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Enablers of gender equitable scientific career progression in Sub-Saharan Africa: Insights from the DELTAS Africa Initiative 撒哈拉以南非洲性别平等科学职业发展的推动者:来自三角洲非洲倡议的见解
AAS Open Research Pub Date : 2021-08-16 DOI: 10.12688/aasopenres.13243.1
M. Liani, I. Nyamongo, J. Pulford, R. Tolhurst
{"title":"Enablers of gender equitable scientific career progression in Sub-Saharan Africa: Insights from the DELTAS Africa Initiative","authors":"M. Liani, I. Nyamongo, J. Pulford, R. Tolhurst","doi":"10.12688/aasopenres.13243.1","DOIUrl":"https://doi.org/10.12688/aasopenres.13243.1","url":null,"abstract":"Background: This paper present findings on current strategies utilised within selected Developing Excellence in Leadership, Training and Science in Africa’ (DELTAS Africa) consortia to promote gender equitable scientific career progression for researchers, as well as participants’ recommendations for change. Findings are drawn from a wider research study nested within this health-based scientific research capacity strengthening initiative that was aimed at gaining an in-depth understanding of the barriers and enablers of gender equitable scientific career progression for researchers in Sub-Saharan Africa.  Methods: We adopted an exploratory qualitative cross-sectional study design. The main method of data collection was in-depth interviews (IDIs) with trainees/research fellows at various career stages affiliated to three purposively selected DELTAS Africa Research Consortia. In addition, key informant interviews (KIIs) with consortia research leaders/directors, co-investigators, and management team were also conducted to corroborate information gathered from the IDIs, and to provide additional insights on the enabling factors/actions and policy processes that were currently in place or proposed to enhance gender equitable career progression. In total, fifty-eight IDIs (32 female and 26 male) and twenty KIIs (4 female and 16 male) were conducted. Interviews were carried out between May and December 2018 in English. Data were analysed inductively based on emergent themes, and aligned to the developed integrated conceptual framework. Results: Three overarching themes were identified. First: micro level efforts - individual coping mechanisms and familial level support. Second: Meso level efforts -existing enabling mechanisms at the institutional level. Third: proposed solutions for positive change towards enhancing gender equitable career progression at micro, meso and macro levels.  Conclusions: These findings have implications for future research capacity strengthening programming, including DELTAS Africa II initiative (2021-2025); they provide valuable insights on potential strategies and actions aiming to narrow gender inequities in scientific career progression in the context of sub-Saharan African research institutions.","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47234174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The body cannot be cheated: sexual practices and modern contraceptive use among street-involved young people in two South West States in Nigeria. 身体不能被欺骗:尼日利亚西南部两个州街头年轻人的性行为和现代避孕措施的使用
AAS Open Research Pub Date : 2021-08-04 eCollection Date: 2021-01-01 DOI: 10.12688/aasopenres.13241.1
Mary O Obiyan, Atinuke O Olaleye, Macellina Y Ijadunola, Morenike O Folayan
{"title":"The body cannot be cheated: sexual practices and modern contraceptive use among street-involved young people in two South West States in Nigeria.","authors":"Mary O Obiyan, Atinuke O Olaleye, Macellina Y Ijadunola, Morenike O Folayan","doi":"10.12688/aasopenres.13241.1","DOIUrl":"10.12688/aasopenres.13241.1","url":null,"abstract":"<p><p><b>Background</b>: Young people aged 10-24 years constitute about one-third of the total population of Nigeria. Street-involved young people (SIYP) face a double burden of living condition instability and lack of adequate parental monitoring. This leaves them vulnerable to poor sexual and reproductive health (SRH) choices and behaviour. Risky sexual behaviour with poor access to SRH information and interventions increases their vulnerability to adverse SRH outcomes. This study explored the use of modern contraceptives and sexual practices among male and female SIYP (10-24 years) in Nigeria. <b>Methods:</b> This qualitative study used an exploratory research design to guide the development of the focus group discussion (FGD) and in-depth interview (IDI) guides. Participants were asked questions on background information, lived experiences and SRH practices. The FGDs were stratified by sex and age. Both FGD discussions and IDI interviews were recoded; transcripts