A. El Gazzar, Khaled M. Belal, T. Essawy, Neveen Abd-Elfattah
{"title":"A study of plasma copeptin level as a predictor of severity during acute exacerbation of bronchial asthma","authors":"A. El Gazzar, Khaled M. Belal, T. Essawy, Neveen Abd-Elfattah","doi":"10.4103/ejb.ejb_61_18","DOIUrl":"https://doi.org/10.4103/ejb.ejb_61_18","url":null,"abstract":"Background An exacerbation of asthma is an episode, characterized by a progressive increase in one or more typical asthma symptoms (shortness of breath, wheezing, cough, and chest tightness). Copeptin is a 39-amino acid glycopeptide that is derived from the c-terminal part of the pre–pro-hormone of arginine vasopressin. Aim The aim of our study was to evaluate the role of copeptin in asthmatic patients and its relationship to disease severity. Patients and methods This was a prospective observational study carried out on 45 patients during acute exacerbation of bronchial asthma (15 mild, 15 moderate, and 15 severe cases) and 15 healthy participants. Results Our study showed no significant difference in age, sex, and BMI between case and control groups. There was a statistical highly significant differences in pulmonary function tests, partial pressure of oxygen in arterial blood, partial pressure of carbon dioxide in arterial blood, and oxygen saturation among mild, moderate, and severe cases, and significant increase in total leukocytic count and hospital stay in severe cases than mild and moderate cases. There was a highly significant increase of plasma copeptin in moderate and severe cases than mild cases and control groups. There were nonsignificant correlations between copeptin and pulmonary function tests in mild cases; a significant negative correlation between copeptin and forced expiratory volume in 1 s (FEV1) actual in moderate cases; significant negative correlations between copeptin, FEV1 actual, FEV1% predicted, forced vital capacity% predicted, and peak expiratory flow% predicted in severe cases; and highly significant negative correlations between copeptin and partial pressure of oxygen in arterial blood and oxygen saturation in all cases (P<0.001). Partial pressure of carbon dioxide in arterial blood exhibited a nonsignificant positive correlation with copeptin (P<0.05). Conclusion Copeptin is proven to be a novel biomarker and is increased in patients with asthma as compared with healthy controls.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46418218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eman Elfeky, Ayman Abd El-Zaher, Amal ElBendary, Salwa Ganna
{"title":"Study of serum cystatin C levels in patients with obstructive sleep apnea","authors":"Eman Elfeky, Ayman Abd El-Zaher, Amal ElBendary, Salwa Ganna","doi":"10.4103/ejb.ejb_31_19","DOIUrl":"https://doi.org/10.4103/ejb.ejb_31_19","url":null,"abstract":"Background Serum cystatin C is a sensitive indicator for early renal impairment in patients with obstructive sleep apnea (OSA). In patients with OSA without known chronic kidney disease (CKD), serum cystatin C was found to be elevated, indicating latent renal disease, which may be caused by recurrent episodes of hypoxemia and reoxygenation that trigger inflammatory process. Objective To evaluate serum levels of cystatin C in otherwise healthy patients with OSA to predict the future risk of latent renal impairment in these patients. Patients and methods A total of 30 patients were classified into two groups: group I included 10 healthy controls, and group II included 20 patients with OSA. The following were done: full history taking, clinical examination, pulmonary function tests, subjective evaluation of daytime sleepiness using the Epworth Sleepiness Scale, and overnight polysomnography. Finally, serum cystatin C levels at the end of polysomnography and glomerular filtration rate was calculated using modification of diet in renal disease formula and CKD-Epidemiology Collaboration cystatin equation. Results In patients with OSA, the mean level of serum cystatin C was statistically significantly higher than that in controls. These higher levels were sex, age, and BMI independently. Moreover, serum levels of cystatin C in patients with OSA were significantly correlated with OSA severity (apnea-hypopnea index) and degree of nocturnal hypoxia through positive correlation with total sleep time less than 90%, total sleep time less than 80%, and respiratory disturbance index and negative correlation with average SPO2%, lowest SPO2%, and estimated glomerular filtration rate by CKD-Epidemiology Collaboration cystatin equation. Conclusions Higher serum levels of cystatin C were detected in patients with OSA without known comorbidities, which indicates that these patients are at a higher risk of developing CKD. Intermittent hypoxia seems to have the main role in the progression of this process.