Clinical Infection in Practice最新文献

{"title":"Carbapenemase-producing Enterobactericeae screening: Focused patient insights","authors":"Saba Farrukh ,&nbsp;Jessica Martin ,&nbsp;Caroline Chilton ,&nbsp;Gillian Fox ,&nbsp;Christopher Michael Rooney","doi":"10.1016/j.clinpr.2025.100491","DOIUrl":"10.1016/j.clinpr.2025.100491","url":null,"abstract":"<div><h3>Background</h3><div>Anti-microbial resistance (AMR) is predicted to cause 10 million deaths annually by 2050. This prediction has shaped local policies, with a focus on antimicrobial stewardship and source isolation. However, the impact of these interventions on the individual patient is often overlooked, and the patient perspective is infrequently included in AMR strategies.</div></div><div><h3>Aim(s)/Objective(s)</h3><div>Our objective was to explore the lived patient experience through a Carbapemase Producing Enterobacterales (CPE) Outbreak. Specifically, we aimed to understand the patient’s knowledge of CPE, risks associated with AMR and their experience with rectal screening and source isolation.</div></div><div><h3>Method(s)</h3><div>Using a PPIE (public and patient involvement and engagement) framework, during a CPE outbreak, we engaged in one to one conversations with adult inpatients who had capacity, discussing the effects of AMR exposure. CPE-positive (n = 8) and CPE-negative (n = 2) participants were included. The latter had undergone &gt; 3 CPE screens, were high-risk of AMR acquisition and in source isolation.</div></div><div><h3>Results</h3><div>Our one-on-one conversations revealed poor levels of patient knowledge about CPE and AMR risk, with many participants expressing concerns about the limited or lack of information provided by healthcare providers. Experiences with rectal screening was generally reported as uncomfortable, with passive acceptance for it. Opinions on source isolation were mixed, with feelings of being bored or lonely emerging as a common sentiment.</div></div><div><h3>Discussion and/or Conclusion(s)</h3><div>These discussions underscore the necessity for improved patient education and communication surrounding CPE and antibiotic resistance, specifically tailored to meet the needs of frailer populations. This study also highlights the critical role of healthcare staff in consistently providing clear information to patients. It is vital patient empowerment is encouraged, and focused efforts made to close this knowledge gap and enhance the patient experience.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"26 ","pages":"Article 100491"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Listeria infections: The unexpected risks in everyday foods","authors":"Samriddhi Sharma ,&nbsp;Arnav Gandhi ,&nbsp;Sanjit Sah ,&nbsp;Mahendra Pratap Singh ,&nbsp;Guru Datt Sharma ,&nbsp;Amogh Verma","doi":"10.1016/j.clinpr.2025.100489","DOIUrl":"10.1016/j.clinpr.2025.100489","url":null,"abstract":"<div><div>Listeria monocytogenes remains a major public health concern due to its ability to survive in diverse environments, including under refrigerated conditions, and cause severe illness in vulnerable populations. In July 2024, a Listeria outbreak linked to deli-sliced meats in the United States resulted in 61 confirmed cases, 60 hospitalizations, and 10 deaths across 19 states, underscoring persistent challenges in food safety. Historical outbreaks involving dairy, produce, and processed meats highlight the complexity of contamination routes and the importance of comprehensive preventive measures. As an intracellular pathogen, Listeria requires prompt diagnosis and targeted antibiotic therapy, typically involving ampicillin and gentamicin. Control efforts are complicated by the bacterium’s propensity for biofilm formation and its resilience under cold storage. Advances in sanitation protocols, whole-genome sequencing, and public health initiatives are key to reducing the incidence of listeriosis. Nevertheless, continued outbreaks emphasize the need for rigorous food safety practices, high-risk population awareness, and ongoing surveillance.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"26 ","pages":"Article 100489"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Clinical manifestations and outcomes of human mpox infection from 1970 to 2023: A systematic literature review” [Clin. Infect. Pract. 