{"title":"Impact of COVID-19 pandemic on cardiovascular health in sedentary and athletes: Consensus, uncertainties, and ways for mitigation","authors":"","doi":"10.1016/j.smhs.2024.06.003","DOIUrl":"10.1016/j.smhs.2024.06.003","url":null,"abstract":"","PeriodicalId":33620,"journal":{"name":"Sports Medicine and Health Science","volume":"6 3","pages":"Pages 205-208"},"PeriodicalIF":2.3,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666337624000659/pdfft?md5=a7b31f2d2d6be484c49b0e2fb046a2de&pid=1-s2.0-S2666337624000659-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141404131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of COVID-19 on the cardiovascular system: A mendelian randomization study","authors":"","doi":"10.1016/j.smhs.2024.06.001","DOIUrl":"10.1016/j.smhs.2024.06.001","url":null,"abstract":"<div><p>Infections with the coronavirus disease 2019 (COVID-19) and disorders of the heart and blood vessels are causally related. To ascertain the causal relationship between COVID-19 and cardiovascular disease (CVD), we carried out a Mendelian randomization (MR) study through a method known as inverse variance weighting (IVW). When analyzing multiple SNPs, MR can meta-aggregate the effects of multiple loci by using IVW meta-pooling method. The weighted median (WM) is the median of the distribution function obtained by ranking all individual SNP effect values according to their weights. WM yields robust estimates when at least 50% of the information originates from valid instrumental variables (IVs). Directed gene pleiotropy in the included IVs is permitted because MR–Egger does not require a regression straight line through the origin. For MR estimation, IVW, WM and MR-Egger were employed. Sensitivity analysis was conducted using funnel plots, Cochran's <em>Q</em> test, MR–Egger intercept test, MR–PRESSO, and leave-one-out analysis. SNPs related to exposure to COVID-19 and CVD were compiled. CVD for COVID-19 infection, COVID-19 laboratory/self-reported negative, and other very severe respiratory diagnosis and population were randomly assigned using MR. The COVID-19 laboratory/self-reported negative results and other very severe respiratory confirmed cases versus MR analysis of CVD in the population (<em>p</em> > 0.05); COVID-19 infection to CVD (<em>p</em> = 0.033, <em>OR</em> = 1.001, 95%<em>CI</em>: 1.000–1.001); and the MR–Egger results indicated that COVID-19 infection was associated with CVD risk. This MR study provides preliminary evidence for the validity of the causal link between COVID-19 infection and CVD.</p></div>","PeriodicalId":33620,"journal":{"name":"Sports Medicine and Health Science","volume":"6 3","pages":"Pages 266-272"},"PeriodicalIF":2.3,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666337624000635/pdfft?md5=06179cb20f40d6207945f1019d19bb35&pid=1-s2.0-S2666337624000635-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141411272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effects of prolonged sitting behavior on resting-state brain functional connectivity in college students post-COVID-19 rehabilitation: A study based on fNIRS technology","authors":"","doi":"10.1016/j.smhs.2024.06.002","DOIUrl":"10.1016/j.smhs.2024.06.002","url":null,"abstract":"<div><p>Functional near-infrared spectroscopy (fNIRS) was used to explore the effects of sedentary behavior on the brain functional connectivity characteristics of college students in the resting state after recovering from Corona Virus Disease 2019 (COVID-19). Twenty-two college students with sedentary behavior and 22 college students with sedentary behavior and maintenance of exercise habits were included in the analysis; moreover, 8 min fNIRS resting-state data were collected. Based on the concentrations of oxyhemoglobin (HbO<sub>2</sub>) and deoxyhemoglobin (HbR) in the time series, the resting-state functional connection strength of the two groups of subjects, including the prefrontal cortex (PFC) and the lower limb supplementary motor area (LS), as well as the functional activity and functional connections of the primary motor cortex (M1) were calculated. The following findings were demonstrated. (1) Functional connection analysis based on HbO<sub>2</sub> demonstrated that in the comparison of the mean functional connection strength of homologous regions of interest (ROIs) between the sedentary group and the exercise group, there was no significant difference in the mean functional strength of the ROIs between the two groups (<span><math><mi>p</mi><mspace></mspace><mo>></mo><mspace></mspace><mn>0.05</mn></math></span>). In the comparison