Residência Pediátrica最新文献_第9页

Pediatric clinical trial profile for COVID-19 at ClinicalTrials.gov: a systematic review ClinicalTrials.gov上针对COVID-19的儿科临床试验概况:一项系统综述

Residência Pediátrica Pub Date : 1900-01-01 DOI: 10.25060/residpediatr-2021.v11n2-614

M. Covolan, Luiza Tsuruda, D. Silva, David Barbosa, R. Pasa, K. Kavalco, F. Menegídio

{"title":"Pediatric clinical trial profile for COVID-19 at ClinicalTrials.gov: a systematic review","authors":"M. Covolan, Luiza Tsuruda, D. Silva, David Barbosa, R. Pasa, K. Kavalco, F. Menegídio","doi":"10.25060/residpediatr-2021.v11n2-614","DOIUrl":"https://doi.org/10.25060/residpediatr-2021.v11n2-614","url":null,"abstract":"INTRODUCTION: COVID-19 is an extremely serious infectious disease. However, few studies have focu-sed on the drug treatment of pediatric patients affected by COVID-19. OBJECTIVE: Thus, this study conducted a review of clinical trials registered in the Clinical Trials database on drug treatment in pe-diatric patients with COVID-19. METHODS: A systematic search was conducted in the Clinical Trials database (https://clinicaltrials.gov/) using the web tracking technique to collect registered clinical tri-als that conducted drug treatment in pediatric patients aged 0 to 17 years. After the drugs used were identified, their dosage and other pertinent information were obtained from the DrugBank databases (https://go.drugbank.com) and the DrugBase (https://www.drugbase.de). RESULTS: Eight clinical trials were found in the research, classified as completed and 34 in progress, aimed at pediatric patients. The United States was the country that most research involving the drug use in patients with pedia-tric COVID-19. Hydroxychloroquine was the most observed drug in the treatment of pediatric pa-tients, followed by remdesivir. An increase in phase 3 and randomized trials was also observed among ongoing research when compared to completed research. CONCLUSION: Compared to adults, pedia-tric COVID-19 has distinct treatment needs. Thus, it is important to complete the clinical trials de-scribed in the present study, in addition to more randomized clinical trials, before any therapy or other objects related to the clinical management processes for COVID-19 can be properly recom-mended and applied in pediatric treatment.","PeriodicalId":338092,"journal":{"name":"Residência Pediátrica","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134170057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethics in medical research 医学研究中的伦理学

Residência Pediátrica Pub Date : 1900-01-01 DOI: 10.25060/residpediatr-2020.v10n3-04

Carlindo Silva

引用次数: 0

Epilepsy due to pyridoxine dependence: a case report 吡哆醇依赖所致癫痫1例

Residência Pediátrica Pub Date : 1900-01-01 DOI: 10.25060/residpediatr-2023-600

L. Paiva, Luigi Reis, Rinara Andrade, S. Brito, Giulia Chieppe, Isabel Freire

引用次数: 0

Near infrared spectroscopy (NIRS) in neonatal intensive care unit: experience of a brazilian university hospital 近红外光谱(NIRS)在新生儿重症监护室:巴西大学医院的经验

Residência Pediátrica Pub Date : 1900-01-01 DOI: 10.25060/residpediatr-2023.v13n2-525

Luciana Almeida, G. Variane, R. Pietrobom, M. Magalhães, D. Rodrigues, Renato Gasperini, Alexandre Netto

{"title":"Near infrared spectroscopy (NIRS) in neonatal intensive care unit: experience of a brazilian university hospital","authors":"Luciana Almeida, G. Variane, R. Pietrobom, M. Magalhães, D. Rodrigues, Renato Gasperini, Alexandre Netto","doi":"10.25060/residpediatr-2023.v13n2-525","DOIUrl":"https://doi.org/10.25060/residpediatr-2023.v13n2-525","url":null,"abstract":"Near-infrared spectroscopy (NIRS) is a non-invasive method to assess regional brain and/or renal oxygenation, and an important tool for a better clinical management. The aim of this study was to describe clinical cases of newborns admitted to the Neonatal Intensive Care Unit of a Brazilian university hospital who were monitored with NIRS, and to evaluate the applicability of NIRS demonstrating its use as a continuous monitoring method for newborns at high risk for brain injury. This study was part of the Conclusion Work of Medical Residency in Neonatology in Neonatology. Case 1: Persistent ductus arteriosus-NIRS guided indication for drug treatment. Case 2: Septic shock-NIRS was helpful identifying the need of inotropes. Case 3: Anemia of prematurity-NIRS showed an increase of cerebral oxygenation after red blood cells transfusions. Case 4: Hypoxic-ischemic encephalopathy-NIRS identified sign of poor neurological prognostic. NIRS is a continuous cerebral and renal perfusion monitoring method that has easy and good applicability and no complications. The cases reflect the importance and potential of NIRS in clinical practice and in helping diagnose for newborns, as well as enabling prognostic assessment. NIRS proved to be a method of good applicability, without short-term complications. Observing brain oxygenation values can help to avoid conditions associated with the development of neurological sequelae.","PeriodicalId":338092,"journal":{"name":"Residência Pediátrica","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115213754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leptospirosis encephalitis in a pediatric patient: case report 小儿钩端螺旋体病脑炎1例报告

