Addiction and HealthPub Date : 2024-10-01Epub Date: 2024-10-29DOI: 10.34172/ahj.1634
Christopher Alan Lewis, Sarah Davis, Mehdi Sharifi, Manijeh Firoozi
{"title":"Farsi Translation of Four Additional Items for the Addictive Features Section of the Ottawa Self-injury Inventory Version 3.1.","authors":"Christopher Alan Lewis, Sarah Davis, Mehdi Sharifi, Manijeh Firoozi","doi":"10.34172/ahj.1634","DOIUrl":"10.34172/ahj.1634","url":null,"abstract":"","PeriodicalId":33943,"journal":{"name":"Addiction and Health","volume":"16 4","pages":"305-306"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Addiction and HealthPub Date : 2024-10-01Epub Date: 2024-10-29DOI: 10.34172/ahj.1590
Zachary I Merhavy, Marcos Flores, Eliu Rivera, Jordanne Gizzarelli, Samir Ruxmohan, Jonathan Quinonez
{"title":"Navigating Buprenorphine Therapy: A Closer Look at Microdosing vs. Macrodosing for Pain Management and Opioid Addiction - A Narrative Review.","authors":"Zachary I Merhavy, Marcos Flores, Eliu Rivera, Jordanne Gizzarelli, Samir Ruxmohan, Jonathan Quinonez","doi":"10.34172/ahj.1590","DOIUrl":"10.34172/ahj.1590","url":null,"abstract":"<p><strong>Background: </strong>Buprenorphine therapy has emerged as a primary therapy method for both opioid addiction and chronic pain; however, the «one size fits all» approach to buprenorphine administration is no longer tenable. This review analyzes the pharmacology of both dosing approaches and their clinical outcomes, safety profiles, and societal implications, providing valuable insights for healthcare professionals.</p><p><strong>Methods: </strong>Multiple databases were used in conjunction with a set of inclusion and exclusion criteria to source articles to assess the consensus of best methods for treating opioid use disorder (OUD). This comprehensive review discusses two distinct dosing strategies, microdosing and macrodosing, through a detailed literature search to assess the differences and similarities of each strategy.</p><p><strong>Findings: </strong>Microdosing entails administering minimal buprenorphine doses, with promise in pain alleviation and addiction management while mitigating the risks of dependence and side effects typically associated with traditional opioids. In contrast, macrodosing employs higher buprenorphine doses, which is well-established for OUD and chronic pain management but raises concerns concerning misuse and overdose.</p><p><strong>Conclusion: </strong>Tailoring buprenorphine therapy to patients' individual needs is essential in the face of contemporary healthcare challenges related to pain management and opioid addiction.</p>","PeriodicalId":33943,"journal":{"name":"Addiction and Health","volume":"16 4","pages":"279-285"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Addiction and HealthPub Date : 2024-10-01Epub Date: 2024-10-29DOI: 10.34172/ahj.1529
Sahar Yari Oskouei, Nastaran Mansouriyeh
{"title":"The effectiveness of brain wave synchronization in the theta band on depression and anxiety in opioid-dependent patients.","authors":"Sahar Yari Oskouei, Nastaran Mansouriyeh","doi":"10.34172/ahj.1529","DOIUrl":"10.34172/ahj.1529","url":null,"abstract":"<p><strong>Background: </strong>Addiction is one of the most common psychiatric disorders and is closely related to depression and anxiety disorders. The presence of these disorders makes the process of addiction treatment difficult. Binaural beats are the representation and perception of a stimulus that does not exist in the outside world but is the brain's mental perception error of a virtual third sound, that is, the slight frequency difference between the two sounds.</p><p><strong>Methods: </strong>The present study was conducted to assess the effectiveness of brain synchronization using binaural beats in the theta band on depression and anxiety in opioid-dependent patients in Tabriz city. The method of conducting quasi-experimental research with two test and control groups is pretest-posttest. The statistical population was all opioid-dependent people referring to outpatient clinics in Tabriz city. The research sample included 30 opioid-dependent people who completed the informed consent form and Beck's depression and anxiety questionnaire. The subjects were randomly assigned to two experimental and control groups and received eight sessions of 7.5 Hz binaural beats, 20 minutes each, by headphones. The questionnaires above were administered again after the completion of the treatment sessions.</p><p><strong>Findings: </strong>This study analyzed the obtained data by ANCOVA using SPSS20 software. The reasult showed binaural beat in Tetha band (7.5 Hz) have a significant effect on depression and anxiety (<i>P</i>=0.000).</p><p><strong>Conclusion: </strong>According to the results, the binaural beats in the theta band reduce anxiety and depression in opioid-dependent patients.</p>","PeriodicalId":33943,"journal":{"name":"Addiction and Health","volume":"16 4","pages":"248-252"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Addiction and HealthPub Date : 2024-10-01Epub Date: 2024-10-29DOI: 10.34172/ahj.1326