were transcribed and translated from local dialect into English language. Content analysis was conducted thematically with the aid of NVivo. <b>Results:</b> In total, 17 IDIs and 11 FGDs were conducted among SIYP aged 10-24 years. The total number of respondents interviewed was 109. There is high awareness of modern contraceptives among SIYP; the commonly known method was condom with a few also aware of emergency contraceptives pills. However, participants reported low use of modern contraceptives. The common reasons alluded for not using condoms were reduced sexual pleasure, cost and associated myths. The five themes that emerged under sexual practices of SIYP included early age at first sexual encounter, multiple sex partners, transactional sex, same-sex relationships, and transactional sex. <b>Conclusions:</b> There is low utilization of contraceptives by SIYP against the background of their high-risk sexual practices. SIYP would benefit from free contraceptive education, social safety nets and interventions to dissuade them from transactional sex and other unhealthy sexual practices.</p>","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":"1 1","pages":"41"},"PeriodicalIF":0.0,"publicationDate":"2021-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11190648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66399937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An ecological study on the association between early childhood caries and intimate partner violence in 20 low- and middle-income countries: 2007-2017. 2007-2017年,20个低收入和中等收入国家儿童早期龋齿与亲密伴侣暴力之间关系的生态学研究。
AAS Open Research Pub Date : 2021-07-26 eCollection Date: 2021-01-01 DOI: 10.12688/aasopenres.13237.3
Morenike Oluwatoyin Folayan, Mary O Obiyan, Maha El Tantawi, Arthur Kemoli, Ola B Al-Batayneh, Balgis Gaffar, Robert J Schroth
{"title":"An ecological study on the association between early childhood caries and intimate partner violence in 20 low- and middle-income countries: 2007-2017.","authors":"Morenike Oluwatoyin Folayan,&nbsp;Mary O Obiyan,&nbsp;Maha El Tantawi,&nbsp;Arthur Kemoli,&nbsp;Ola B Al-Batayneh,&nbsp;Balgis Gaffar,&nbsp;Robert J Schroth","doi":"10.12688/aasopenres.13237.3","DOIUrl":"https://doi.org/10.12688/aasopenres.13237.3","url":null,"abstract":"<p><p><b>Background:</b> Women are the worst affected by intimate partner violence (IPV), and this impacts negatively on the health of the children they care for. This study aimed to determine the associations between IPV and the prevalence of early childhood caries (ECC) in 3-5-year-olds. <b>Methods:</b> This was an ecological study using IPV (physical, sexual, emotional) data extracted from the Demographic Health Survey of 20 low- and middle-income countries and ECC data for 3-5-year-olds of the same countries for the period 2007-2017. Linear regression analysis was used to assess the relationship between the percentage of 3-5-year-olds with ECC (outcome variable) and IPV indicators (physical, sexual, emotional). The model was adjusted for the country's gross national income and the percentage of women with secondary or higher education. Partial eta squared (ηp <sup>2</sup>), regression coefficients, confidence intervals and p-values were calculated. <b>Results:</b> Data on ECC in 3-5-year-olds and IPV were available for six low-income-countries, 10 lower-middle-income-countries and four upper-middle-income-countries. The most prevalent form of IPV was physical violence (10.09%). The Democratic Republic of Congo had the highest prevalence of physical violence (45.8%), sexual violence (25.4%), and ECC (80.0%). The strongest association was between the prevalence of ECC and emotional violence (ηp <sup>2</sup>=0.01), followed by physical violence (ηp <sup>2</sup>=0.005), and sexual violence (ηp <sup>2</sup>=0.003). For every 1% higher prevalence of emotional violence, there was 0.28% higher prevalence of ECC, and for every 1% higher percentage of physical violence, there was 0.21% higher prevalence of ECC. On the contrary, for every 1% higher prevalence of sexual violence, there was 0.35% lower prevalence of ECC prevalence. <b>Conclusions:</b> Emotional and sexual violence where the two types of IPV associated with the prevalence of ECC. The associations were minor and the directions of their effects were difference. These findings need to be studied further.</p>","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":" ","pages":"39"},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40486146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Double burden of malnutrition among school-aged children and adolescents: evidence from a community-based cross-sectional survey in two Nigerian States. 学龄儿童和青少年营养不良的双重负担:来自尼日利亚两个州基于社区的横断面调查的证据。
