International Journal of Mass Spectrometry最新文献

A membrane deposition - laser ablation - inductively coupled plasma mass spectrometry approach for the trace determination of dysprosium, gadolinium, and ytterbium in high-purity cerium oxide 膜沉积-激光烧蚀-电感耦合等离子体质谱法测定高纯氧化铈中痕量镝、钆和镱

IF 1.7 3区化学

International Journal of Mass Spectrometry Pub Date : 2026-04-01 Epub Date: 2026-01-08 DOI: 10.1016/j.ijms.2026.117579

Zhe Fang , Lei Wang , Kai Li , Chaogang Wang , Lizhi Ren , Yaqiang Li , Yihui Wang , Ming Chen , Haizhou Wang

{"title":"A membrane deposition - laser ablation - inductively coupled plasma mass spectrometry approach for the trace determination of dysprosium, gadolinium, and ytterbium in high-purity cerium oxide","authors":"Zhe Fang , Lei Wang , Kai Li , Chaogang Wang , Lizhi Ren , Yaqiang Li , Yihui Wang , Ming Chen , Haizhou Wang","doi":"10.1016/j.ijms.2026.117579","DOIUrl":"10.1016/j.ijms.2026.117579","url":null,"abstract":"<div><div>A membrane deposition–laser ablation sampling system was developed, in which the generated dry aerosol was introduced into an inductively coupled plasma mass spectrometer (ICP-MS). Based on this system, a micro-sampling method was established for the determination of gadolinium (Gd), dysprosium (Dy), and ytterbium (Yb) in high-purity cerium oxide. The gas composition in the ablation cell, carrier-gas flow rates, and laser spot sizes were systematically optimized. Carrier gas 1 was argon (Ar) at 1.0 L/min, and carrier gas 2 was helium (He) at 1.1 L/min. An optical aperture diameter of 2.75 mm was found to provide optimal performance. The membrane-deposition efficiency was evaluated from the ratio of the generated analyte mass to the mass determined post-deposition by ICP-MS/MS. Results showed that when the sampling volume was 100 μL and the cerium (Ce) matrix concentration exceeded 100 mg/L, the deposition efficiency approached 100 %. Internal-standard correction was applied to minimize fractionation and matrix effects, and the most suitable internal standards were identified. Under these optimized conditions, the detection limits for Gd, Dy, and Yb were 0.52, 0.18, and 0.21 ng/g, respectively. Analysis of three high-purity CeO<sub>2</sub> samples showed that this method produced significantly lower Gd and Yb values than conventional ICP-MS, effectively eliminated hydroxide and oxide interferences, exhibited superior resistance to spectral interference, and provided results consistent with those from ICP-MS/MS.</div></div>","PeriodicalId":338,"journal":{"name":"International Journal of Mass Spectrometry","volume":"522 ","pages":"Article 117579"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An improved single-column separating procedure of copper, iron, and zinc from geological samples for their isotopic measurements by MC-ICP-MS 用MC-ICP-MS从地质样品中分离铜、铁和锌的改进单柱分离程序

IF 1.7 3区化学

International Journal of Mass Spectrometry Pub Date : 2026-04-01 Epub Date: 2026-01-31 DOI: 10.1016/j.ijms.2026.117592

Wenwu Yang , Can You , Xiaofei Qiu , Xirun Tong , Shansong Lu , Guiling Duan , Yingxiong Cai , Hanyu Deng , Hongmei Yang

{"title":"An improved single-column separating procedure of copper, iron, and zinc from geological samples for their isotopic measurements by MC-ICP-MS","authors":"Wenwu Yang , Can You , Xiaofei Qiu , Xirun Tong , Shansong Lu , Guiling Duan , Yingxiong Cai , Hanyu Deng , Hongmei Yang","doi":"10.1016/j.ijms.2026.117592","DOIUrl":"10.1016/j.ijms.2026.117592","url":null,"abstract":"<div><div>It can provide valuable information about geological and environmental processes that study Cu, Fe, and Zn isotopic compositions in natural samples. Generally, the chemical separation of Cu, Fe, and Zn from a matrix was achieved by independent methods, but only a few methods could simultaneously separate all three elements through a single anion-exchange column. In this study, we present an optimized method for combined separation of Cu, Fe and Zn from geological samples by the anion exchange chromatography. It required only one pass-through the resin to produce the quantitative and pure Cu, Fe and Zn isolate, respectively, which can minimize the handling time, reagent consumption and total analytical blanks. The isobaric interferences from matrix elements were virtually eliminated for the consequent multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) analysis of the isotopic compositions of these Cu, Fe and Zn isolates. The accuracy and precision of Cu, Fe and Zn isotopic analyses were evaluated by replicate measurements of the reference materials. The isotopic results demonstrate fully-reproducible, accurate and precise analyses. The long-term external reproducibility is better than ±0.05‰, ±0.06‰ and ±0.06‰ (2SD) for δ<sup>65</sup>Cu, δ<sup>56</sup>Fe and δ<sup>66</sup>Zn, respectively. Employing these techniques, we report Cu, Fe and Zn isotopic compositions of fourteen commercially accessible geological reference materials with a wide range of matrices. This dataset can serve as a reference for Cu, Fe and Zn isotopic studies for both the quality assurance and inter-laboratory calibration.</div></div>","PeriodicalId":338,"journal":{"name":"International Journal of Mass Spectrometry","volume":"522 ","pages":"Article 117592"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Welcoming “Protocols in Mass Spectrometry” 欢迎“质谱分析规程”

