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Healthcare-associated infections in children in Ukraine during 2009–2021 2009-2021年乌克兰儿童保健相关感染情况
CHILD`S HEALTH Pub Date : 2023-07-06 DOI: 10.22141/2224-0551.18.3.2023.1588
O. Korniychuk, I. Tymchuk, S.Y. Pavliy, Y. Konechnyi
{"title":"Healthcare-associated infections in children in Ukraine during 2009–2021","authors":"O. Korniychuk, I. Tymchuk, S.Y. Pavliy, Y. Konechnyi","doi":"10.22141/2224-0551.18.3.2023.1588","DOIUrl":"https://doi.org/10.22141/2224-0551.18.3.2023.1588","url":null,"abstract":"Background. Healthcare-associated infections (HCAIs) now include the development of infectious processes in various organ systems of patients and at hospitals of different work directions. It is believed that HCAIs are infections that first occur 48 hours or later after hospitalization or 30 days after receiving medical care. The aim of our research was a retrospective analysis of the incidence of HCAIs among children in Ukraine during 2009–2021. Materials and methods. Statistical analysis of the prevalence of registered cases of HCAIs in Ukraine for 2009–2021, according to the Center for Public Health of the Ministry of Health of Ukraine. Results. On average, 966 ± 489 cases of HCAIs were registered annually in Ukraine among children of various ages. According to the age distribution, the number of annual cases of HCAIs among newborns of up to 1 month of age averaged 65.8 %, for those aged 1 month to 1 year — 5.9 %, from 1 to 17 years — 28.3 %. According to the nosological structure of HCAIs, infections of certain conditions occurring in the perinatal period prevailed among children. On average, the number of such diseases for 2010–2021 was 49.5 ± 7.5 % (among children 0–17 years old) and 13.8 % of the total cases of HCAIs in Ukraine. Conclusions. In recent years, there has been an underestimation of HCAI cases in Ukraine among adult patients and children. Nevertheless, indicators provided by institutions of some regions (Odesa and Kyiv regions) make it possible, with a certain degree of probability, to get an idea of the structure of HCAI incidence in the country. According to the age structure, HCAIs in children (0–17 years) for 2009–2021 accounted for 22.06 % of the total number of HCAIs. Most cases during the specified period were recorded among newborns, 65.8 % of all children with HCAIs. Therefore, the primary efforts should be aimed at reducing HCAIs among newborns.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114845018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scientific substantiation of approaches to physical rehabilitation of children with recurrent bronchial obstruction 反复支气管梗阻患儿物理康复方法的科学依据
CHILD`S HEALTH Pub Date : 2023-07-06 DOI: 10.22141/2224-0551.18.3.2023.1584
I. Karimdzhanov, U. Zakirova, N. Israilova, N.B. Sodikova
{"title":"Scientific substantiation of approaches to physical rehabilitation of children with recurrent bronchial obstruction","authors":"I. Karimdzhanov, U. Zakirova, N. Israilova, N.B. Sodikova","doi":"10.22141/2224-0551.18.3.2023.1584","DOIUrl":"https://doi.org/10.22141/2224-0551.18.3.2023.1584","url":null,"abstract":"Background. The main objectives of the treatment of bronchopulmonary diseases in children are to control the disease, achieve a stable remission of the process, restore the function of external respiration, the nervous system, increase the body’s tolerance to the action of allergens. Kinesiotherapy is one of the most effective methods in non-drug rehabilitation. The purpose of our study was the pathogenetic justification of the use of kinesiohydrotherapy by the method of controlling the function of external respiration at the stage of rehabilitation of children with recurrent bronchial obstruction. Results. A comparative analysis of spirometric indicators in children with recurrent bronchial obstruction before and after kinesiohydrotherapy in the experimental and control groups showed the effectiveness of the method of comprehensive rehabilitation with the inclusion of kinesiohydrotherapy with special breathing exercises on land and in the pool. After a one-year rehabilitation period, violations of the ventilation capacity of the lungs by the obstructive type maintained in mild form. Сhildren with recurrent bronchial obstruction who did not effectively use physical rehabilitation with additional medical recommendations and physiotherapy as in experimental group, still had violations of the function of external respiration during the recovery period. Clinically, the children of control group continued to have frequent relapses of bronchial obstruction on the background of acute respiratory infections. Therefore, they belong to the group with a prolonged course of bronchial obstruction and the risk of transition to bronchial asthma. After the course of treatment, the cough became much less frequent, there were no night attacks, and the body temperature was steadily normal. Auscultation of wheezing was not heard, breathing had a harsh tinge. Conclusions. Thus, the use of therapeutic water procedures and respiratory physical exercises, i.e. kinesiohydrotherapy, is an effective method in the rehabilitation of children with recurrent bronchial obstruction.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114344592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The value of the S100β marker in patients with COVID-19 S100β标志物在COVID-19患者中的价值