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44350897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of different classes of obesity on the pulmonary functions among adult Egyptians: a cross-sectional study","authors":"A. Hatem, M. Ismail, Y. El-Hinnawy","doi":"10.4103/ejb.ejb_21_19","DOIUrl":"https://doi.org/10.4103/ejb.ejb_21_19","url":null,"abstract":"Introduction Obesity is a common chronic disease, representing a major health hazard. Obesity has several delirious effects on the respiratory functions. Aim of the study To study the effect of obesity on pulmonary functions among our local population of obese adults and to assess the correlation between the severity of lung function impairment and the degree of obesity. Patients and methods Healthy nonsmoker adult patients were recruited in our cross-sectional study. After full medical evaluation, measurement of height and weight, and calculation of BMI, patients underwent spirometry tests with measurement of forced expiratory volume in first second (FEV1), forced vital capacity (FVC), forced mid-expiratory flow, and peak expiratory flow rate. Then, they were classified according to their BMI into five groups. Results The study included 293 patients divided into five groups according to their BMI. Significant statistical differences were noticed between nonobese patients and patients with classes II and III obesity regarding FVC, FEV1, and forced mid-expiratory flow, but no differences regarding peak expiratory flow rate and FEV1/FVC ratio. Overall, 28.9% of the total obese patients presented with restrictive pattern of spirometry, 2.8% with obstructive, and 2.4% with mixed patterns. Conclusion Obesity of especially marked degrees with BMI of more than 35 kg/m2 negatively affects the spirometric parameters. Restrictive pattern was the commonest abnormality observed in the spirometry of obese patients.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42514414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hend M. Esmaeel, Hamdy A. Mohammadien, Abd-elbaset Saleh, Fatma Mohamed
{"title":"Prepolysomnography evaluation can predict obstructive sleep apnea and is correlated to its severity","authors":"Hend M. Esmaeel, Hamdy A. Mohammadien, Abd-elbaset Saleh, Fatma Mohamed","doi":"10.4103/ejb.ejb_19_19","DOIUrl":"https://doi.org/10.4103/ejb.ejb_19_19","url":null,"abstract":"Background Obstructive sleep apnea (OSA) is increasingly identified as a disease with major health consequences. The limited availability of the gold standard diagnostic test, polysomnography (PSG), mandates careful clinical evaluation of suspected patients. This can allow better patient selection for referral for confirmatory diagnostic test. Objective The study aimed at identifying the importance of pre-PSG evaluation in prediction of obstructive sleep apnea and its relation to disease severity. Patients and methods A total of 170 patients were included. Detailed demographic characteristics, anthropometric measures, and comorbid conditions were recorded. Correlation to PSG results was done, and multivariate analysis was used to identify predictors of disease. Results OSA was diagnosed in 58.8% of our studied patients. The patients with OSA and notably the severe subgroup were of older age, predominantly male, and current or ex-smoker. Mean BMI was highest in the patients with severe OSA (41.99±8.92) and same for mean neck and waist circumference, both were significantly higher in patients with severe OSA. In multivariate logistic regression analysis, significant predictive factors for OSA were older age, male sex, being nonemployed, having hypertension, and larger tonsillar size. Conclusion Patient demographics, anthropometric characteristics, and presence of comorbid conditions such as hypertension are strong predictors of having OSA and justify referral for diagnostic sleep study.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47471775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impulse oscillometry usefulness in small-airway dysfunction in asthmatics and its utility in asthma control","authors":"R. Sharshar","doi":"10.4103/ejb.ejb_16_19","DOIUrl":"https://doi.org/10.4103/ejb.ejb_16_19","url":null,"abstract":"Background Small-airway affection and its relation to clinical status in asthmatic patients became an increasing interest during the last decade. Spirometry is a basic diagnostic tool for measuring pulmonary function in asthmatics but not fully illustrative especially in assessing small airways. Impulse oscillometry (IOS) can be considered a complementary and sometimes alternative technique to spirometry because it is used during quiet breathing and so gives more data about small-airways affection in asthmatic patients. Aim To evaluate IOS usefulness in the detection of small-airways disease in asthma and its correlation to the level of disease control. Patients and methods The study was conducted on 44 asthmatic patients who were classified into two groups: controlled asthma and uncontrolled asthma by asthma control test questionnaire (ACT score). Spirometry and IOS were performed on all patients. Results Small-airway IOS values (R5–20, X5, and AX) were found to be statistically significant between two groups. Moreover, they strongly correlated significantly with clinical symptoms, assessed by ACT. There was high sensitivity and specificity of (R5–20) 80 and 82%, (X5) 80 and 86%, and (AX) 86 and 89%, while for spirometric data only forced expiratory flow (FEF25–75%) showed a statistically significant difference between the two groups, and not FEV1% and there was poor correlation between ACT and FEF25–75%. Conclusion IOS provides an easy and rapid tool to diagnose and assess small-airways disease in adult, asthmatic patients","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42097875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Khalil, H. Salem, Hossam-Eldin Abdil-Hamid, M. Zakaria
