regulate mitogenic responses in cancer cells in an autocrine or paracrine manner. However, the inherent intracellular signaling pathways triggered are unknown. Using a highly specific antibody to human GnRH receptor we show that T47D breast cancer cells express GnRH receptors on their surface and that a GnRH analogue Cetrorelix inhibits proliferation of these cells, possibly via inhibition of processes that trigger cAMP formation.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":"23 1","pages":"71 - 85"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80076202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Stem cells and extra cellular matrices: Applications in tissue engineering 干细胞和细胞外基质:在组织工程中的应用
Biomedical Research Journal Pub Date : 2014-01-01 DOI: 10.4103/2349-3666.241004
M. Kanitkar, V. Kale
{"title":"Stem cells and extra cellular matrices: Applications in tissue engineering","authors":"M. Kanitkar, V. Kale","doi":"10.4103/2349-3666.241004","DOIUrl":"https://doi.org/10.4103/2349-3666.241004","url":null,"abstract":"The ability to artificially simulate the ‘mechanical’ niche, broadly termed as Extracellular Matrix (ECM), of the bone marrow determines success for stem cell growth, architectural organization and differentiation viz. tissue engineering. The advent of various natural and synthetic polymers has greatly influenced tissue engineering. The focus of the review is on various artificial niche simulations, ECM, scaffolds such as hydrogels, electrospun nano and micro fibers, bone-strengthening scaffolds and tissue infills. The utility of the ECMs in the treatment of various medical conditions including bone and cartilage tissues, nervous tissues, spinal cord and tendon tissues as well as wound healing, along with the ability of some ECMs in entrapment of elusive cell secretomes will be discussed. The future of tissue engineering has indeed got a new lease of life with polymer scaffolds and it is feasible that certain goals, thought of impossible so far, may become possible.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":"363 1","pages":"95 - 107"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82993154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cultivation and cryopreservation of cord tissue MSCs with Cord Blood AB Plasma 脐带血AB血浆培养及超低温保存脐带血MSCs
Biomedical Research Journal Pub Date : 2014-01-01 DOI: 10.4103/2349-3666.240999
Manasi Taiwadekarr, D. Kadekar, Sonal Rangole, Nikhat Khan, V. Kale, L. Limaye
{"title":"Cultivation and cryopreservation of cord tissue MSCs with Cord Blood AB Plasma","authors":"Manasi Taiwadekarr, D. Kadekar, Sonal Rangole, Nikhat Khan, V. Kale, L. Limaye","doi":"10.4103/2349-3666.240999","DOIUrl":"https://doi.org/10.4103/2349-3666.240999","url":null,"abstract":"Neonatal tissues, cord and placenta, are explored as alternate sources of mesenchymal stem cells (MSCs) for their therapeutic applications. Conventionally, MSCs isolated from cord tissues are maintained and propagated in FBS containing medium for promotion of growth and survival of cells. However, for therapeutic use, FBS use is not encouraged as it is of animal origin. Thus, there is a need for replacement of FBS by equally potent and clinically acceptable cost effective sources. The current study is designed to compare the effect of cord blood plasma (CBP) with MSC qualified FBS (M FBS) during culture and cryopreservation of MSCs. MSCs were isolated from cord and placenta and propagated in either M FBS or CBP. The efficiency of the cultures was analyzed by growth curve, morphology, phenotype and functionality. The cryo-protective role of the CBP was evaluated by using it in freezing medium of MSCs. Our data showed that CBP is equivalent to M FBS for culturing placental MSCs with respect to the phenotype, proliferation rate and differentiation to various lineages. However, cord MSCs displayed slow growth rate and reduction in surface expression of CD105 marker in CBP, whereas, the other parameters were comparable. Freezing of MSCs with CBP resulted in reduction of the late apoptotic and necrotic population. Thus, CBP imparts superior protection against cryogenic insults, and appears to be a valuable substitute to M FBS for cultivation and freezing of MSCs.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":"1 1","pages":"126 - 136"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74948398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Implications of cancer stem cells in radiotherapy current understanding and future perspectives 肿瘤干细胞在放射治疗中的意义，目前的认识和未来的展望
Biomedical Research Journal Pub Date : 2014-01-01 DOI: 10.4103/2349-3666.241000
M. Balla, Amit Kumar, B. Pandey