CHILD`S HEALTH Pub Date : 2023-07-06 DOI: 10.22141/2224-0551.18.3.2023.1587
I. Seriakova
{"title":"The value of the S100β marker in patients with COVID-19","authors":"I. Seriakova","doi":"10.22141/2224-0551.18.3.2023.1587","DOIUrl":"https://doi.org/10.22141/2224-0551.18.3.2023.1587","url":null,"abstract":"Background. The purpose of the work was to determine the level of S100β protein in children with COVID-19 and to investigate the correlation of this neurobiomarker with the severity of COVID-19 and the age of the patients. Materials and methods. We conducted a retrospective, cohort, observational, post-registration study. We examined 88 children aged 1 month to 17 years with laboratory-confirmed COVID-19 who underwent inpatient treatment at the Kyiv City Children’s Clinical Infectious Diseases Hospital (Kyiv, Ukraine) in 2021–2022. Children were divided according to the course of the disease into two groups: the control group, which had a complicated course of COVID-19, and the main group without complications. We also made a division by age groups: 0–12 months, 1–6, 6–10 and 10–17 years. The main laboratory indicators, data of anamnesis and objective examination were taken into account. During the comprehensive routine examination of the patients on the first day of their stay in the hospital, the blood serum was collected for further examination for the level of S100β neurobiomarker by enzyme immunoassay. CanAg S100 EIA kit (Fujirebio) with a working measurement range of 1–3500 ng/L for S100β marker was used. The research was carried out in accordance with the Declaration of Helsinki principles. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of parents and children was obtained. In the study, we used statistical research, analytical methods, and the method of empirical research. Results. When comparing the main and control groups by age, the age of patients from birth to 12 months was a significant indicator (44.8 % in the main group vs. 23.3 % in controls), p = 0.049. When conducting a study on S100β correlation with D-dimer, a linear correlation was found (r = 0.141; 95% CI –1... 0.311; p < 0.1), as well as a negative linear correlation with prothrombin index (r = –0.204; 95% CI –1... 0.0131; p = 0.03) and age (r = –0.184; 95% CI –1... 0.0077; p = 0.04). Conclusions. A correlation between S100β neurobiomarker, age and severity of COVID-19 was revealed. Higher indicators were noted in the group of patients with a complicated course of the disease. A tendency towards a higher level of protein S100 at a younger age was revealed, as well as a linear relationship of neuromarkers with prothrombin index and D-dimer.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130559551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Problems of providing medical care to children of Ukraine as a result of russian aggression 由于俄罗斯的侵略,向乌克兰儿童提供医疗保健的问题
CHILD`S HEALTH Pub Date : 2023-07-06 DOI: 10.22141/2224-0551.18.3.2023.1578
Corresponding Member of Namnu Oleksandr Volosovets, O. Volosovets, O. V. Vyhovska, S. Kryvopustov, O. Mozyrska, O. Yemets, A. Volosovets, W. Feleszko
{"title":"Problems of providing medical care to children of Ukraine as a result of russian aggression","authors":"Corresponding Member of Namnu Oleksandr Volosovets, O. Volosovets, O. V. Vyhovska, S. Kryvopustov, O. Mozyrska, O. Yemets, A. Volosovets, W. Feleszko","doi":"10.22141/2224-0551.18.3.2023.1578","DOIUrl":"https://doi.org/10.22141/2224-0551.18.3.2023.1578","url":null,"abstract":"Background. The russian aggression in Ukraine has caused numerous casualties among civilians, including children. Military actions lead directly or indirectly to increased morbidity in adults and children and to chronic stress, especially in children. The purpose of this research was to analyze the problems of providing medical assistance to the children of Ukraine who are suffering from the russian invasion. Materials and methods. We have used the official statistical and own data for 2022–2023. Results. Currently, more than 7.5 million Ukrainian children are suffering from the war, not only due to physical injuries but also violations of their mental and psycho-emotional state. A special problem for Ukrainian paediatricians at the beginning of 2023 was an increase in the incidence of acute