Ali Bazzi, Mohammad Javad Ghazanfari, Iraj Aghaei, Abdolhossien Emami Sigaroudi, Mahmood Moosazadeh, Touraj Assadi, Samad Karkhah
{"title":"A Systematic Review of Knowledge and Attitude of Nurses Towards Substance Use or Users.","authors":"Ali Bazzi, Mohammad Javad Ghazanfari, Iraj Aghaei, Abdolhossien Emami Sigaroudi, Mahmood Moosazadeh, Touraj Assadi, Samad Karkhah","doi":"10.34172/ahj.1326","DOIUrl":"10.34172/ahj.1326","url":null,"abstract":"<p><strong>Background: </strong>Substance use disorders (SUDs) pose substantial challenges to society, creating widespread negative effects. Given their frequent and direct contact with patients, nurses hold a vital position in managing and addressing these disorders. This systematic review aimed to examine nurses' understanding of substance use and their perceptions of individuals affected by these conditions.</p><p><strong>Methods: </strong>This systematic review involved a comprehensive search of online databases such as PubMed, Web of Science, and Scopus, utilizing relevant keywords up to July 9, 2021. Only studies published in English and aligned with the review's objectives were considered. The quality of the included studies was evaluated using the AXIS tool.</p><p><strong>Findings: </strong>A total of 3273 nurses participated across 12 studies. The results indicated that nurses' knowledge about substance use was moderate, and their attitudes toward substance users were generally positive. Knowledge-related factors included variables such as age, gender, and work experience. Similarly, age, gender, ethnicity, education level, job position, work experience, participation in workshops on substance use, interest in patient care, hours spent on substance use courses during education, and continuing education hours related to substance use were identified as potential factors influencing attitudes.</p><p><strong>Conclusion: </strong>Therefore, holding workshops and improving guidelines for patient care with SUDs can enhance nurses' knowledge and attitudes and, ultimately, the quality of nursing care.</p>","PeriodicalId":33943,"journal":{"name":"Addiction and Health","volume":"16 4","pages":"297-304"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Addiction and HealthPub Date : 2024-10-01Epub Date: 2024-10-29DOI: 10.34172/ahj.1547
Danyal Ewaz, Ali Rahimi, Sharareh Shayan, Nasar Ahmad Shayan
{"title":"Tobacco Use Patterns Among University Students in Herat, Afghanistan: A Cross-sectional Study.","authors":"Danyal Ewaz, Ali Rahimi, Sharareh Shayan, Nasar Ahmad Shayan","doi":"10.34172/ahj.1547","DOIUrl":"10.34172/ahj.1547","url":null,"abstract":"<p><strong>Background: </strong>Tobacco use is highly prevalent in Afghanistan, posing a significant challenge among young people, including university students. This study aims to investigate tobacco product usage patterns and associated factors among male students at Herat University, Afghanistan, addressing the critical need for understanding and addressing this public health issue.</p><p><strong>Methods: </strong>In this cross-sectional study conducted between April and May 2021, 640 male university students were surveyed using interview-based stratified random sampling to assess cigarette, smokeless tobacco (ST), hookah, and e-cigarette use alongside sociodemographic factors. Logistic regression identified significant predictors.</p><p><strong>Findings: </strong>The prevalence was 35.3% for cigarette smoking, 15% for ST use, 14.1% for e-cigarette vaping, and 35.5% for hookah smoking. In the cigarette model, predictors included age (OR=1.20), mother's education (secondary/high school OR=2.19; university OR=2.68), friends' use (OR=9.54), and employment status (OR=2.52). The hookah model highlighted friends' use (OR=31.05), marital status (OR=2.10), employment status (OR=1.76), and mother's education (secondary/high school OR=2.18; university OR=3.57) as predictors. In the ST model, predictors were friends' use (OR=20.12), employment status (OR=3.37), and mother's education (secondary/high school OR=2.91). Lastly, the e-cigarette model revealed the predictors of friends' use (OR=7.91) and employment status (OR=1.87).</p><p><strong>Conclusion: </strong>Tobacco use among Afghan male university students is significantly influenced by peer behavior, employment status, and parental education. Interventions should target accessibility and sociocultural attitudes and include educational programs and policy measures to reduce tobacco consumption in the university setting.