Biomedical Research Journal最新文献

A case of COVID-19 triggered Rhino-Orbital Pulmonary Mucormycosis in Central India 印度中部一例COVID-19引发的鼻-眶肺毛霉菌病

Biomedical Research Journal Pub Date : 2021-01-01 DOI: 10.4103/bmrj.bmrj_8_21

Chandra Singh Rathore, Shirin Ansari, T. Bajpai

引用次数: 4

Clinical governance in radiologic practice: Evaluating the appropriateness of radiologic investigation considering patient clinical information using the radiology request form 放射学实践中的临床治理:利用放射学申请表考虑患者临床信息，评估放射学调查的适当性

Biomedical Research Journal Pub Date : 2021-01-01 DOI: 10.4103/bmrj.bmrj_19_20

E. Robinson, Olukumni Ijeruh, W. Wonodi, Rufus Abam

{"title":"Clinical governance in radiologic practice: Evaluating the appropriateness of radiologic investigation considering patient clinical information using the radiology request form","authors":"E. Robinson, Olukumni Ijeruh, W. Wonodi, Rufus Abam","doi":"10.4103/bmrj.bmrj_19_20","DOIUrl":"https://doi.org/10.4103/bmrj.bmrj_19_20","url":null,"abstract":"Introduction: Clinical governance in radiology is an improved quality assurance program where the patient well-being is the central focus concerning radiologic service using the radiology request form (RRF). Methodology: The study was a 6-month descriptive study conducted from January 2020 to June 2020. A total of 2053 request forms were collated retrospectively and evaluated to ascertain the appropriateness of the clinical information with the investigation requested. A 3 stage Likert scale of appropriate somewhat appropriate and inappropriate was used and the data analyzed using the statistical package for the social sciences (SPSS) IBM Corp. version 23.0 (Armonk, NY: USA). The results were expressed in percentages and frequencies and presented in tables and charts. Results: Of the 2053 request forms, X-rays constitute 32.54% while ultrasound scans and computed tomography (CT) investigations constitute 43.21% and 5.46%, respectively. Clinical information was indicated in 51.39% of the RRF, out of which 75.95% of the clinical information were adequate while 13.93% were not in keeping with the investigation. Ultrasound scan request had the highest inappropriate clinical information (54.68%) followed by plain radiography request (41.73%) whereas all the CT request was in tandem with the investigation. Conclusion: There are occasional clinical information and radiologic request mismatch. This may be due to the filling of the RRF by medical interns or nonmedical personnel such as allied health workers with less knowledge on radiologic imaging modalities. The audit recommends proper supervision of young clinicians and continues medical education concerning the rational use of imaging modality.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83046989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of different thermal change tests of micro tensile strength behavior bio-composite materials; In vitro study 不同热变化试验对生物复合材料微拉伸强度行为的影响体外研究

Biomedical Research Journal Pub Date : 2021-01-01 DOI: 10.4103/bmrj.bmrj_6_21

E. Yilmaz, R. Sadeler

{"title":"Effect of different thermal change tests of micro tensile strength behavior bio-composite materials; In vitro study","authors":"E. Yilmaz, R. Sadeler","doi":"10.4103/bmrj.bmrj_6_21","DOIUrl":"https://doi.org/10.4103/bmrj.bmrj_6_21","url":null,"abstract":"Background: The thermal changes in environments that composite materials are exposed to has a great effect on fatigue and wear behavior. Aim: Micro-cracks and interfacial deformations occur in the composite material structure because of heating and cooling environments occurring on material surfaces. Considering the environment to which bio-composite materials used in the human body are exposed, it is inevitable that they are exposed to a thermal change cycle environment. Material and Method: In this study, the mechanical behaviors of Silorane, X-Trafil and Valux-Plus bio-composite materials were examined after being exposed to thermal cycles in an artificial mouth environment in the temperature range of minimum 5 °C and maximum 65 °C. Micro-tensile strengths of bio-composite materials after thermal cycle test procedures were determined using a universal micro tensile tester device. In addition, microstructural analyzes of bio-composite materials were evaluated using scanning electron microscopy (SEM). Results: Within the scope of the data obtained as a result of this study, it was concluded that the thermal changes in environments significantly affects the micro-shrinkage behavior of bio-composite materials. Conclusion: The behavior of the matrix structure of the composite material significantly affected the formation of micro cracks.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85711723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The outcomes of fetal cell microchimerism in the mother 母体胎儿细胞微嵌合的结果

Biomedical Research Journal Pub Date : 2021-01-01 DOI: 10.4103/bmrj.bmrj_9_21

A. Alekar

{"title":"The outcomes of fetal cell microchimerism in the mother","authors":"A. Alekar","doi":"10.4103/bmrj.bmrj_9_21","DOIUrl":"https://doi.org/10.4103/bmrj.bmrj_9_21","url":null,"abstract":"The presence of small quantities of genetically heterogeneous cells in an organism is known as microchimerism. Fetal microchimerism is the presence of small quantities of fetal cells in the maternal system during and after pregnancy. Since these cells are semi-allogeneic in the mother's body, they have an impact on the mother's health. Recent studies suggest contradictory outcomes. Some suggest an involvement in autoimmune diseases and cancer. Others suggest involvement in tissue repair and wound healing. Fetal cells have been detected in maternal organs decades after pregnancy. It was found that these cells participate in the healing process post a chronic injury. In other cases, these cells initiate an immune response which may lead to the development of autoimmune diseases. Further, studies show that fetal cells have been discovered in the tumor microenvironment, either aiding in cancer development or eradicating the cancer cells. Here, I review the different outcomes that can occur in the female body because of fetal cell microchimerism. I discuss the presence of fetal cells in maternal organs such as the heart and the central nervous system organs and their involvement in disease development and tissue repair in the mother.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86580702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is three-parent IVF the answer to preventing mitochondrial defects? 三亲体外受精是预防线粒体缺陷的答案吗?