respiratory diseases, COVID-19 and stress disorders in children due to a shortage of medical personnel and infrastructure. Also, in conditions of limited access to medical care and medicines, it is necessary to pay attention to chronic diseases, in particular, asthma and other allergic diseases. Paediatricians from the departments of the Bogomolets National Medical University provided voluntary assistance to children in frontline regions. Conclusions. In the new conditions of warfare, where civilians and life support infrastructure have become the target of armed attacks, children have become the most vulnerable group. The issues of restoration of full medical care for children, including emergency and urgent care, provision with doctors of certain paediatric specialties, full supply of medicines and medical devices, and restoration of destroyed medical infrastructure remain extremely relevant to the health system in the frontline and liberated areas.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"55 8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129854802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The role of microRNA in the development of liver diseases. Part 2 微小RNA在肝病发展中的作用。第二部分
CHILD`S HEALTH Pub Date : 2023-07-06 DOI: 10.22141/2224-0551.18.3.2023.1593
A. Abaturov, V. Babуch
{"title":"The role of microRNA in the development of liver diseases. Part 2","authors":"A. Abaturov, V. Babуch","doi":"10.22141/2224-0551.18.3.2023.1593","DOIUrl":"https://doi.org/10.22141/2224-0551.18.3.2023.1593","url":null,"abstract":"The scientific review shows the role of miRNA in the development of liver diseases, namely hepatocellular carcinoma. To write the article, we have searched for information in the Scopus, Web of Science, MedLine, PubMed, Google Scholar, ­EMBASE, Global Health, The Cochrane Library databases. In the development of hepatocellular carcinoma, the role of miRNAs involved in the regulation of the cell cycle, apoptosis, invasion, metastasis, and angiogenesis is emphasized. Scientists believe that loss of ­miR-122 expression in liver cancer correlates with inhibition of the liver phenotype and increased risk of metastasis. It is noted that the development of hepatocellular carcinoma is accompanied by an increase in the level of let-7, miR-26, miR-101 and a decrease in the concentration of miR-17-92, miR-181, miR-221 in blood serum, which can be used as diagnostic criteria. MiR-21 is considered a typical onco-microRNA and the level of circulating miR-21 in peripheral blood can serve as a potential biomarker of the early stage of hepatocellular carcinoma. In hepatocellular carcinoma, a low content of miR-34 is noted, which leads to the activation of the cyclin Е and an increase in the proliferative potential, which favors hepatocarcinogenesis. MiR-34a has an inhibitory effect on almost all oncogenic cellular processes. The researchers demonstrated that the change in the microRNA spectrum is mediated by the primary change in the generation of some circular single-stranded RNAs — circular RNAs. Thus, scientific studies of recent years confirm that miRNAs in the development of hepatocellular carcinoma are involved in the regulation of the cell cycle, apoptosis, invasion, metastasis, angiogenesis. As a potential biomarker of the early stage of hepatocellular carcinoma, the researchers identify the level of miR-21 in blood serum and consider it a typical onco-microRNA. MiR-34a has an inhibitory effect on almost all oncogenic cellular processes in hepatocellular carcinoma. Therefore, microRNAs play a very important role in the development of hepatocellular carcinoma and can be used as diagnostic and prognostic criteria, and factors of pathogenesis whose medicinal modulation will contribute to increasing the effectiveness of therapy.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical hemolytic uremic syndrome: a pediatric case report 非典型溶血性尿毒症综合征:儿科病例报告
CHILD`S HEALTH Pub Date : 2023-07-06 DOI: 10.22141/2224-0551.18.3.2023.1592
K. Hodiatska, T. Mavropulo, T. Bordii, S. Alifanova, V. F. Doroshenko, L. M. Cherhinets
{"title":"Atypical hemolytic uremic syndrome: a pediatric case report","authors":"K. Hodiatska, T. Mavropulo, T. Bordii, S. Alifanova, V. F. Doroshenko, L. M. Cherhinets","doi":"10.22141/2224-0551.18.3.2023.1592","DOIUrl":"https://doi.org/10.22141/2224-0551.18.3.2023.1592","url":null,"abstract":"Background. Atypical hemolytic uremic syndrome (aHUS) is an extremely rare but life-threatening di­s­order in children since it may cause acute kidney injury. Patients with aHUS are at risk of recurrence. Hence, in this paper, we present a case of a 9-year-old boy with aHUS relapse. The child was admitted to the emergency department on the fifth day of illness with main complaints of facial puffiness and decreased urine output. Based on the medical history, the patient