IF 1.7 3区化学

International Journal of Mass Spectrometry Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1016/j.ijms.2026.117585

Julia Laskin, Stephen Blanksby, Isabelle Fournier

引用次数: 0

Identification of microplastics and additives from the Lake Erie watershed and the Cuyahoga River via MALDI-MS and DART-MS 利用MALDI-MS和DART-MS鉴定伊利湖流域和凯霍加河的微塑料及其添加剂

IF 1.7 3区化学

International Journal of Mass Spectrometry Pub Date : 2026-03-01 Epub Date: 2026-01-09 DOI: 10.1016/j.ijms.2026.117581

Luciana Rivera Molina , Robert Brand , Calum Bochenek , Chrys Wesdemiotis

{"title":"Identification of microplastics and additives from the Lake Erie watershed and the Cuyahoga River via MALDI-MS and DART-MS","authors":"Luciana Rivera Molina , Robert Brand , Calum Bochenek , Chrys Wesdemiotis","doi":"10.1016/j.ijms.2026.117581","DOIUrl":"10.1016/j.ijms.2026.117581","url":null,"abstract":"<div><div>Micro(nano)plastics have received increased attention as environmental contaminants due to their harmful effects on ecosystems and human health. Conventional extraction methods for microplastic analysis are often lengthy and complicated, resulting in the loss of important chemical components such as additives. In this study, we provide a complementary approach, utilizing matrix-assisted laser desorption/ionization (MALDI) and direct analysis in real time (DART) mass spectrometry (MS) techniques, with minimal extraction and sample preparation to preserve both polymer and additive information. MALDI-MS was applied to aqueous samples collected along the shores of Lake Erie and the Cuyahoga River, successfully identifying the base polymer(s) in the micro(nano)plastics content of these samples, which included polyethylene oxide (PEO), polypropylene oxide (PPO), polyethylene (PE), and polymethylmethacrylate (PMMA). Simultaneously, DART-MS was used to analyze macroplastics debris collected from the same locations, enabling sensitive detection of the additives and plasticizers that are likely leaching into the aquatic environment. DART-MS macroplastics analysis additionally revealed the presence of PE and PEO chains in the plastic litter, corroborating the MALDI-MS data from the water samples and providing strong evidence for contaminant transfer from discarded plastics to the aquatic environment. Finally, DART-MS analysis of the water samples showed additives and plasticizers matching those present in the litter. This study combined both MALDI-MS and DART-MS analysis for the first time, offering a more comprehensive assessment of the base polymer composition and associated additives. By minimizing extraction steps, this approach improves the detection of compounds often lost by conventional methods, ultimately providing deeper insight into microplastic pollution and its toxicological implications.</div></div>","PeriodicalId":338,"journal":{"name":"International Journal of Mass Spectrometry","volume":"521 ","pages":"Article 117581"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The review of time of flight secondary ion mass spectrometry technology in LIBs LIBs飞行时间二次离子质谱技术研究进展

IF 1.7 3区化学

International Journal of Mass Spectrometry Pub Date : 2026-03-01 Epub Date: 2026-01-15 DOI: 10.1016/j.ijms.2026.117584

Zixuan Huang, Ran Tian, Yun Gao

{"title":"The review of time of flight secondary ion mass spectrometry technology in LIBs","authors":"Zixuan Huang, Ran Tian, Yun Gao","doi":"10.1016/j.ijms.2026.117584","DOIUrl":"10.1016/j.ijms.2026.117584","url":null,"abstract":"<div><div>Lithium-ion batteries (LIBs) are pivotal in advancing electronic technology and sustainable energy systems. However, characterizing lithium, the central element in LIBs, remains challenging due to its low atomic mass, which limits its detection by conventional techniques like energy-dispersive X-ray spectroscopy (EDS). Time-of-flight secondary ion mass spectrometry (TOF-SIMS) emerges as a powerful solution, leveraging its high surface sensitivity and capability to detect all elements, including lithium. This review outlines the fundamental principles of TOF-SIMS and highlights its pivotal applications in analyzing LIB components, including anodes, cathodes, and solid-state electrolytes.We critically assess specific testing methodologies and operational modes, providing a clear perspective on how TOF-SIMS elucidates interfacial phenomena and component distribution. Finally, we offer an outlook on the future utilization of TOF-SIMS to deepen the understanding of electrochemical mechanisms in LIBs. This review aims to establish a new pathway for lithium characterization, thereby accelerating the development of high-performance LIBs.</div></div>","PeriodicalId":338,"journal":{"name":"International Journal of Mass Spectrometry","volume":"521 ","pages":"Article 117584"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of cleavable crosslinking for characterization of proteoform structural differences by top-down mass spectrometry 自顶向下质谱法评价可切割交联对蛋白质形态结构差异表征的影响