AAS Open Research Pub Date : 2021-07-21 eCollection Date: 2021-01-01 DOI: 10.12688/aasopenres.13257.1
Adeleye Adeomi, Adesegun Fatusi, Kerstin Klipstein-Grobusch
{"title":"Double burden of malnutrition among school-aged children and adolescents: evidence from a community-based cross-sectional survey in two Nigerian States.","authors":"Adeleye Adeomi,&nbsp;Adesegun Fatusi,&nbsp;Kerstin Klipstein-Grobusch","doi":"10.12688/aasopenres.13257.1","DOIUrl":"https://doi.org/10.12688/aasopenres.13257.1","url":null,"abstract":"<p><p><b>Background:</b> Double burden of malnutrition (DBM) is the co-existence of overweight/obesity and undernutrition. Rising prevalence rates of childhood overweight/obesity in Nigeria have been reported, whilst undernutrition continues to be prevalent. This study aimed to estimate the prevalence and distribution of underweight, stunting, thinness, overweight/obesity, and DBM among school-aged children and adolescents in two Nigerian States. <b>Methods:</b> This was a community-based cross-sectional study carried out in Osun and Gombe States. A total of 1,200 children aged 6 - 19 years were recruited using multi-stage sampling technique. Weight, height and data on demographic, socio-economic, household/family characteristics of the children were collected using structured interviewer administered questionnaires. Nutritional status was calculated using the WHO 2007 reference values using BMI-for-age (thinness, overweight/obesity), height-for-age (stunting) and weight-for-age (underweight). DBM was described at the population and individual levels. <b>Results:</b> The mean age of the respondents was 11.6 ± 3.8 years. The overall prevalence rate of stunting was 34.9%, underweight was 13.5%, thinness was 10.3% and overweight/obese was 11.4% and 4.0% had individual level DBM, which typifies the DBM at individual and population levels. These rates differed significantly across demographic, socio-economic and household/family characteristics (p < 0.05). Gombe State, which is in the Northern part of Nigeria, had significantly higher burden of stunted, underweight and thin children than Osun State, while Osun State, in the Southern part of Nigeria, had a significantly higher burden of overweight/obesity. <b>Conclusions:</b> The study found evidence of DBM both at population and individual levels. The overall prevalence rates of stunting, underweight, thinness and overweight/obesity in this study were high, and they differed significantly across the demographic, socio-economic and household/family characteristics. There is the need for government and all other stakeholders to design nutritional educational programmes that will target both under- and over-nutrition among older children in the different contexts.</p>","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":" ","pages":"38"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39734391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Community-level influences on women’s experience of intimate partner violence and modern contraceptive use in Nigeria: a multilevel analysis of nationally representative survey 社区层面对尼日利亚妇女遭受亲密伴侣暴力和使用现代避孕药具的影响:对全国代表性调查的多层次分析
AAS Open Research Pub Date : 2021-07-16 DOI: 10.12688/AASOPENRES.13247.1
S. Adedini, Ololade G. Adewole, F. Oyinlola, O. Fayehun
{"title":"Community-level influences on women’s experience of intimate partner violence and modern contraceptive use in Nigeria: a multilevel analysis of nationally representative survey","authors":"S. Adedini, Ololade G. Adewole, F. Oyinlola, O. Fayehun","doi":"10.12688/AASOPENRES.13247.1","DOIUrl":"https://doi.org/10.12688/AASOPENRES.13247.1","url":null,"abstract":"Background: Modern contraceptives (MC) are important strategies for reducing unwanted pregnancies, unsafe abortion and maternal mortality, but MC remains low at 18% in Nigeria. Similarly, while there is increasing prevalence of intimate partner violence (IPV) in Nigeria, its effects on contraceptive use remain unclear. This study examined the influence of IPV on MC use, while adjusting for individual- and community-level confounders. Methods: The study utilized 2018 Nigeria Demographic and Health Survey data. We performed multilevel binary logistic regression analysis on 24,973 married women aged 15-49, who were sexually active and were not pregnant at the time of the survey. Results: Findings show that use of MC was higher among married women who reported experience of IPV than those without IPV exposure. After adjusting for individual-level and contextual factors, the odds of using MC was significantly higher among women who experienced any form of IPV (OR: 