IF 4.9 1区化学

GIANT Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.giant.2025.100378

Jinmiao Ma , Mengmeng Han , Xusen Li , Haoying Liu , Cong Gao , Shipeng Chen , Jie Han

{"title":"A non-helical supramolecular chiral catalyst for the asymmetric diels-alder reaction","authors":"Jinmiao Ma , Mengmeng Han , Xusen Li , Haoying Liu , Cong Gao , Shipeng Chen , Jie Han","doi":"10.1016/j.giant.2025.100378","DOIUrl":"10.1016/j.giant.2025.100378","url":null,"abstract":"<div><div>The research of supramolecular chiral catalyst morphology is critically important in asymmetric catalysis, yet current research predominantly focuses on helical architectures, with non-helical systems remaining underexplored. Herein, we present a new type of nanosheet (NS)-like supramolecular chiral catalyst self-assembled from <em><span>l</span></em>-threonine-based amphiphilie (<em>L</em>-ThrC<sub>16</sub>) and Cu(II), which achieves obvious asymmetric catalysis in the Diels-Alder reaction between aza-chalcone and cyclopentadiene (91% yield and 45% ee) despite its non-helical nanostructure. Compared with monomeric counterpart of <em><span>l</span></em>-ThrC<sub>16<img></sub>Cu(II) catalyst displaying racemic product, the stronger interaction between aza-chalcone and <em><span>l</span></em>-ThrC<sub>16<img></sub>NS-Cu(II) have been confirmed, which facilitates the chirality transfer from the supramolecular scaffold to aza-chalcone and thereby leading to enantioselectivity. This work not only challenges the conventional paradigm of helical dominance in chiral induction but also establishes a foundation for developing scalable, high-performance non-helical catalysts, thereby expanding the design principles for supramolecular asymmetric synthesis.</div></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"26 ","pages":"Article 100378"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GSH-triggered CD44/FRβ dual-targeting nanoprodrug for acute myeloid leukemia eradication via cascade DNA damage and mitochondrial oxidative storm gsh触发CD44/FRβ双靶向纳米前药通过级联DNA损伤和线粒体氧化风暴根除急性髓系白血病

IF 4.9 1区化学

GIANT Pub Date : 2025-12-01 Epub Date: 2025-09-21 DOI: 10.1016/j.giant.2025.100374

Yanrong Shuai , Xiaojuan Miao , Yan Wang , Chaozheng Zhang , Yu Liu , Yuening Cao , Tingting Zhang , Jun Lu , Yilan Liu

{"title":"GSH-triggered CD44/FRβ dual-targeting nanoprodrug for acute myeloid leukemia eradication via cascade DNA damage and mitochondrial oxidative storm","authors":"Yanrong Shuai , Xiaojuan Miao , Yan Wang , Chaozheng Zhang , Yu Liu , Yuening Cao , Tingting Zhang , Jun Lu , Yilan Liu","doi":"10.1016/j.giant.2025.100374","DOIUrl":"10.1016/j.giant.2025.100374","url":null,"abstract":"<div><div>Conventional DNA double-strand breaks (DSBs)-inducing chemotherapeutics for acute myeloid leukemia (AML) are often limited by poor solubility, non-selectivity, and drug resistance stemming from robust tumor DNA repair mechanisms. Here, we report a glutathione (GSH)-responsive, dual-targeting nano-prodrug, designated HA-FA@Etp-Olp, for efficient AML cell eradication. The HA-FA@Etp-Olp system was constructed through the conjugation of the PARP inhibitor Olaparib (Olp) with etoposide (Etoposide) via a disulfide linkage, forming an Etp-Olp heterodimeric prodrug. This hydrophobic conjugate was encapsulated within a polymeric carrier composed of poly (ethylene glycol)-modified hyaluronic acid (HA) functionalized with folic acid (FA), self-assembling into well-refined nanoparticles. Exhibiting excellent circulatory stability, HA-FA@Etp-Olp achieved efficient accumulation within AML cells leveraging CD44/FR dual-receptor-mediated active targeting, followed by GSH-triggered disassembly and specific drug release in response to elevated intracellular GSH levels. Furthermore, HA-FA@Etp-Olp elicited a synergistic cytotoxic effect against AML through a dual-pronged mechanism: \"DNA damage-repair blockade\" cascade and significant augmentation of mitochondrial oxidative stress, effectively inducing apoptotic cell death. This strategy provides a promising targeted nanotherapeutic approach with enhanced efficacy and reduced systemic toxicity, demonstrating significant potential for the precise treatment of AML.</div></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"26 ","pages":"Article 100374"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Mesomorphic phases of the electrostatic complexes of amphiphilic surfactants with low-generation dendrimers” [Giant, 25 (2025) 100369] “具有低代树突状分子的两亲表面活性剂静电络合物的介形相”的勘误表[巨人，25 (2025)100369]