Residência Pediátrica Pub Date : 1900-01-01 DOI: 10.25060/residpediatr-2023.v13n2-555

Camila Cabrera, Ana Paula Sazaki, D. Almeida

引用次数: 0

Genital ambiguity in a 46,XY individual: case report 46,xy个体生殖器模糊1例报告

Residência Pediátrica Pub Date : 1900-01-01 DOI: 10.25060/RESIDPEDIATR-2020.V10N2-104

Jadi Colaço, A. Tochetto, Amanda Magdaleno, C. Moreira, T. Rodrigues, L. Leitzke, P. Nader, Guilherme Guaragna Filho

引用次数: 0

Efeitos do corticoide antenatal em prematuros de muito baixo peso 产前皮质激素对极低体重早产儿的影响

Residência Pediátrica Pub Date : 1900-01-01 DOI: 10.25060/residpediatr-2019.v9n1-06

G. Nunes, M. Colvero

{"title":"Efeitos do corticoide antenatal em prematuros de muito baixo peso","authors":"G. Nunes, M. Colvero","doi":"10.25060/residpediatr-2019.v9n1-06","DOIUrl":"https://doi.org/10.25060/residpediatr-2019.v9n1-06","url":null,"abstract":"Introduction: The benefits of antenatal corticosteroid (AC) to preterm infants are well established. Its action in multiple tissues promotes maturity of fetal structures, with significant impact in the reduction of neonatal morbimortality. Objective: Evaluate the effects of AC in very low birth weight preterm infants (VLBWPI). Methods: Data from the Rede Gaúcha de Neonatologia of those VLBWPI born between 01/01/2008 and 12/31/2014 at the Fêmina Hospital in Porto Alegre was used. The exposure to AC (one or two doses of intramuscular 12mg betamethasone) and its relation to mortality and following comorbidities were analyzed: respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), retinopathy of prematurity (ROP), necrotizing enterocolitis (NEC), patent ductus arteriosus (PDA), and bronchopulmonary dysplasia (BPD). Results: A total of 496 patients were obtained, of whom 68% received at least one dose of CA and 32% received none. A significant reduction in the incidence of RDS was obtained in the group that exposed to AC (OR 0.468, p = 0.001). A 60% reduction in IVH (OR 0.401, p < 0.001) was noted. A reduction in the incidence of BPD was also observed with the use of AC (OR 0.296-0.903, p = 0.018). No statistical difference was observed in the incidence of PVL (p = 0.3), PDA (p = 0.68), NEC (p = 0.44) or ROP (p = 0.58). Neonatal death was significantly reduced by 78% in those treated with AC (OR 0.22, p < 0.001). Conclusion: exposure to AC, regardless of the number of doses, confers lower morbidity and lower mortality to VLBWPI. Palavras-chave: Doenças do Prematuro, Prematuro, Glucocorticoides, Recém-Nascido de muito Baixo Peso.","PeriodicalId":338092,"journal":{"name":"Residência Pediátrica","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116140888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interconsultas em reumatologia pediátrica: casuística de hospital terciário no Sul do Brasil 儿科风湿病会诊:巴西南部一家三级医院的诡辩

Residência Pediátrica Pub Date : 1900-01-01 DOI: 10.25060/residpediatr-2022.v12n3-520