1.61, 95% CI: 1.17-2.21, p<0.005) compared to those who reported no IPV experience. Around one-quarter of the total variance in contraceptive use with respect to the different types of IPV could be explained at the community level. Conclusion: The study provides empirical evidence that there is significant community effect on IPV exposure and women’s contraceptive uptake. Attention must therefore be given to the context-specific social and gender norms that affect women’s sexual and reproductive health in Nigeria.","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47969442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Knowledge and attitude of secondary school students in Nakaseke, Uganda towards HIV transmission and treatment. 乌干达Nakaseke中学生对艾滋病毒传播和治疗的知识和态度。
AAS Open Research Pub Date : 2021-07-12 eCollection Date: 2021-01-01 DOI: 10.12688/aasopenres.13210.2
Patricia Nabisubi, Stephen Kanyerezi, Grace Kebirungi, Gerald Mboowa
{"title":"Knowledge and attitude of secondary school students in Nakaseke, Uganda towards HIV transmission and treatment.","authors":"Patricia Nabisubi,&nbsp;Stephen Kanyerezi,&nbsp;Grace Kebirungi,&nbsp;Gerald Mboowa","doi":"10.12688/aasopenres.13210.2","DOIUrl":"https://doi.org/10.12688/aasopenres.13210.2","url":null,"abstract":"<p><p><b>Background:</b> One of the major health concerns in Nakaseke district, Uganda is the high prevalence of HIV/AIDS. According to the Joint United Nations Programme on HIV/AIDS (UNAIDS), as of March 2014, the prevalence rate of the disease in the district was estimated at about 8%, compared to the national average of 6.5%, making Nakaseke district have the sixth-highest prevalence rate of HIV/AIDS in the entire country. We set out to explore the knowledge and attitude of secondary school students in Nakaseke, Uganda on HIV transmission and treatment. <b>Methods:</b> This was a cross sectional survey-based study with data collected during the month of February 2020. Data were analyzed using R programming language version 3.6.2. <b>Results:</b> A total of 163 participants volunteered for the study, 53.37% males and 46.63% females with ages ranging from 12 - 20 years. Participants came from 5 senior classes (S1, S2, S3, S4 and S6). In total, 87.73% participants were aware of HIV/AIDS while 12.27% were not. The major source of information was through teachers/schools. 96.50% knew the mode of transmission of HIV/AIDS and 95.11% were conversant with HIV/AIDS prevention. 63.6% were aware of the terms DNA and genes whereas 36.36% were not. <b>Discussion: </b>Generally, the students in Nakaseke district, Uganda had a high level of awareness of HIV/AIDS based on Bloom's cut-off point. However, with regards to aspects such as the cause and modern prevention methods like taking prep and prevention of mother to child transmission were less known to them. Efforts to find a cure for HIV/AIDS are still in vain. Therefore, strong emphasis on up to date control and prevention methods should be implemented to fight the HIV/AIDS scourge <b>.</b></p>","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":" ","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39369746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends and correlates of girl-child marriage in 11 West African countries: evidence from recent Demographic and Health Surveys. 11个西非国家女童婚姻的趋势和相关关系:来自最近人口与健康调查的证据。
AAS Open Research Pub Date : 2021-06-22 DOI: 10.12688/aasopenres.13248.1
A. Fatusi, S. Adedini, J. W. Mobolaji
{"title":"Trends and correlates of girl-child marriage in 11 West African countries: evidence from recent Demographic and Health Surveys.","authors":"A. Fatusi, S. Adedini, J. W. Mobolaji","doi":"10.12688/aasopenres.13248.1","DOIUrl":"https://doi.org/10.12688/aasopenres.13248.1","url":null,"abstract":"Background: West Africa historically has a high prevalence of girl-child marriage and requires substantial reduction to meet the United Nation's Sustainable Development Goals (SDG) target of ending child marriage by 2030, but current data on progress is sparce. We aimed to determine the trend in child marriage in West Africa and assess the influence of selected socio-demographic factors. Methods: We analysed data on women aged 18-24 years from the two most recent Demographic and Health Surveys (conducted between 2006 and 2014) for 11 West African countries to determine the prevalence and trend of girl-child marriage. Multivariable logistic regression analysis was used to assess the relationship between girl-child marriage and selected socio-demographic factors. Results: The prevalence of child marriage in West Africa is 41.5%. An overall decrease of 4.6% (annual rate of 0.01%) was recorded over a