IF 4.9 1区化学

GIANT Pub Date : 2025-12-01 Epub Date: 2025-09-08 DOI: 10.1016/j.giant.2025.100372

Yi-Cheng Lai , Chun-Yu Chen , Chun-Jen Su , Hsin-Lung Chen

引用次数: 0

Biosynthesis of CuO-nanoparticles using extracts of Mespilus germanica, Crataegus spp., and Wild barberry and their synergistic antibacterial activity 德国山楂、山楂和野小檗提取物合成纳米cuo的研究及其协同抗菌活性

IF 4.9 1区化学

GIANT Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.giant.2025.100379

Hassan Koohestani , Ali Balooch , Hamid Staji

{"title":"Biosynthesis of CuO-nanoparticles using extracts of Mespilus germanica, Crataegus spp., and Wild barberry and their synergistic antibacterial activity","authors":"Hassan Koohestani , Ali Balooch , Hamid Staji","doi":"10.1016/j.giant.2025.100379","DOIUrl":"10.1016/j.giant.2025.100379","url":null,"abstract":"<div><div>The green synthesis of nanoparticles is gaining attention as a sustainable and eco-friendly alternative to conventional chemical methods. In this study, copper oxide nanoparticles (CuO<img>NPs) were biosynthesized using leaf extracts of <em>Mespilus germanica</em> (M-CuO), <em>Wild barberry</em> (B-CuO), and <em>Crataegus</em> spp. (C<img>CuO) as natural reducing and stabilizing agents. The synthesized nanoparticles were characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and Field-emission scanning electron microscopy (FESEM). XRD results confirmed the formation of crystalline CuO with high purity. FESEM analysis revealed that the nanoparticles were nearly spherical with size ranges of 50–70 nm (M-CuO), 60–100 nm (B-CuO), and 50–80 nm (C<img>CuO). FTIR spectra indicated the presence of functional groups such as hydroxyl (-OH) and carbon-oxygen (C<img>O), along with characteristic Cu-O bond vibrations in the 500–700 cm-¹ range. The antibacterial activity of the CuO<img>NPs was tested against Gram-positive and Gram-negative bacteria, showing considerable inhibition. A synergistic effect was observed when combining the different types of CuO<img>NPs, resulting in enhanced antibacterial performance. These findings highlight the potential of plant-mediated CuO<img>NPs as promising candidates for biomedical and antibacterial applications.</div></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"26 ","pages":"Article 100379"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lanthanum-substituted CaMo-MOF via controlled metal nitrate ratios for Electrochemical Performance 镧取代CaMo-MOF的电化学性能研究

IF 4.9 1区化学

GIANT Pub Date : 2025-12-01 Epub Date: 2025-10-31 DOI: 10.1016/j.giant.2025.100380

P. Arularasan , Mohd Arif Dar , Mohammad Rezaul Karim , P Rajesh , M Pavithra , Sambasivam Sangaraju

引用次数: 0

Controlled orientation of polystyrene-b-poly(L-lactide) nanostructured thin films by air plasma treatment via thermal annealing 热退火空气等离子体处理聚苯乙烯-b-聚（l -丙交酯）纳米薄膜的取向控制

IF 4.9 1区化学

GIANT Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.giant.2025.100367

Wen-Chi Huang , Thanmayee Shastry , Pin-Chia Chen, Ashika A P, Kang-Ping Liu, Rong-Ming Ho