Ricardo Ribeiro, M. Bandeira

{"title":"Interconsultas em reumatologia pediátrica: casuística de hospital terciário no Sul do Brasil","authors":"Ricardo Ribeiro, M. Bandeira","doi":"10.25060/residpediatr-2022.v12n3-520","DOIUrl":"https://doi.org/10.25060/residpediatr-2022.v12n3-520","url":null,"abstract":"OBJECTIVE: To describe the clinico-epidemiological profile of pediatric patients seen via inter-consultation in a pediatric rheumatology (PR) outpatient clinic. METHODS: Cross-sectional and observational study that analyzed the medical records of patients seen in the form of inter-consultations in a PR outpatient clinic of a tertiary hospital for 14 months. Epidemiological, clinical history and laboratory tests data were collected and descriptive statistics were performed. RESULTS: 37 patients were included, 27 (73%) female and 10 (27%) male, with a median age of 12.4 years (min.: 1.3/max.: 15.9). Having performed several complementary exams, patients were referred by 13 different specialties, with a predominance of pediatric dermatology. In the first consultation with a pediatric rheumatologist, the main complaints were arthralgia (51.3%), skin blemishes (32.4%) and skin rash (29.7%). The period between the onset of symptoms and the consultation ranged between 16 and 4554 days, with a median of 730 days. Twenty (54.1%) patients had the exclusion of a rheumatological disease, three (8.1%) lost follow-up and 14 (37.8%) were diagnosed with rheumatological diseases, the most common being linear scleroderma (28.6%), juvenile systemic lupus erythematosus (28.6%), juvenile idiopathic arthritis (14.3%), and juvenile dermatomyositis (14.3%). CONCLUSION: The main complaints of patients referred to RP were arthralgia and skin lesions, with a long period of symptom evolution, in addition to a wide age range and the predominant role of female patients. In addition, it is noted that previously the evaluation of the pediatric rheumatologist, patients consulted several specialties and were exposed to several complementary exams.","PeriodicalId":338092,"journal":{"name":"Residência Pediátrica","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123079785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid sequence intubation in pediatrics: an update and proposed protocol 儿科快速顺序插管:更新和建议的方案

Residência Pediátrica Pub Date : 1900-01-01 DOI: 10.25060/residpediatr-2023.v13n1-774

Ana Paula Couto, A. Koliski, W. Vita, M. Rodrigues

引用次数: 0

PARACOCCIDIOIDOMICOSE EM UM ADOLESCENTE IMUNOCOMPETENTE: UMA DOENÇA NEGLIGENCIADA 免疫能力青少年副球孢子菌病:一种被忽视的疾病

Residência Pediátrica Pub Date : 1900-01-01 DOI: 10.25060/residpediatr-2023-682

A. Cabral, Cecília Silva, Márcia Cristina Chita Espírito Santo, D. Castro, Tainá Ventura, Rafael Silva, Naiany Rego

{"title":"PARACOCCIDIOIDOMICOSE EM UM ADOLESCENTE IMUNOCOMPETENTE: UMA DOENÇA NEGLIGENCIADA","authors":"A. Cabral, Cecília Silva, Márcia Cristina Chita Espírito Santo, D. Castro, Tainá Ventura, Rafael Silva, Naiany Rego","doi":"10.25060/residpediatr-2023-682","DOIUrl":"https://doi.org/10.25060/residpediatr-2023-682","url":null,"abstract":"Acute Paracoccidioidomycosis (PCM) represents 5 to 10% of total PCM cases. The estimated incidence varies between 1-4 cases for 100.000 inhabitants in the endemic regions of Brazil. It is known that PCM can coexist with other systemic mycoses such as Histoplasmosis. We report a case of a 10-year-old adolescent from Barra Mansa, RJ, Brazil. He was hospitalized after recurrent visits to the emergency department for approximately one month, presenting with non-bloody diarrhea, weight-loss of 6kg in six weeks, dry cough and nocturnal fever (average temperature 38ºC). Counterimmunoelectrophoresis and lymph node biopsy were positive for Paracoccidioides brasiliensis. The treatment consisted of Amphotericin B IV 0,6 mg/kg of body weight per day for 10 days and Itraconazole PO 200mg per day for 12 months. After 5 years, the patient remains asymptomatic. Reports of similar cases are scant in the literature and, the few encountered, are of immunocompromised children. The incidence and prevalence estimation of PCM might be inaccurate due to underdiagnosis and under-reporting","PeriodicalId":338092,"journal":{"name":"Residência Pediátrica","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122992757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0