IF 1.7 3区化学

International Journal of Mass Spectrometry Pub Date : 2026-03-01 Epub Date: 2026-01-03 DOI: 10.1016/j.ijms.2026.117570

Erika A. Renbarger , Ian K. Webb

{"title":"Evaluation of cleavable crosslinking for characterization of proteoform structural differences by top-down mass spectrometry","authors":"Erika A. Renbarger , Ian K. Webb","doi":"10.1016/j.ijms.2026.117570","DOIUrl":"10.1016/j.ijms.2026.117570","url":null,"abstract":"<div><div>Cleavable crosslinking has traditionally been employed in bottom-up mass spectrometry to elucidate protein structure and protein-protein interactions through identification of peptides bearing characteristic mass adducts. Here, we demonstrate the application of cleavable crosslinking in top-down mass spectrometry to enhance fragmentation efficiency and enable precise localization of crosslink sites. We first validated this approach using cytochrome <em>c, a</em> well-characterized model protein. Subsequently, we extended top-down cleavable crosslinking to transthyretin, a natively homotetrameric protein exhibiting extensive proteoform heterogeneity, to investigate whether proteoform variations induce structural changes detectable by this method. Our results confirm that cleavable crosslinks can be detected and characterized by top-down mass spectrometry, with crosslinker cleavage under collisional activation significantly enhancing fragmentation. Application to transthyretin (intramolecular crosslinks) yielded complex crosslinking patterns that precluded complete identification of crosslinks. However, the crosslinking data provided valuable information on solvent-accessible residues, functioning effectively as a covalent labeling strategy. This work establishes cleavable crosslinking as a viable chemical crosslinking approach for top-down mass spectrometry applications.</div></div>","PeriodicalId":338,"journal":{"name":"International Journal of Mass Spectrometry","volume":"521 ","pages":"Article 117570"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145940117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and analysis of resolution-limiting factors in an alpha time-of-flight spectrometer 飞行时间光谱仪分辨率限制因素的识别与分析

IF 1.7 3区化学

International Journal of Mass Spectrometry Pub Date : 2026-03-01 Epub Date: 2026-01-09 DOI: 10.1016/j.ijms.2026.117571

M. Azizi , B. Ghasemi , O. Kakuee , A. Biganeh

引用次数: 0

Impact of supercharging on top-down characterization of monoclonal antibodies by collision induced dissociation 增压对碰撞诱导解离单克隆抗体自上而下表征的影响

IF 1.7 3区化学

International Journal of Mass Spectrometry Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.ijms.2026.117578

Lasini Amunugama, Jared B. Shaw

{"title":"Impact of supercharging on top-down characterization of monoclonal antibodies by collision induced dissociation","authors":"Lasini Amunugama, Jared B. Shaw","doi":"10.1016/j.ijms.2026.117578","DOIUrl":"10.1016/j.ijms.2026.117578","url":null,"abstract":"<div><div>Native top-down characterization of monoclonal antibodies (mAbs) is an attractive approach due to the narrow charge state distribution of the intact mAb and the spectral decongestion afforded by relatively low charge product ions being spread over a broad <em>m/z</em> range. However, low precursor charge and extensive disulfide bonding together greatly limit characterization by collision induced dissociation (CID). This study evaluates solution phase supercharging in ammonium acetate electrospray solutions to produce charge state distributions with intermediate charge, i.e., somewhere between native and fully denatured. Sequence coverage and interchain disulfide bond cleavage were evaluated as a function of precursor charge and collision energy for denatured, native, and supercharged “native” mAb precursor ions. Native ESI produced low charge precursors (z∼22–23) that required high collision energies (∼200–225 eV/q) for interchain disulfide cleavages (i.e., light chain (LC) release) and yielded modest sequence coverage. Formic acid, 50:50 acetonitrile/water with formic acid, dimethyl sulfoxide, propylene carbonate, and sulfolane were compared as additives; many increased precursors charge states but produced broader envelopes and degraded spectral quality. In contrast 3 % sulfolane in 100 mM ammonium acetate increased average charges to ∼39 for Infliximab and ∼42 for SigmaMAb and reduced the dissociation threshold to 125 eV/q as expected for higher charge precursor ions. Optimized conditions produced abundant [LC-S]/[LC]/[LC+S] triplets and extended b/y ions into CDR3 regions. Overall, adding 3 % sulfolane in ammonium acetate provides a practical way to overcome key CID limitations for intact mAbs and enables more extensive sequence characterization.</div></div>","PeriodicalId":338,"journal":{"name":"International Journal of Mass Spectrometry","volume":"521 ","pages":"Article 117578"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in tapping-mode scanning probe electrospray ionization (t-SPESI): Instrumental development for high-spatial-resolution ambient mass spectrometry imaging 挖掘模式扫描探针电喷雾电离（t-SPESI）的研究进展：高空间分辨率环境质谱成像仪器的开发

