CHILD`S HEALTH最新文献

{"title":"Comparative study of the analgesic and anti-stress effect of inhalation anesthesia in children with cancer and trauma pathology during surgical treatment","authors":"V. Snisar, D.V. Myronov","doi":"10.22141/2224-0551.18.2.2023.1571","DOIUrl":"https://doi.org/10.22141/2224-0551.18.2.2023.1571","url":null,"abstract":"Background. Adequate anesthesia is of great importance for patient safety, it reduces stress reactions to surgery and trauma. The perfection of modern anesthesia allows performing complex operations in different age periods in patients at high surgical and anesthetic risk. To limit the activation of neuroendocrine, inflammatory and immune reactions during surgery, new methods of anesthesia are constantly being searched for, different inhalation and non-inhalation drugs for anesthesia are compared in order to find an ideal “stress-free” anesthetic. Currently, during cancer surgeries, sevoflurane is widely used, but there are few studies showing efficiency of this inhalation anesthetic in children during surgical treatment of tumors and its effect on operative trauma and the reaction of the child’s body to stress. The purpose of our research is to study the extent to which sevoflurane limits the activation of neurovegetative, inflammatory, and immune responses in children during cancer surgery. Materials and methods. Twenty-seven children (first group) aged from 1 to 17 years (6.04 ± 5.84 years), who came for surgical treatment of cancer, were examined. To compare the studied indicators, 23 children (second group) aged from 2 to 17 years (10.68 ± 4.21 years) were additionally examined, they were scheduled for surgical treatment of trauma pathology. Results. Evaluation of the adequacy of sevoflurane anesthesia during operations in cancer and trauma patients showed that most hemodynamic parameters had similar changes at all stages, which is typical for this type of anesthesia. We studied changes in C-reactive protein and circulating cytokines before and after anesthesia with sevoflurane in children with cancer and trauma pathology. C-reactive protein level increased 4 times, but initially its level was 2–2.5 times higher in cancer patients. Similar dynamics was demonstrated with pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor). By the end of surgical intervention, a significant increase of cortisol was noted; however, in the children of the second group, the level of this hormone increased more compared with cancer patients. All spectral indicators of heart rate variability, which testified to the tension of the autonomic nervous system, had a significant difference between the groups. Conclusions. During inhalation anesthesia with sevoflurane, the profile of stress response in children with cancer differs from that in patients with trauma pathology.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124839446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and mathematical prediction of the physiotherapy results in adolescents with primary hypertension training on a stationary bike","authors":"O. Ivanko, M. Patsera, A. Tovma","doi":"10.22141/2224-0551.18.2.2023.1570","DOIUrl":"https://doi.org/10.22141/2224-0551.18.2.2023.1570","url":null,"abstract":"Background. The aim of the research is to clarify the indications for physical rehabilitation of adolescents with primary hypertension based on the individual clinical and mathematical prediction of long-term treatment outcomes. Materials and methods. There were observed 82 adolescents, 44 boys and 38 girls, aged 17.10 ± 0.05 years with a newly diagnosed primary hypertension. Physical rehabilitation for 7 months in the form of exercises on a statio­nary bike was prescribed to 44 patients who formed the main group. The rest of 38 adolescents who did not complete the stationary bike course and adhered to the recommendations for a healthy lifestyle formed the control group. Results. According to the ROC analysis, predictors of an adverse outcome of an attempt at physical rehabilitation were as follows: the ave­rage systolic blood pressure above 130 mm Hg at the start of a program, pulse rate variability index pNN50 of more than 16.6 % and body mass index above 25 kg/m2. Also, for the development of stable hypertension and an increase in the left ventricular posterior wall thickness in diastole above 8.0 mm, the average heart rate at night more than 68 bpm accor­ding to the Holter monitoring and the daily pulse pressure for 24-h monitoring more than 57 mm Hg were unfavorable. Conclusions. Аdolescents with primary hypertension should train at stationary bike in conditions of waiting for an effect of treatment. If an unfavorable course of the disease is predicted, physical rehabilitation must be combined with drug treatment.