of the mean functional connection strengths of the two groups of heterologous ROIs, the functional connection strengths of the right PFC and the right LS (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.009</mn><mspace></mspace><mn>7</mn></mrow></math></span>), the left LS (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.012</mn><mspace></mspace><mn>7</mn></mrow></math></span>), and the right M1 (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.030</mn><mspace></mspace><mn>5</mn></mrow></math></span>) in the sedentary group were significantly greater. The functional connection strength between the left PFC and the right LS (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.031</mn><mspace></mspace><mn>2</mn></mrow></math></span>) and the left LS (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.037</mn><mspace></mspace><mn>0</mn></mrow></math></span>) was significantly greater. Additionally, the functional connection strength between the right LS and the right M1 (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.037</mn><mspace></mspace><mn>0</mn></mrow></math></span>) and the left LS (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.043</mn><mspace></mspace><mn>8</mn></mrow></math></span>) was significantly greater. (2) Functional connection analysis based on HbR demonstrated that there was no significant difference in functional connection strength between the sedentary group and the exercise group (<span><math><mi>p</mi><mspace></mspace><mo>></mo><mspace></mspace><mn>0.05</mn></math></span>) or between the sedentary group and the exercise group (<span><math><mi>p</mi><mspace></mspace><mo>></mo><mspace></mspace><mn>0.05</mn></ma","PeriodicalId":33620,"journal":{"name":"Sports Medicine and Health Science","volume":"6 3","pages":"Pages 287-294"},"PeriodicalIF":2.3,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666337624000647/pdfft?md5=02068de309ea5708de4c1538e6411dbd&pid=1-s2.0-S2666337624000647-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141404518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship between infection, physical and mental health and exercise habits of some Chinese residents after recovery from COVID-19","authors":"","doi":"10.1016/j.smhs.2024.04.005","DOIUrl":"10.1016/j.smhs.2024.04.005","url":null,"abstract":"<div><p>This study aimed to determine the infection status, exercise habits, anxiety levels, and sleep quality in Chinese residents who recovered from infection during the period of coronavirus disease 2019 (COVID-19) period. It also aimed to investigate the influencing factors of recovery status and aid in improving intervention measures for COVID-19 recovery. This study is a sub-study nested within a cross-sectional investigation of infection and physical and mental health among partially recovered residents in all 34 provincial areas of China during the COVID-19 pandemic. A total of 1 013 participants (374 males and 639 females) completed the study. Cardiopulmonary endurance was significantly lower after infection than before infection (<em>p</em> < 0.001). Women (3.92 ± 4.97) exhibited higher levels of anxiety than men (3.33 ± 4.54, <em>p</em> = 0.015). The sleep score was significantly higher after infection (8.27 ± 7.05) than before infection (4.17 ± 4.97, <em>p</em> < 0.001). The active and regular exercise groups exhibited significantly shorter durations of fever than the sedentary and irregular groups (<em>p</em> = 0.033; <em>p</em> = 0.021). Additionally, the active group demonstrated significantly fewer recovery days ([7.32 ± 3.24] days) than the sedentary group ([7.66 ± 3.06] days, <em>p</em> = 0.035). We found a correlation between age and the recovery time of symptoms after COVID-19. We noted that a greater number of symptoms corresponded to poorer cardiopulmonary fitness and sleep quality. Individuals who engage in sedentary lifestyles and irregular exercise regimens generally require prolonged recovery periods. Therefore, incorporating moderate exercise, psychological support, sleep hygiene and other health interventions into post-COVID-19 recovery measures is imperative.