Effect of adding inhalation of sodium bicarbonate 8.4% to the usual treatment on smear-positive pulmonary tuberculosis: a prospective controlled study

IF 1 Q4 RESPIRATORY SYSTEM
Mohammad El-badrawy, Eman O. Arram, D. Abdalla, Dina Al-Sagheer, A. Zahran, M. AboElEla, A. El-Badrawy, Wagdy Amin
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引用次数: 4

Abstract

Background Pulmonary tuberculosis (TB) lesion is acidic, and changing this acidic pH may affect growth of TB bacilli and response to therapy. We aimed to assess the effect of adjuvant inhalation of sodium bicarbonate (SB) 8.4% on clinical, radiological, and microbiological responses in patients with sputum-positive drug-sensitive pulmonary TB. Patients and methods One hundred and three patients with pulmonary TB completed the study, and they were classified into two groups: group I included 55 patients who received standard anti-TB regimen plus SB inhalation, and group II included 48 patients who received anti-TB regimen only. The responses in both groups were evaluated clinically, microbiologically, and radiologically. Results There was no statistically significant difference between both groups in baseline bacillary load, clinical picture, and radiology. Both groups improved clinically 1 month after start of therapy. In group I only, there was a statistically significant improvement in chest radiograph after 1 month (P<0.001). The median duration of smear conversion for group I was 3 weeks (1–8) compared with 9.5 (2–17) in group II, with a statistically significant difference (P<0.001). Moreover, the median duration of culture conversion for group I was 1 month (1–3) compared with 3 months (1–4) in group II, with a statistically significant difference (P<0.001). Conclusion Adjuvant inhalation of SB in smear-positive pulmonary TB to standard anti-TB drugs accelerates smear conversion, culture conversion, and clinical and radiological improvement.
在常规治疗基础上加吸8.4%碳酸氢钠治疗涂阳肺结核的效果:一项前瞻性对照研究
背景肺结核(TB)病变是酸性的,改变酸性pH可能会影响结核杆菌的生长和对治疗的反应。我们旨在评估8.4%碳酸氢钠辅助吸入对痰阳性药物敏感肺结核患者的临床、放射学和微生物学反应的影响。患者和方法103例肺结核患者完成了本研究,他们被分为两组:第一组包括55例接受标准抗结核方案加SB吸入的患者,第二组包括48例仅接受抗结核方案的患者。对两组患者的反应进行了临床、微生物学和放射学评估。结果两组在基线细菌载量、临床表现和放射学方面无统计学差异。两组患者在开始治疗后1个月临床症状均有改善。仅在第I组中,1个月后胸部X线片有统计学意义的改善(P<0.001)。第I组的中位涂片转化持续时间为3周(1-8),而第II组为9.5周(2-17),具有统计学意义的差异(P=0.001)。此外,I组培养转化的中位持续时间为1个月(1-3),而II组为3个月(1-4),差异具有统计学意义(P<0.001)。
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来源期刊
Egyptian Journal of Bronchology
Egyptian Journal of Bronchology RESPIRATORY SYSTEM-
自引率
7.70%
发文量
56
审稿时长
9 weeks
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