{"title":"Controlled orientation of polystyrene-b-poly(L-lactide) nanostructured thin films by air plasma treatment via thermal annealing","authors":"Wen-Chi Huang , Thanmayee Shastry , Pin-Chia Chen, Ashika A P, Kang-Ping Liu, Rong-Ming Ho","doi":"10.1016/j.giant.2025.100367","DOIUrl":"10.1016/j.giant.2025.100367","url":null,"abstract":"<div><div>This work aims to develop a new approach for controlling the orientation of nanostructured block copolymer (BCP) thin films <em>via</em> thermal annealing. A thin layer of polystyrene-<em>block</em>-poly(L-lactide) (PS-<em>b</em>-PLLA) thin film is prepared by spin coating followed by air plasma treatment, giving a layer with randomly crosslinked PS and PLLA. This layer will serve as a neutral substrate for the second layer of PS-<em>b</em>-PLLA thin film to develop perpendicular PLLA cylinder in PS matrix from the bottom of the thin film by thermal annealing. Subsequently, the second air plasma treatment is carried on the second layer of PS-<em>b</em>-PLLA thin film to give a topcoat neutral layer for the development of perpendicular PLLA cylinders from the top of the thin film after thermal annealing, giving film-spanning perpendicular PLLA cylinders through self-alignment process. With the degeneration of the PLLA in the PS-<em>b</em>-PLLA monolith, it is possible to create PS film with prolonged cylindrical nanochannels that is appealing for applications such as NanoMEMS manufacturing, membrane fabrication and templated synthesis.</div></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"25 ","pages":"Article 100367"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gradient hydrogels based on photo-initiated polymerization-induced self-assembly 基于光引发聚合诱导自组装的梯度水凝胶

IF 4.9 1区化学

GIANT Pub Date : 2025-10-01 Epub Date: 2025-08-13 DOI: 10.1016/j.giant.2025.100371

Yingchu Zhou , Ziqi Liu , Yi Zeng , Li Luo , Jie Chen , Diyuan Zheng , Zhao Wu , Chao Lang

{"title":"Gradient hydrogels based on photo-initiated polymerization-induced self-assembly","authors":"Yingchu Zhou , Ziqi Liu , Yi Zeng , Li Luo , Jie Chen , Diyuan Zheng , Zhao Wu , Chao Lang","doi":"10.1016/j.giant.2025.100371","DOIUrl":"10.1016/j.giant.2025.100371","url":null,"abstract":"<div><div>Gradient materials enable performance optimization by adjusting composition or structure across one or more dimensions while minimizing interfacial incompatibility. However, current preparation procedures are often complicated, requiring multiple steps and complex post-processing. In this study, we report the fabrication of a unidirectional mechanical gradient hydrogel via a one-pot synthesis enabled by reversible addition-fragmentation chain transfer (RAFT)-mediated polymerization-induced self-assembly (PISA). Through concurrent photo-initiated RAFT polymerization and macro-CTA end-group cleavage, compositional and structural gradients were simultaneously created based on the distance from the light source. The near-light region displays a structure of disordered spheres primarily composed of triblock copolymer, while the far-light region features bicontinuous structure with a higher homopolymer content. This gradient design results in significantly different mechanical properties such as strength, resilience, modulus, and loss factors across the hydrogel. Moreover, gradient hydrogel demonstrates exceptional impact resistance, where the soft region efficiently absorbs and dissipates energy while the hard region provides structural support. This study highlights the potential of PISA in developing high-performance gradient materials with tailored mechanical properties, offering promising applications in protective sports equipment, energy absorption systems, soft robotics, and biomedical implants.</div></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"25 ","pages":"Article 100371"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesomorphic phases of the electrostatic complexes of amphiphilic surfactants with low-generation dendrimers 低代树状大分子两亲表面活性剂静电配合物的介晶相

IF 4.9 1区化学

GIANT Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI: 10.1016/j.giant.2025.100369