</p></div>","PeriodicalId":33620,"journal":{"name":"Sports Medicine and Health Science","volume":"6 3","pages":"Pages 260-265"},"PeriodicalIF":2.3,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266633762400057X/pdfft?md5=a26db81372aed31043c20e3f516a2c64&pid=1-s2.0-S266633762400057X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140783817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changes in physical activity and sleep following the COVID-19 pandemic on a university campus: Perception versus reality","authors":"","doi":"10.1016/j.smhs.2024.04.003","DOIUrl":"10.1016/j.smhs.2024.04.003","url":null,"abstract":"<div><p>It has been hypothesized that key lifestyle behaviors of physical activity and sleep worsened in response to the Coronavirus disease (COVID-19) pandemic. However, there have been inconsistencies in findings of changes in these key lifestyle behaviors across populations likely due to the wide variety of assessment methods. The purpose of the study was to compare physical activity and sleep before and after the COVID-19 pandemic using accelerometers and self-reported behaviors. A longitudinal follow-up was conducted on students, faculty, and staff at a university campus in the United States. In the periods before March 2020 (covering the academic years of 2018–2019 or 2019–2020) and again in April–June 2021, participants completed surveys to evaluate their physical activity and sleep behaviors and wore an accelerometer. A total of 44 participants completed the survey at both timepoints and 32 completed accelerometer assessment at both timepoints. Fifty-seven percent of participants reported a perceived decline in physical activity, while 30% reported a worsening in sleep. From self-reported data, overall physical activity did not change, but there was a decrease in active transport (<em>p</em> < 0.001) and increase in domestic physical activity (<em>p</em> = 0.012). Sleep quality decreased as evidenced by an increase in Pittsburgh Sleep Quality Index scores (<em>p</em> = 0.045). There were no changes in accelerometer measured physical activity or sleep. There were no changes in physical or mental health. While perceptions of physical activity declined from prior to the COVID-19 pandemic, there were no changes in device-measured physical activity, and changes in self-reported physical activity differed by domain.</p></div>","PeriodicalId":33620,"journal":{"name":"Sports Medicine and Health Science","volume":"6 3","pages":"Pages 246-251"},"PeriodicalIF":2.3,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666337624000556/pdfft?md5=8118631aac14134b6589aab6ecc5ca2c&pid=1-s2.0-S2666337624000556-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140766479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiovascular abnormalities of long-COVID syndrome: Pathogenic basis and potential strategy for treatment and rehabilitation","authors":"","doi":"10.1016/j.smhs.2024.03.009","DOIUrl":"10.1016/j.smhs.2024.03.009","url":null,"abstract":"<div><p>Cardiac injury and sustained cardiovascular abnormalities in long-COVID syndrome, i.e. post-acute sequelae of coronavirus disease 2019 (COVID-19) have emerged as a debilitating health burden that has posed challenges for management of pre-existing cardiovascular conditions and other associated chronic comorbidities in the most vulnerable group of patients recovered from acute COVID-19. A clear and evidence-based guideline for treating cardiac issues of long-COVID syndrome is still lacking. In this review, we have summarized the common cardiac symptoms reported in the months after acute COVID-19 illness and further evaluated the possible pathogenic factors underlying the pathophysiology process of long-COVID. The mechanistic understanding of how Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) damages the heart and vasculatures is critical in developing targeted therapy and preventive measures for limiting the viral attacks. Despite the currently available therapeutic interventions, a considerable portion of patients recovered from severe COVID-19 have reported a reduced functional reserve due to deconditioning. Therefore, a rigorous and comprehensive cardiac rehabilitation program with individualized exercise protocols would be instrumental for the patients with long-COVID to regain the physical fitness levels comparable to their pre-illness baseline.</p></div>","PeriodicalId":33620,"journal":{"name":"Sports Medicine and Health Science","volume":"6 3","pages":"Pages 221-231"},"PeriodicalIF":2.3,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666337624000374/pdfft?md5=3e88073339e8479f4a86716b61037f29&pid=1-s2.0-S2666337624000374-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidence of respiratory infections and SARS-CoV-2 is higher during contact phases in student rugby players – Lessons learnt from COVID-19 risk mitigation strategies–AWARE V","authors":"","doi":"10.1016/j.smhs.2024.03.005","DOIUrl":"10.1016/j.smhs.2024.03.005","url":null,"abstract":"<div><p>The incidence of acute respiratory infections (ARinf), including