24 (2024) 100397]","authors":"Chukwuyem Abejegah ,&nbsp;Kennedy O. Obohwemu ,&nbsp;Mselenge Mdegela","doi":"10.1016/j.clinpr.2025.100492","DOIUrl":"10.1016/j.clinpr.2025.100492","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"26 ","pages":"Article 100492"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of Candida albicans-associated meningitis; A case report study","authors":"Solmaz Askari ,&nbsp;Mahila Monajati ,&nbsp;Sedigheh Erfani ,&nbsp;Narges Lashkarbolouk ,&nbsp;Seyedeh Sedigheh Hosseini","doi":"10.1016/j.clinpr.2025.100490","DOIUrl":"10.1016/j.clinpr.2025.100490","url":null,"abstract":"<div><h3>Background</h3><div>Fungal infections of the Central Nervous System (CNS) are rare but can have devastating consequences. In immunocompromised patients, such as those on chronic dexamethasone therapy, Candida can invade the bloodstream and enter the CNS, causing meningitis. Diagnosis of fungal infections often relies on pathogen culture, which is time-consuming and insensitive.</div></div><div><h3>Case presentation</h3><div>we present a 60-year-old female with chronic use of dexamethasone, with <em>Candida albicans</em>-associated meningitis, diagnosed using phenotyping, genotyping, and sequencing methods. Unfortunately, her condition deteriorated despite antifungal therapy, and she eventually succumbed to severe sepsis and septic shock.</div></div><div><h3>Conclusion</h3><div>Physicians must remain vigilant regarding fungal infections, particularly those affecting the brain, in immunosuppressed patients. Prompt diagnosis and the early treatment is crucial in preventing adverse outcomes. The efficacy of treatment may differ based on the infection’s severity and the patient’s immune status, making the early identification of clinical deterioration vital for effective management and prognosis.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"26 ","pages":"Article 100490"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New comorbidities and mortality up to 5 years post blood stream infection (BSI) with Escherichia coli","authors":"A. Richards ,&nbsp;Y.W. Phong ,&nbsp;N. Easom ,&nbsp;P.J. Lillie","doi":"10.1016/j.clinpr.2025.100494","DOIUrl":"10.1016/j.clinpr.2025.100494","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"26 ","pages":"Article 100494"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue encephalitis as an underrecognized cause of acute coma and neuroendocrine dysfunction: A case report with literature review","authors":"Chowdhury Adnan Sami ,&nbsp;K.F.M. Ayaz ,&nbsp;Sumaiya Farah Marisa ,&nbsp;Anika Tabassum ,&nbsp;Husna Rafsana ,&nbsp;Md. Imrul Hasan ,&nbsp;Mohammad Mahfuzur Rahman ,&nbsp;Sayat Quayum Mohona ,&nbsp;Shahedur Rahman ,&nbsp;Muhammad Mahmudul Hasan","doi":"10.1016/j.clinpr.2025.100493","DOIUrl":"10.1016/j.clinpr.2025.100493","url":null,"abstract":"<div><h3>Background</h3><div>Dengue virus infection is a globally prevalent arboviral illness with a wide clinical spectrum. Although most cases are mild or self-limiting, neurological manifestations, such as encephalitis, are increasingly reported, especially in endemic regions. Dengue encephalitis is a rare but life-threatening complication characterized by viral neuroinvasion, cerebral edema, and, in severe cases, herniation. Even rarer is the occurrence of central diabetes insipidus (CDI), which may signal hypothalamic or pituitary axis involvement.</div></div><div><h3>Case presentation</h3><div>We report a fatal case of Dengue encephalitis in a previously healthy 32-year-old woman from Dhaka, Bangladesh, who presented with fever and hypotension. A few hours after admission, she had generalized seizures and rapid neurologic deterioration. CT imaging showed bilateral thalamic and basal ganglia edema, and she was admitted to the intensive care unit for neuroprotective management. Dengue was confirmed by RT-PCR from the blood sample. She experienced marked polyuria, hypernatremia, and low urine osmolality consistent with CDI on day 2 of hospitalization, likely due to brainstem or hypothalamic injury. MRI showed diffuse encephalitic changes with uncal herniation. She died of brain herniation on the fourth day of hospitalization despite ventilatory support, anticonvulsants, desmopressin, and vasopressors.