{"title":"Correlation between ventricular function as assessed by echocardiography and six-minute walk test as a surrogate of functional capacity in patients with chronic obstructive pulmonary disease","authors":"M. Khalil, H. Salem, Hossam-Eldin Abdil-Hamid, M. Zakaria","doi":"10.4103/ejb.ejb_48_19","DOIUrl":"https://doi.org/10.4103/ejb.ejb_48_19","url":null,"abstract":"Background Exercise intolerance is common in patients with chronic obstructive pulmonary disease (COPD), which has multiple mechanisms underlying its progression. Ventricular dysfunction may play a role in the development of exercise incapacity in patients with COPD. Aim To investigate the possible contribution of left ventricular (LV) and right ventricular (RV) dysfunction (either systolic or diastolic) in development of exercise intolerance in patients with COPD. Patients and methods A total of 60 patients with diagnosis of COPD were categorized according to GOLD spirometric stage into two groups (group 1: mild to moderate COPD, and group 2: severe to very severe COPD). Both groups were evaluated by spirometry, ECG, chest radiography, routine laboratory investigation, 6-min walk test, and echocardiography including tissue Doppler imaging. Results The average age in the whole study group was 56.63±10.33 years. Male patients in the study were 46 (76.7%) and female patients were 14 (23.3%). Mean maximum walk distance among the whole group was 342.75±54.85 m. There was a significant correlation between 6-min walk distance and transtricuspid E velocity, tricuspid E/A, and transtricuspid deceleration time (P=0.011, 0.015, and 0.021, respectively). There was no significant correlation between 6-min walk distance and parameters of LV diastolic dysfunction. Prevalence of ventricular dysfunction was as follow: LV systolic dysfunction 3.3%, LV diastolic dysfunction 30%, RV systolic dysfunction 21%, and RV diastolic dysfunction 46%. Conclusion RV diastolic dysfunction may be a contributing factor in the progression of exercise intolerance in COPD. Although LV diastolic dysfunction may not be associated with exercise intolerance, it is still prevalent in COPD and must be assessed and managed through the course of the disease and especially during exacerbation.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45150000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sherif El-Fatah, Radwa El-Hefny, R. Ahmed, Doaa M. A. El-Tawab
{"title":"Lung rockets and pulmonary functions","authors":"Sherif El-Fatah, Radwa El-Hefny, R. Ahmed, Doaa M. A. El-Tawab","doi":"10.4103/ejb.ejb_55_18","DOIUrl":"https://doi.org/10.4103/ejb.ejb_55_18","url":null,"abstract":"Introduction The ultrasound (US) of the chest is useful in the diagnosis of different parenchymal, pleural, and chest wall diseases. The US is preferred because no radiation is used (safe during pregnancy), is not expensive, is easy portability, provides real-time imaging, and has the ability to make a dynamic imaging. Aim This study aimed for the correlation between B-lines and spirometry, arterial blood gases, 6-minute walk test (6MWT), and pulmonary artery systolic pressure (PASP) in patients with diffuse parenchymal lung disease (DPLD). Design A prospective study was conducted. Setting The study was conducted at Fayoum University Hospital in Egypt between January 2017 and June 2017. Patients and methods This study was done on 60 patients with DPLD. They were subjected to a full medical history, a detailed clinical examination, high-resolution computed tomography, echocardiography, arterial blood gases analysis, spirometry, 6MWT, and chest US. Results The studied group showed female predominance, with 54 (90%) patients. They had a wide range of age from 20 to 75 years, and their mean age was 47.5±13.6 years. Most of them were involved in breeding birds, exposed to biomass, and nonsmokers. The studied patients had bilateral B-lines. The number of B-lines was positively correlated with PaO2, 6MWT, forced vital capacity, and PASP and negatively correlated with high-resolution computed tomography affection, whereas the distance between B-lines was inversely correlated with each of PaO2, numbers of B-line, 6MWT, forced vital capacity, and PASP. Most of patients had irregular and thickened pleura (71.6%), and abolished lung sliding was seen in 51.6%. Conclusion Chest US may be used in the evaluation of DPLD. Multiple B-lines with thickened and irregular pleural line are suggestive of DPLD.