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133471893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of selenium on the course of inflammatory diseases of the upper gastrointestinal tract in children","authors":"T. Sorokman, S. Sokolnyk, O. Makarova","doi":"10.22141/2224-0551.18.2.2023.1572","DOIUrl":"https://doi.org/10.22141/2224-0551.18.2.2023.1572","url":null,"abstract":"Background. Impaired homeostasis of the essential microelements in the body of children plays a significant role in the etiology, pathogenesis and therapy of a number of diseases. Stu­dies on the exchange of bioelements in gastrointestinal diseases, in particular, the content of selenium (Se), have not been conducted enough. Aim: to evaluate selenium influence on the course of inflammatory diseases of the upper gastrointestinal tract in children. Materials and me­thods. The study included 112 school-age children with inflammatory diseases of the upper gastrointestinal tract (55 with chronic gastritis (CG), 57 with chronic gastroduodenitis (CGD)) as the main group and 20 practically healthy children of the corresponding age as the comparison group. Verification of CG and CGD diagnosis was based on clinical and endoscopic data according to the Houston mo­dification of the Sydney classification of chronic gastritis (1996) with assessment of topography and morphology. Quantitative determination of Se in blood plasma was carried out using mass spectrometry. Results. The average level of Se in blood plasma of children with inflammation of the gastric and duodenal mucosa was (75.82 ± 11.23) μg/l, in children of the comparison group — (85.42 ± 9.44) μg/l (p > 0.05). We did not find gender and age differences in Se plasma levels. Deficiency of Se in the blood of children with CG and CGD was found in 78 cases (69.6 %), while in the comparison group, a decrease in Se level was observed in only 4 children (20 %). There were no significant differences in the content of Se in children with CG and CGD. However, the analysis of indicators depending on the acti­vity of the inflammatory process revealed probable differences: with the first degree of the activity of the inflammatory process in the mucous membrane, the level of Se in the blood plasma was significantly lower ((66.2 ± 6.1) μg/ml), while with the second it was (78.5 ± 7.3) μg/ml (p < 0.05) and with the third — (86.9 ± 9.3) μg/ml (p < 0.01). Conclusions. The concentration of selenium, the essential trace element, in the blood plasma of children with chronic inflammatory diseases of the upper gastrointestinal tract was found to be probably lower than that of healthy children. The level of selenium in the blood plasma of these children probably positively correlated with the degree of inflammation in the mucous membrane of the gastroduodenal region. Changes in the concentration of selenium can affect the general condition of children, the duration and severity of the disease, which must be taken into account during the treatment of inflammatory diseases.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117322167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some immunological biomarkers of the severity of neonatal sepsis in newborns depending on different inflammatory response","authors":"O. Koloskova, N. Bogutska, O. Vlasova, S. Tarnavska, O.O. Shakhova","doi":"10.22141/2224-0551.18.2.2023.1573","DOIUrl":"https://doi.org/10.22141/2224-0551.18.2.2023.1573","url":null,"abstract":"Background. Objective: to study the diagnostic value and indicators of clinical and epidemiological risk of some immunological biomarkers as indicators of the severity of the clinical course of neonatal sepsis in order to improve treatment outcomes in newborns with neonatal sepsis with an alternative serum content of C-reactive protein. Materials and methods. A comprehensive clinical and paraclinical examination of 56 children with neonatal sepsis was conducted. The severity of neonatal sepsis was determined using the constellation-diagnostic scales of multiple organ dysfunction such as SNAPII, SNAPРЕII, PELOD, SOFA, ­nSOFA, PEMOD, SCRIB, NEOMOD. The comprehensive immunological examination with evaluation of immunoglobulin A, G, M, C-reactive protein, presepsin, procalcitonin, interleukins (IL) 6, 8, 10 content in blood serum was conducted in all newborns. Two clinical groups were formed. The clinical group I included 25 infants with neonatal sepsis with a serum level of C-reactive protein < 20 mg/l (boys — 52.0 %, city residents — 80.0 %, the average content of C-reactive protein — 8.80 ± 