{"title":"Implications of cancer stem cells in radiotherapy current understanding and future perspectives","authors":"M. Balla, Amit Kumar, B. Pandey","doi":"10.4103/2349-3666.241000","DOIUrl":"https://doi.org/10.4103/2349-3666.241000","url":null,"abstract":"Many theories were put forward about origin of cancer and immense research was carried out to understand the mechanisms involved in the origin and progression of the disease. The gain in scientific knowledge about cancer biology and technical advancement in treatment modalities resulted in improvement of clinical outcome in cancer therapy. However, recurrence and metastasis after therapy poses a major concern to clinicians. Resistant nature against therapeutic modalities and metastatic potential of cancer stem cells (CSCs), which even though form a fraction of tumor mass, result in failure of existing modalities of cancer treatment. The current article reviews the historical background of CSCs, involvement of various signaling pathways in the mechanism(s) of radioresistance and potential targets to be exploited in radiotherapy.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":"22 1","pages":"137 - 145"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84646385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Advances in biotechnology and implications in clinical medicine 生物技术的进展及其对临床医学的影响
Biomedical Research Journal Pub Date : 2014-01-01 DOI: 10.4103/2349-3666.241002
D. Saranath, A. Khanna
{"title":"Advances in biotechnology and implications in clinical medicine","authors":"D. Saranath, A. Khanna","doi":"10.4103/2349-3666.241002","DOIUrl":"https://doi.org/10.4103/2349-3666.241002","url":null,"abstract":"","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":"152 1","pages":"86 - 89"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76464371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next generation sequencing in healthcare 医疗保健领域的下一代测序
Biomedical Research Journal Pub Date : 2014-01-01 DOI: 10.4103/2349-3666.241003
T. Fernández
{"title":"Next generation sequencing in healthcare","authors":"T. Fernández","doi":"10.4103/2349-3666.241003","DOIUrl":"https://doi.org/10.4103/2349-3666.241003","url":null,"abstract":"The year 2013 was an eventful year witnessing revolutionary discoveries in the world of extraordinary medical advances and healthcare technology. We saw a spate of new and promising discoveries ranging from detecting lung cancer with a cough, pancreatic cancer with accurate faster, cheaper paper diagnostics, to the possibility of using the Human Immunodeficiency Virus to treat genetic disorders in children (Radcliffe, 2013). Emerging newer technologies have fuelled the momentum of the ‘genomic revolution’. The completion of sequencing of the human genome project in 2003 (National Human Genome Research Institute, 2010), translated into the rise of the ‘omics’ era creating mega scientific data. It also gave rise to a breed of genomic companies that focused on application of the emerging technologies, particularly in medical science.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":"77 1","pages":"90 - 94"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83231506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanocarrier mediated intracellular delivery of neutralizing antibodies for the management of abrin lethality 纳米载体介导的中和抗体的细胞内递送管理的阿布毒素致命性
Biomedical Research Journal Pub Date : 1900-01-01 DOI: 10.4103/2349-3666.240592
M. Kumar, Ambily Abraham, H. Savithri, A. Karande
{"title":"Nanocarrier mediated intracellular delivery of neutralizing antibodies for the management of abrin lethality","authors":"M. Kumar, Ambily Abraham, H. Savithri, A. Karande","doi":"10.4103/2349-3666.240592","DOIUrl":"https://doi.org/10.4103/2349-3666.240592","url":null,"abstract":"Abrin is a highly lethal ribosome-inactivating protein of high relevance in bio-warfare. Neutralizing antibodies to abrin reported so far afford protection in a very small window with no rescue observed post-abrin exposure. The utility of the most specific mode of defense against abrin poisoning is thus undermined. We proposed that intracellular delivery of antibodies which otherwise lack the ability to enter cells would increase the therapeutic potential. Towards this, we analyzed the use of silica nanoparticles and chimeric Sesbania mosaic virus-like particles in delivering antibodies inside cells. The antibody-nanocarrier conjugate was found to be effective in protecting cells from abrin-mediated toxicity when administered as long as 9 h prior and up to 1 h post abrin exposure. These results highlight the potential of nanocarrier-based intracellular delivery of neutralizing antibodies in widening the therapeutic window for prophylaxis and to some extent post-exposure treatment of abrin poisoning.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":"27 1","pages":"67 - 81"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81121449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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