SARS-CoV-2, in unvaccinated student rugby players during phases from complete lockdown during the COVID-19 pandemic to returning to competition is unknown. The aim of the study was to determine the incidence of ARinf (including SARS-CoV-2) during non-contact and contact phases during the COVID-19 pandemic to evaluate risk mitigation strategies. In this retrospective cohort study, 319 top tier rugby players from 17 universities completed an online questionnaire. ARinf was reported during 4 phases over 14 months (April 2020–May 2021): phase 1 (individual training), phase 2 (non-contact team training), phase 3 (contact team training) and phase 4 (competition). Incidence (per 1 000 player days) and Incidence Ratio (IR) for ‘All ARinf’, and subgroups (SARS-CoV-2; ‘Other ARinf’) are reported. Selected factors associated with ARinf were also explored. The incidence of ‘All ARinf’ (0.31) was significantly higher for SARS-CoV-2 (0.23) vs. ‘Other ARinf’ (0.08) (<em>p</em> < 0.01). The incidence of ‘All ARinf’ (IR = 3.6; <em>p</em> < 0.01) and SARS-CoV-2 (IR = 4.2; <em>p</em> < 0.01) infection was significantly higher during contact (phases 3 + 4) compared with non-contact (phases 1 + 2). Demographics, level of sport, co-morbidities, allergies, influenza vaccination, injuries and lifestyle habits were not associated with ARinf incidence. In student rugby, contact phases are associated with a 3–4 times higher incidence of ARinf/SARS-CoV-2 compared to non-contact phases. Infection risk mitigation strategies in the contact sport setting are important. Data from this study serve as a platform to which future research on incidence of ARinf in athletes within contact team sports, can be compared.</p></div>","PeriodicalId":33620,"journal":{"name":"Sports Medicine and Health Science","volume":"6 3","pages":"Pages 252-259"},"PeriodicalIF":2.3,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666337624000337/pdfft?md5=774c9986f3bf749352a2d8ac689724dc&pid=1-s2.0-S2666337624000337-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The missing hydrogen ion, Part-3: Science and the human flaws that compromise it","authors":"Robert Robergs, Bridgette O'Malley, Sam Torrens","doi":"10.1016/j.smhs.2024.03.008","DOIUrl":"10.1016/j.smhs.2024.03.008","url":null,"abstract":"<div><p>The purpose of this research was to use a historical method and core principles from scientific philosophy to explain why mistakes were made in the development of the lactic acidosis construct. On a broader scope, this research explains what science is, why some scientists despite good intention, often get it wrong, and why it takes so long (decades) to correct these errors. Science is a human behaviour that consists of the identification of a problem based on the correct application of prior knowledge, the development of a method to best resolve or test the problem, completion of these methods to acquire results, and then a correct interpretation of the results. If these steps are done correctly there is an increased probability (no guarantee) that the outcome is likely to be correct. Thomas Kuhn proposed that you can understand what science is from how it has been performed, and from his essays he revealed a very dysfunctional form of science that he called ‘normal’ (due the preponderance of its presence) science. Conversely, Karl Popper was adamant that the practice of ‘normal’ science revealed numerous flaws that deviate from fundamental principles that makes science, science. Collectively, the evidence reveals that within the sports medicine and health sciences, as with all disciplines, errors in science are more frequent than you might expect. There is an urgent need to improve how we educate and train scientists to prevent the pursuit of ‘normal’ science and the harm it imparts on humanity.</p></div>","PeriodicalId":33620,"journal":{"name":"Sports Medicine and Health Science","volume":"6 2","pages":"Pages 193-199"},"PeriodicalIF":0.0,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666337624000362/pdfft?md5=1ef364e76d27434a680eba8f979ffd96&pid=1-s2.0-S2666337624000362-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Myocarditis – A silent killer in athletes: Comparative analysis on the evidence before and after COVID-19 pandemic","authors":"","doi":"10.1016/j.smhs.2024.03.003","DOIUrl":"10.1016/j.smhs.2024.03.003","url":null,"abstract":"<div><p>Myocarditis is a rare cardiomyocyte inflammatory process, typically caused by viruses, with potentially devastating cardiac sequalae in both competitive athletes and in the general population. Investigation into myocarditis