Precision Clinical Medicine最新文献_第10页

Pharmacogenomics 药物基因组学

IF 5.3 4区医学

Precision Clinical Medicine Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-819834-6.00006-9

J. Crabtree

引用次数: 0

Index 指数

IF 5.3 4区医学

Precision Clinical Medicine Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-819834-6.20001-3

引用次数: 0

Translating current biomedical therapies for long duration, deep space missions. 将目前的生物医学疗法转化为长时间的深空任务。

IF 5.3 4区医学

Precision Clinical Medicine Pub Date : 2019-12-01 Epub Date: 2019-11-15 DOI: 10.1093/pcmedi/pbz022

Sonia Iosim, Matthew MacKay, Craig Westover, Christopher E Mason

{"title":"Translating current biomedical therapies for long duration, deep space missions.","authors":"Sonia Iosim, Matthew MacKay, Craig Westover, Christopher E Mason","doi":"10.1093/pcmedi/pbz022","DOIUrl":"https://doi.org/10.1093/pcmedi/pbz022","url":null,"abstract":"It is been shown that spaceflight-induced molecular, cellular, and physiologic changes cause alterations across many modalities of the human body, including cardiovascular, musculoskeletal, hematological, immunological, ocular, and neurological systems. The Twin Study, a multi-year, multi-omic study of human response to spaceflight, provided detailed and comprehensive molecular and cellular maps of the human response to radiation, microgravity, isolation, and stress. These rich data identified epigenetic, gene expression, inflammatory, and metabolic responses to spaceflight, facilitating a better biomedical roadmap of features that should be monitored and safe-guarded in upcoming missions. Further, by exploring new developments in pre-clinical models and clinical trials, we can begin to design potential cellular interventions for exploration-class missions to Mars and potentially farther. This paper will discuss the overall risks astronauts face during spaceflight, what is currently known about human response to these risks, what pharmaceutical interventions exist for use in space, and which tools of precision medicine and cellular engineering could be applied to aerospace and astronaut medicine.","PeriodicalId":33608,"journal":{"name":"Precision Clinical Medicine","volume":"2 4","pages":"259-269"},"PeriodicalIF":5.3,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/pcmedi/pbz022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37498866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

DNA methylome study of human cerebellar tissues identified genes and pathways possibly involved in essential tremor. 人类小脑组织的DNA甲基组研究鉴定了可能与特发性震颤有关的基因和途径。

IF 5.3 4区医学

Precision Clinical Medicine Pub Date : 2019-12-01 Epub Date: 2019-12-08 DOI: 10.1093/pcmedi/pbz028

Jennifer L Paul, Khashayar Dashtipour, Zhong Chen, Charles Wang

{"title":"DNA methylome study of human cerebellar tissues identified genes and pathways possibly involved in essential tremor.","authors":"Jennifer L Paul, Khashayar Dashtipour, Zhong Chen, Charles Wang","doi":"10.1093/pcmedi/pbz028","DOIUrl":"https://doi.org/10.1093/pcmedi/pbz028","url":null,"abstract":"Background: Essential tremor (ET) is a neurological syndrome of unknown origin with poorly understood etiology and pathogenesis. It is suggested that the cerebellum and its tracts may be involved in the pathophysiology of ET. DNA methylome interrogation of cerebellar tissue may help shine some light on the understanding of the mechanism of the development of ET. Our study used postmortem human cerebellum tissue samples collected from 12 ET patients and 11 matched non-ET controls for DNA methylome study to identify differentially methylated genes in ET.Results: Using Nugen's Ovation reduced representation bisulfite sequencing (RRBS), we identified 753 genes encompassing 938 CpG sites with significant differences in DNA methylation between the ET and the control group. Identified genes were further analyzed with Ingenuity Pathway Analysis (IPA) by which we identified certain significant pathways, upstream regulators, diseases and functions, and networks associated with ET.Conclusions: Our study provides evidence that there are significant differences in DNA methylation patterns between the ET and control samples, suggesting that the methylation alteration of certain genes in the cerebellum may be associated with ET pathogenesis. The identified genes allude to the GABAergic hypothesis which supports the notation that ET is a neurodegenerative disease, particularly involving the cerebellum.","PeriodicalId":33608,"journal":{"name":"Precision Clinical Medicine","volume":"2 4","pages":"221-234"},"PeriodicalIF":5.3,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/pcmedi/pbz028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37498865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gut viruses firm the “Great Wall” 肠道病毒筑起“长城”

IF 5.3 4区医学

Precision Clinical Medicine Pub Date : 2019-12-01 DOI: 10.1093/pcmedi/pbz027

Anmin Wang, Shu Zhu

引用次数: 0

5G and intelligence medicine-how the next generation of wireless technology will reconstruct healthcare? 5G与智能医疗——下一代无线技术将如何重构医疗?