0.41 mg/l). The clinical group II was formed by 31 children with neonatal sepsis and C-reactive protein blood concentration > 20 mg/l (with 62.8 % of boys, p > 0.05; 57.1 % of city residents, p > 0.05; the average content of C-reactive protein — 29.70 ± 1.89 mg/l, р < 0.05). According to the main clinical characteristics, the observation groups were comparable. Results. The conducted studies showed that the severity of the clinical course of neonatal sepsis, determined using the constellation-diagnostic scales of multiple organ dysfunction (SNAPII, SNAPРЕII, PELOD, SOFA, nSOFA, PEMOD, SCRIB, NEOMOD), did not reveal any significant differences in the comparison groups. It was found that in newborns with a C-reactive protein content < 20 mg/l, compared to representatives of the clinical group II, the concentration of IL-6, IL-8 and IL-10 was lower by 1.7, 1.5 and 1.8 times, respectively. Thus, patients of the group II had the risk of increasing serum content of IL-6 > 31.4 pg/ml (relative risk (RR) 1.7 (95% confidence interval (CI): 1.3–2.2) with an odds ratio (OR) 2.8 (95% CI: 1.6–5.1)), IL-10 > 18 pg/ml (RR 1.7 (95% CI: 1.1–2.4) with an OR 2.9 (95% CI: 1.6–5.3)), and IL-8 > 24.0 pg/ml (RR 1.9 (95% CI: 1.2–3.1) with an OR 4.7 (95% CI: 2.5–8.8)). Among the studied immunological biomarkers, the concentration of presepsin > 1,000 ng/ml was accompanied by the best indicators of the clinical and epidemiological risk of severe sepsis according to the constellation-diagnostic scales of multiple organ dysfunction (odds ratio 4.3–6.0, relative risk 2.3–2.5, attributable risk 32.0–42.0 %). Conclusions. Elevated content of some markers of neonatal sepsis (presepsin, procalcitonin) and interleukins (IL-6, IL-8) can be considered a biomarker of a severe course of neonatal sepsis with probable development of multiple organ dysfunction.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128128820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the tolerability of inhalation therapy as a stage of a personalized approach in the treatment of children with cystic fibrosis","authors":"K. Skriabinа, S. Ilchenko, A. Fialkovska","doi":"10.22141/2224-0551.18.2.2023.1569","DOIUrl":"https://doi.org/10.22141/2224-0551.18.2.2023.1569","url":null,"abstract":"Background. Considering the features of basic therapy for chronic inflammatory bronchopulmonary process in cystic fibrosis (CF), which includes almost daily inhalation of pharmacological drugs (mucolytics, hypertonic saline (HS), antibiotics), evaluation of their tolerability is relevant in practice. The purpose of the study is to create a prognostic scale convenient for use in practical medicine, which would predict development of bronchial hyperreactivity syndrome in children with CF, based on clinical and anamnestic data, the results of molecular genetic research and inhalation tests with increasing concentrations of HS to prescribe personalized treatment. Materials and methods. The results of clinical and anamnestic, microbiological, biochemical, molecular and genetic studies and inhalation tests with increasing concentrations of HS were analyzed in 40 children with CF. The creation of the predictive algorithm was based on the application of correlation analysis, receiver operating characteristic analysis, binary logistic regression, Wald and Kullback method. Results. Two prognostic models have been created that can be used at different stages of providing medical care. Model 1 was built for the ambulatory stage of providing medical care to patients with CF, considering clinical and anamnestic data, molecular genetic predictors, as well as clinical symptoms during inhalation tests with increasing concentrations of HS. This model also can be used in young children who cannot perform spirometry to assess their external breathing function. For the highly specialized medical care, model 2 was created, which considers indicators of spirometric data of inhalation tests with increasing concentrations of HS and the level of exhaled nitric oxide. Conclusions. The developed models make it possible to calculate with high probability the risk of developing bronchial hyperreactivity to perform a personalized selection of HS and choose preventive brocholytic therapy as needed.