</p>","PeriodicalId":33943,"journal":{"name":"Addiction and Health","volume":"16 4","pages":"237-247"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Prevalence and the Contributing Factors of Substance Abuse Among Medical Sciences Students.","authors":"Hamidreza Gilasi, Sayyed Alireza Talaei, Mahtab Hodavand, Hossein Biqam, Hamzeh Arbab, Fatemeh Mohebbi","doi":"10.34172/ahj.1508","DOIUrl":"10.34172/ahj.1508","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of substance abuse (SA) among youth has increased in recent years. However, limited data exist about SA among medical sciences students. Therefore, this study assessed SA prevalence and contributing factors among medical sciences students.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in 2019. Participants were 238 medical sciences students randomly selected from Kashan University of Medical Sciences, Kashan, Iran. The data collection instrument was the SA prevalence assessment questionnaire developed by the Mental Health Center of the Ministry of Health of Iran. Data were analyzed using the SPSS (v. 22.0) software.</p><p><strong>Findings: </strong>The most commonly abused substances were waterpipe tobacco (31.9%), cigarettes (20.2%), and alcoholic beverages (10.5%). Most participants with a history of SA had started SA before entering university. The prevalence rates of waterpipe tobacco smoking, cigarette smoking, and alcohol consumption were 9.2%, 8.8%, and 4.2% in the past month and 16.4%, 18.1%, and 7.6% in the past year, respectively. The prevalence of SA among dormitory students and students with lower grade point averages was significantly higher than among non-dormitory students and students with higher grade point averages.</p><p><strong>Conclusion: </strong>The onset age of SA was mainly before eighteen years, so strategies are needed to reduce SA in secondary schools. Moreover, strategies are needed to prevent and reduce SA at universities, particularly among dormitory students and students with lower grade point averages. University authorities should use effective educational and counseling programs to prevent student SA.</p>","PeriodicalId":33943,"journal":{"name":"Addiction and Health","volume":"16 4","pages":"262-268"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Addiction and HealthPub Date : 2024-10-01Epub Date: 2024-10-29DOI: 10.34172/ahj.1515
Masoud Soltaninejad, Yasaman Naderi, Leili Rouhi, Mohammad Banazadeh
{"title":"Substance Abuse and Sexual Functioning: An Overview of Mechanisms.","authors":"Masoud Soltaninejad, Yasaman Naderi, Leili Rouhi, Mohammad Banazadeh","doi":"10.34172/ahj.1515","DOIUrl":"10.34172/ahj.1515","url":null,"abstract":"<p><p>Sexuality remains a subject of ongoing debate, with significant implications for self-perception and self-esteem, and addiction is a factor that can adversely affect it. Sexual dysfunction heavily burdens people with substance use disorders, as it can cause severe issues such as erectile dysfunction, loss of libido, dyspareunia, and delayed ejaculation. These issues can be caused by hormonal imbalances, loss of vaginal lubrication, lowered blood flow to the penile tissue, and problems with other organs, such as the liver. There could be some therapies to resolve such issues at least partially, for example, medication (oral and injectable), low-intensity focused shockwave therapy, vacuum constriction device, promoting exercise, and testosterone replacement therapy. Utilizing such methods could be helpful, but we could not be sure of their effectiveness. The current review aims to give a brief overview of sexual function, substance use disorders, and their impact on sexuality.</p>","PeriodicalId":33943,"journal":{"name":"Addiction and Health","volume":"16 4","pages":"286-296"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Addiction and HealthPub Date : 2024-10-01Epub Date: 2024-10-29DOI: 10.34172/ahj.1511
Melika Farhadi, Mansoureh Sabzalizadeh, Ali Shamsara, Mohammad Reza Afarinesh
{"title":"The Effect of Valproic Acid Administration on Learning, Social Interaction, and Depression Induced by Withdrawal Syndrome in Morphine-dependent Mice.","authors":"Melika Farhadi, Mansoureh Sabzalizadeh, Ali Shamsara, Mohammad Reza Afarinesh","doi":"10.34172/ahj.1511","DOIUrl":"10.34172/ahj.1511","url":null,"abstract":"<p><strong>Background: </strong>Opioids can lead to mood disorders, anxiety, depression, and cognitive impairment. Valproic acid (VPA) has neuroprotective effects that can prevent neural degeneration. This study aims to examine the impact of VPA on learning, social interaction, and depression in mice dependent on morphine.</p><p><strong>Methods: </strong>Subjects were divided into four groups and received injections of saline, VPA, morphine, or a combination of VPA and morphine for eight days. Behavioral tests were conducted on day 8, and then administration of VPA and morphine was stopped, leading to spontaneous withdrawal syndrome. Behavioral tests were repeated on day 11, and histological analysis was performed on the hippocampus.