Biomedical Research Journal Pub Date : 2021-01-01 DOI: 10.4103/bmrj.bmrj_10_21

Shloka Shetty

引用次数: 0

An Overview on the Application of Nanodiagnostics in Cancer 纳米诊断技术在癌症中的应用综述

Biomedical Research Journal Pub Date : 2020-02-01 DOI: 10.4103/bmrj.bmrj_14_20

Kavita Gala, Ekta Khattar

{"title":"An Overview on the Application of Nanodiagnostics in Cancer","authors":"Kavita Gala, Ekta Khattar","doi":"10.4103/bmrj.bmrj_14_20","DOIUrl":"https://doi.org/10.4103/bmrj.bmrj_14_20","url":null,"abstract":"In the battle against cancer, timely diagnosis is critical for successful treatment. The major limitation in detecting cancer at early development stages is the unavailability of sensitive and specific detection methods. Nanobiology combines biology with physics and chemistry to generate several new areas such as nanodiagnostics and nanotheranostics. Nanodiagnostics involve the development of new strategies and innovations to enhance the current detection methods in tumor biology. Another important aspect of nanodiagnostics is to improve personalized cancer detection and real-time monitoring of treatments assisted by imaging modalities. Nanotheranostics combines therapy and diagnosis in a single model for cancer detection and treatment thus providing the advantage of targeted drug delivery and fewer side effects to normal tissues. In this review, we have outlined diverse nanoparticle systems for early cancer detection and therapy. A wide variety of nanomaterial-based approaches such as nanobubbles, quantum dots, liposomes, or nanotubes demonstrate huge potential in improving imaging methods to screen and monitor cancer progression. Although a significant amount of contributions have been directed to develop nanodiagnostics systems, they are still at preclinical stage. Thus, it is a dynamic area for research with encouraging development towards the clinical stage.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75595172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remdesivir and Dexamethasone: The Two Eligible Candidate Drugs Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) Infection 瑞德西韦和地塞米松:两种抗严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染的候选药物

Biomedical Research Journal Pub Date : 2020-02-01 DOI: 10.4103/BMRJ.BMRJ_10_20

Y. Sikandar, Ilora Kheya, R. Noor

引用次数: 5

Doctors' Perception of Assisted Death: The Effect of Career Stage 医生对协助死亡的认知:职业阶段的影响

Biomedical Research Journal Pub Date : 2020-02-01 DOI: 10.4103/BMRJ.BMRJ_11_20

Smitha S. Bhat

{"title":"Doctors' Perception of Assisted Death: The Effect of Career Stage","authors":"Smitha S. Bhat","doi":"10.4103/BMRJ.BMRJ_11_20","DOIUrl":"https://doi.org/10.4103/BMRJ.BMRJ_11_20","url":null,"abstract":"Introduction: Doctors' role in care is changing to the extent that their responsibility now includes not only preserving life and its quality but extends to end of life care as well. Patients -are now asking for more autonomy in choosing the how and when of end of life care and processes. Doctors have different opinions regarding these methods of assisted death , and these opinions are determined by various personal and professional factors. Indian literature regarding the influence of career stage on doctors' approach to assisted death is scanty and our project aimed to assess this influence, as well as find the reasons for favouring or not favouing the various modalities of assisted death. Materials and Methods: In this study, a prevalidated, piloted questionnaire regarding the different types of assisted death was administered by the interviewer to professors, associate professors, assistant professors, senior residents and post graduate residents of a medical college. Results: Post graduate residents, senior residents and Assistant professors opined that Legalization of DNR, Physician assisted suicide and euthanasia might be acceptable under certain circumstances. Reasons for favouring assisted death included medical futility and patient suffering. Those who opposed assisted death did so on the grounds of medical ethics and humanity. Conclusion: Junior cadres tended to be more accepting of assisted death than their more senior colleagues.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73215892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Uses of Monoclonal Antibodies for COVID-19 COVID-19单克隆抗体的治疗用途

Biomedical Research Journal Pub Date : 2020-02-01 DOI: 10.4103/bmrj.bmrj_15_20

Tarun Kumar Suvvari

引用次数: 2

Erratum: Molecular Docking Study for Evaluation of Neuroprotective Potential of Sericin against Cerebral Stroke and Exploring Its Biomaterial Properties 对丝胶蛋白抗脑卒中神经保护潜能的分子对接研究及其生物材料特性的探索

Biomedical Research Journal Pub Date : 2020-02-01 DOI: 10.4103/2349-3666.305772

引用次数: 0