</div></div><div><h3>Conclusion</h3><div>This case highlights the virulent nature of dengue encephalitis and the risk of rare but devastating complications of dengue infection, such as CDI. Neuroimaging showing bilateral thalamic involvement and hemorrhagic lesions should alert the clinician to consider dengue encephalitis in endemic areas. Early identification, neuroimaging, and multidisciplinary supportive care are vital, but fulminant cases continue to have poor prognoses. More awareness and reporting of such atypical presentations are necessary for the recognition, management strategies, and outcomes of neuroinvasive dengue.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"26 ","pages":"Article 100493"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated cutaneous blastomycosis acquired in Mexico: A case report and literature review","authors":"Mina Kang ,&nbsp;Penelope J. Teoh ,&nbsp;Rachel Southern-Thomas ,&nbsp;Peter Rae ,&nbsp;Christopher B. Bunker ,&nbsp;Sarah Logan ,&nbsp;Neil Stone","doi":"10.1016/j.clinpr.2025.100484","DOIUrl":"10.1016/j.clinpr.2025.100484","url":null,"abstract":"<div><h3>Background</h3><div>Blastomycosis is caused by species of the dimorphic fungus <em>Blastomyces</em>, (<em>B. dermatitidis</em> and <em>B. gilchristi).</em> It is an endemic mycosis that causes a spectrum of disease, most often pulmonary and cutaneous. It is rarely diagnosed in the United Kingdom (UK) where it is non-endemic.</div></div><div><h3>Case Report</h3><div>A 35-year-old immunocompetent Caucasian male presented to our hospital with a 2-week history of rash, fever and joint pain following work travel to rural Mexico. On examination he had centrally umbilicated and haemorrhagic crusted nodules on face, nose and extremities. Punch skin biopsy demonstrated a dermal neutrophilic infiltrate with microabscesses and an associated vasculitis. <em>Blastomyces</em> serology was strongly positive. He was treated with itraconazole orally with excellent clinical response.</div></div><div><h3>Discussion</h3><div><em>Blastomyces</em> is endemic in the Eastern United States and South-East Canada, occupying an ecological niche of wooded areas with decomposing organic matter. In this case, the likely exposure was inhalation of spores, followed by cutaneous dissemination. Diagnosis was based upon positive serology without any cross-reactivity with assays for other endemic mycoses. The good clinical response to itraconazole supported the diagnosis.</div></div><div><h3>Conclusion</h3><div>Blastomycosis can present with disseminated skin lesions and requires a high index of suspicion to diagnose in a non-endemic setting. Our case demonstrates the importance of considering endemic mycosis such as blastomycosis, in patients who have travelled to areas not classically thought of as endemic, and the importance of a detailed travel and exposure history.</div></div>","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"26 ","pages":"Article 100484"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising burden of human metapneumovirus: A call for global preparedness","authors":"Shriyansh Srivastava ,&nbsp;Dheeraj Sharma ,&nbsp;Sathvik Belagodu Sridhar ,&nbsp;Sachin Kumar ,&nbsp;G.S.N. Koteswara Rao ,&nbsp;Roja Rani Budha ,&nbsp;Rachana Mehta ,&nbsp;Aroop Mohanty ,&nbsp;Sanjit Sah","doi":"10.1016/j.clinpr.2025.100416","DOIUrl":"10.1016/j.clinpr.2025.100416","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"26 ","pages":"Article 100416"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"57 PWID study: PromethION sequencing to understand the epidemiology of Staph aureus blood stream infections in people who inject drugs","authors":"Phillipa Burns ,&nbsp;Alexander Richardson ,&nbsp;Patrick J. Lillie ,&nbsp;Michelle Rudden ,&nbsp;Mat Hardman","doi":"10.1016/j.clinpr.2025.100470","DOIUrl":"10.1016/j.clinpr.2025.100470","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100470"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"21 Staphylococcus aureus bacteraemia acquired through injection drug use represents a distinct clinical phenotype","authors":"Emily Heppenstall ,&nbsp;Karla Berry ,&nbsp;George Cooper ,&nbsp;Wynne Sim ,&nbsp;Rui Shian Lee ,&nbsp;Tze Yi Gan ,&nbsp;William Donlon ,&nbsp;Antonia Besu ,&nbsp;Luke Tysall ,&nbsp;Clark.D. Russell","doi":"10.1016/j.clinpr.2025.100446","DOIUrl":"10.1016/j.clinpr.2025.100446","url":null,"abstract":"","PeriodicalId":33837,"journal":{"name":"Clinical Infection in Practice","volume":"25 ","pages":"Article 100446"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}