</p><p><strong>Findings: </strong>The preference index (PI%) decreased in the novel object recognition test in the VPA and morphine sulfate (MOR) groups compared to the control (CTL) group in the chronic phase. The concomitant administration of VPA and morphine caused an increase in social interaction criteria in both the chronic and withdrawal phases. The decrease in immobility time in the VPA and MOR+VPA groups compared to the CTL group in the withdrawal phase was not statistically significant in the tail suspension test (TST). In Nissl staining, the combination of MOR+VPA led to a significant decrease in the DC/All cell ratio compared to the individual MOR and VPA groups (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>VPA may improve social relationships and depression indices during morphine withdrawal. VPA may potentially mitigate the cellular changes in the CA1 of the hippocampus induced by morphine.</p>","PeriodicalId":33943,"journal":{"name":"Addiction and Health","volume":"16 4","pages":"253-261"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Addiction and HealthPub Date : 2024-07-01Epub Date: 2024-07-29DOI: 10.34172/ahj.1487
Aida Norouzi, Tahereh Dehghani, Ebrahim Eftekhar
{"title":"Water-pipe Tobacco Components and their Association with Oxidative Stress.","authors":"Aida Norouzi, Tahereh Dehghani, Ebrahim Eftekhar","doi":"10.34172/ahj.1487","DOIUrl":"https://doi.org/10.34172/ahj.1487","url":null,"abstract":"<p><p>Oxidative stress (OS) results from an imbalance between the formation and detoxification of reactive species. Although reactive species at low or moderate levels play numerous physiological roles, high concentrations can lead to disturbances in signaling and metabolic pathways and cause different metabolic, chronic, and age-related disorders. Several endogenous and exogenous processes may lead to the formation of reactive species. The severity of OS can be reduced with the help of antioxidants. Tobacco is one of the most important environmental factors contributing to reactive species production. After cigarette smoking, water-pipe tobacco (WPT) smoking is ranked as the second most popular tobacco product. Its popularity is proliferating due to flavored products, social acceptability, etc. However, studies have shown that WPT smoking is associated with an increased risk of arterial stiffness, ischemic heart disease, and several cancer types. In this study, we aimed to review the most recent evidence on WPT smoking constituents and their association with OS.</p>","PeriodicalId":33943,"journal":{"name":"Addiction and Health","volume":"16 3","pages":"205-212"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Addiction and HealthPub Date : 2024-07-01Epub Date: 2024-07-29DOI: 10.34172/ahj.1537
Jaison Joseph, Deepika C Khakha
{"title":"Alcohol Abstinence, Adherence, and Attitudes toward Disulfiram Treatment for Alcohol Dependence among Patients Attending a Tertiary Care Setting in North India.","authors":"Jaison Joseph, Deepika C Khakha","doi":"10.34172/ahj.1537","DOIUrl":"https://doi.org/10.34172/ahj.1537","url":null,"abstract":"<p><strong>Background: </strong>Disulfiram is the first Food and Drug Administration (FDA)-approved drug for the treatment of alcohol dependence, primarily acting as a deterrent agent. The available literature on disulfiram treatment for alcohol dependence among individuals in low-income and middle-income countries is scarce, while numerous factors impact the acceptance and adherence to such treatment.</p><p><strong>Methods: </strong>The study utilized a purposive sampling methodology. The participants were contacted by telephone at 4 weeks, 12 weeks, and 24 weeks after the initiation of disulfiram treatment. Alcohol abstinence was calculated using the self-reported total alcohol-free days, and adherence and attitudes toward disulfiram treatment were measured using the Treatment Compliance Assessment Scale (TCAS).</p><p><strong>Findings: </strong>The participants had a mean age of 39.30±7.7 years. Nearly 62% and 46% of the subjects reported maintenance of alcohol abstinence after initiation of 12 and 24 weeks of disulfiram treatment, respectively. The proportion of non-adherent subjects increased from 36.3% to 57.2% during the 12-week and 24-week follow-up periods. Attitudes toward disulfiram treatment varied significantly across different time points. A strong positive correlation was observed in the alcohol abstinence, adherence, and attitude scores at different time points (<i>P</i><0.01).</p><p><strong>Conclusion: </strong>The present study's findings unveiled that nearly 60% and 40% of the study subjects were maintaining alcohol abstinence and adherence at 12 weeks and 24 weeks after initiation of disulfiram treatment, respectively. Disulfiram could be a viable psychological tool for alcohol abstinence, but objective measurements are required to underpin its utility in this setting.</p>","PeriodicalId":33943,"journal":{"name":"Addiction and Health","volume":"16 3","pages":"152-158"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}