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126516202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender characteristics of health-related quality of life indicators in children with high normal blood pressure and primary hypertension","authors":"Y. Marushko, T. Hyshchak, T. Marushko, N.G. Kostinska, O. Khomych","doi":"10.22141/2224-0551.18.2.2023.1566","DOIUrl":"https://doi.org/10.22141/2224-0551.18.2.2023.1566","url":null,"abstract":"Background. The study of health-related quality of life (HRQoL) has great practical importance for patients with hypertension. The aim of the work was to investigate the gender characteristics of HRQoL in children with primary hypertension and high normal blood pressure. Material and methods. One hundred and ninety-nine patients (107 boys and 92 girls) aged 9–17 years were examined. Among them, 81 children had high normal blood pressure, 44 were with stage 1 hypertension, 38 patients had hypertension stage 1 аnd 36 children had normal blood pressure. All patients underwent ambulatory blood pressure monitoring. The Ukrainian version of the PedsQL 4.0 scale was used to assess HRQoL. Results. In girls with high normal blood pressure and in the initial stages of the stable hypertension, a higher frequency of complaints of headache, dizziness, heart pain was found compared to boys, as well as a moderate and significant negative correlation between the frequency of these complaints and HRQoL indicators. The lo­west PedsQL indicators were in girls with hypertension stage 2 (total score of the PedsQL 4.0 scale was 67.41 ± 9.94 points). Boys with hypertension stage 2 had normal PedsQL scores. Regardless of gender, psychosocial health indicators were found to be low in children with high normal blood pressure compared to the control group: in girls — 70.68 ± 12.46 points (р < 0.05), in boys — 70.23 ± 13.09 points (p < 0.05). The indicators of social functioning in all children did not differ from the data of the control group. Conclusions. HRQoL indicators in children aged 9–17 years with hypertension and high normal blood pressure depend on the level of blood pressure and have gender characteristics. Girls with hypertension stage 2, except for social functioning data, have worse HRQoL indicators compared to boys with stable hypertension stage 2. Children with high normal blood pressure, regardless of gender, have lower psychosocial health indicators compared to the control group. HRQoL indicators are negatively correlated with complaints of headache (more pronounced in boys), dizziness and heart pain (more pronounced in girls). These data should be taken into account when assessing the state of children with high normal blood pressure and hypertension.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"195 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114185756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of clinical and paraclinical findings in children with community-acquired pneumonia and comorbid chronic tonsillitis","authors":"O. Teslitskyi, O. Koloskova, T. Bilous, G. Bilyk, V. Khodorovskyy, T. Shchudrova","doi":"10.22141/2224-0551.18.2.2023.1567","DOIUrl":"https://doi.org/10.22141/2224-0551.18.2.2023.1567","url":null,"abstract":"Background. Respiratory morbidity is the most frequent cause for children consulting a doctor, accounting for about one-quarter of primary care consultations. The current research aimed to analyze the clinical and paraclinical features of community-acquired pneumonia (CAP) with comorbid chronic tonsillitis in children and to assess the prognostic value of the proposed diagnostic procedures to optimize the management of patients. Materials and methods. The study was conducted at the Pulmonology and Allergology and Infectious Department of the Municipal Medical Establishment “Chernivtsi Regional Children’s Clinical Hospital”, Ukraine. Clinical group I included 20 children (mean age 9.40 ± 1.56 years) with uncomplicated community-acquired pneumonia and concomitant chronic tonsillitis, and the clinical group II consisted of 16 patients (mean age 9.60 ± 1.13 years) with CAP without concomitant pathology of the upper respiratory tract. Results. Community-acquired pneumonia in children with comorbid chronic tonsillitis is characterized by an intense proinflammatory response in the airways, which manifests itself in fever (odds ratio (OR) 6.0), malaise and fatigue (OR 14.3), persistent cough and dyspnea (OR 3.7), leukocytosis (OR 2.0), high levels of acute phase proteins (OR 4.5), activation of the oxidative protein modification according to the exhaled breath condensate examination (OR 6.0–30.0), and more frequent fungal-bacterial association according to the microbiological examination of sputum and oropharyngeal swab (OR 11.1). The obtained data suggest that parenteral antibiotic therapy was used in 20 % of patients from group I and 12.5 % from group II, while 6.3 % of children from group II received only oral antibiotics. In children with CAP and chronic tonsillitis versus comparison group, the ОR of receiving parenteral antibiotic