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42234029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mediastinal lesions, spectrum, and modalities of diagnosis: a retrospective multicenter-based experience","authors":"M. Hantera, H. Abdalla, M. Ibrahim","doi":"10.4103/ejb.ejb_39_19","DOIUrl":"https://doi.org/10.4103/ejb.ejb_39_19","url":null,"abstract":"Context Diagnosis of mediastinal lesions start with clinical evaluation combined with specific /boratory investigation and different imaging modalities till biopsy that can obtained by percutaneous approach, endoscopic approach, or finally open approach. Aims A retrospective assessment of different mediastinal lesions was performed of the diagnosis and the different modalities of sampling used in three different Egyptian centers (Cairo, Mansoura, and Tanta universities) during the period 2017–2018. Settings and design This was a retrospective study. Patients and methods Study enrolled 92 patients with mediastinal lesions, collected from medical records of the three chest department during the period 2017–2018, were retrospectively analyzed. Data included clinical presentation, diagnostic methods, and diagnostic outcome. Results Mediastinal lymphadenopathies were the most common lesions. Endobronchial ultrasound was the sampling modality most used successfully (39.13%) to achieve the final diagnosis, followed by computed tomography-guided trucut biopsy (25%). The most frequent pathological finding was lymphomas, 34.78%, followed by adenocarcinomas, 26%. Conclusion Malignancy was the commonest diagnosis among cases enrolled in our study.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43051085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of sexual function and depression in married women with interstitial lung diseases","authors":"D. Magdy, A. Metwally, Randa A. El Zohne","doi":"10.4103/ejb.ejb_91_18","DOIUrl":"https://doi.org/10.4103/ejb.ejb_91_18","url":null,"abstract":"Background Little is known about female sexual function and interstitial lung disease (ILD). The purpose of this study was to evaluate sexual function and depression in married women with ILD. Patients and methods Of the 65 participants enrolled, 45 patients with ILD fulfilled the inclusion criteria, comprising 12 patients with idiopathic pulmonary fibrosis, 25 with connective tissue disease-associated interstitial pneumonias, eight patients with other interstitial pneumonias. Moreover, 20 age-matched normal individuals were recruited as controls. All participants were evaluated for clinical data, including age, BMI, comorbidities, duration of ILD, usage of glucocorticoids (dose and duration), and number of exacerbation within the past year. All women fulfilled the female sexual function index (FSFI) and Beck depression inventory. Results The mean age of the ILD group was 40.4±8.9 years. Overall, 33.3% were hypertensive and 53.3% had pulmonary hypertension, whereas diabetes mellitus and dyslipidemia were found in 26.6 and 15.5%, respectively. The mean duration since diagnosis of ILD and using glucocorticoids was 8.46±2.77 and 9.23±2.31 years. No differences in forced vital capacity and forced expiratory volume in 1 s were observed. There was a significant decrease in mean diffusion capacity (diffusion lung capacity for carbon monoxide) (61.8±7.10 vs. 68.7±6.86%) when compared with control (P=0.000FNx01). Using FSFI, there was a significant decrease in global FSFI score and each domain in patients with ILD as compared with control (P=0.000FNx01). The overall prevalence of depression was 80%. Correlation was found between total FSFI and disease duration, duration of glucocorticoids and dosage (≥20 mg), and depression (Beck depression inventory). Conclusion Despite mild impairment in pulmonary function, female patients with ILD have reported sexual dysfunction and increased depression. Thus, physicians should be reminded that patients with ILD need a comprehensive evaluation for sexual function.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70714619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Farrag, Haytham S. Diab, Muhammed R. Al Aziz Taha
{"title":"Evaluation of rapid pleurodesis technique in patients with malignant pleural effusion","authors":"M. Farrag, Haytham S. Diab, Muhammed R. Al Aziz Taha","doi":"10.4103/ejb.ejb_102_17","DOIUrl":"https://doi.org/10.4103/ejb.ejb_102_17","url":null,"abstract":"Background The objective of this study is to see whether a rapid method of pleurodesis is superior to the standard protocol in patients with symptomatic malignant pleural effusion. Patients and methods This is a prospective, randomized control study that was held in Ain-Shams University Hospitals and included 30 patients diagnosed with malignant pleural effusion. Thirty patients who had been diagnosed with malignant pleural effusion histologically and/or cytologically were assessed and they were divided into two groups. Group A: 10 patients submitted to the standard pleurodesis technique using 24 or 28 F thoracotomy tube. Group B: 20 patients submitted to the rapid pleurodesis technique using pigtail (12 F). Pleurodesis was done by vibramycin and follow up of the patients was done with chest radiography at 1, 3, and 6 months after pleurodesis. Results There was no statistically significant difference in the demographic features, site of the primary tumor, disease characteristics, and response rates in any evaluation period in both groups. However, the number of days of drainage and hospitalization were significantly lower in the second group. Conclusion This new pleurodesis method provided a shorter hospital stay resulting in superior cost-effectiveness and palliation without sacrificing the efficacy of pleurodesis.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46185003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}