Yi-Cheng Lai , Chun-Yu Chen , Chun-Jen Su , Hsin-Lung Chen

{"title":"Mesomorphic phases of the electrostatic complexes of amphiphilic surfactants with low-generation dendrimers","authors":"Yi-Cheng Lai , Chun-Yu Chen , Chun-Jen Su , Hsin-Lung Chen","doi":"10.1016/j.giant.2025.100369","DOIUrl":"10.1016/j.giant.2025.100369","url":null,"abstract":"<div><div>Through the microphase separation between the polar and nonpolar components, the complexation of macromolecule with an amphiphilic surfactant has the potential to construct a broad spectrum of mesomorphic phase with long-range order. This study explores the self-assembly behavior of the electrostatic complexes formed between poly(amidoamine) (PAMAM) dendrimers of generation two (G2) and generation three (G3) with two surfactants: dodecylbenzenesulfonic acid (DBSA) and sodium dodecyl sulfate (SDS). Long-range ordered lamellar structures formed in the complexes of DBSA with both PAMAM G2 and G3 dendrimers via acid-base interaction. A detailed analysis of the lamellar structure revealed that the thickness of the polar layer containing the dendrimer was virtually independent of the dendrimer generation number. This phenomenon even extended to the complexes of DBSA with PAMAM G4 and G6 dendrimers, indicating that the dendrimer molecules were in general highly compressed along the lamellar interface due to the electrostatic attraction. The complexations of protonated dendrimer systems with SDS driven by the entropic gain from counterion release yielded a higher-curvature structure, where the SDS formed cylindrical micelles packed in a 2D hexagonal lattice, as the original spherical SDS micelles merged into cylinders to enhance the charge matching with the dendrimers. The subtle variation of the relative intensities of the diffraction peaks in the small angle X-ray scattering pattern suggested that, as the binding density of the surfactant to the dendrimer increased, the cross section of the cylindrical micelle progressively deformed from nearly circular to elliptical shape to facilitate the charge matching under the hexagonal packing symmetry.</div></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"25 ","pages":"Article 100369"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a mechanically tunable triblock copolyester with partial chemical recyclability 具有部分化学可回收性的机械可调三嵌段共聚聚酯的研制

IF 4.9 1区化学

GIANT Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI: 10.1016/j.giant.2025.100370

Jiawei Wang, Hao Chen, Chenlin Pan, Jinlin He, Peihong Ni

{"title":"Development of a mechanically tunable triblock copolyester with partial chemical recyclability","authors":"Jiawei Wang, Hao Chen, Chenlin Pan, Jinlin He, Peihong Ni","doi":"10.1016/j.giant.2025.100370","DOIUrl":"10.1016/j.giant.2025.100370","url":null,"abstract":"<div><div>Triblock copolymers can significantly enhance material properties due to their unique microphase separation structures and have become important candidates for the development of sustainable polymers. However, research reports on recyclable block copolyesters remain relatively limited. 3,4-Dihydro-2H-benzo [b][1,4]dioxepin-2-one (BDXO) is a renewable monomer derived from lactones, and its homopolymer exhibits excellent thermal properties and tensile strength but low flexibility. Copolymerizing various cyclic esters and leveraging their respective advantages for modification has emerged as a highly promising strategy to address this issue. In this study, a partially chemically recyclable triblock copolyesters was designed and synthesized using poly(trimethylene carbonate) (PTMC) as the soft chain and poly(3,4-dihydro-2H-benzo[b][1,4]dioxepin-2-one) (PBDXO) as the hard segment. The synthesized triblock copolyesters were characterized for their chemical structure, molecular weight, and thermal properties using proton nuclear magnetic resonance (<sup>1</sup>H NMR), size exclusive chromatography (SEC), matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). Mechanical tests revealed that the mechanical strength the copolyesters can be tuned by the proportion of the soft and hard segments as well as the total molecular weight. Leveraging the disparity in ceiling temperature (<em>T</em><sub>c</sub>) between the hard and soft segments enables efficient selective chemical recycling of the PBDXO hard segment, with the PTMC soft segment being substantially remained. This offers a facile and sustainable approach to the design of recyclable block copolyesters.</div></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"25 ","pages":"Article 100370"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144828822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing bound rubber of additively manufactured silicone rubber at an expanded scale: A contrast variation spin-echo small-angle neutron scattering investigation 增材制造硅橡胶粘结橡胶的扩展尺度表征：对比变化自旋回波小角中子散射研究

1区化学

GIANT Pub Date : 2025-08-05 DOI: 10.1016/j.giant.2025.100368

Jingjing Han, Xiaoqing Tu, Z. H. Qu, Kun Song, Yue Yin, Xiang Luo, A. Lu, Guangai Sun, Chengzhen Geng, Dong Liu

引用次数: 1

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