therapy for longer than 7 days reached 10.0, and the OR of oral antibiotic therapy for longer than 5 days reached 4.0. Conclusions. The results obtained from the study show that children with CAP and comorbid chronic tonsillitis have more pronounced clinical symptoms, accompanied by paraclinical signs of inflammation that last longer during hospital treatment and require comprehensive therapy (OR 3.3) of longer duration (OR 4.0–10.0).","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130885291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Роль вітаміну D при метаболічно нездоровому ожирінні в дітей","authors":"A. Abaturov, A. Nikulina","doi":"10.22141/2224-0551.18.2.2023.1568","DOIUrl":"https://doi.org/10.22141/2224-0551.18.2.2023.1568","url":null,"abstract":"Актуальність. Дефіцит вітаміну D пов’язаний із порушенням толерантності до глюкози, інсулінорезистентністю, метаболічним синдромом і підвищеним ризиком цукрового діабету 2-го типу. Мета: вивчити роль рівня вітаміну D, пов’язаного з однонуклеотидними варіантами (single nucleotide variants — SNV) гена рецептора вітаміну D (vitamin D receptor — VDR), у розвитку метаболічно нездорового ожиріння (МНО) у дітей. Матеріали та методи. Обстежено 210 дітей з ожирінням віком 6–18 років. Основну групу (n = 125) становили пациєнти з МНО. Контрольну групу (n = 85) представили діти з метаболічно здоровим ожирінням (МЗО). У рандомізовано обраних 31 дитини основної та 21 дитини контрольної груп проведено повногеномне секвенування (CeGaТ, Germany). В усіх дітей вимірювали рівень сироваткового 25-гідроксивітаміну D (Synevo, Ukraine). Для верифікації результатів розраховували коефіцієнт кореляції Спірмена (r) і p-значення для кожної змінної, а також проводили біоінформаційний аналіз. Результати. Середній рівень 25-гідроксивітаміну D у сироватці крові був вірогідно нижчим у пацієнтів із МНО і становив 14,57 ± 1,63 нг/мл, а в дітей із МЗО — 28,82 ± 1,93 нг/мл (t = 5,64; p = 0,00061). При МНО рівень 25-гідроксивітаміну D у сироватці пов’язаний з наступними предикторами (p < 0,05). Високозначущі фактори (0,7 ≤ |r| < 1): остеопенія (r = –0,73). Фактори середньої значущості (0,3 ≤ |r| < 0,7): пролактинемія (r = –0,57); індекс співвідношення окружності талії до зросту > 0,5 (r = –0,41); AA генотип SNP VDR rs12721365 (r = –0,41) та AA генотип SNP VDR rs2228572 (r = –0,39); метаболічно-асоційована жирова хвороба печінки (r = –0,39); фізіологічна постпрандіальна глікемія (r = 0,38); рівень інтерлейкіну-1β (r = –0,36); тригліцеридемія (r = –0,34); індекс маси тіла (r = –0,33); адипонектинемія (r = 0,32); артеріальна діастолічна гіпертензія (r = –0,32). Низькозначущі фактори (0 < |r| < 0,3): синдром полікістозних яєчників (r = –0,28); GG генотип SNP VDR rs2228570 (r = 0,27); окружність талії (r = –0,27); екстремальне ожиріння (r = –0,27); чоловіча стать (r = 0,26); окружність стегон (r = –0,24); рівні ліпопротеїнів високої щільності (r = 0,24); гамма-глутамілтранспептидази сироватки (r = –0,23); вільного тироксину (r = 0,22); тиреотропного гормону (r = –0,22); вільного трийодтироніну (r = 0,2). ­Висновки. Розвиток кардіометаболічного ризику та дефіциту вітаміну D у дітей із ожирінням пов’язують із наявністю генотипів AA/AG SNV VDR rs12721365, rs2228572, rs2228570.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126807813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of miRNAs in the development of hepatobiliary diseases","authors":"O. Abaturov, V. Babуch","doi":"10.22141/2224-0551.18.1.2023.1561","DOIUrl":"https://doi.org/10.22141/2224-0551.18.1.2023.1561","url":null,"abstract":"The role of miRNA in the development of hepatobiliary diseases is considered in the scientific review. To write the article, information was searched using Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library databases. The authors provided information on the generation of a certain spectrum of miRNA by diffe­rent types of cells of the hepatobiliary system. The authors state that miR-122-5p, miR-101, miR-192, miR-193, miR-194, ­miR-802 are hepatocyte-associated microRNAs. It is known that nume­rous microRNAs are involved in the regulation of the inflammatory process: miR-21, miR-29a, miR-96, miR-122, miR-125b, ­miR-132, miR-155, miR-146a, miR-150, miR-155, miR-181 and let-7. Among the many microRNAs involved in the regulation of inflammation in the liver, miR-122 and miR-155 are the most stu­died. It is stated that microRNAs such as let-7d, miR-15b, ­miR-19b, ­miR-21, ­miR-24, miR-29c, miR-122, miR-145, ­miR-155, ­miR-199, miR-200c, miR-378a are the most important modulators for the activity of fibrosis development in various tissues of the body, including liver tissue. MicroRNAs