IF 1.7 3区化学

International Journal of Mass Spectrometry Pub Date : 2026-03-01 Epub Date: 2025-12-29 DOI: 10.1016/j.ijms.2025.117569

Yoichi Otsuka

{"title":"Advances in tapping-mode scanning probe electrospray ionization (t-SPESI): Instrumental development for high-spatial-resolution ambient mass spectrometry imaging","authors":"Yoichi Otsuka","doi":"10.1016/j.ijms.2025.117569","DOIUrl":"10.1016/j.ijms.2025.117569","url":null,"abstract":"<div><div>Mass spectrometry imaging (MSI) is an essential technique for visualizing the distribution of molecules in biological tissues. Ambient sampling ionization-based MSI has attracted attention for its ability to analyze samples directly; however, improving spatial resolution remains a major technical challenge. Young Scientist developed a tapping-mode scanning probe electrospray ionization (t-SPESI) method that uniquely combines the core technologies of electrospray ionization (ESI) and atomic force microscopy (AFM). By using an oscillating capillary probe to periodically supply minute amounts of solvent to the sample surface, t-SPESI enables spatiotemporal separation of the extraction and ionization processes, allowing rapid, soft ionization of analytes in micro-regions of the sample. In addition, the oscillating probe senses the sample surface, minimizing the influence of surface topography on extraction and ionization during MSI. Young Scientist has further advanced high-spatial-resolution t-SPESI-MSI through the development of feedback-control methods, probe fabrication techniques, and miniaturization of t-SPESI units. This paper provides an overview of the progress made in the development of t-SPESI instrumentation and highlights MSI results obtained from tissues and single cells.</div></div>","PeriodicalId":338,"journal":{"name":"International Journal of Mass Spectrometry","volume":"521 ","pages":"Article 117569"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145874131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paper spray analysis of crude oil samples: comparing traditional characterization schemes with mass spectrometric outcomes 原油样品的纸喷分析：传统表征方案与质谱结果的比较

IF 1.7 3区化学

International Journal of Mass Spectrometry Pub Date : 2026-02-01 Epub Date: 2025-11-25 DOI: 10.1016/j.ijms.2025.117554

Theis I. Solling , Nathan F. Dalleska , Syed S. Hussain , J.L. Beauchamp

{"title":"Paper spray analysis of crude oil samples: comparing traditional characterization schemes with mass spectrometric outcomes","authors":"Theis I. Solling , Nathan F. Dalleska , Syed S. Hussain , J.L. Beauchamp","doi":"10.1016/j.ijms.2025.117554","DOIUrl":"10.1016/j.ijms.2025.117554","url":null,"abstract":"<div><div>Crude oil constitutes one of the most complex mixtures in the world and its characterization is challenging yet absolutely essential in any upstream related production context. Traditionally, this has been addressed in fractionation of the oil into saturates, aromatics, resins and asphaltenes; the SARA protocol. We have employed this conventional approach on three crude oils to compare results with mass spectrometric analysis in paper spray ionization mode where the crude does not enter inlets nor does it adhere to interfaces and therefore leaves no memory effects. Thus, it has proven to be an extremely convenient method for oil characterization as crude normally tends to damage analytical equipment by contamination. We have found that the densities of the three crude oils align very well with their SARA analyses in the sense that more saturates (alkanes) correspond to less dense oils. The paper spray ionization mass spectrometry handles the oil that consists of mostly saturates poorly and results in ill-defined peak shapes. A few peaks stand out and are most likely highly polar production compounds that are more easily ionized. On the other hand, the oils with aromatic components result in nice spectra and coupling the paper spray to HRMS clearly reveals the alkyl-aromatics. The combined results show that paper spray provides a fast valuable, non-contaminating route to oil characterization that provides actual structural insights; something that the traditional oil characterization methods can never be brought to do. We also show that production-relevant surfactants are readily characterized with paper spray. Thus, with some development it will facilitate the characterization of residual production chemicals in light crudes and guide the refining process.</div></div>","PeriodicalId":338,"journal":{"name":"International Journal of Mass Spectrometry","volume":"520 ","pages":"Article 117554"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0