prevalence in the Coronavirus disease 2019 (COVID-19) era suggests that infection with Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is an independent risk factor for myocarditis, which is confirmed mainly through cardiovascular magnetic resonance imaging. Recent studies indicated that athletes have a decreased risk of myocarditis after recent COVID-19 infection compared to the general population. However, given the unique nature of competitive athletics with their frequent participation in high-intensity exercise, athletes possess distinct factors of susceptibility for the development of myocarditis and its subsequent severe cardiac complications (e.g., sudden cardiac death, fulminant heart failure, etc.). Under this context, this review focuses on comparing myocarditis in athletes versus non-athletes, owing special attention to the distinct clinical presentations and outcomes of myocarditis caused by different viral pathogens such as cytomegalovirus, Epstein-Barr virus, human herpesvirus-6, human immunodeficiency virus, and Parvovirus B19, both before and after the COVID-19 pandemic, as compared with SARS-CoV-2. By illustrating distinct clinical presentations and outcomes of myocarditis in athletes versus non-athletes, we also highlight the critical importance of early detection, vigilant monitoring, and effective management of viral and non-viral myocarditis in athletes and the necessity for further optimization of the return-to-play guidelines for athletes in the COVID-19 era, in order to minimize the risks for the rare but devastating cardiac fatality.</p></div>","PeriodicalId":33620,"journal":{"name":"Sports Medicine and Health Science","volume":"6 3","pages":"Pages 232-239"},"PeriodicalIF":2.3,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666337624000313/pdfft?md5=dc03c34d5d7a25284229faf0cceb3e71&pid=1-s2.0-S2666337624000313-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140273642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew George , Brendan M. Holderread , Bradley S. Lambert , Joshua D. Harris , Patrick C. McCulloch
{"title":"Post-operative protein supplementation following orthopaedic surgery: A systematic review","authors":"Andrew George , Brendan M. Holderread , Bradley S. Lambert , Joshua D. Harris , Patrick C. McCulloch","doi":"10.1016/j.smhs.2023.08.002","DOIUrl":"10.1016/j.smhs.2023.08.002","url":null,"abstract":"<div><p>Decreased mechanical loading after orthopaedic surgery predisposes patients to develop muscle atrophy. The purpose of this review was to assess whether the evidence supports oral protein supplementation can help decrease postoperative muscle atrophy and/or improve patient outcomes following orthopaedic surgery. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). PubMed (MEDLINE), Embase, Scopus, and Web of Science were searched for randomized controlled trials that assessed protein or amino acid supplementation in patients undergoing orthopaedic surgery. Two investigators independently conducted the search using relevant Boolean operations. Primary outcomes included functional or physiologic measures of muscle atrophy or strength. Fourteen studies including 611 patients (224 males, 387 females) were analyzed. Three studies evaluated protein supplementation after ACL reconstruction (ACLR), 3 after total hip arthroplasty (THA), 5 after total knee arthroplasty (TKA), and 3 after surgical treatment of hip fracture. Protein supplementation showed beneficial effects across all types of surgery. The primary benefit was a decrease in muscle atrophy compared to placebo as measured by muscle cross sectional area. Multiple authors also demonstrated improved functional measures and quicker achievement of rehabilitation benchmarks. Protein supplementation has beneficial effects on mitigating muscle atrophy in the postoperative period following ACLR, THA, TKA, and surgical treatment of hip fracture. These effects often correlate with improved functional measures and quicker achievement of rehabilitation benchmarks. Further research is needed to evaluate long-term effects of protein supplementation and to establish standardized population-specific regimens that maximize treatment efficacy in the postoperative period.</p></div>","PeriodicalId":33620,"journal":{"name":"Sports Medicine and Health Science","volume":"6 1","pages":"Pages 16-24"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666337623000501/pdfft?md5=ed530e260a62d3df30545735248a6c87&pid=1-s2.0-S2666337623000501-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43667313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}