seven-year inter-survey period. Three countries (Cote d'Ivoire, Nigeria, and Niger) recorded increased prevalence while the rate was unchanged in Burkina Faso, and the other six countries had reduced prevalence between the last two surveys. Sierra Leone recorded the highest decrease in prevalence (22%) and an annual reduction rate of 0.04%; Cote d'Ivore had the highest increase (65.3%). In virtually all countries, rural residence, low education, poor household economic status and non-Christian religious affiliation were significantly associated with higher odds of girl-child marriage. Conclusions: The prevalence of girl-child marriage remains high in West Africa and the trend shows very slow progress. While substantial inter-country variations exist in overall rate and trend of child marriage, the rate of progress is inadequate across all countries.","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":"4 1","pages":"35"},"PeriodicalIF":0.0,"publicationDate":"2021-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66400000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Single motherhood, social independence and non-communicable disease (NCD) outcomes among young females (15-24 years old) in South Africa 南非年轻女性(15-24岁)的单身母亲、社会独立和非传染性疾病后果
AAS Open Research Pub Date : 2021-06-14 DOI: 10.12688/AASOPENRES.13238.1
N. Wet-Billings
{"title":"Single motherhood, social independence and non-communicable disease (NCD) outcomes among young females (15-24 years old) in South Africa","authors":"N. Wet-Billings","doi":"10.12688/AASOPENRES.13238.1","DOIUrl":"https://doi.org/10.12688/AASOPENRES.13238.1","url":null,"abstract":"Background: Non-communicable diseases (NCDs) acquired during youth follow into and affect adulthood. The association between young mother’s social independence and NCD status is of policy interest due to its effect on economic and social development. This study aimed to determine the causal relationship between social independence and NCD outcomes among young, single mothers in South Africa. Methods: Data from the South African National Income Dynamics Survey (NIDS) in 2008 and 2017 was used to determine if single mothers developed hypertension, diabetes or asthma by various indicators of social independence, including highest level of education and employment status. The sample was initially made-up of unmarried females (15-24 years old) without any children in 2008. Both fertility and social independence was followed-up to 2017. Results: In total, 66 young females developed an NCD by 2017 and 87% (n=57) of these women had a child in the interim period. Employment of young females increased from 4.78% in 2008 to 37.79% in 2017, but completion of secondary or tertiary education declined from 67.94% in 2008 to 56.01% in 2017. In addition, half (50.88%) of the young females were partially independent by 2017, with only 11.03% being fully independent at this time. Finally, logistic regression results showed that the likelihood of developing an NCD increased if young females with children were not socially independent. Conclusions: The relationship between social independence and NCDs suggest that policies and programmes in South Africa need to incorporate socioeconomic status as a determinant of disease and in particular, need to address socioeconomic indicators as additive measures and not autonomous indicators.","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":"4 1","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2021-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66399879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Pharmacological management of seizures in patients with COVID-19: a systematic review. COVID-19患者癫痫发作的药物管理:一项系统综述
AAS Open Research Pub Date : 2021-06-09 eCollection Date: 2021-01-01 DOI: 10.12688/aasopenres.13224.2
Priscilla Kolibea Mante, Nana Ofori Adomako, John-Paul Omuojine, Paulina Antwi
{"title":"Pharmacological management of seizures in patients with COVID-19: a systematic review.","authors":"Priscilla Kolibea Mante,&nbsp;Nana Ofori Adomako,&nbsp;John-Paul Omuojine,&nbsp;Paulina Antwi","doi":"10.12688/aasopenres.13224.2","DOIUrl":"https://doi.org/10.12688/aasopenres.13224.2","url":null,"abstract":"<p><p><b>Background:</b> Some patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported to exhibit neurological symptoms such as seizures and impaired consciousness. Our study reviews reported cases to assess the pharmacological approach to managing seizures in SARS-CoV-2 patients and associated outcomes. <b>Methods:</b> A systematic review of case reports on the incidence of seizures following coronavirus disease 2019 (COVID-19) among patients that reported use