involved in the development of TGF-β1-induced liver fibrosis are presented. Scientists believe that since microRNAs regulate the cell cycle, proliferation and apoptosis of cells, they are factors that significantly affect the development of hepatobiliary tumors. It is emphasized that changes in miRNA profile in liver tissue or blood serum have their diagnostic value. Modulations of microRNAs are shown, which are associated with specific diseases of the liver and biliary tract with a high degree of probability. Thus, various miRNAs play an important role in the development of hepatobiliary diseases. A certain spectrum of ­miRNAs is generated by different cell types and plays an important role in the maturation and functioning of the hepatobiliary system. MicroRNAs indirectly participate in the synthesis of proteins, differentiation of cells, tissues and play an important pathogenetic role in the development of hepatobiliary diseases. The most important feature of microRNAs is their high resistance to the action of enzymatic substances, which allows them to be used as diagnostic or prognostic biomarkers.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114106122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of combined therapy with calcium salts and vitamin D on the concentration of macro- and microelements in saliva in young children","authors":"O. Abaturov, T. Kryuchko, O. Kryvusha, V. Babych, N. Tokareva, O. Tkachenko","doi":"10.22141/2224-0551.18.1.2023.1552","DOIUrl":"https://doi.org/10.22141/2224-0551.18.1.2023.1552","url":null,"abstract":"Background. A balanced supply of macro- and microelements to various organs and systems is a prerequisite for maintaining human health. Deficiency or excess of macro- and microelements in saliva can be associated with both inflammation and oxidative damage to the oral tissues. Provision of calcium in the human body significantly affects the state of salivary ionome. However, currently there are few studies on the effect of Ca and vitamin D on the state of salivary ionome in healthy children. Purpose: to study the effect of combined use of prophylactic doses of Ca and vitamin D on the concentration of macro- and microelements in saliva of young children. Materials and methods. Under our supervision, there were 36 clinically healthy young children who received Calcicare 2.5 ml 3 times a day for 2 months. The study of the content of macro- and microelements in urine was carried out by optical emission spectrometry with an inductively coupled plasma. Statistical analysis of the results was performed using the application package Statistica 6.1 on a personal computer based on Intel Pentium processor. Results. The study showed that the combined use of calcium carbonate and vitamin D significantly changes the concentration of some macro- and microelements in saliva of young children. The level of some trace elements in saliva before the start of therapy with Calcicare correlated with the frequency of acute respiratory infections. Thus, a higher incidence of acute respiratory infections was observed in children with reduced salivary excretion of Ca and S. Young children had a low concentration of Ca and Mg in saliva before the course of Calcicare therapy. Treatment with Calcicare led to an activation of the metabolism of these macronutrients in saliva of young children, which was characterized by an increase in the level of Ca from 29.5 ± 4.4 mg/l to 60.1 ± 6.8 mg/l (p < 0.01), Mg from 4.9 ± 0.6 mg/l to 9.3 ± 0.8 mg/l (p < 0.01), S from 336.3 ± 3.8 mg/l to 2501.6 ± 275.4 mg/l (p < 0.01), and P from 5.6 ± 0.3 mg/l to 15.8 ± 0.7 mg/l (p < 0.01). An increase in the concentration of Ca and P in saliva after the treatment with Calcicare probably has an anti-caries effect. An increase in the level of Mg in saliva after the course of Calcicare may have anti-inflammatory and antitumor effect on the oral mucosa. Co-administration of calcium carbo­nate and vitamin D led to the disappearance of salivary excretion of some trace elements such as B, Cd, Li, Pb, which may relieve the oral mucosa and dental tissues from the toxic effects of these trace elements. Conclusions. The combined use of calcium carbonate and vitamin D (Calcicare) for 2 months in young children is accompanied by changes in salivary ionome, which are of anti-inflammatory and anti-caries nature. After taking calcium carbonate and vitamin D, there was a cessation of salivary excretion of some trace elements, which have a toxic effect on the oral tissues. The use of Calcicare in the recommended dose ","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116508602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}