developed the second episode of aHUS after 6 years of complete recovery from the first episode. There was no preceding diarrheal illness, instead, the clinical manifestation of both aHUS episodes was triggered by a respiratory tract infection. The results of diagnostic studies performed during the first episode of aHUS were as follows: stool tests for Esche­richia coli and Shiga toxins were negative; a complement assay showed no abnormalities; ADAMTS13 activity and anti-complement factor H antibodies were normal. The results of the kidney ultrasonography and biopsy were consistent with the diagnosis. Family history was remarkable for aHUS in a younger sibling confirmed by molecular genetic testing, in particular, a pathogenic variant in the CD46/MCP (membrane cofactor protein) gene in the heterozygous state has been identified. Physical examination revealed paleness, facial swelling, moderate hypertension, and oliguria. Laboratory findings demonstrated hemolytic anemia, thrombocytopenia, significant azotemia, a severe reduction in the glomerular filtration rate, a high level of aspartate aminotransferase, insignificant electrolyte imbalance, and proteinuria. Supportive treatment included fluid and electrolyte management, fresh frozen plasma, furosemide, and dexamethasone. The child commenced acute hemodialysis due to severe acute kidney injury. Conclusions. A recurrence of aHUS is characterized by severe renal failure requiring acute hemodialysis. Viral infections are potential triggers of aHUS. A relapsing course of the disease and a family history of aHUS indicate the importance of genetic screening, as familial aHUS should be considered.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134092112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of microRNA in the development of liver diseases. Part 1 microRNA在肝脏疾病发展中的作用。第1部分
CHILD`S HEALTH Pub Date : 2023-06-03 DOI: 10.22141/2224-0551.18.2.2023.1574
A. Abaturov, V. Babуch
{"title":"The role of microRNA in the development of liver diseases. Part 1","authors":"A. Abaturov, V. Babуch","doi":"10.22141/2224-0551.18.2.2023.1574","DOIUrl":"https://doi.org/10.22141/2224-0551.18.2.2023.1574","url":null,"abstract":"The scientific review shows the role of miRNA in the development of liver diseases, namely: acute liver failure, non-alcoholic fatty liver disease. To write the article, information was searched using the databases Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka. The authors indicate the importance of some miRNAs in the development of liver diseases. It was established that the development of acute liver failure is associated with a significant increase in the concentration of ­miR-21, ­miR-122, miR-221 and miR-192 in blood serum. The authors present the features of changes in miRNA content in acute liver failure in children. It is stated that drug-induced acute liver fai­lure is accompanied by an increase in the concentration level of ­miR-122, ­miR-1246, miR-4270, miR-4433, ­miR-4463, ­miR-4484, ­miR-4532, pre-miR-4767 and a decrease in the concentration level miR-455-3p, miR-1281 and pre-miR-4274 in serum. MicroRNAs ­miR-224-5p, miR-320a, miR-449a and ­miR-877-5p regulate the process of metabolizing acetaminophen by inhibiting enzymes (CYP3A4, HNF1A, HNF4A and NR1I2). The authors demonstrated that transfection of exogenous ­miR-224-5p, miR-320a, miR-449a and miR-877-5p into HepaRG cells protects them from the toxic effect of acetaminophen. The scientists demonstrated that patients with non-alcoholic steatohepatitis had more than two-fold increased concentrations of miR-19a and miR-19b, miR-122, ­miR-125b, miR-192 and miR-375 in their blood serum. It is emphasized that overexpression of miR-122 is associated with high activity of alanine aminotransferase. Thus, the association of micro-RNA generation with the development of liver diseases has become the goal of research by scientists around the world in recent years. The development of acute liver failure is associated with a significant increase in the concentration of ­miR-21, ­miR-122, ­miR-221 and miR-192 in blood serum. A high level of ­miR-27b-3p, ­miR-122-5p, miR-192-5p, miR-1290 in blood serum is a highly diagnostic marker of non-alcoholic fatty liver disease. Therefore, microRNAs play an important role in the development of acute liver failure and non-alcoholic fatty liver disease and can be used as diagnostic and prognostic criteria, which, in the future, may contribute to increasing the effectiveness of therapy.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"322 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133109607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Etiological spectrum of pneumonia in children in Kyiv, Ukraine 乌克兰基辅儿童肺炎的病原学谱
CHILD`S HEALTH Pub Date : 2023-06-03 DOI: 10.22141/2224-0551.18.2.2023.1565