of antiepileptic drugs (AEDs) in management was performed by using the PRISMA (preferred reporting items for systematic reviews and meta-analysis) guidelines. Databases used included EMBASE, PubMed, SCOPUS, and Google Scholar. Data was presented as qualitative and descriptive data. <b>Results:</b> In total, 67 articles were selected for full-text assessment, of which 18 were included in the final review. Patients had a median age of 54 years, most of whom were male. Remdisivir, dexamethasone, Laninamivir, hydroxychloroquine, azithromycin, and Lopinavir-ritonavir were common agents used in the management of COVID-19. Most patients presented with either generalized tonic-clonic seizures or status epilepticus. Most patients received levetiracetam as drug choice or as part of their regimen. Other AEDs commonly prescribed included midazolam and sodium valproate. Some patients received no antiepileptic drug therapy. Most of the patients who died had more than one comorbidity. Also, most of the patients who died received COVID-19 treatment drugs. None of the patients who received midazolam as drug choice or as part of their regimen developed recurrent seizures in contrast to patients who received levetiracetam and sodium valproate as drug choice or as part of their regimen. Interestingly, none of the patients who received no AEDs suffered recurrent seizures or died. <b>Conclusions:</b> Standard guidelines for managing seizures in COVID-19 patients may be required. A limitation of this review is that it involved the use of case reports with no controls and a small number of patients.</p>","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":" ","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40484329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Outdoor-Resting Behaviour in Malaria Vectors Consistent? Short Report From Northern Ghana. 疟疾媒介的户外休息行为一致吗?来自加纳北部的简短报道。
AAS Open Research Pub Date : 2021-06-07 DOI: 10.21203/RS.3.RS-572080/V1
M. Hamid-Adiamoh, D. Nwakanma, I. Sr, A. Amambua-Ngwa, Y. Afrane
{"title":"Is Outdoor-Resting Behaviour in Malaria Vectors Consistent? Short Report From Northern Ghana.","authors":"M. Hamid-Adiamoh, D. Nwakanma, I. Sr, A. Amambua-Ngwa, Y. Afrane","doi":"10.21203/RS.3.RS-572080/V1","DOIUrl":"https://doi.org/10.21203/RS.3.RS-572080/V1","url":null,"abstract":"\u0000 BackgroundRecent reports of a change in the resting behaviour of malaria vectors, from predominantly indoor resting to outdoor resting following blood feeding, have been attributed to selection pressure from use of vector control tools such as indoor residual spraying and long-lasting insecticide-treated nets. Recent studies have observed vectors resting predominantly outdoors in settings where anti-vector tools are extensively deployed. This present study examined if the outdoor resting behaviour in the vector population, is random or indicative of a consistent preference of one resting site over the other. MethodsMark-release-recapture (MRR) experiments were conducted with outdoor-resting Anopheles gambiae and An. funestus mosquitoes collected from pit shelters, animal houses and granaries in two villages in Northern Ghana. Mosquitoes were marked with fluorescent dyes and released indoors. The experiments were controlled with indoor-resting mosquitoes, which were marked and released outdoors. Species of all recaptured mosquitoes were identified and assessed for consistency in their resting behaviour. ResultsA total of 4,460 outdoor-resting mosquitoes comprising An. gambiae sensu lato (s.l.) (59%) and An. funestus complex (41%) were marked and released. Overall, 31 (0.7%) mosquitoes (25 An. gambiae s.l. and 6 An. funestus complex) were recaptured mostly from outdoor location. Only 3 of the recaptured mosquitoes were found resting indoors where they were released. The majority of the outdoor-recaptured mosquitoes were An. arabiensis (11, 39%), followed by An. coluzzii (7, 25%); whereas the indoor-recaptured mosquitoes were mainly (3) An. coluzzii. For the control experiment, 324 indoor-resting mosquitoes constituting 313 An. gambiae s.l. and 11 An. funestus complex were marked and released. However, none of these was recaptured neither indoors nor outdoors.ConclusionsThe mosquitoes demonstrated the tendency to retain their outdoor-resting behaviour. Further investigations are required to ascertain if emerging preference for outdoor resting behaviour in malaria vector populations is consistent or a random occurrence.","PeriodicalId":34179,"journal":{"name":"AAS Open Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47332633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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