IF 5.3 4区医学

Precision Clinical Medicine Pub Date : 2019-12-01 Epub Date: 2019-10-18 DOI: 10.1093/pcmedi/pbz020

Dong Li

引用次数: 122

Uveitis-glaucoma-hyphema syndrome associated with an in-the-bag square-edge intraocular lens 葡萄膜炎-青光眼-前房积血综合征与袋内方边人工晶状体相关

IF 5.3 4区医学

Precision Clinical Medicine Pub Date : 2019-11-29 DOI: 10.1093/pcmedi/pbz026

Jin Yang, Xiaodi Qiu, Lei Cai, Qi Fan, Anjian Wang, Kang Zhang, Yi Lu

引用次数: 2

Effect of autologous NK cell immunotherapy on advanced lung adenocarcinoma with EGFR mutations 自体NK细胞免疫治疗晚期EGFR突变肺腺癌的疗效观察

IF 5.3 4区医学

Precision Clinical Medicine Pub Date : 2019-11-22 DOI: 10.1093/pcmedi/pbz023

Guodai Hong, Xuemei Chen, Xizhuo Sun, Meiling Zhou, Bing Liu, Zhu Li, Zhen-dong Yu, Wenbin Gao, Tao Liu

{"title":"Effect of autologous NK cell immunotherapy on advanced lung adenocarcinoma with EGFR mutations","authors":"Guodai Hong, Xuemei Chen, Xizhuo Sun, Meiling Zhou, Bing Liu, Zhu Li, Zhen-dong Yu, Wenbin Gao, Tao Liu","doi":"10.1093/pcmedi/pbz023","DOIUrl":"https://doi.org/10.1093/pcmedi/pbz023","url":null,"abstract":"Abstract This study investigated the efficiency of natural killer (NK) cell immunotherapy on non-small cell lung cancer with and without EGFR mutations in order to evaluate the response rate (RR) and progression-free survival (PFS). Among the 48 patients recruited, 24 were clinically confirmed to be EGFR mutation positive. The study group was treated with autologous NK cell immunotherapy. Comparisons of the lymphocyte number, serum tumour-related biomarkers, circulating tumour cells (CTC), Karnofsky Performance Status (KPS) and survival curves were carried out before and after NK cell immunotherapy. The safety and short-term effects were evaluated, followed by median PFS and RR assessments. The serum CEA and CA125 values were found lower in the NK cell therapy group than that of the non-NK treatment group (p < 0.05). The χ2 test showed a 75% RR of the study group A, significantly higher than that of the control group B (16.7%; p < 0.01). The RR of groups C (58.3%) and D (41.7%) were not statistically significant. The p values of the 4 groups were 0.012, 0.012, 0.166 and 1 from group A to group D, respectively. The median PFS was 9 months in EGFR mutation positive group undergoing NK cell infusion interference. By evaluating the changes in immune function, tumour biomarkers, CTC, KPS and PFS, we demonstrated that NK cell therapy had better clinical therapeutic effects on EGFR mutation-positive lung adenocarcinoma.","PeriodicalId":33608,"journal":{"name":"Precision Clinical Medicine","volume":"27 1","pages":"235 - 245"},"PeriodicalIF":5.3,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83731076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Genome-wide characterization of copy number variations in diffuse large B-cell lymphoma with implications in targeted therapy 弥漫性大b细胞淋巴瘤拷贝数变异的全基因组特征及其靶向治疗的意义

IF 5.3 4区医学

Precision Clinical Medicine Pub Date : 2019-11-21 DOI: 10.1093/pcmedi/pbz024

Prashanthi Dharanipragada, N. Parekh

{"title":"Genome-wide characterization of copy number variations in diffuse large B-cell lymphoma with implications in targeted therapy","authors":"Prashanthi Dharanipragada, N. Parekh","doi":"10.1093/pcmedi/pbz024","DOIUrl":"https://doi.org/10.1093/pcmedi/pbz024","url":null,"abstract":"Abstract Diffuse large B-cell lymphoma (DLBCL) is the aggressive form of haematological malignancies with relapse/refractory in ~ 40% of cases. It mostly develops due to accumulation of various genetic and epigenetic variations that contribute to its aggressiveness. Though large-scale structural alterations have been reported in DLBCL, their functional role in pathogenesis and as potential targets for therapy is not yet well understood. In this study we performed detection and analysis of copy number variations (CNVs) in 11 human DLBCL cell lines (4 activated B-cell–like [ABC] and 7 germinal-centre B-cell–like [GCB]), that serve as model systems for DLBCL cancer cell biology. Significant heterogeneity observed in CNV profiles of these cell lines and poor prognosis associated with ABC subtype indicates the importance of individualized screening for diagnostic and prognostic targets. Functional analysis of key cancer genes exhibiting copy alterations across the cell lines revealed activation/disruption of ten potentially targetable immuno-oncogenic pathways. Genome guided in silico therapy that putatively target these pathways is elucidated. Based on our analysis, five CNV-genes associated with worst survival prognosis are proposed as potential prognostic markers of DLBCL.","PeriodicalId":33608,"journal":{"name":"Precision Clinical Medicine","volume":"43 1","pages":"246 - 258"},"PeriodicalIF":5.3,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85122718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Mutation spectrum in GNAQ and GNA11 in Chinese uveal melanoma 中国葡萄膜黑色素瘤GNAQ和GNA11突变谱

IF 5.3 4区医学

Precision Clinical Medicine Pub Date : 2019-11-13 DOI: 10.1093/pcmedi/pbz021

Edward D. Zhang, Meixia Zhang, Gen Li, Charlotte L. Zhang, Zhihuan Li, Guangxi Zang, Z. Su, Ming Zhang, Daoman Xiang, Ling Zhao, Jie Zhu

引用次数: 3