V. Khomenko, O. Iemets, O. Volosovets, S. Kryvopustov, O. Mozyrska
{"title":"Etiological spectrum of pneumonia in children in Kyiv, Ukraine","authors":"V. Khomenko, O. Iemets, O. Volosovets, S. Kryvopustov, O. Mozyrska","doi":"10.22141/2224-0551.18.2.2023.1565","DOIUrl":"https://doi.org/10.22141/2224-0551.18.2.2023.1565","url":null,"abstract":"Background. In Ukraine over the past 20 years, the incidence of pneumonia in children has increased. The aim of the study is to assess the contribution of respiratory viruses and bacteria to pneumonia in children in Ukraine. Materials and methods. The etiology of community-acquired pneumonia was studied in 175 children at Medical Center “Eurolab” and Clinical Hospital 2 (Kyiv, Ukraine) over 2018–2022. Viral and bacterial pathogens were detected using polymerase chain reaction, chromatographic immunoassay. Results. The prevalence of viral pneumonia among total cases of pneumonia was 78.9 % in Kyiv during 2018–2022. Thirty-seven (21.1 %) cases of CAP were classified as bacterial. The most common were respiratory syncytial virus (18.1 %), metapneumovirus (13 %), adenovirus (10.1 %), parainfluenza virus (10.1 %). The other causative viral agents were influenza virus type A (7.2 %), rhinovirus (5 %), bocavirus (2.9 %), SARS-CoV-2 (1.4 %) and measles virus (1.4 %). Etiological spectrum is similar to the results of stu­dies conducted in other European countries. Conclusions. Respiratory viruses, particularly respiratory syncytial virus and metapneumovirus, are the major contributors to community-acquired pneumonia in children in Kyiv.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114631476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral gonarthrosis as the onset of Crohn’s disease in children: a clinical presentation 双侧关节病作为儿童克罗恩病的发病:临床表现
CHILD`S HEALTH Pub Date : 2023-06-03 DOI: 10.22141/2224-0551.18.2.2023.1576
V. Ivanova, I. Samoilenko, T. R. Polesova, N. Shishkanova, M. V. Miroshnichenko, O.O. Dzyuba, V.V. Krivosheeva, M. Momot
{"title":"Bilateral gonarthrosis as the onset of Crohn’s disease in children: a clinical presentation","authors":"V. Ivanova, I. Samoilenko, T. R. Polesova, N. Shishkanova, M. V. Miroshnichenko, O.O. Dzyuba, V.V. Krivosheeva, M. Momot","doi":"10.22141/2224-0551.18.2.2023.1576","DOIUrl":"https://doi.org/10.22141/2224-0551.18.2.2023.1576","url":null,"abstract":"Crohn’s disease is an immune-mediated disease cha­racterized by nonspecific granulomatous transmural inflammation with segmental damage to any part of the gastrointestinal tract with the formation of extraintestinal and systemic complications. The disease is complex, multifactorial, which lasts throug­hout life and affects the physical and psychological development of the individual. According to modern ideas, the occurrence of Crohn’s disease is influenced by external environmental factors against the background of genetic predisposition. According to the literature, in most cases, patients with Crohn’s disease complain of abdominal pain, diarrhea, unexplained anemia, fever, weight loss, or growth retardation. The classic triad of abdominal pain, diarrhea and weight loss occurs in only 25 % cases. Extraintestinal manifestations such as skin lesions, vasculitis, joint syndrome, aphthous stomatitis or para-anal lesions (anal it­ching, macerations, fissures, paraproctitis, fistulas) may be the first symptoms in 6–23 % of cases. The diagnosis of Crohn’s disease in children is made on the basis of anamnestic and clinical data, the results of using special research methods, including endoscopic, radiological, ultrasound, histological, spiral computer tomo­graphy, magnetic resonance ima­ging, as well as immunological and genetic markers. Achieving and maintaining remission can minimize psychological problems and improve patients’ quality of life. A clinical case of Crohn’s disease is presented, which was diagnosed in a 14-year-old child who was treated for juvenile idio­pathic oligoarthritis since the age of two and had frequent bacterial and inflammatory diseases. The difficulties of diagnostic search are reflected, which are caused by various symptoms and early onset. Treatment and clinical monitoring were carried out in accordance with the international recommendations of the European Society for Pediatric Gastroenterology, Hepato­logy and Nutrition (ESPGHAN) 2021. The authors emphasize the need for dynamic clinical monitoring of the patient’s condition, as well as a personalized approach to treatment.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133403393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Newborn screening for severe combined immunodeficiency: lessons from a pilot study and prospects 新生儿严重联合免疫缺陷筛查:从试点研究的经验教训和前景
CHILD`S HEALTH Pub Date : 2023-06-03 DOI: 10.22141/2224-0551.18.2.2023.1575
O. Boyarchuk, N. Yarema, H. Makukh
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